{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T21:29:19Z","timestamp":1785619759783,"version":"3.56.0"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Gates Foundation and Gavi, the Vaccine Alliance","award":["INV-034281, OPP1157270 \/ INV-009125"],"award-info":[{"award-number":["INV-034281, OPP1157270 \/ INV-009125"]}]},{"name":"Gates Foundation and Gavi, the Vaccine Alliance","award":["INV-034281, OPP1157270 \/ INV-009125"],"award-info":[{"award-number":["INV-034281, OPP1157270 \/ INV-009125"]}]},{"name":"Gates Foundation and Gavi, the Vaccine Alliance","award":["INV-034281, OPP1157270 \/ INV-009125"],"award-info":[{"award-number":["INV-034281, OPP1157270 \/ INV-009125"]}]},{"name":"Gates Foundation and Gavi, the Vaccine Alliance","award":["INV-034281, OPP1157270 \/ INV-009125"],"award-info":[{"award-number":["INV-034281, OPP1157270 \/ INV-009125"]}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP223fa627004"],"award-info":[{"award-number":["JP223fa627004"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31AI167535, T32AI165369"],"award-info":[{"award-number":["F31AI167535, T32AI165369"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosglobalpublichealth.org"],"crossmark-restriction":false},"short-container-title":["PLOS Glob Public Health"],"abstract":"<jats:p>\n                    The basic reproduction number, R\n                    <jats:sub>0<\/jats:sub>\n                    , is an epidemiological measure to describe the transmissibility of infectious diseases and evaluate the potential effect of interventions. Measles R\n                    <jats:sub>0<\/jats:sub>\n                    has historically been considered to be between 12\u201318, with contextual factors contributing to its heterogeneity, but has rarely been estimated using data across multiple countries. Our study aims to estimate measles R\n                    <jats:sub>0<\/jats:sub>\n                    in low- and middle-income countries using a standardised database of population-based serosurveys. We fitted an age-structured compartmental model of measles transmission dynamics and vaccination (DynaMICE) to the age-specific seroprevalence data extracted from a recent systematic review. Using Markov Chain Monte Carlo, we estimated setting-specific posterior distributions of R\n                    <jats:sub>0<\/jats:sub>\n                    in 172 studies with unique survey years and locations from 57 countries. Bootstrapped samples of R\n                    <jats:sub>0<\/jats:sub>\n                    estimates were pooled by study characteristics, including survey period, geography, and overall bias in sampling, measurement, and reporting results. Measles R\n                    <jats:sub>0<\/jats:sub>\n                    estimates varied substantially across serostudies, ranging from 0.93 (95% credible interval (CrI): 0.70\u20131.00) to 147 (95% CrI: 76.5\u2013208), with fewer than 13% of studies having median R\n                    <jats:sub>0<\/jats:sub>\n                    values in the range of 12\u201318. Pooled R\n                    <jats:sub>0<\/jats:sub>\n                    estimates showed smaller medians and variation in serostudies conducted after 2000 or including the adult population, while no distinguishable variation was identified across the World Health Organization regions. Our revised estimates demonstrated the wide range of measles R\n                    <jats:sub>0<\/jats:sub>\n                    across low- and middle-income settings and highlighted the importance of considering the heterogeneity in measles transmissibility when modelling epidemics and planning interventions and vaccination strategies.\n                  <\/jats:p>","DOI":"10.1371\/journal.pgph.0006731","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:44:46Z","timestamp":1784310286000},"page":"e0006731","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgph.