{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T05:57:24Z","timestamp":1783749444340,"version":"3.55.0"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T00:00:00Z","timestamp":1655424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["106698"],"award-info":[{"award-number":["106698"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Belgian Kids Fund for Pediatric Research"}],"content-domain":{"domain":["www.plosglobalpublichealth.org"],"crossmark-restriction":false},"short-container-title":["PLOS Glob Public Health"],"abstract":"<jats:p>Very high unconjugated bilirubin plasma concentrations in neonates (neonatal hyperbilirubinaemia; NH) may cause neurologic damage (kernicterus). Both increased red blood cell turn-over and immaturity of hepatic glucuronidation contribute to neonatal hyperbilirubinaemia. The incidence of NH requiring phototherapy during the first week of life on the Thailand-Myanmar border is high (approximately 25%). On the Thailand-Myanmar border we investigated the contribution of genetic risk factors to high bilirubin levels in the first month of life in 1596 neonates enrolled in a prospective observational birth cohort study. Lower gestational age (&lt;38 weeks), mutations in the genes encoding glucose-6-phosphate dehydrogenase (G6PD) and uridine 5\u2032-diphospho-glucuronosyltransferase (UGT) 1A1 were identified as the main independent risk factors for NH in the first week, and for prolonged jaundice in the first month of life. Population attributable risks (PAR%) were 61.7% for lower gestational age, 22.9% for hemi or homozygous and 9.9% for heterozygous G6PD deficiency respectively, and 6.3% for UGT1A1*6 homozygosity. In neonates with an estimated gestational age \u2265 38 weeks, G6PD mutations contributed PARs of 38.1% and 23.6% for \u201cearly\u201d (\u2264 48 hours) and \u201clate\u201d (49\u2013168 hours) NH respectively. For late NH, the PAR for UGT1A1*6 homozygosity was 7.7%. Maternal excess weight was also a significant risk factor for \u201cearly\u201d NH while maternal mutations on the beta-globin gene, prolonged rupture of membranes, large haematomas and neonatal sepsis were risk factors for \u201clate\u201d NH. For prolonged jaundice during the first month of life, G6PD mutations and UGT1A1*6 mutation, together with lower gestational age at birth and presence of haematoma were significant risk factors. In this population, genetic factors contribute considerably to the high risk of NH. Diagnostic tools to identify G6PD deficiency at birth would facilitate early recognition of high risk cases.<\/jats:p>","DOI":"10.1371\/journal.pgph.0000475","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T17:24:19Z","timestamp":1655486659000},"page":"e0000475","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgph.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Contribution of genetic factors to high rates of neonatal hyperbilirubinaemia on the Thailand-Myanmar 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Turner","year":"2013","journal-title":"PloS one"},{"issue":"10","key":"pgph.0000475.ref016","doi-asserted-by":"crossref","first-page":"e0258127","DOI":"10.1371\/journal.pone.0258127","article-title":"High levels of pathological jaundice in the first 24 hours and neonatal hyperbilirubinaemia in an epidemiological cohort study on the Thailand-Myanmar border","volume":"16","author":"L Thielemans","year":"2021","journal-title":"PloS one"},{"key":"pgph.0000475.ref017","doi-asserted-by":"crossref","first-page":"72","DOI":"10.12688\/wellcomeopenres.12338.1","article-title":"Prevalences of inherited red blood cell disorders in pregnant women of different ethnicities living along the Thailand-Myanmar border","volume":"2","author":"G Bancone","year":"2017","journal-title":"Wellcome open research"},{"issue":"1","key":"pgph.0000475.ref018","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12887-017-0798-8","article-title":"Neonatal Hyperbilirubinemia in a Marginalized Population on 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Neonatal jaundice: clinical guideline. 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promoter region and first exon of UGT1A1 gene polymorphisms in Vietnamese newborns","volume":"88","author":"TT Nguyen","year":"2020","journal-title":"Pediatric research"},{"key":"pgph.0000475.ref038","doi-asserted-by":"crossref","first-page":"7803175","DOI":"10.1155\/2018\/7803175","article-title":"Identification of Genetic Risk Factors for Neonatal Hyperbilirubinemia in Fujian Province, Southeastern China: A Case-Control Study","volume":"2018","author":"J Zhou","year":"2018","journal-title":"Biomed Res Int"},{"issue":"1","key":"pgph.0000475.ref039","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0022-3476(66)80422-5","article-title":"Studies of prolonged neonatal jaundice in the breast-fed infant","volume":"68","author":"LM Gartner","year":"1966","journal-title":"The Journal of pediatrics"},{"issue":"1","key":"pgph.0000475.ref040","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1136\/adc.2010.199984","article-title":"NICE recommendations for the formal 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