{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:56:42Z","timestamp":1782928602389,"version":"3.54.5"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014895","name":"Open Philanthropy Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008309","name":"Johns Hopkins Bloomberg School of Public Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008309","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosglobalpublichealth.org"],"crossmark-restriction":false},"short-container-title":["PLOS Glob Public Health"],"abstract":"<jats:p>Kenya faces a heightened risk of emerging and\/or reemerging infectious disease (EID) outbreaks of zoonotic origins due to climate-induced extreme weather events and other environmental drivers. We aimed to obtain the perspectives of stakeholders on the development of a newly conceptualized integrated risk analysis (IRA) framework to address environmentally driven EIDs. We addressed the study aim by learning from stakeholders\u2019 experiences with the operationalization of the Joint Risk Assessment Operational Tool (JRA OT) in Kenya. We conducted an exploratory and explanatory qualitative study using a constructivist approach. National- and county-level government representatives, representatives from the Quadripartite institutions (FAO\/UNEP\/WHO\/WOAH), and other partner institutions related to One Health (OH) in Kenya were recruited to participate in semi-structured key informant interviews from 22\/02\/2024 to 30\/03\/2024. A total of twenty-eight interviews were conducted, transcribed verbatim and analyzed using a thematic framework analysis. Study participant pool comprised sixteen, five, and seven county-level, national-level, and partner institution representatives respectively. Four major themes emerged from the study data as essential components of an IRA framework: (i) Improving cross-sectoral data sharing and integration; (ii) Early stakeholder inclusion and holistic engagement; (iii) Proactive cross-sectoral resource mobilization and allocation; and (iv) Policies and legislation for addressing OH governance challenges. Improving IRA processes to ensure integration of the environment sector into the OH approach will enhance preparedness for and response to environmentally driven zoonotic biological threats. National and sub-national OH policies are needed to enable routine operationalization of risk-based OH activities like Joint Risk Assessments (JRAs) and other aspects of risk analysis to inform cross-sectoral decision making for pandemic prevention.<\/jats:p>","DOI":"10.1371\/journal.pgph.0006560","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:22:54Z","timestamp":1782926574000},"page":"e0006560","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgph.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Improving risk analysis of environmentally driven zoonotic biological threats as a primary pandemic prevention approach: A case study of the Tripartite Joint Risk Assessment Operational Tool operationalization in Kenya"],"prefix":"10.1371","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7135-0207","authenticated-orcid":true,"given":"Oluwayemisi","family":"Ajumobi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1267-6422","authenticated-orcid":true,"given":"Anthony","family":"Etyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth Munge","family":"Kabubei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadondi","family":"Kasera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabera","family":"Kenyanya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine Marie","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"von DobSchuetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Nuzzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"pgph.0006560.ref001","unstructured":"Cohen J, Horne F, Rall K, Human Rights Watch (Organization). \u201cThere Is No Time Left\u201d: Climate Change, Environmental Threats, and Human Rights in Turkana County, Kenya."},{"key":"pgph.0006560.ref002","unstructured":"Eastern Africa: El Ni\u00f1o Impact Snapshot (November 2023) - Somalia | ReliefWeb. [cited 2024 Jun 3]. https:\/\/reliefweb.int\/report\/somalia\/eastern-africa-el-nino-impact-snapshot-november-2023"},{"key":"pgph.0006560.ref003","unstructured":"Republic of Kenya M of E Climate Change and Forestry Meteorological Department. Climate Outlook for the \u201cLong Rains\u201d (March - May 2024) and Review of the October - December 2023 \u201cShort Rains\u201d Season."