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While alternative treatments may offer symptomatic relief, the cornerstone of TB management remains anti-tubercular therapy (ATT) as recommended by the World Health Organization (WHO). Yet, many individuals with TB-like symptoms first consult traditional healers and AYUSH (Ayurveda, Yoga, Naturopathy, Unani, Siddha, and Homeopathy) practitioners, resulting in delays in diagnosis and treatment initiation. This quasi-experimental study evaluated the impact of strengthening linkages between non-allopathic and allopathic providers, through formal referral systems, alongside the implementation of a free chest X-ray (CXR) screening system for presumptive TB patients. A mixed methods design found the significant role of friends and family in influencing care-seeking patterns, while a regression analysis within a Difference-in-Differences approach found the intervention to reduce diagnostic delay by over eight days (-8.6, 95% CI: \u221216.6, \u22120.5). The accelerated pathway to diagnosis was observed irrespective of which provider was first visited by the patient, holding promise for future such interventions, especially in high-burden regions, with significant reliance on informal providers.<\/jats:p>","DOI":"10.1371\/journal.pgph.0004416","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T17:39:44Z","timestamp":1775669984000},"page":"e0004416","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgph.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Strengthening TB care pathways: Integrating informal and AYUSH practitioners for early diagnosis and referral"],"prefix":"10.1371","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2401-1065","authenticated-orcid":true,"given":"Ridhima","family":"Sodhi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8018-339X","authenticated-orcid":true,"given":"Shruti","family":"Goel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5231-0531","authenticated-orcid":true,"given":"Rohit","family":"Baghel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7601-0780","authenticated-orcid":true,"given":"Kiran","family":"Rade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1001-6001","authenticated-orcid":true,"given":"Kshitij","family":"Khaparde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0219-3282","authenticated-orcid":true,"given":"Harkesh","family":"Dabas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4530-0694","authenticated-orcid":true,"given":"Shamim","family":"Mannan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8514-1014","authenticated-orcid":true,"given":"Manoj","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"pgph.0004416.ref001","unstructured":"Global Programme on Tuberculosis & Lung Health. 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