{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:29:14Z","timestamp":1792682954165,"version":"4.5.0"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 AI007291-32"],"award-info":[{"award-number":["T32 AI007291-32"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI136977"],"award-info":[{"award-number":["R01AI136977"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosglobalpublichealth.org"],"crossmark-restriction":false},"short-container-title":["PLOS Glob Public Health"],"abstract":"<jats:p>Understanding the epidemiology and ecology of yellow fever in endemic regions is critical for preventing future outbreaks. Ghana is a high-risk country for yellow fever. In this study we estimate the disease burden, ecological cycles, and areas at risk for yellow fever in Ghana based on historical outbreaks. We identify 2387 cases and 888 deaths (case fatality rate 37.7%) from yellow fever reported in Ghana from 1910 to 2022. During the approximately 30-year periods before and after implementation of routine childhood vaccination in 1992, the reported mean annual number of cases decreased by 80%. The geographic distribution of yellow fever cases has also changed over the past century. While there have been multiple large historical outbreaks of yellow fever in regions throughout Ghana, recent outbreaks have originated in northern regions. Comparing the locations where yellow fever outbreaks have emerged, we find patterns with seasons and different ecological transmission cycles. Using an ecological niche modeling framework, we predict areas in Ghana that are similar to where prior yellow fever outbreaks have originated based on temperature, precipitation, vegetation, and human population density. We find that these predictions differ depending on the ecological cycles of outbreaks. Ultimately, these findings and methods could be used to inform further subnational risk assessments for yellow fever in Ghana and other high-risk countries.<\/jats:p>","DOI":"10.1371\/journal.pgph.0003337","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T13:28:59Z","timestamp":1729517339000},"page":"e0003337","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgph.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Yellow fever in Ghana: Predicting emergence and ecology from historical outbreaks"],"prefix":"10.1371","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9911-7839","authenticated-orcid":true,"given":"Seth D.","family":"Judson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest","family":"Kenu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9954-4267","authenticated-orcid":true,"given":"Trevon","family":"Fuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin","family":"Asiedu-Bekoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberta","family":"Biritwum-Nyarko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee F.","family":"Schroeder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Dowdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,10,21]]},"reference":[{"key":"pgph.0003337.ref001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41541-022-00552-3","article-title":"Yellow fever resurgence: An avoidable crisis?","volume":"7","author":"NP Lindsey","year":"2022","journal-title":"npj Vaccines"},{"key":"pgph.0003337.ref002","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jcv.2014.08.030","article-title":"Yellow fever","volume":"64","author":"TP Monath","year":"2015","journal-title":"Journal of Clinical Virology"},{"key":"pgph.0003337.ref003","unstructured":"Risk assessment on yellow fever virus circulation in endemic countries. [cited 7 Nov 2023]. Available: https:\/\/www.who.int\/publications-detail-redirect\/WHO-HSE-PED-CED-2014-2."},{"key":"pgph.0003337.ref004","doi-asserted-by":"crossref","first-page":"e1007355","DOI":"10.1371\/journal.pcbi.1007355","article-title":"Quantifying model evidence for yellow fever transmission routes in Africa","volume":"15","author":"KAM Gaythorpe","year":"2019","journal-title":"PLoS Comput Biol"},{"key":"pgph.0003337.ref005","doi-asserted-by":"crossref","first-page":"e0008304","DOI":"10.1371\/journal.pntd.0008304","article-title":"Eliminating yellow fever epidemics in Africa: Vaccine demand forecast and impact modelling","volume":"14","author":"K Jean","year":"2020","journal-title":"PLOS Neglected Tropical Diseases"},{"key":"pgph.0003337.ref006","unstructured":"Regional Committee for Africa. Progress report on the implementation of the regional strategy for health security and emergencies 2016\u20132020: information document. World Health Organization. Regional Office for Africa; 2019. Report No.: AFR\/RC69\/INF.DOC\/1. Available: https:\/\/apps.who.int\/iris\/handle\/10665\/331442."