{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T18:30:23Z","timestamp":1767205823796,"version":"3.48.0"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosglobalpublichealth.org"],"crossmark-restriction":false},"short-container-title":["PLOS Glob Public Health"],"abstract":"<jats:p>Polycystic ovary syndrome (PCOS) is a common hormonal disorder of reproductive-aged women all over the world. Low- and middle-income countries, such as Bangladesh, often give inadequate attention to mental health issues. As a result, a growing number of women with PCOS are dealing with mental health issues, including an under diagnosis and under-treatment of psychological illnesses. The study assesses the prevalence and psychological impacts of PCOS among women in the reproductive age as well as compared the mental health inequalities between rural and urban women in Bangladesh. A sample of 212 women in the reproductive age was collected using a convenience sampling procedure. Additionally, for diagnosis of PCOS, the Rotterdam criteria were used. Depression, anxiety, stress, and insomnia were measured using DASS-21 and ISI-7 tool. To analyze the association and impact of PCOS on mental health problems, a chi-square test and multivariate binary logistic regression were conducted. The Mann-Whitney U test was implemented to assess mental health disparities among rural-urban reproductive women. Among the participants, the PCOS prevalence was 50.9%, and the rates of depression, anxiety, stress, and insomnia were 51.4%, 62.3%, 46.7%, and 53.3%, respectively. Based on the Rotterdam criteria, women with PCOS had a significantly greater prevalence of psychological disorders than women without PCOS. Women residing in rural region were more prone to meet Rotterdam criteria and had higher anxiety and insomnia syndrome. Women who met two or three diagnostic criteria had a higher chance of experiencing psychological distress than others. Furthermore, relationship status and BMI are useful predictive factors of mental health consequences. The findings showed a substantial prevalence of emotional distress among PCOS women in Bangladesh. Additionally, a comprehensive mental health investigation is suggested for PCOS. Addressing both the physical and psychological aspects of PCOS is essential to develop women\u2019s overall well-being and quality of life.<\/jats:p>","DOI":"10.1371\/journal.pgph.0004937","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T18:28:27Z","timestamp":1767205707000},"page":"e0004937","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgph.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polycystic ovary syndrome and psychological distress: Urban\u2013rural comparison among reproductive-aged women in Bangladesh"],"prefix":"10.1371","volume":"5","author":[{"given":"Anup","family":"Talukder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahmina Akter","family":"Tithi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maruf Hasan","family":"Rumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2765-7868","authenticated-orcid":true,"given":"Abdul","family":"Muyeed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"issue":"1","key":"pgph.0004937.ref001","doi-asserted-by":"crossref","first-page":"62","DOI":"10.5694\/mja11.10553","article-title":"Prevalence of polycystic ovary syndrome in a sample of Indigenous women in Darwin, Australia","volume":"196","author":"JA Boyle","year":"2012","journal-title":"Med J Aust"},{"issue":"1","key":"pgph.0004937.ref002","doi-asserted-by":"crossref","DOI":"10.1186\/s43042-019-0031-4","article-title":"Hyperandrogenism in polycystic ovarian syndrome and role of CYP gene variants: a review","volume":"20","author":"S Ashraf","year":"2019","journal-title":"Egypt J Med Hum Genet"},{"issue":"11","key":"pgph.0004937.ref003","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.1210\/jc.2007-0761","article-title":"Identification of a polycystic ovary syndrome susceptibility variant in fibrillin-3 and association with a metabolic phenotype","volume":"92","author":"M Urbanek","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"pgph.0004937.ref004","unstructured":"Polycystic ovary syndrome n.d. 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