},{"key":"pgph.0006560.ref004","unstructured":"Kenya: Heavy Rains and Flooding Update - Flash Update #7 (19 June 2024) - Kenya | ReliefWeb. [cited 2024 Jul 1]. https:\/\/reliefweb.int\/report\/kenya\/kenya-heavy-rains-and-flooding-update-flash-update-7-19-june-2024"},{"issue":"7","key":"pgph.0006560.ref005","article-title":"Potential impact of climate change on livestock production and health in East Africa: a review","volume":"25","author":"EG Kimaro","year":"2013","journal-title":"Livest Res Rural Dev"},{"key":"pgph.0006560.ref006","first-page":"191","article-title":"Viral haemorrhagic fevers in Tanzania: Seroprevalence and associated risk factors","volume":"23","author":"SE Rugarabamu","year":"2022","journal-title":"Tanzania J Health Res"},{"issue":"8","key":"pgph.0006560.ref007","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.3390\/v14081743","article-title":"Outbreak of Middle East respiratory syndrome coronavirus in camels and probable spillover infection to humans in Kenya","volume":"14","author":"I Ngere","year":"2022","journal-title":"Viruses"},{"key":"pgph.0006560.ref008","unstructured":"Ministry of Agriculture L Fisheries and Cooperatives, Ministry of Health. Zoonotic Disease Unit: One Health Strategic Plan for the Prevention and Control of Zoonotic Diseases in Kenya (2021-2025). 2021."},{"key":"pgph.0006560.ref009","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s10393-024-01684-9","article-title":"Spatial examination of social and environmental drivers of Middle East respiratory syndrome coronavirus (MERS-CoV) across Kenya","volume":"21","author":"TJ Lawrence","year":"2024","journal-title":"Ecohealth"},{"issue":"11","key":"pgph.0006560.ref010","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.3201\/eid2911.230362","article-title":"Micro\u2012global positioning systems for identifying nightly opportunities for Marburg virus spillover to humans by Egyptian Rousette Bats","volume":"29","author":"BR Amman","year":"2023","journal-title":"Emerg Infect Dis"},{"issue":"3","key":"pgph.0006560.ref011","doi-asserted-by":"crossref","first-page":"581","DOI":"10.3201\/eid3003.231488","article-title":"Biphasic MERS-CoV Incidence in Nomadic Dromedaries with Putative Transmission to Humans, Kenya, 2022\u20132023","volume":"30","author":"BM Ogoti","year":"2024","journal-title":"Emerg Infect Dis"},{"issue":"10","key":"pgph.0006560.ref012","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1089\/vbz.2021.0024","article-title":"Livestock presence influences the seroprevalence of Crimean Congo hemorrhagic fever virus on sympatric wildlife in Kenya","volume":"21","author":"V Obanda","year":"2021","journal-title":"Vector Borne Zoonotic Dis"},{"key":"pgph.0006560.ref013","article-title":"Targeting transmission pathways for emerging zoonotic disease surveillance and control","author":"EH Loh","year":"2013","journal-title":"Vector Borne Zoonotic Dis"},{"issue":"1","key":"pgph.0006560.ref014","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1017\/S0031182016001414","article-title":"Eco-social processes influencing infectious disease emergence and spread","volume":"144","author":"BA Jones","year":"2017","journal-title":"Parasitology"},{"issue":"3","key":"pgph.0006560.ref015","first-page":"113","article-title":"Towards a sustainable one health approach to Crimean-Congo hemorrhagic fever prevention: focus areas and gaps in knowledge","volume":"5","author":"TE Sorvillo","year":"2020","journal-title":"Trop Med Infect Dis"},{"key":"pgph.0006560.ref016","unstructured":"Food and Agricultural Organization WO for AH World Health Organization. Joint Risk Assessment Operational Tool (JRA OT): Operational Tool of the Tripartite Zoonoses Guide. [cited 2022 Aug 3]. https:\/\/www.who.int\/initiatives\/tripartite-zoonosis-guide\/joint-risk-assessment-operational-tool"},{"key":"pgph.0006560.ref017","doi-asserted-by":"crossref","unstructured":"Petrone ME, Holmes EC, Harvey E. Through an ecological lens: An ecosystem-based approach to zoonotic risk assessment. EMBR. https:\/\/doi.org\/10.15252\/embr.202256578","DOI":"10.15252\/embr.202256578"},{"key":"pgph.0006560.ref018","unstructured":"Environment UN. UNEP strategy for Environmental Education and Training | UNEP - UN Environment Programme. 