},{"key":"pgph.0003337.ref007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-021-06728-x","article-title":"The incidence and mortality of yellow fever in Africa: a systematic review and meta-analysis","volume":"21","author":"AU Nwaiwu","year":"2021","journal-title":"BMC Infectious Diseases"},{"key":"pgph.0003337.ref008","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-23926-y","article-title":"Seasonality of agricultural exposure as an important predictor of seasonal yellow fever spillover in Brazil","volume":"12","author":"A Hamlet","year":"2021","journal-title":"Nature communications"},{"key":"pgph.0003337.ref009","volume-title":"A global strategy to eliminate yellow fever epidemics (EYE) 2017\u20132026","author":"World Health Organization","year":"2018"},{"key":"pgph.0003337.ref010","unstructured":"Eliminate yellow fever epidemics (EYE) strategy 2017\u20132026. [cited 5 Mar 2023]. Available: https:\/\/www.who.int\/initiatives\/eye-strategy."},{"key":"pgph.0003337.ref011","unstructured":"WHO. Mid-term evaluation of the Global Strategy to Eliminate Yellow Fever Epidemics (\u200eEYE)\u200e 2017\u20132026: Annexes. [cited 6 Aug 2024]. Available: https:\/\/www.who.int\/publications\/i\/item\/WHO-DGO-EVL-2023.6."},{"key":"pgph.0003337.ref012","first-page":"232","article-title":"Leveraging Lessons Learned from Yellow Fever and Polio Immunization Campaigns during COVID-19 Pandemic, Ghana, 2021\u2014Volume 28, Supplement\u2014November 2022\u2014Emerging Infectious Diseases journal\u2014CDC","volume":"28","author":"K Amponsa-Achiano","year":"2022","journal-title":"Emerging infectious diseases"},{"issue":"9","key":"pgph.0003337.ref013","first-page":"1818","article-title":"Molecular Characterization of Circulating Yellow Fever Viruses from Outbreak in Ghana, 2021\u20132022","volume":"29","author":"JHK Bonney","year":"2023","journal-title":"Emerg Infect Dis"},{"key":"pgph.0003337.ref014","unstructured":"World Health Organization. Disease Outbreak News; Yellow Fever\u2014Ghana. 1 Dec 2021 [cited 1 Aug 2023]. Available: https:\/\/www.who.int\/emergencies\/disease-outbreak-news\/item\/yellow-fever\u2014ghana."},{"key":"pgph.0003337.ref015","unstructured":"Word Health Organization. Yellow Fever\u2014West and Central Africa. In: Disease Outbreak News [Internet]. 23 Dec 2021 [cited 17 Jan 2024]. Available: https:\/\/www.who.int\/emergencies\/disease-outbreak-news\/item\/yellow-fever\u2014west-and-central-africa."},{"key":"pgph.0003337.ref016","unstructured":"WHO Immunization Data portal\u2014Yellow Fever (YF) vaccination coverage. In: Immunization Data [Internet]. [cited 6 Aug 2024]. Available: https:\/\/immunizationdata.who.int\/global\/wiise-detail-page\/yellow-fever-(yf)-vaccination-coverage?CODE=Global&YEAR=."},{"key":"pgph.0003337.ref017","first-page":"1","article-title":"Review of data and knowledge gaps regarding yellow fever vaccine-induced immunity and duration of protection","volume":"5","author":"JE Staples","year":"2020","journal-title":"npj Vaccines 2020 5:1"},{"key":"pgph.0003337.ref018","article-title":"Translating Predictions of Zoonotic Viruses for Policymakers","author":"SD Judson","year":"2017","journal-title":"EcoHealth"},{"key":"pgph.0003337.ref019","first-page":"1","article-title":"Yellow fever surveillance suggests zoonotic and anthroponotic emergent potential","volume":"5","author":"A Aliaga-Samanez","year":"2022","journal-title":"Communications Biology 2022 5:1"},{"key":"pgph.0003337.ref020","doi-asserted-by":"crossref","first-page":"e0008691","DOI":"10.1371\/journal.pntd.0008691","article-title":"Spatial epidemiology of yellow fever: Identification of determinants of the 2016\u20132018 epidemics and at-risk areas in Brazil","volume":"14","author":"B de Thoisy","year":"2020","journal-title":"PLOS Neglected Tropical Diseases"},{"key":"pgph.0003337.ref021","doi-asserted-by":"crossref","first-page":"e270","DOI":"10.1016\/S2214-109X(18)30024-X","article-title":"Existing and potential infection risk zones of yellow fever worldwide: a modelling analysis","volume":"6","author":"FM Shearer","year":"2018","journal-title":"The Lancet Global Health"},{"key":"pgph.0003337.ref022","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1186\/s12879-023-08717-8","article-title":"A systematic review of the data, methods and environmental covariates used to map Aedes-borne arbovirus transmission risk","volume":"23","author":"A-Y Lim","year":"2023","journal-title":"BMC Infectious Diseases"},{"key":"pgph.0003337.ref023","doi-asserted-by":"crossref","first-page":"e0000023","DOI":"10.1371\/journal.pclm.0000023","article-title":"Revisiting the agro-climatic zones of Ghana: A re-classification in conformity with climate change and variability","volume":"2","author":"EI Yamba","year":"2023","journal-title":"PLOS Climate"},{"key":"pgph.0003337.ref024","unstructured":"WHO report on global surveillance of epidemic-prone infectious diseases. [cited 2 Dec 2023]. Available: https:\/\/www.who.int\/publications-detail-redirect\/WHO-CDS-CSR-ISR-2000.1."