{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T19:18:26Z","timestamp":1771528706082,"version":"3.50.1"},"reference-count":61,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012400","name":"Sigma Theta Tau International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012400","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011493","name":"Whitney and Betty MacMillan Center for International and Area Studies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011493","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosglobalpublichealth.org"],"crossmark-restriction":false},"short-container-title":["PLOS Glob Public Health"],"abstract":"<jats:p>Studies on diabetes-related stigma rarely focus on identifying or examining protective factors (e.g., social support and healthcare environment) that can mitigate the adverse effect of this social phenomenon. In this cross-sectional study, we examined perceived autonomy support, a concept from the self-determination theory, as a moderator of the association between diabetes-related stigma and its adverse behavioral and psychological (depression, diabetes distress, and anxiety) correlates. We recruited 190 adults with type 2 diabetes (T2D) from a tertiary hospital in Ghana. We assessed diabetes-related stigma, depression, anxiety, diabetes distress, diabetes self-management, and perceived autonomy support using psychometric instruments. Hierarchical multivariable linear regressions were used to evaluate moderation effects of perceived autonomy support. Participants had an average age of 59.44 (standard deviation [SD] = 10.7) years, were mostly female (70.5%, n\u2009=\u2009134), and had had T2D diagnosis for a median of 14.5 years. Autonomy support was directly associated with lower anxiety and depression and better diabetes self-management behaviors. Greater perceived autonomy support reduced the negative association between diabetes-related stigma and diabetes self-management (\u03b2\u2009=\u20090.20, 95% confidence interval [CI]: 0.01 to 0.39; p\u2009=\u20090.041). Perceived autonomy support buffered the negative effects of diabetes stigma on self-management. These findings highlight autonomy-supportive care as a promising strategy to address the adverse effects of diabetes-related stigma in Ghana.<\/jats:p>","DOI":"10.1371\/journal.pgph.0006027","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T18:32:02Z","timestamp":1771525922000},"page":"e0006027","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgph.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigating the role of perceived autonomy support in moderating the association between diabetes stigma and psychological and diabetes self-management outcomes among adults with type 2 diabetes in Ghana"],"prefix":"10.1371","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1654-2774","authenticated-orcid":true,"given":"Samuel","family":"Akyirem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail","family":"Melkus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8951-5419","authenticated-orcid":true,"given":"Soohyun","family":"Nam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Micah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9122-4135","authenticated-orcid":true,"given":"Emmanuel","family":"Ekpor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2630-602X","authenticated-orcid":true,"given":"LaRon E.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"pgph.0006027.ref001","unstructured":"International Diabetes Federation. 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