{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:39:59Z","timestamp":1783420799572,"version":"3.54.6"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006506","name":"Minist\u00e9rio da Sa\u00fade","doi-asserted-by":"publisher","award":["No. 01 06 0010.00 RS, 01 06 0212.00 BA, 01 06 0300.00 ES, 01 06 0278.00 MG, 01 06 0115.00 SP, 01 06 0071.00 RJ]."],"award-info":[{"award-number":["No. 01 06 0010.00 RS, 01 06 0212.00 BA, 01 06 0300.00 ES, 01 06 0278.00 MG, 01 06 0115.00 SP, 01 06 0071.00 RJ]."]}],"id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003545","name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Inova\u00e7\u00e3o","doi-asserted-by":"publisher","award":["No. 01 06 0010.00 RS, 01 06 0212.00 BA, 01 06 0300.00 ES, 01 06 0278.00 MG, 01 06 0115.00 SP, 01 06 0071.00 RJ]."],"award-info":[{"award-number":["No. 01 06 0010.00 RS, 01 06 0212.00 BA, 01 06 0300.00 ES, 01 06 0278.00 MG, 01 06 0115.00 SP, 01 06 0071.00 RJ]."]}],"id":[{"id":"10.13039\/501100003545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosglobalpublichealth.org"],"crossmark-restriction":false},"short-container-title":["PLOS Glob Public Health"],"abstract":"<jats:p>Despite obesity being associated with negative metabolic and cardiovascular outcomes, there is a subgroup of individuals considered healthy. However, there are questions about the stability of the Metabolically Healthy Obesity phenotype. This is a longitudinal study using the ELSA-Brasil cohort, conducted from 2008\/10\u20132017\/19 aiming to describe the trajectory of metabolic status of individuals with obesity, as well as the factors associated with the transition into the unhealthy status. Metabolic status was determined using measures of blood pressure, fasting glucose\/glycated hemoglobin, triglycerides, and HDL-cholesterol, no previous diagnosis of alteration in any of these parameters nor taking medication to control them. SPSS v.21.0 was used, considering p\u2009&lt;\u20090.05 as significant. The sample consisted of 190 Metabolically Healthy Individuals with Obesity at baseline, of whom 75.8% transitioned to Metabolically Unhealthy status on the third wave of the study. The baseline data indicates that 8.6% of individuals with obesity were metabolically healthy, and in the follow-up, the prevalence was 5.5%. Alcohol use was a risk factor for metabolic status transition [RR: 1.359 (95%CI: 1.005\u20131.838)]. Also, each 1\u2009cm increase in waist circumference contributed to a 1% increase in the risk of transitioning from healthy to unhealthy metabolic status [RR: 1.011 (95%CI: 1.004\u20131.018)]. Being a metabolically healthy individual with obesity is a transient state and alcohol consumption as well as increases in waist circumference are risk factors for the metabolic transition.<\/jats:p>","DOI":"10.1371\/journal.pgph.0004325","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T17:48:34Z","timestamp":1745948914000},"page":"e0004325","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgph.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["From healthy to unhealthy obesity: A longitudinal study of adults in ELSA-Brasil"],"prefix":"10.1371","volume":"5","author":[{"given":"Fernanda Duarte","family":"Mendes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hully Cant\u00e3o","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Geraldo","family":"Mill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8614-988X","authenticated-orcid":true,"given":"Maria Del Carmen Bisi","family":"Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria de F\u00e1tima H. 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Report of a WHO consultation","volume":"894","year":"2000","journal-title":"World Health Organ Tech Rep Ser"},{"key":"pgph.0004325.ref019","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1590\/S0034-8910.2013047003807","article-title":"Logistics of collection and transportation of biological samples and the organization of the central laboratory in the ELSA-Brasil","volume":"47 Suppl 2","author":"LG Fedeli","year":"2013","journal-title":"Rev Saude Publica"},{"issue":"2","key":"pgph.0004325.ref020","first-page":"379","article-title":"Reproducibility and relative validity of the Food Frequency Questionnaire used in the ELSA-Brasil","volume":"29","author":"MDCB Molina","year":"2013","journal-title":"Cad Saude Publica"},{"key":"pgph.0004325.ref021","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1590\/1516-3180.2014.00533004","article-title":"Comparison of a short version of the Food Frequency Questionnaire with its long version - a cross-sectional analysis in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).","volume":"133","author":"LW Mannato","year":"2015","journal-title":"Sao Paulo Med J"},{"issue":"1\u20133","key":"pgph.0004325.ref022","first-page":"28","article-title":"NOVA. The star shines bright.","volume":"7","author":"CA Monteiro","year":"2016","journal-title":"World Nutrition"},{"issue":"2","key":"pgph.0004325.ref023","first-page":"5","article-title":"Question\u00e1rio Internacional De Atividade F\u00edsica (ipaq): estupo de validade e reprodutibilidade no Brasil","volume":"6","author":"S Matsudo","year":"2001","journal-title":"Rev. Bras. Ativ. Fis. 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