{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T01:38:43Z","timestamp":1783388323695,"version":"3.54.6"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosglobalpublichealth.org"],"crossmark-restriction":false},"short-container-title":["PLOS Glob Public Health"],"abstract":"<jats:p>Scientific literature suggests that pregnant women are at greater risk of acquiring a more severe form of COVID-19 exposing both mother and child to a higher risk of obstetric and neonatal complications. These include increased hospitalization rates, ICU admissions, or ventilatory support among pregnant women when compared to COVID-19 negative pregnant womenA case-control study was conducted at the Aga Khan University Hospital, Karachi, Pakistan with the objective of evaluating the clinical presentation of COVID-19 in pregnancy and its effect on maternal and neonatal outcomes. Data was retrospectively collected from April 2020 till January 2022 of obstetric patients with COVID-19 positive cases and were compared with COVID-19 negative cases from the same time. A total of 491 women were included in the study, 244 cases and 247 controls. The most common complication amongst cases was gestational diabetes mellitus (n = 59, 24%), followed by gestational hypertension (n = 16, 31.7%), pre-eclampsia (n = 13, 5%) Pre-rupture of membrane (85.7%). Amongst the COVID positive mothers the most common presenting complaints were fever followed by dry cough, headache, and shortness of breath. It was observed that COVID-19 did not result in increased adverse maternal or neonatal outcomes compared to COVID-19 negative mothers.<\/jats:p>","DOI":"10.1371\/journal.pgph.0002139","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T17:20:53Z","timestamp":1691774453000},"page":"e0002139","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgph.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of COVID-19 on feto-maternal and neonatal health in Karachi, Pakistan, A retrospective cohort study"],"prefix":"10.1371","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9446-3468","authenticated-orcid":true,"given":"Syeda Mahjabeen","family":"Zehra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4693-0169","authenticated-orcid":true,"given":"Sadia","family":"Parkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3669-0851","authenticated-orcid":true,"given":"Zaubina","family":"Kazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9157-1711","authenticated-orcid":true,"given":"Asma","family":"Pethani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2553-9569","authenticated-orcid":true,"given":"Ayesha","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Mirza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1238-4414","authenticated-orcid":true,"given":"Falak","family":"Abro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan Abdul","family":"Jabbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Faisal","family":"Saleem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,8,11]]},"reference":[{"issue":"2","key":"pgph.0002139.ref001","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s11166-020-09337-2","article-title":"Pricing the global health risks of the COVID-19 pandemic","volume":"61","author":"WK Viscusi","year":"2020","journal-title":"Journal of Risk and Uncertainty"},{"issue":"3","key":"pgph.0002139.ref002","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1057\/s41271-020-00229-y","article-title":"The COVID-19 infection: lessons from the Italian experience","volume":"41","author":"P Romagnani","year":"2020","journal-title":"Journal of public health policy"},{"issue":"7","key":"pgph.0002139.ref003","doi-asserted-by":"crossref","first-page":"e0235590","DOI":"10.1371\/journal.pone.0235590","article-title":"Elderly people and responses to COVID-19 in 27 Countries.","volume":"15","author":"J-F Daoust","year":"2020","journal-title":"PloS one"},{"issue":"2","key":"pgph.0002139.ref004","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.wombi.2020.09.022","article-title":"The experiences of pregnant women during the COVID-19 pandemic in Turkey: A qualitative study.","volume":"34","author":"BM Sahin","year":"2021","journal-title":"Women and Birth"},{"issue":"1","key":"pgph.0002139.ref005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-021-92885-7","article-title":"Inflammatory biomarkers in pregnant women with COVID-19: a retrospective cohort study.","volume":"11","author":"A Lombardi","year":"2021","journal-title":"Scientific Reports"},{"key":"pgph.0002139.ref006","author":"M. 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