{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:24:27Z","timestamp":1787163867008,"version":"build-2736575974"},"reference-count":12,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K01AI151083"],"award-info":[{"award-number":["K01AI151083"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Stop TB Partnership\u2019s TB REACH initiative","award":["STBP\/TBREACH\/GSA\/W6-1"],"award-info":[{"award-number":["STBP\/TBREACH\/GSA\/W6-1"]}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K23AI186597"],"award-info":[{"award-number":["K23AI186597"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosglobalpublichealth.org"],"crossmark-restriction":false},"short-container-title":["PLOS Glob Public Health"],"abstract":"<jats:p>We assessed 188 children diagnosed with extrapulmonary tuberculosis in Bangladesh. Over half were aged 10\u201314 years old. Common symptoms included fever (91.5%), weight loss (88.3%), and decreased appetite (72.9%). Four children died prior to treatment; of 176 children on treatment, 4.0% had unsuccessful outcomes, potentially influenced by age and low weight. Findings highlight the need for improved diagnosis and management in children.<\/jats:p>","DOI":"10.1371\/journal.pgph.0006971","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:28:28Z","timestamp":1787160508000},"page":"e0006971","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgph.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identifying pediatric extrapulmonary tuberculosis through an active screening program: Findings and programmatic implications from Bangladesh"],"prefix":"10.1371","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7911-584X","authenticated-orcid":true,"given":"Giordano","family":"Sosa Soto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey I.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amyn A.","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4054-4946","authenticated-orcid":true,"given":"Md. Mahfuzur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzana","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suchitra","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamruzzaman","family":"Kamrul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Toufiq","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4885-940X","authenticated-orcid":true,"given":"Jacob","family":"Creswell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamidah","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8133-2634","authenticated-orcid":true,"given":"Tapash","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8431-5517","authenticated-orcid":true,"given":"Meredith B.","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"pgph.0006971.ref001","volume-title":"Global tuberculosis report 2025","author":"World Health Organization","year":"2025"},{"issue":"9","key":"pgph.0006971.ref002","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1128\/JCM.43.9.4357-4362.2005","article-title":"Diagnosis of extrapulmonary tuberculosis by smear, culture, and PCR using universal sample processing technology","volume":"43","author":"S Chakravorty","year":"2005","journal-title":"J Clin Microbiol"},{"key":"pgph.0006971.ref003","volume-title":"Operational Handbook on Tuberculosis","author":"Organization World Health","year":"2021"},{"key":"pgph.0006971.ref004","author":"B National Tuberculosis Control Programme","year":"2022"},{"key":"pgph.0006971.ref005","doi-asserted-by":"crossref","first-page":"04024","DOI":"10.7189\/jogh.15.04024","article-title":"Age- and sex-specific care cascades to detect gaps in the care of children with tuberculosis in Bangladesh: a cohort study","volume":"15","author":"D Ramirez","year":"2025","journal-title":"J Glob Health"},{"issue":"1","key":"pgph.0006971.ref006","doi-asserted-by":"crossref","first-page":"26","DOI":"10.5588\/pha.24.0050","article-title":"Evaluation of treatment outcomes and associated risk factors in children with TB in Bangladesh","volume":"15","author":"A Madan","year":"2025","journal-title":"Public Health Action"},{"issue":"8","key":"pgph.0006971.ref007","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1097\/INF.0000000000003584","article-title":"Age-specific Clinical Presentation and Risk Factors for Extrapulmonary Tuberculosis Disease in Children","volume":"41","author":"MM Dubois","year":"2022","journal-title":"Pediatr Infect Dis J"},{"key":"pgph.0006971.ref008","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.3389\/fimmu.2018.02946","article-title":"The Wonder Years: What Can Primary School Children Teach Us About Immunity to Mycobacterium tuberculosis?","volume":"9","author":"JA Seddon","year":"2018","journal-title":"Front Immunol"},{"issue":"1","key":"pgph.0006971.ref009","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4103\/PMRR.PMRR_43_23","article-title":"Risk factors of childhood extrapulmonary tuberculosis compared to pulmonary tuberculosis in Bangladesh: a hospital-based study","volume":"1","author":"R Pervin","year":"2024","journal-title":"Prev Med Res Rev"},{"issue":"2","key":"pgph.0006971.ref010","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1093\/jpids\/piy138","article-title":"Using Changes in Weight-for-Age z Score to Predict Effectiveness of Childhood Tuberculosis Therapy","volume":"9","author":"SS Chiang","year":"2020","journal-title":"J Pediatric Infect Dis Soc"},{"issue":"9","key":"pgph.0006971.ref011","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1093\/infdis\/jiy675","article-title":"Undernutrition and Tuberculosis: Public Health Implications","volume":"219","author":"P Sinha","year":"2019","journal-title":"J Infect Dis"},{"issue":"6","key":"pgph.0006971.ref012","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3390\/pathogens13060467","article-title":"Pediatric Tuberculosis: A Review of Evidence-Based Best Practices for Clinicians and Health Care Providers","volume":"13","author":"BK Moore","year":"2024","journal-title":"Pathogens"}],"container-title":["PLOS Global Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgph.0006971","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:28:30Z","timestamp":1787160510000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgph.0006971"}},"subtitle":[],"editor":[{"given":"Graeme","family":"Hoddinott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,8,19]]},"references-count":12,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgph.0006971","relation":{},"ISSN":["2767-3375"],"issn-type":[{"value":"2767-3375","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,19]]}}}