},{"key":"pgph.0003337.ref025","volume-title":"Yellow Fever Cases Reported in Ghana, 1950\u20132004","author":"WHO","year":"2005"},{"key":"pgph.0003337.ref026","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms10101914","article-title":"Arbovirus Epidemiology: The Mystery of Unnoticed Epidemics in Ghana, West Africa","author":"E Agboli","year":"2022"},{"key":"pgph.0003337.ref027","article-title":"Yellow Fever in Ghana: Predicting Emergence and Ecology from Historical Outbreaks (Datasets).","author":"S. Judson","year":"2024","journal-title":"figshare"},{"key":"pgph.0003337.ref028","volume-title":"Epidemic Disease in Ghana 1901\u20131960","author":"D. Scott","year":"1965"},{"key":"pgph.0003337.ref029","first-page":"285","article-title":"Yellow fever in Africa and South America, 2011\u20132012 = Fi\u00e8vre jaune en Afrique et en Am\u00e9rique du Sud, 2011\u20132012","volume":"88","author":"WHO","year":"2013","journal-title":"Weekly Epidemiological Record = Relev\u00e9 \u00e9pid\u00e9miologique hebdomadaire"},{"key":"pgph.0003337.ref030","first-page":"577","article-title":"Yellow fever in Ghana, 1977\u201380","volume":"62","author":"VK Agadzi","year":"1984","journal-title":"Bulletin of the World Health Organization"},{"key":"pgph.0003337.ref031","doi-asserted-by":"crossref","first-page":"e0234675","DOI":"10.1371\/journal.pone.0234675","article-title":"Species composition and risk of transmission of some Aedes-borne arboviruses in some sites in Northern Ghana","volume":"16","author":"J Joannides","year":"2021","journal-title":"PLOS ONE"},{"key":"pgph.0003337.ref032","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/0035-9203(57)90079-2","article-title":"A small outbreak of yellow fever in the Gold Coast","volume":"51","author":"JPT Boorman","year":"1957","journal-title":"Transactions of The Royal Society of Tropical Medicine and Hygiene"},{"key":"pgph.0003337.ref033","first-page":"99","article-title":"Surveillance of yellow fever in Ghana, 1960 et 1970","volume":"10","author":"EG Beausoleil","year":"1972","journal-title":"ORSTOM Ser Entomol Med Parasitol"},{"key":"pgph.0003337.ref034","article-title":"Recent Yellow Fever Epidemics in Ghana (1969\u20131983)","volume":"63","year":"1986","journal-title":"EAST AFRICAN MEDICAL JOURNAL"},{"key":"pgph.0003337.ref035","first-page":"69","article-title":"Weekly Epidemiological Record, 2008, vol. 83, 08 [full issue]","volume":"83","author":"World Health Organization","year":"2008","journal-title":"Weekly Epidemiological Record = Relev\u00e9 \u00e9pid\u00e9miologique hebdomadaire"},{"key":"pgph.0003337.ref036","first-page":"353","article-title":"Weekly Epidemiological Record, 1998, vol. 73, 46 [full issue]","volume":"73","author":"World Health Organization","year":"1998","journal-title":"Weekly Epidemiological Record = Relev\u00e9 \u00e9pid\u00e9miologique hebdomadaire"},{"key":"pgph.0003337.ref037","unstructured":"WHO. Yellow fever in Ghana. In: Disease Outbreak News [Internet]. 3 Feb 2012 [cited 3 Dec 2023]. Available: https:\/\/www.who.int\/emergencies\/disease-outbreak-news\/item\/2012_02_03b-en."},{"key":"pgph.0003337.ref038","doi-asserted-by":"crossref","first-page":"220086","DOI":"10.1098\/rsos.220086","article-title":"Environmental determinants predicting population vulnerability to high yellow fever incidence","volume":"9","author":"JL Servadio","journal-title":"R Soc Open Sci"},{"key":"pgph.0003337.ref039","doi-asserted-by":"crossref","first-page":"e0006284","DOI":"10.1371\/journal.pntd.0006284","article-title":"The seasonal influence of climate and environment on yellow fever transmission across Africa","volume":"12","author":"A Hamlet","year":"2018","journal-title":"PLOS Neglected Tropical Diseases"},{"key":"pgph.0003337.ref040","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1002\/joc.1276","article-title":"Very high resolution interpolated climate surfaces for global land areas","volume":"25","author":"RJ Hijmans","year":"2005","journal-title":"International Journal of Climatology"},{"key":"pgph.0003337.ref041","unstructured":"Normalised Difference Vegetation Index 1999\u20132020 (raster 1 km), global, 10-daily\u2013version 3. [cited 27 Apr 2024]. Available: https:\/\/land.copernicus.eu\/en\/products\/vegetation\/normalised-difference-vegetation-index-v3-0-1km."