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This study utilises Poisson regression models to assess the seasonality of six important infections in tropical Australia and their association with climatic factors and severe weather events over a 21-year period. Melioidosis and leptospirosis showed marked wet season predominance, while more cases of rickettsial disease and cryptococcosis were seen in cooler, drier months.<jats:italic>Staphylococcus aureus<\/jats:italic>infections were not seasonal, while influenza demonstrated inter-seasonality. The climate did not significantly change during the 21 years of the study period, but the incidence of melioidosis and rickettsial disease increased considerably, highlighting the primacy of other factors\u2014including societal inequality, and the impact of urban expansion\u2014in the incidence of these infections. While anthropogenic climate change poses a threat to the region\u2014and may influence the burden of these infections in the future\u2014this study highlights the fact that, even for seasonal diseases, other factors presently have a greater effect on disease incidence. Public health strategies must also target these broader drivers of infection if they are to be effective.<\/jats:p>","DOI":"10.1371\/journal.pgph.0000506","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T17:28:38Z","timestamp":1653499718000},"page":"e0000506","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgph.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["The seasonality of infections in tropical Far North Queensland, Australia: A 21-year retrospective evaluation of the seasonal patterns of six endemic pathogens"],"prefix":"10.1371","volume":"2","author":[{"given":"Lee J.","family":"Fairhead","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1845-4476","authenticated-orcid":true,"given":"Beatrice Z.","family":"Sim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3266-3250","authenticated-orcid":true,"given":"Alexandra G. 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