{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:19:00Z","timestamp":1791778740343,"version":"4.3.4"},"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosglobalpublichealth.org"],"crossmark-restriction":false},"short-container-title":["PLOS Glob Public Health"],"abstract":"<jats:p>Vaccine hesitancy remains a significant barrier to the success of global vaccination campaigns and vaccine programs. Understanding people\u2019s perceptions of vaccines on social media during disease outbreaks can aid in reducing socially induced vaccine hesitancy and improve program implementation. Social media is an increasingly valuable tool for assessing public perceptions on critical issues, including vaccine adoption. This study examines perceptions surrounding the COVID-19 vaccine among Twitter users in the United States, Brazil, and India within a few weeks post-vaccine release. These countries are associated with anti-vaccine movements and outbreaks of vaccine-preventable diseases. We identified and analyzed key themes related to vaccine perception in 2,858 Twitter posts. Using a qualitative interpretive approach to analyze tweets, we found that mistrust in vaccine science, politics of vaccination, and religious pushbacks were the main themes that emerged from the analysis. Perceptions harbored by individuals and communicated frequently via mass communication platforms may erode public trust and disarticulate avenues of communication between public health officials and communities. Thus, we suggest that harnessing vaccine hesitancy-related information on social media can enhance understanding of public perceptions about vaccines while providing opportunities for interventional communications to educate the public.<\/jats:p>","DOI":"10.1371\/journal.pgph.0004317","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T17:24:49Z","timestamp":1751909089000},"page":"e0004317","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgph.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Preparing for future pandemics: A qualitative exploration of social media in light of the COVID-19 pandemic and vaccine hesitancy"],"prefix":"10.1371","volume":"5","author":[{"given":"Emmanuel 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Ashkenazi","year":"2020","journal-title":"Vaccine"},{"key":"pgph.0004317.ref022","article-title":"Public Health COVID-19 Impact Assessment: Lessons Learned and Compelling Needs","volume":"2021","author":"K DeSalvo","year":"2021","journal-title":"NAM Perspect"},{"issue":"5","key":"pgph.0004317.ref023","doi-asserted-by":"crossref","DOI":"10.1016\/S2468-2667(22)00095-0","article-title":"COVID-19 pandemic: what\u2019s next for public health?","volume":"7","author":"The Lancet Public Health","year":"2022","journal-title":"Lancet Public Health"},{"key":"pgph.0004317.ref024","author":"WHO","year":"2021"},{"key":"pgph.0004317.ref025","author":"WHO","year":"2021"},{"issue":"7851","key":"pgph.0004317.ref026","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/d41586-021-00728-2","article-title":"Five reasons why COVID herd immunity is probably impossible","volume":"591","author":"C Aschwanden","year":"2021","journal-title":"Nature"},{"issue":"8","key":"pgph.0004317.ref027","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1038\/s41591-021-01454-y","article-title":"COVID-19 vaccine acceptance and hesitancy in low- and middle-income countries","volume":"27","author":"JS Sol\u00eds Arce","year":"2021","journal-title":"Nat Med"},{"issue":"9","key":"pgph.0004317.ref028","article-title":"COVID-19 Vaccine Perception in South Korea: Web Crawling Approach","volume":"7","author":"H Lee","year":"2021","journal-title":"JMIR Public Health Surveill"},{"issue":"1","key":"pgph.0004317.ref029","doi-asserted-by":"crossref","DOI":"10.2196\/25636","article-title":"Characterization of Vaccine Tweets During the Early Stage of the COVID-19 Outbreak in the United States: Topic Modeling Analysis","volume":"1","author":"LC Jiang","year":"2021","journal-title":"JMIR Infodemiology"},{"key":"pgph.0004317.ref030","doi-asserted-by":"crossref","unstructured":"Gligori\u0107 K, Anderson 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How constraints affect content: The case of Twitter\u2019s switch from 140 to 280 characters. 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