{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T04:10:39Z","timestamp":1746850239212,"version":"3.40.5"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100009054","name":"U.S. President\u2019s Emergency Plan for AIDS Relief","doi-asserted-by":"publisher","award":["A"],"award-info":[{"award-number":["A"]}],"id":[{"id":"10.13039\/100009054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["A"],"award-info":[{"award-number":["A"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosglobalpublichealth.org"],"crossmark-restriction":false},"short-container-title":["PLOS Glob Public Health"],"abstract":"<jats:p>Whilst a quarter of the world\u2019s population is estimated to be infected with <jats:italic>Mycobacterium tuberculosis<\/jats:italic>, it is unknown whether TB infection (TBI) increases the risk of severe COVID-19, which is relevant in TB-endemic settings, especially where HIV co-infection is also common. A convenience cohort of symptomatic and asymptomatic COVID-19 patients aged 8\u201380 years in western Kenya was followed daily for 14 days to assess disease progression using the validated inFLUenza-Patient-Reported-Outcome Plus signs and symptom tool. Nasal swabbing for SARS-CoV-2 was conducted to confirm the virus using polymerase chain reaction. QuantiFERON-TB Gold Plus was used to diagnose TBI. HIV status was based on self-reports. Between January 3, 2021, and January 20, 2022, 373 out of 387 participants had conclusive QuantiFERON results. At baseline, 5.9% (22\/373) had self-reported severe COVID-19, 33.2% (124\/373) had TBI, and 11.1% (38\/341) reported being HIV-infected. Median follow-up of the cohort was 105 days (range 0\u2013368). Self-reported severe COVID-19 was experienced by 10 of 124 (8.1%) participants compared with 12 of 249 (4.8%) without TBI (odds ratio [OR] 1.73, 95% CI 0.73-4.12, p\u2009=\u20090.21). HIV was not associated with self-reported severe COVID-19 (OR 3.13, 0.96-8.77, p\u2009=\u20090.039, adjusted OR 2.77, 95%CI 0.84-7.93, p\u2009=\u20090.070), but age\u2009\u2265\u200950 years was associated with self-reported severe COVID-19 (OR 3.73, 1.47-9.07, p\u2009=\u20090.004, adjusted OR 2.91, 95%CI 1.02-7.69, p\u2009=\u20090.035). One participant died of COVID-19 three days after diagnosis, and another participant developed active TB 128 days after his COVID-19 diagnosis and was successfully treated. Both were QuantiFERON positive. Self-reported severe COVID-19 was associated with older age and not TBI. Our finding that increased age was associated with self-reported severe COVID-19 is consistent with findings in multiple settings around the world.<\/jats:p>","DOI":"10.1371\/journal.pgph.0004372","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T18:03:32Z","timestamp":1746813812000},"page":"e0004372","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgph.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Self-reported COVID-19 severity among persons with tuberculosis infection in western Kenya, 2021"],"prefix":"10.1371","volume":"5","author":[{"given":"Hellen 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