{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T11:30:07Z","timestamp":1787830207642,"version":"build-2784847793"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1127625"],"award-info":[{"award-number":["OPP1127625"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002992","name":"Department for International Development","doi-asserted-by":"publisher","award":["MC-A760-5QX00"],"award-info":[{"award-number":["MC-A760-5QX00"]}],"id":[{"id":"10.13039\/501100002992","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["220225\/Z\/20\/Z"],"award-info":[{"award-number":["220225\/Z\/20\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/P023347\/1"],"award-info":[{"award-number":["MR\/P023347\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","award":["MR\/S018425\/1"],"award-info":[{"award-number":["MR\/S018425\/1"]}],"id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosglobalpublichealth.org"],"crossmark-restriction":false},"short-container-title":["PLOS Glob Public Health"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Introduction<\/jats:title><jats:p>Iron deficiency is among the leading risk factors for poor cognitive development. However, interventions targeting iron deficiency have had mixed results on cognitive outcomes. This may be due to previous interventions focusing on the correction of iron deficiency anaemia in late infancy and early childhood, at which point long lasting neural impacts may already be established. We hypothesise that the relationship between iron status and cognitive development will be observable in the first months of life and will not be recovered by 5 years of age.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methods<\/jats:title><jats:p>Using data from the Brain Imaging for Global Health (BRIGHT) Study in Gambia (n = 179), we conducted mixed effects modelling to assess the relationship between iron status at 5 months of age and trajectories of cognitive development from 5 months\u2013 5 years using (i) a standardised measure of cognitive development (Mullen Scales of Early Learning) and (ii) an eye-tracking assessment of attention processing (visual disengagement time).<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>All infants were iron sufficient at 1 month of age. At 5 and 12 months of age 30% and 55% of infants were iron deficient respectively. In fully adjusted analyses, infants in the lowest tercile of soluble transferrin receptor (sTfR) (best iron status) achieved MSEL Cognitive Scores on average 1.9 points higher than infants in the highest sTfR tercile (p = 0.009, effect size = 0.48). There was no evidence that this group difference was recovered by 5 years of age. Infants in the lowest sTfR tercile had visual disengagement time 57ms faster than the highest tercile (p = 0.001, effect size = 0.59). However, this difference diminished by early childhood (p = 0.024).<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusion<\/jats:title><jats:p>Infants are at risk of iron deficiency in early infancy. A relationship between iron status and cognitive development is apparent from 5 months of age and remains observable at 5 years of age. One mechanism by which iron availability in early infancy impacts brain development may be through effects on early attentional processing, which is rapidly developing and has substantial nutritional requirements during this period. To support neurocognitive development, prevention of iron deficiency in pre- and early postnatal life may be more effective than correcting iron deficiency once already established.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pgph.0002531","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T17:29:21Z","timestamp":1698859761000},"page":"e0002531","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgph.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Iron status in early infancy is associated with trajectories of cognitive development up to pre-school age in rural Gambia"],"prefix":"10.1371","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7445-4692","authenticated-orcid":true,"given":"Samantha","family":"McCann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9590-0869","authenticated-orcid":true,"given":"Bosiljka","family":"Milosavljevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebrima","family":"Mbye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebou","family":"Touray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alhassan","family":"Colley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6742-9889","authenticated-orcid":true,"given":"Sarah","family":"Lloyd-Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare E.","family":"Elwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie E.