{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:30:55Z","timestamp":1740184255449,"version":"3.37.3"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01 DA037440"],"award-info":[{"award-number":["R01 DA037440"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["K24 AA027483"],"award-info":[{"award-number":["K24 AA027483"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["P30 AI050410"],"award-info":[{"award-number":["P30 AI050410"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosglobalpublichealth.org"],"crossmark-restriction":false},"short-container-title":["PLOS Glob Public Health"],"abstract":"<jats:p>The confluence of injection drug use (IDU), alcohol consumption, and viral hepatitis increases morbidity among persons living with HIV (PWH). We present a secondary analysis of a randomized controlled trial of alcohol reduction interventions in Thai Nguyen, Vietnam conducted between 2016\u20132018. We assessed hepatitis B (HBV) and hepatitis C (HCV) coinfection among PWH reporting hazardous alcohol consumption and examined differences in IDU and alcohol use by coinfection status. Participants were \u226518 years old, living with HIV, and reported hazardous alcohol consumption per the WHO Alcohol Use Disorders Identification Test Consumption (AUDIT-C; score \u22654 for men, score \u22653 for women). At enrollment, participants were tested for hepatitis coinfection with HBV surface antigen tests and rapid serological HCV tests. Demographic information, IDU, and recent alcohol consumption were assessed via behavioral survey and 30-day timeline follow back. Fishers Exact and Kruskal-Wallis tests were used for statistical testing. Hepatitis coinfection was common among the 440 enrolled PWH: HCV: n = 355 (81%); HBV: n = 5 (1%); HBV and HCV: n = 37 (8%). Only 10% (n = 43) of participants had no hepatitis coinfection. Among those who tested positive for HBV, 36% had previously been diagnosed with HBV; among those who tested seropositive for HCV, 18% had previously received an HCV diagnosis. History of IDU was higher among those with hepatitis coinfection (HBV or HCV coinfection: 88%; HBV and HCV coinfections: 97%) than those without hepatitis coinfection (7%; p&lt;0.01). Median days of alcohol consumption in the last 30 days was higher among those with coinfection (HBV or HCV coinfection: 20 (Interquartile Range (IQR): 10\u201330); HBV and HCV coinfections: 22 (IQR: 13\u201328) than those without hepatitis coinfection (10; IQR: 6\u201321; p&lt;0.01). The syndemic conditions of HIV, hepatitis, IDU, and alcohol use are deeply entangled and challenging to parse out. Integrated health services are warranted to reduce the risk of liver-related morbidity.<\/jats:p>","DOI":"10.1371\/journal.pgph.0003744","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T18:51:10Z","timestamp":1733424670000},"page":"e0003744","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgph.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of hepatitis coinfection and substance use among antiretroviral therapy clinic clients with hazardous alcohol use in Vietnam"],"prefix":"10.1371","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7648-0651","authenticated-orcid":true,"given":"Jane S.","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5558-526X","authenticated-orcid":true,"given":"Sara 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F.","family":"Go","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2216-6330","authenticated-orcid":true,"given":"Geetanjali","family":"Chander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,12,5]]},"reference":[{"issue":"12","key":"pgph.0003744.ref001","doi-asserted-by":"crossref","first-page":"e1192","DOI":"10.1016\/S2214-109X(17)30375-3","article-title":"Global prevalence of injecting drug use and sociodemographic characteristics and prevalence of HIV, HBV, and HCV in people who inject drugs: a multistage systematic review","volume":"5","author":"L Degenhardt","year":"2017","journal-title":"Lancet Glob Health"},{"issue":"9","key":"pgph.0003744.ref002","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1007\/s00705-020-04716-1","article-title":"Global prevalence of HCV and\/or HBV 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(AUDIT-C): an effective brief screening test for problem drinking. Ambulatory Care Quality Improvement Project (ACQUIP). Alcohol Use Disorders Identification Test.","volume":"158","author":"K Bush","year":"1998","journal-title":"Arch Intern Med"},{"issue":"11","key":"pgph.0003744.ref014","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1111\/j.1360-0443.1989.tb00737.x","article-title":"Assessment of alcohol withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA-Ar).","volume":"84","author":"JT Sullivan","year":"1989","journal-title":"Br J Addict."},{"key":"pgph.0003744.ref015","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/978-1-4612-0357-5_3","volume-title":"Measuring alcohol consumption: Psychosocial and biochemical methods.","author":"LC Sobell","year":"1992"},{"issue":"6","key":"pgph.0003744.ref016","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1258\/0956462011923309","article-title":"Assessing sexual risk behaviour with the Timeline Followback (TLFB) approach: continued development and psychometric evaluation with psychiatric outpatients.","volume":"12","author":"MP Carey","year":"2001","journal-title":"Int J STD AIDS."},{"issue":"1","key":"pgph.0003744.ref017","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12889-021-12429-6","article-title":"Prevalence and the associated factors of hepatitis B and hepatitis C viral infections among HIV-positive individuals in same-day antiretroviral therapy initiation program in Bangkok, Thailand.","volume":"22","author":"S Thitipatarakorn","year":"2022","journal-title":"BMC Public Health."},{"issue":"1","key":"pgph.0003744.ref018","first-page":"49","article-title":"Epidemiology of Hepatitis B and C Virus Infections and Liver Cancer in Vietnam.","volume":"5","year":"2015","journal-title":"Euroasian J Hepatogastroenterol"},{"issue":"2","key":"pgph.0003744.ref019","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1440-1746.2011.06974.x","article-title":"Liver disease in Viet Nam: screening, surveillance, management and education: a 5-year 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hepatitis B virus infection: a systematic review of data published between 1965 and 2013","volume":"386","author":"A Schweitzer","year":"2015","journal-title":"Lancet"},{"issue":"5","key":"pgph.0003744.ref023","doi-asserted-by":"crossref","first-page":"E1072","DOI":"10.1093\/cid\/ciaa1814","article-title":"Assessment and Simplification of Treatment Eligibility Among Patients With Chronic Hepatitis B Infection in Vietnam","volume":"73","author":"V Vu Hai","year":"2021","journal-title":"Clin Infect Dis"},{"issue":"10","key":"pgph.0003744.ref024","doi-asserted-by":"crossref","first-page":"e0223733","DOI":"10.1371\/journal.pone.0223733","article-title":"Knowledge, attitudes and medical practice regarding hepatitis B prevention and management among healthcare workers in Northern Vietnam.","volume":"14","author":"TTH Pham","year":"2019","journal-title":"PLoS 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