},{"key":"pgph.0003337.ref042","volume-title":"Gridded Species Distribution: Global Mammal Richness Grids, 2015 Release","author":"International Union for Conservation of Nature\u2014IUCN, Center for International Earth Science Information Network\u2014CIESIN\u2014Columbia University","year":"2015"},{"key":"pgph.0003337.ref043","volume-title":"Gridded Population of the World, Version 4 (GPWv4): Population Density Adjusted to Match 2015 Revision UN WPP Country Totals, Revision 11","author":"Center for International Earth Science Information Network\u2014CIESIN\u2014Columbia University","year":"2018"},{"key":"pgph.0003337.ref044","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1038\/s41559-019-0972-5","article-title":"A checklist for maximizing reproducibility of ecological niche models","volume":"3","author":"X Feng","year":"2019","journal-title":"Nature Ecology & Evolution 2019 3:10"},{"key":"pgph.0003337.ref045","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1111\/aec.13234","article-title":"Checking bioclimatic variables that combine temperature and precipitation data before their use in species distribution models","volume":"47","author":"TH Booth","year":"2022","journal-title":"Austral Ecology"},{"key":"pgph.0003337.ref046","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1365-2699.2006.01594.x","article-title":"Townsend Peterson a. Predicting species distributions from small numbers of occurrence records: A test case using cryptic geckos in Madagascar","volume":"34","author":"RG Pearson","year":"2007","journal-title":"Journal of Biogeography"},{"key":"pgph.0003337.ref047","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ecolmodel.2013.08.011","article-title":"Estimating optimal complexity for ecological niche models: A jackknife approach for species with small sample sizes","volume":"269","author":"M Shcheglovitova","year":"2013","journal-title":"Ecological Modelling"},{"key":"pgph.0003337.ref048","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ecolmodel.2005.03.026","article-title":"Maximum entropy modeling of species geographic distributions","volume":"190","author":"SJ Phillips","year":"2006","journal-title":"Ecological Modelling"},{"key":"pgph.0003337.ref049","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/ecog.01509","article-title":"Minimum required number of specimen records to develop accurate species distribution models","volume":"39","author":"ASJ van Proosdij","year":"2016","journal-title":"Ecography"},{"key":"pgph.0003337.ref050","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1111\/2041-210X.13628","article-title":"ENMeval 2.0: Redesigned for customizable and reproducible modeling of species\u2019 niches and distributions","volume":"12","author":"JM Kass","year":"2021","journal-title":"Methods in Ecology and Evolution"},{"key":"pgph.0003337.ref051","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/ecog.03049","article-title":"Opening the black box: an open-source release of Maxent","volume":"40","author":"SJ Phillips","year":"2017","journal-title":"Ecography"},{"key":"pgph.0003337.ref052","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1111\/j.1600-0587.2013.07872.x","article-title":"A practical guide to MaxEnt for modeling species\u2019 distributions: what it does, and why inputs and settings matter","volume":"36","author":"C Merow","year":"2013","journal-title":"Ecography"},{"key":"pgph.0003337.ref053","first-page":"1","article-title":"The effect of climate change on yellow fever disease burden in Africa","volume":"9","author":"KAM Gaythorpe","year":"2020","journal-title":"eLife"},{"key":"pgph.0003337.ref054","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1016\/j.vaccine.2020.04.011","article-title":"Arboviruses: A global public health threat","volume":"38","author":"M Girard","year":"2020","journal-title":"Vaccine"},{"key":"pgph.0003337.ref055","doi-asserted-by":"crossref","first-page":"e0000733","DOI":"10.1371\/journal.pgph.0000733","article-title":"Knowledge, attitudes and practice towards yellow fever among nomadic populations: A cross-sectional study in yellow fever outbreak communities in Ghana","volume":"3","author":"A-W Inusah","year":"2023","journal-title":"PLOS Global Public Health"},{"key":"pgph.0003337.ref056","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S1473-3099(11)70147-5","article-title":"The revised global yellow fever risk map and recommendations for vaccination, 2010: consensus of the Informal WHO Working Group on Geographic Risk for Yellow Fever","volume":"11","author":"ES Jentes","year":"2011","journal-title":"The Lancet Infectious Diseases"},{"key":"pgph.0003337.ref057","article-title":"The global burden of yellow fever","volume":"10","author":"KAM Gaythorpe","year":"2021","journal-title":"eLife"}],"container-title":["PLOS Global Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgph.0003337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T13:29:16Z","timestamp":1729517356000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgph.0003337"}},"subtitle":[],"editor":[{"given":"Megan","family":"Coffee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,10,21]]},"references-count":57,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgph.0003337","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.01.29.24301911","asserted-by":"object"}]},"ISSN":["2767-3375"],"issn-type":[{"value":"2767-3375","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,21]]}}}