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the BRIGHT Study Team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,11,1]]},"reference":[{"issue":"1","key":"pgph.0002531.ref001","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1016\/S2214-109X(13)70001-9","article-title":"Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995\u20132011: a systematic analysis of population-representative data","volume":"1","author":"G. Stevens","year":"2013","journal-title":"The Lancet Global Health"},{"issue":"9556","key":"pgph.0002531.ref002","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0140-6736(07)60076-2","article-title":"Child development: risk factors for adverse outcomes in developing countries","volume":"369","author":"S. Walker","year":"2007","journal-title":"Lancet"},{"issue":"3","key":"pgph.0002531.ref003","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.spen.2006.08.004","article-title":"Iron deficiency and brain development","volume":"13","author":"B. Lozoff","year":"2006","journal-title":"Semin Pediatr Neurol"},{"issue":"1","key":"pgph.0002531.ref004","doi-asserted-by":"crossref","DOI":"10.1186\/s12887-018-1118-7","article-title":"The effect of universal maternal antenatal iron supplementation on neurodevelopment in offspring: A systematic review and meta-analysis","volume":"18","author":"C. Jayasinghe","year":"2018","journal-title":"BMC Pediatrics"},{"key":"pgph.0002531.ref005","first-page":"19","article-title":"A systematic literature review of the relation between iron status\/anemia in pregnancy and offspring neurodevelopment","volume":"19","author":"J. Janbek","year":"2019","journal-title":"European Journal of Clinical Nutrition"},{"issue":"2","key":"pgph.0002531.ref006","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.1016\/S2214-109X(13)70046-9","article-title":"Effect of daily iron supplementation on health in children aged 4\u201323 months: A systematic review and meta-analysis of randomised controlled trials","volume":"1","author":"S. Pasricha","year":"2013","journal-title":"The Lancet Global Health"},{"issue":"4","key":"pgph.0002531.ref007","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1542\/peds.2012-2256","article-title":"Effects of daily iron supplementation in 2- to 5-year-old children: Systematic review and meta-analysis","volume":"131","author":"J. Thompson","year":"2013","journal-title":"Pediatrics"},{"issue":"6","key":"pgph.0002531.ref008","article-title":"Iron therapy for improving psychomotor development and cognitive function in children under the age of three with iron deficiency anaemia","volume":"2013","author":"B. Wang","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"Suppl 6","key":"pgph.0002531.ref009","doi-asserted-by":"crossref","first-page":"1588s","DOI":"10.3945\/ajcn.117.155846","article-title":"Iron assessment to protect the developing brain","volume":"106","author":"M Georgieff","year":"2017","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"pgph.0002531.ref010","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.spen.2006.08.004","article-title":"Iron Deficiency and Brain Development","volume":"13","author":"B. Lozoff","year":"2006","journal-title":"Seminars in Pediatric Neurology"},{"issue":"7","key":"pgph.0002531.ref011","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.3390\/nu12072001","article-title":"The Role of Iron in Brain Development: A Systematic Review","volume":"12","author":"S. McCann","year":"2020","journal-title":"Nutrients"},{"issue":"1","key":"pgph.0002531.ref012","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/MPG.0000000000000206","article-title":"Iron requirements of infants and toddlers","volume":"58","author":"M. Domell\u00f6f","year":"2014","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"8","key":"pgph.0002531.ref013","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.3324\/haematol.2018.210146","article-title":"Rapid growth is a dominant predictor of hepcidin suppression and declining ferritin in Gambian infants","volume":"104","author":"A. Armitage","year":"2019","journal-title":"Haematologica"},{"key":"pgph.0002531.ref014","doi-asserted-by":"crossref","first-page":"101555","DOI":"10.1016\/j.infbeh.2021.101555","article-title":"Visual disengagement in young infants in relation to age, sex, SES, developmental level and adaptive functioning","volume":"63","author":"M. Siqueiros Sanchez","year":"2021","journal-title":"Infant Behavior and Development"},{"key":"pgph.0002531.ref015","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1146\/annurev.psych.52.1.337","article-title":"The development of visual attention in infancy","volume":"52","author":"J. Colombo","year":"2001","journal-title":"Annu Rev Psychol"},{"issue":"2","key":"pgph.0002531.ref016","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1080\/87565641.2018.1564310","article-title":"Beyond the Bayley: Neurocognitive Assessments of Development During Infancy and Toddlerhood","volume":"44","author":"N. Brito","year":"2019","journal-title":"Developmental Neuropsychology"},{"key":"pgph.0002531.ref017","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.12688\/gatesopenres.12951.2","article-title":"Implementing neuroimaging and eye tracking methods to assess neurocognitive development of young infants in low- and middle-income countries","volume":"3","author":"L. Katus","year":"2019","journal-title":"Gates Open