2017. [cited 2025 Oct 31]. https:\/\/www.unep.org\/about-un-environment\/policies-and-strategies\/un-environment-strategy-environmental-education-and"},{"key":"pgph.0006560.ref019","first-page":"114652","volume-title":"Incorporating epidemics risk in the INFORM Hazard-dependent Global Risk Index, EUR 29603 EN","author":"K Marin-Ferrer","year":"2018"},{"issue":"4","key":"pgph.0006560.ref020","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgh-2025-019162","article-title":"Improving risk analysis of the environmental drivers of the spillover, emergence\/re-emergence and spread of Crimean-Congo haemorrhagic fever virus, Marburg virus and Middle East respiratory syndrome coronavirus in the East Africa Region","volume":"10","author":"O Ajumobi","year":"2025","journal-title":"BMJ Glob Health"},{"key":"pgph.0006560.ref021","unstructured":"The Power of Constructivist Grounded Theory for Critical Inquiry - Kathy Charmaz. 2017. [cited 2025 Oct 31]. https:\/\/journals.sagepub.com\/doi\/10.1177\/1077800416657105"},{"issue":"6","key":"pgph.0006560.ref022","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/intqhc\/mzm042","article-title":"Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups","volume":"19","author":"A Tong","year":"2007","journal-title":"Int J Qual Health Care"},{"key":"pgph.0006560.ref023","unstructured":"World Health Organization. Health Emergency and Disaster Risk Management Framework. 2019."},{"issue":"1","key":"pgph.0006560.ref024","doi-asserted-by":"crossref","first-page":"91","DOI":"10.20506\/rst.38.1.2944","article-title":"Integration of wildlife and environmental health into a One Health approach","volume":"38","author":"JM Sleeman","year":"2019","journal-title":"Rev Sci Tech"},{"key":"pgph.0006560.ref025","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1201\/9781003263494-3","article-title":"Environmental viruses in livestock production","volume-title":"Environmental and food virology: Impacts and challenges in one health approach","author":"JRC Zanella","year":"2023"},{"key":"pgph.0006560.ref026","unstructured":"United Nations Office for Disaster Risk Reduction (UNDRR). Projecting Effects of Climate Change in the Framework of the INFORM Risk Index. 2022."},{"issue":"10113","key":"pgph.0006560.ref027","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1016\/S0140-6736(17)32092-5","article-title":"Local, national, and regional viral haemorrhagic fever pandemic potential in Africa: a multistage analysis","volume":"390","author":"DM Pigott","year":"2017","journal-title":"Lancet"},{"key":"pgph.0006560.ref028","unstructured":"FAO focuses on strengthening of One Health preparedness and response to Ebola Virus Disease and other Priority Zoonotic Diseases. FAOinKenya. [cited 2026 Apr 11]. https:\/\/www.fao.org\/kenya\/news\/newsdetails\/FAO-focuses-on-strengthening-of-One-Health-preparedness-and-response-to-Ebola-Virus-Disease-and-other-Priority-Zoonotic-Diseases-\/en"},{"key":"pgph.0006560.ref029","unstructured":"Food and Agriculture Organization, EcoHealth Alliance. Policy Brief: How Natural Resource Management Sectors Can Contribute to Reducing Emerging Infectious Diseases: The Example of Forest Ecosystems. 2023."},{"issue":"2","key":"pgph.0006560.ref030","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.exis.2016.08.009","article-title":"Mining and emerging infectious diseases: Results of the Infectious Disease Risk Assessment and Management (IDRAM) initiative pilot","volume":"4","author":"F Viliani","year":"2017","journal-title":"Extract Ind Soc"},{"issue":"4","key":"pgph.0006560.ref031","doi-asserted-by":"crossref","DOI":"10.1016\/S2542-5196(21)00031-0","article-title":"Land use-induced spillover: a call to action to safeguard environmental, animal, and human health","volume":"5","author":"RK Plowright","year":"2021","journal-title":"Lancet Planet Health"},{"key":"pgph.0006560.ref032","volume-title":"One Health Joint Plan of Action, 2022\u20132026","author":"FAO; UNEP; WHO","year":"2022"}],"container-title":["PLOS Global Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgph.0006560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:23:20Z","timestamp":1782926600000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgph.0006560"}},"subtitle":[],"editor":[{"given":"Syed Shahid","family":"Abbas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":32,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgph.0006560","relation":{},"ISSN":["2767-3375"],"issn-type":[{"value":"2767-3375","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]}}}