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Estimating the basic reproduction number of measles in low-and middle-income settings using 172 seroprevalence studies: A modelling approach"],"prefix":"10.1371","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8934-7347","authenticated-orcid":true,"given":"Han","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa N.","family":"Sbarra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0563-1576","authenticated-orcid":true,"given":"Kaja","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Auzenbergs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Jit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"pgph.0006731.ref001","unstructured":"World Health Organization. Immunization data. Accessed 2023 November 20. https:\/\/immunizationdata.who.int\/listing.html"},{"issue":"45","key":"pgph.0006731.ref002","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.15585\/mmwr.mm7345a4","article-title":"Progress toward measles elimination - worldwide, 2000-2023","volume":"73","author":"AA Minta","year":"2024","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"4536","key":"pgph.0006731.ref003","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1126\/science.7063839","article-title":"Directly transmitted infections diseases: control by vaccination","volume":"215","author":"RM Anderson","year":"1982","journal-title":"Science"},{"issue":"12","key":"pgph.0006731.ref004","doi-asserted-by":"crossref","DOI":"10.1016\/S1473-3099(17)30307-9","article-title":"The basic reproduction number (R0) of measles: a systematic review","volume":"17","author":"FM Guerra","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"pgph.0006731.ref005","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/1471-2458-14-147","article-title":"Measuring underreporting and under-ascertainment in infectious disease datasets: a comparison of methods","volume":"14","author":"CL Gibbons","year":"2014","journal-title":"BMC Public Health"},{"issue":"6","key":"pgph.0006731.ref006","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3390\/vaccines12060585","article-title":"Evaluating scope and bias of population-level measles serosurveys: a systematized review and bias assessment","volume":"12","author":"AN Sbarra","year":"2024","journal-title":"Vaccines (Basel)"},{"issue":"8","key":"pgph.0006731.ref007","doi-asserted-by":"crossref","DOI":"10.1016\/S2214-109X(23)00220-6","article-title":"Health effects of routine measles vaccination and supplementary immunisation activities in 14 high-burden countries: a Dynamic Measles Immunization Calculation Engine (DynaMICE) modelling study","volume":"11","author":"M Auzenbergs","year":"2023","journal-title":"Lancet Glob Health"},{"issue":"1","key":"pgph.0006731.ref008","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1186\/s12916-021-02157-4","article-title":"Effect of evidence updates on key determinants of measles vaccination impact: a DynaMICE modelling study in ten high-burden countries","volume":"19","author":"H Fu","year":"2021","journal-title":"BMC Med"},{"issue":"10","key":"pgph.0006731.ref009","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.vaccine.2014.11.050","article-title":"Controlling measles using supplemental immunization activities: a mathematical model to inform optimal policy","volume":"33","author":"S Verguet","year":"2015","journal-title":"Vaccine"},{"key":"pgph.0006731.ref010","article-title":"Measles vaccines.","volume-title":"Plotkin SA, Orenstein WA, Offit PA, Edwards KM, editors. Plotkin\u2019s Vaccines","author":"PM Strebel","year":"2018","edition":"7"},{"key":"pgph.0006731.ref011","unstructured":"United Nations Population Division. World population prospects 2024. https:\/\/population.un.org\/wpp\/. Accessed 23 July 2024."},{"issue":"7","key":"pgph.0006731.ref012","article-title":"Projecting contact matrices in 177 geographical regions: an update and comparison with empirical data for the COVID-19 era","volume":"17","author":"Centre for the Mathematical Modelling of Infectious Diseases COVID-19 Working Group","year":"2021","journal-title":"PLoS Comput Biol"},{"issue":"3","key":"pgph.0006731.ref013","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.vaccine.2019.10.090","article-title":"The effect of time since measles vaccination and age at first dose on measles vaccine effectiveness - A systematic review","volume":"38","author":"SL Hughes","year":"2020","journal-title":"Vaccine"},{"key":"pgph.0006731.ref014","article-title":"Effectiveness of measles vaccination and vitamin A treatment","author":"CR Sudfeld","year":"2010","journal-title":"Int J Epidemiol"},{"issue":"6","key":"pgph.0006731.ref015","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1063\/1.1699114","article-title":"Equation of State Calculations by Fast Computing Machines","volume":"21","author":"N Metropolis","year":"1953","journal-title":"J Chem Physics"},{"key":"pgph.0006731.ref016","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.c1626","article-title":"Early waning of maternal measles antibodies in era of measles elimination: longitudinal study","volume":"340","author":"E Leuridan","year":"2010","journal-title":"BMJ"},{"key":"pgph.0006731.ref017","unstructured":"United Nations Population Division. Household size and composition. 