{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:15:32Z","timestamp":1788200132608,"version":"build-2803163510"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010897","name":"Newton Fund","doi-asserted-by":"publisher","award":["MC_PC_16020"],"award-info":[{"award-number":["MC_PC_16020"]}],"id":[{"id":"10.13039\/100010897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosglobalpublichealth.org"],"crossmark-restriction":false},"short-container-title":["PLOS Glob Public Health"],"abstract":"<jats:p>Mobile health (mHealth) technologies are increasingly used to support community-based healthcare. However, their real-world impact often remains unclear. Understanding implementation factors is essential for advancing their use and achieving meaningful health outcomes. We evaluated an mHealth tool (AitaHealth) after customising its modules and workflows for household Tuberculosis (TB) contact tracing and other community-based data collection by community health workers (CHWs). We describe the acceptability, feasibility, and implementation fidelity of this approach. We conducted a mixed-methods evaluation in two South African districts: uMkhanyakude and Ekurhuleni. We collected qualitative data through focus group discussions (FGDs) and in-depth interviews (IDIs) with CHWs, team leaders, and key stakeholders. We used deductive thematic analysis grounded in the Technology Acceptance Model (TAM) to assess the acceptability and implementation feasibility of the mHealth tool. We used quantitative data from the AitaHealth metadata to assess implementation fidelity. CHWs appreciated AitaHealth\u2019s efficiency, data security, and credibility. Across the two districts, 103 CHWs recorded data for 2,452 households and 10,649 household members. However, they reported challenges in ease of use, with unreliable devices, weak support, and safety concerns hindering data collection. These issues led to inconsistent engagement, with 48.5% of CHWs logging in fewer than 15 times during implementation. Despite these challenges, when used, AitaHealth ensured high-quality data collection and household coverage, with TB-related fields completed in over 94% of households, demonstrating its potential under better conditions. AitaHealth`s limitations stemmed from system constraints rather than user resistance. To achieve full impact, mHealth tools require reliable infrastructure and supportive environments for both the tools and their implementers.<\/jats:p>","DOI":"10.1371\/journal.pgph.0007120","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T17:26:24Z","timestamp":1788197184000},"page":"e0007120","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgph.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the acceptability, feasibility, and implementation fidelity of a multipurpose mobile health (mHealth) app used for Tuberculosis (TB) contact tracing by Ward-Based Outreach Teams (WBOTs) in South Africa"],"prefix":"10.1371","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2759-3320","authenticated-orcid":true,"given":"Don Lawrence","family":"Mudzengi","sequence":"first","affiliation":[{"name":"The Aurum Institute","place":["Johannesburg, South Africa"]},{"name":"University of the Witwatersrand, School 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Mkhuze: uMkhanyakude District Municipality. 2023."},{"key":"pgph.0007120.ref026","volume-title":"uMkhanyakude District Municipality District Development Plan. Report No","author":"COGTA","year":"2020"},{"issue":"1","key":"pgph.0007120.ref027","first-page":"1","article-title":"The 2022 antenatal HIV sentinel survey: key findings","volume":"2013","author":"T Kufa-Chakezha","year":"2023","journal-title":"Public Health Bulletin South Africa"},{"key":"pgph.0007120.ref028","volume-title":"District health barometer","author":"N Massyn","year":"2020"},{"key":"pgph.0007120.ref029","volume-title":"Annual Report 2021\/22","author":"Ekurhuleni Municipality","year":"2022"},{"key":"pgph.0007120.ref030","volume-title":"Profile: City of Ekurhuleni","author":"COGTA","year":"2020"},{"key":"pgph.0007120.ref031","unstructured":"Strydom C. AitaHealth Platform | Tech for Community Health Workers. MezzanineWare. https:\/\/mezzanineware.com\/aitahealth-4-years-and-1-million-individuals-registered\/. 2018. Accessed 2023 February 21."},{"issue":"1","key":"pgph.0007120.ref032","doi-asserted-by":"crossref","DOI":"10.4102\/phcfm.v12i1.2155","article-title":"Peer-learning reviews to improve Gauteng community-oriented primary care: Findings from AitaHealth\u2122-enabled ward-based outreach teams","volume":"12","author":"TS Marcus","year":"2020","journal-title":"Afr J Prim Health Care Fam Med"},{"key":"pgph.0007120.ref033","article-title":"An investigation of factors associated with antenatal care attendance in Gauteng in 2015","volume":"114","author":"EM Webb","year":"2024","journal-title":"S Afr Med J"},{"key":"pgph.0007120.ref034","unstructured":"Vodafone. User manual Tab mini 7 2016. https:\/\/www.vodafone.com\/sites\/default\/files\/2023-10\/tabmini7-user-manual-english.pdf"},{"issue":"8","key":"pgph.0007120.ref035","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1111\/tmi.12525","article-title":"Evidence on feasibility and effective use of mHealth strategies by frontline health workers in developing countries: systematic review","volume":"20","author":"S Agarwal","year":"2015","journal-title":"Trop Med Int Health"},{"issue":"1","key":"pgph.0007120.ref036","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12911-020-01381-x","article-title":"Mapping evidence of mobile health technologies for disease diagnosis and treatment support by health workers in sub-Saharan Africa: a scoping