Res"},{"key":"pgph.0002531.ref018","article-title":"The Brain Imaging for Global Health (BRIGHT) Project: Longitudinal Cohort Study Protocol","author":"S. Lloyd-Fox","year":"2023","journal-title":"Gates Open Res"},{"issue":"Suppl 1","key":"pgph.0002531.ref019","doi-asserted-by":"crossref","first-page":"359s","DOI":"10.3945\/ajcn.116.141762","article-title":"Adjusting ferritin concentrations for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project","volume":"106","author":"S. Namaste","year":"2017","journal-title":"Am J Clin Nutr"},{"key":"pgph.0002531.ref020","doi-asserted-by":"crossref","first-page":"e12808","DOI":"10.1111\/desc.12808","article-title":"Adaptation of the Mullen Scales of Early Learning for use among infants aged 5- to 24-months in rural Gambia","author":"B. Milosavljevic","year":"2019","journal-title":"Dev Sci"},{"key":"pgph.0002531.ref021","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1007\/978-0-387-79948-3_1570","volume-title":"Encyclopedia of Clinical Neuropsychology","author":"L. Shank","year":"2011"},{"issue":"3","key":"pgph.0002531.ref022","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.biopsych.2012.11.030","article-title":"Disengagement of visual attention in infancy is associated with emerging autism in toddlerhood","volume":"74","author":"M. Elsabbagh","year":"2013","journal-title":"Biol Psychiatry"},{"issue":"5","key":"pgph.0002531.ref023","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1469-7610.2008.02051.x","article-title":"Visual orienting in the early broader autism phenotype: disengagement and facilitation","volume":"50","author":"M. Elsabbagh","year":"2009","journal-title":"Journal of child psychology and psychiatry, and allied disciplines"},{"issue":"4","key":"pgph.0002531.ref024","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0163-6383(97)90035-7","article-title":"Infants\u2019 fast saccades in the gap paradigm and development of visual attention","volume":"20","author":"M. Matsuzawa","year":"1997","journal-title":"Infant Behavior and Development"},{"key":"pgph.0002531.ref025","unstructured":"(UNICEF) WHOUNCsF. Indicators for assessing infant and young child feeding practices: definitions and measurement methods. Geneva, Switzerland 2021."},{"issue":"1","key":"pgph.0002531.ref026","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12916-020-1502-7","article-title":"Estimating the burden of iron deficiency among African children","volume":"18","author":"J. Muriuki","year":"2020","journal-title":"BMC Medicine"},{"issue":"8","key":"pgph.0002531.ref027","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.arcped.2020.08.004","article-title":"Childhood anemia and iron deficiency in sub-Saharan Africa\u2013risk factors and prevention: A review","volume":"27","author":"A. Lemoine","year":"2020","journal-title":"Archives de P\u00e9diatrie"},{"issue":"4","key":"pgph.0002531.ref028","doi-asserted-by":"crossref","first-page":"e0249978","DOI":"10.1371\/journal.pone.0249978","article-title":"Prevalence and determinants of severity levels of anemia among children aged 6\u201359 months in sub-Saharan Africa: A multilevel ordinal logistic regression analysis","volume":"16","author":"G. Tesema","year":"2021","journal-title":"PLOS ONE"},{"issue":"5","key":"pgph.0002531.ref029","doi-asserted-by":"crossref","first-page":"e019654","DOI":"10.1136\/bmjopen-2017-019654","article-title":"Individual, maternal and household risk factors for anaemia among young children in sub-Saharan Africa: a cross-sectional study","volume":"8","author":"P. Moschovis","year":"2018","journal-title":"BMJ Open"},{"issue":"4","key":"pgph.0002531.ref030","doi-asserted-by":"crossref","first-page":"e12386","DOI":"10.1111\/mcn.12386","article-title":"Duration of exclusive breastfeeding is a positive predictor of iron status in 6- to 10-month-old infants in rural Kenya","volume":"13","author":"M. Uyoga","year":"2017","journal-title":"Maternal & Child Nutrition"},{"issue":"8","key":"pgph.0002531.ref031","first-page":"Cd003517","article-title":"Optimal duration of exclusive breastfeeding","volume":"2012","author":"M. Kramer","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"issue":"Suppl 6","key":"pgph.0002531.ref032","doi-asserted-by":"crossref","first-page":"1634S","DOI":"10.3945\/ajcn.117.155960","article-title":"Serum ferritin as an indicator of iron status: what do we need to know?","volume":"106","author":"J. Daru","year":"2017","journal-title":"The American journal of clinical nutrition"},{"issue":"1","key":"pgph.0002531.ref033","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12987-020-00190-8","article-title":"Evidence for communication of peripheral iron status to cerebrospinal fluid: clinical implications for therapeutic strategy","volume":"17","author":"J. Connor","year":"2020","journal-title":"Fluids and Barriers of the CNS"},{"issue":"2\u20133","key":"pgph.0002531.ref034","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000243791","article-title":"The role of hepcidin in iron metabolism","volume":"122","author":"E. Nemeth","year":"2009","journal-title":"Acta