2022. https:\/\/www.un.org\/development\/desa\/pd\/sites\/files\/undesa_pd_2022_hh-size-composition.xlsx"},{"key":"pgph.0006731.ref018","unstructured":"United Nations Development Programme. Human development index. 2024. https:\/\/hdr.undp.org\/sites\/default\/files\/2023-24_HDR\/HDR23-24_Statistical_Annex_HDI_Table.xlsx"},{"key":"pgph.0006731.ref019","unstructured":"World Health Organization. Provisional monthly measles and rubella data. Accessed 2024 June 26. https:\/\/www.who.int\/teams\/immunization-vaccines-and-biologicals\/immunization-analysis-and-insights\/surveillance\/monitoring\/provisional-monthly-measles-and-rubella-data"},{"key":"pgph.0006731.ref020","unstructured":"Global Burden of Disease Collaborative Network. Global Burden of Disease Study 2021 (GBD 2021) results. Institute for Health Metrics and Evaluation; 2022. https:\/\/vizhub.healthdata.org\/gbd-results\/"},{"issue":"10","key":"pgph.0006731.ref021","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/S1473-3099(17)30421-8","article-title":"Measles immunity gaps and the progress towards elimination: a multi-country modelling analysis","volume":"17","author":"F Trentini","year":"2017","journal-title":"Lancet Infect Dis"},{"issue":"9","key":"pgph.0006731.ref022","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1005697","article-title":"Projecting social contact matrices in 152 countries using contact surveys and demographic data","volume":"13","author":"K Prem","year":"2017","journal-title":"PLoS Comput Biol"},{"issue":"3","key":"pgph.0006731.ref023","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1008858","article-title":"Estimates of the basic reproduction number for rubella using seroprevalence data and indicator-based approaches","volume":"18","author":"T Papadopoulos","year":"2022","journal-title":"PLoS Comput Biol"},{"issue":"1","key":"pgph.0006731.ref024","doi-asserted-by":"crossref","first-page":"19645","DOI":"10.1038\/s41598-020-76746-3","article-title":"Clustering of susceptible individuals within households can drive measles outbreaks: an individual-based model exploration","volume":"10","author":"E Kuylen","year":"2020","journal-title":"Sci Rep"},{"issue":"7","key":"pgph.0006731.ref025","doi-asserted-by":"crossref","first-page":"732","DOI":"10.3390\/pathogens11070732","article-title":"Serology as a tool to assess infectious disease landscapes and guide public health policy","volume":"11","author":"AH Haselbeck","year":"2022","journal-title":"Pathogens"},{"issue":"21","key":"pgph.0006731.ref026","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.1002\/sim.8290","article-title":"Estimation and prediction for a mechanistic model of measles transmission using particle filtering and maximum likelihood estimation","volume":"38","author":"KE Eilertson","year":"2019","journal-title":"Stat Med"},{"issue":"10440","key":"pgph.0006731.ref027","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1016\/S0140-6736(24)00367-2","article-title":"Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021","volume":"403","author":"GBD 2021 Causes of Death Collaborators","year":"2024","journal-title":"Lancet"},{"issue":"7","key":"pgph.0006731.ref028","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1111\/risa.12430","article-title":"Systematic review of measles and rubella serology studies","volume":"36","author":"KM Thompson","year":"2016","journal-title":"Risk Anal"},{"issue":"7842","key":"pgph.0006731.ref029","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41586-020-03043-4","article-title":"Mapping routine measles vaccination in low- and middle-income countries","volume":"589","author":"Local Burden of Disease Vaccine Coverage Collaborators","year":"2021","journal-title":"Nat"},{"issue":"1","key":"pgph.0006731.ref030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3201\/eid2501.171901","article-title":"Complexity of the Basic Reproduction Number (R0)","volume":"25","author":"PL Delamater","year":"2019","journal-title":"Emerg Infect Dis"},{"issue":"10","key":"pgph.0006731.ref031","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1093\/infdis\/jiz380","article-title":"What is the evidence to support a correlate of protection for measles? 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