review","volume":"21","author":"E Osei","year":"2021","journal-title":"BMC Med Inform Decis Mak"},{"issue":"1","key":"pgph.0007120.ref037","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13012-023-01286-z","article-title":"Ten years of implementation outcomes research: a scoping review","volume":"18","author":"EK Proctor","year":"2023","journal-title":"Implement Sci"},{"issue":"5","key":"pgph.0007120.ref038","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064662","article-title":"A pilot study of an mHealth application for healthcare workers: poor uptake despite high reported acceptability at a rural South African community-based MDR-TB treatment program","volume":"8","author":"KH Chaiyachati","year":"2013","journal-title":"PLoS One"},{"key":"pgph.0007120.ref039","doi-asserted-by":"crossref","first-page":"30","DOI":"10.21037\/mhealth.2017.07.01","article-title":"Evaluating clinicians\u2019 user experience and acceptability of LearnTB, a smartphone application for tuberculosis in India","volume":"3","author":"T Pande","year":"2017","journal-title":"Mhealth"},{"issue":"1","key":"pgph.0007120.ref040","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s44247-023-00009-0","article-title":"Acceptability and feasibility of a mobile health application for enhancing public private mix for TB care among healthcare Workers in Southwestern Uganda","volume":"1","author":"W Tumuhimbise","year":"2023","journal-title":"BMC Digit Health"},{"key":"pgph.0007120.ref041","unstructured":"Jooste S, Ramlagan S, Magobo R, Shean Y, Sewpaul R, Dukhi N. A national skills audit of community health workers and outreach team leaders employed by the National Department of Health, 2023. 2024."},{"issue":"8","key":"pgph.0007120.ref042","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pdig.0000322","article-title":"Acceptability and feasibility of digital adherence technologies for drug-susceptible tuberculosis treatment supervision: a meta-analysis of implementation feedback","volume":"2","author":"K Guzman","year":"2023","journal-title":"PLOS Digit Health"},{"key":"pgph.0007120.ref043","doi-asserted-by":"crossref","DOI":"10.2196\/51662","article-title":"Acceptability of a digital adherence tool among patients with tuberculosis and tuberculosis care providers in Kilimanjaro Region, Tanzania: Mixed Methods Study","volume":"16","author":"AE Mtenga","year":"2024","journal-title":"Online J Public Health Inform"},{"key":"pgph.0007120.ref044","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.pedn.2025.01.027","article-title":"The acceptability, feasibility and adoption of a co-designed electronic post-injury psychosocial screening tool for carers of children admitted to hospital following injury","volume":"81","author":"MTA Dimanopoulos","year":"2025","journal-title":"J Pediatr Nurs"},{"issue":"2","key":"pgph.0007120.ref045","doi-asserted-by":"crossref","DOI":"10.2196\/jmir.6900","article-title":"Readiness for delivering digital health at scale: lessons from a longitudinal qualitative evaluation of a national digital health innovation program in the United Kingdom","volume":"19","author":"MR Lennon","year":"2017","journal-title":"J Med Internet Res"},{"key":"pgph.0007120.ref046","volume-title":"WHO guideline: recommendations on digital interventions for health system strengthening","author":"World Health Organization","year":"2019"},{"issue":"3","key":"pgph.0007120.ref047","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgph.0002226","article-title":"Mobilisation towards formal employment in the healthcare system: A qualitative study of community health workers in South Africa","volume":"4","author":"H Malatji","year":"2024","journal-title":"PLOS Glob Public Health"},{"issue":"6","key":"pgph.0007120.ref048","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/wvn.12324","article-title":"Making it happen: middle managers\u2019 roles in innovation implementation in health care","volume":"15","author":"R Urquhart","year":"2018","journal-title":"Worldviews on Evidence-Based Nursing"},{"issue":"1","key":"pgph.0007120.ref049","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s12913-024-12129-y","article-title":"Digital health readiness - insights from healthcare leaders in operational management: a cross-sectional survey","volume":"25","author":"I Steenkamp","year":"2025","journal-title":"BMC Health Serv Res"},{"issue":"4","key":"pgph.0007120.ref050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002796","article-title":"Contact tracing versus facility-based screening for active TB case finding in rural South Africa: A pragmatic cluster-randomized trial (Kharitode TB)","volume":"16","author":"CF Hanrahan","year":"2019","journal-title":"PLoS Med"},{"key":"pgph.0007120.ref051","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1745-6215-9-63","article-title":"ZAMSTAR, The Zambia South Africa TB and HIV reduction study: design of a 2 x 2 factorial community randomized trial","volume":"9","author":"HM Ayles","year":"2008","journal-title":"Trials"}],"container-title":["PLOS Global Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgph.0007120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T17:26:34Z","timestamp":1788197194000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgph.0007120"}},"subtitle":[],"editor":[{"given":"Julia","family":"Robinson","sequence":"first","affiliation":[{"name":"PLOS: Public Library of Science","place":["UNITED STATES OF AMERICA"]}],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":51,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgph.0007120","relation":{},"ISSN":["2767-3375"],"issn-type":[{"value":"2767-3375","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]}}}