haematologica"},{"issue":"6108","key":"pgph.0002531.ref035","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1126\/science.1224577","article-title":"Hepcidin and the iron-infection axis","volume":"338","author":"H. Drakesmith","year":"2012","journal-title":"Science"},{"issue":"3","key":"pgph.0002531.ref036","doi-asserted-by":"crossref","first-page":"eaav9020","DOI":"10.1126\/sciadv.aav9020","article-title":"Respiratory infections drive hepcidin-mediated blockade of iron absorption leading to iron deficiency anemia in African children","volume":"5","author":"A. Prentice","year":"2019","journal-title":"Science Advances"},{"issue":"suppl_1","key":"pgph.0002531.ref037","doi-asserted-by":"crossref","first-page":"372S","DOI":"10.3945\/ajcn.116.142232","article-title":"Adjusting soluble transferrin receptor concentrations for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project","volume":"106","author":"F. Rohner","year":"2017","journal-title":"The American Journal of Clinical Nutrition"},{"issue":"5","key":"pgph.0002531.ref038","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1309\/AJCP16NTXZLZFAIB","article-title":"Soluble Transferrin Receptor (sTfR) and sTfR\/log Ferritin Index for the Diagnosis of Iron-Deficiency Anemia A Meta-Analysis","volume":"138","author":"I. Infusino","year":"2012","journal-title":"American Journal of Clinical Pathology"},{"issue":"7","key":"pgph.0002531.ref039","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1080\/00365510500206542","article-title":"Usefulness of soluble transferrin receptor and ferritin in iron deficiency and chronic disease","volume":"65","author":"M. Markovi\u0107","year":"2005","journal-title":"Scand J Clin Lab Invest"},{"issue":"suppl_4","key":"pgph.0002531.ref040","doi-asserted-by":"crossref","first-page":"S193","DOI":"10.1093\/cid\/ciu653","article-title":"The MAL-ED Study: A Multinational and Multidisciplinary Approach to Understand the Relationship Between Enteric Pathogens, Malnutrition, Gut Physiology, Physical Growth, Cognitive Development, and Immune Responses in Infants and Children Up to 2 Years of Age in Resource-Poor Environments","volume":"59","author":"Investigators TM-EN","year":"2014","journal-title":"Clinical Infectious Diseases"},{"issue":"8","key":"pgph.0002531.ref041","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1093\/jn\/nxz055","article-title":"Early Life Child Micronutrient Status, Maternal Reasoning, and a Nurturing Household Environment have Persistent Influences on Child Cognitive Development at Age 5 years: Results from MAL-ED","volume":"149","author":"B. McCormick","year":"2019","journal-title":"The Journal of Nutrition"},{"issue":"2","key":"pgph.0002531.ref042","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1542\/peds.2005-0173","article-title":"Poor predictive validity of the Bayley Scales of Infant Development for cognitive function of extremely low birth weight children at school age","volume":"116","author":"M. Hack","year":"2005","journal-title":"Pediatrics"},{"issue":"1","key":"pgph.0002531.ref043","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev-devpsych-121318-085114","article-title":"Early Development of Visual Attention: Change, Stability, and Longitudinal Associations","volume":"1","author":"A. Hendry","year":"2019","journal-title":"Annual Review of Developmental Psychology"},{"issue":"Suppl 1","key":"pgph.0002531.ref044","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1016\/j.dcn.2011.11.001","article-title":"The role of selective attention on academic foundations: a cognitive neuroscience perspective","volume":"2 Suppl 1","author":"C. Stevens","year":"2012","journal-title":"Dev Cogn Neurosci"},{"issue":"6","key":"pgph.0002531.ref045","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1037\/dev0001030","article-title":"Iron deficiency in infancy and neurocognitive and educational outcomes in young adulthood","volume":"57","author":"P. East","year":"2021","journal-title":"Dev Psychol"},{"key":"pgph.0002531.ref046","first-page":"16","article-title":"The Role of Nutrition in Brain Development: The Golden Opportunity of the \"First 1000 Days\"","volume":"175","author":"S. Cusick","year":"2016","journal-title":"J Pediatr"},{"issue":"7","key":"pgph.0002531.ref047","doi-asserted-by":"crossref","DOI":"10.3390\/nu12072001","article-title":"The Role of Iron in Brain Development: A Systematic Review","volume":"12","author":"S. McCann","year":"2020","journal-title":"Nutrients"},{"issue":"4","key":"pgph.0002531.ref048","doi-asserted-by":"crossref","first-page":"740s","DOI":"10.3945\/jn.110.131169","article-title":"Early iron deficiency has brain and behavior effects consistent with dopaminergic dysfunction","volume":"141","author":"B. Lozoff","year":"2011","journal-title":"J Nutr"},{"issue":"11","key":"pgph.0002531.ref049","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/BF02828117","article-title":"Prevalence of multiple micronutrient deficiencies amongst pregnant women in a rural area of Haryana","volume":"71","author":"P. 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