{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:42:09Z","timestamp":1791999729135,"version":"4.4.0"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["215515\/Z\/19\/Z"],"award-info":[{"award-number":["215515\/Z\/19\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosglobalpublichealth.org"],"crossmark-restriction":false},"short-container-title":["PLOS Glob Public Health"],"abstract":"<jats:p>Sepsis is a major cause of neonatal mortality and children born in low- and middle-income countries (LMICs) are at greater risk of severe neonatal infections than those in higher-income countries. Despite this disparity, there are limited contemporaneous data linking the clinical features of neonatal sepsis with outcome in LMICs. Here, we aimed to identify factors associated with mortality from neonatal sepsis in Vietnam. We conducted a prospective, observational study to describe the clinical features, laboratory characteristics, and mortality rate of neonatal sepsis at a major children\u2019s hospital in Ho Chi Minh City. All in-patient neonates clinically diagnosed with probable or culture-confirmed sepsis meeting inclusion criteria from January 2017 to June 2018 were enrolled. We performed univariable analysis and logistic regression to identify factors independently associated with mortality. 524 neonates were recruited. Most cases were defined as late-onset neonatal sepsis and were hospital-acquired (91.4% and 73.3%, respectively). The median (IQR) duration of hospital stay was 23 (13\u201341) days, 344\/524 (65.6%) had a positive blood culture (of which 393 non-contaminant organisms were isolated), and 69\/524 (13.2%) patients died. Coagulase-negative staphylococci (232\/405; 57.3%), <jats:italic>Klebsiella<\/jats:italic> spp. (28\/405; 6.9%), and <jats:italic>Escherichia coli<\/jats:italic> (27\/405; 6.7%) were the most isolated organisms. Sclerema (OR = 11.4), leukopenia &lt;4,000\/mm<jats:sup>3<\/jats:sup> (OR = 7.8), thrombocytopenia &lt;100,000\/mm<jats:sup>3<\/jats:sup> (OR = 3.7), base excess &lt; \u201320 mEq\/L (OR = 3.6), serum lactate &gt;4 mmol\/L (OR = 3.4), extremely low birth weight (OR = 3.2), and hyperglycaemia &gt;180 mg\/dL (OR = 2.6) were all significantly (<jats:italic>p<\/jats:italic>&lt;0.05) associated with mortality. The identified risk factors can be adopted as prognostic factors for the diagnosis and treatment of neonatal sepsis and enable early risk stratification and interventions appropriate to reduce neonatal sepsis in LMIC settings.<\/jats:p>","DOI":"10.1371\/journal.pgph.0000875","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T17:23:27Z","timestamp":1662139407000},"page":"e0000875","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgph.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Clinical and laboratory factors associated with neonatal sepsis mortality at a major Vietnamese children\u2019s hospital"],"prefix":"10.1371","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0904-9807","authenticated-orcid":true,"given":"Nguyen 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Quoc","family":"Thinh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Kien","family":"Mau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pham Thi Thanh","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cam Ngoc","family":"Phuong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5405-7198","authenticated-orcid":true,"given":"Le Nguyen Thanh","family":"Nhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngo Ngoc Quang","family":"Minh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngo Minh","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tang Chi","family":"Thuong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thanh","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Boinett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Reece","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5179-650X","authenticated-orcid":true,"given":"Abhilasha","family":"Karkey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7843-6280","authenticated-orcid":true,"given":"Jeremy N.","family":"Day","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1308-5755","authenticated-orcid":true,"given":"Stephen","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"issue":"3","key":"pgph.0000875.ref001","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S2213-2600(18)30063-8","article-title":"The global burden of paediatric and neonatal sepsis: a systematic review","volume":"6","author":"C Fleischmann-Struzek","year":"2018","journal-title":"Lancet Respir Med"},{"issue":"6","key":"pgph.0000875.ref002","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/PCC.0000000000000157","article-title":"Time for a neonatal-specific consensus definition for sepsis","volume":"15","author":"J Wynn","year":"2014","journal-title":"Pediatr Crit Care 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Gleason","year":"2012","edition":"9"},{"key":"pgph.0000875.ref037","volume-title":"Fanaroff and Martin\u2019s Neonatal-Perinatal medicine: Diseases of the Fetus and Infant","author":"R Martin","year":"2015","edition":"1"},{"issue":"12","key":"pgph.0000875.ref038","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1111\/apa.12764","article-title":"Meta-analysis shows that infants who have suffered neonatal sepsis face an increased risk of mortality and severe complications","volume":"103","author":"S Bakhuizen","year":"2014","journal-title":"Acta Paediatr"},{"issue":"1","key":"pgph.0000875.ref039","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1471-2393-12-48","article-title":"Risk factors and prognosis for neonatal sepsis in southeastern Mexico: analysis of a four-year historic cohort follow-up","volume":"12","author":"Y Leal","year":"2012","journal-title":"BMC Pregnancy 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