{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:43:04Z","timestamp":1793288584707,"version":"4.5.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T00:00:00Z","timestamp":1164672000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosmedicine.org"],"crossmark-restriction":false},"short-container-title":["PLoS Med"],"DOI":"10.1371\/journal.pmed.0030466","type":"journal-article","created":{"date-parts":[[2006,11,22]],"date-time":"2006-11-22T21:43:26Z","timestamp":1164231806000},"page":"e466","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmed.corrections_policy","source":"Crossref","is-referenced-by-count":650,"title":["OPC-67683, a Nitro-Dihydro-Imidazooxazole Derivative with Promising Action against Tuberculosis In Vitro and In Mice"],"prefix":"10.1371","volume":"3","author":[{"given":"Makoto","family":"Matsumoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Hashizume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Tomishige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Kawasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetsugu","family":"Tsubouchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Shimokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Komatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2006,11,28]]},"reference":[{"key":"journal-pmed-0030466-b002","first-page":"677","volume":"282","author":"Dye","year":"1999","journal-title":"JAMA","ISSN":"https:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"key":"journal-pmed-0030466-b003","first-page":"213","volume":"72","author":"Dolin","year":"1994","journal-title":"Bull World Health Organ","ISSN":"https:\/\/id.crossref.org\/issn\/0042-9686","issn-type":"print"},{"key":"journal-pmed-0030466-b004","first-page":"44","volume":"83","author":"Espinal","year":"2003","journal-title":"Tuberculosis (Edinb)","ISSN":"https:\/\/id.crossref.org\/issn\/1472-9792","issn-type":"print"},{"key":"journal-pmed-0030466-b005","author":"Farmer","year":"1999","journal-title":"The global impact of drug resistant tuberculosis"},{"key":"journal-pmed-0030466-b008","first-page":"S19","volume":"90","author":"Raether","year":"2003","journal-title":"Parasitol Res","ISSN":"https:\/\/id.crossref.org\/issn\/0044-3255","issn-type":"print"},{"key":"journal-pmed-0030466-b009","first-page":"183","volume":"37","author":"Ashtekar","year":"1993","journal-title":"Antimicrob Agents Chemother","ISSN":"https:\/\/id.crossref.org\/issn\/0066-4804","issn-type":"print"},{"key":"journal-pmed-0030466-b010","first-page":"631","volume":"24","author":"Nagarajan","year":"1989","journal-title":"Eur J Med Chem","ISSN":"https:\/\/id.crossref.org\/issn\/0223-5234","issn-type":"print"},{"key":"journal-pmed-0030466-b011","author":"Matsumoto","year":"2006","journal-title":"Screening for novel antituberculosis agents that are effective against multidrug resistant tuberculosis"},{"key":"journal-pmed-0030466-b012","first-page":"377","volume":"76","author":"Saito","year":"1995","journal-title":"Tuber Lung Dis","ISSN":"https:\/\/id.crossref.org\/issn\/0962-8479","issn-type":"print"},{"key":"journal-pmed-0030466-b013","first-page":"77","volume":"41","author":"Sato","year":"1998","journal-title":"J Antimicrob Chemother","ISSN":"https:\/\/id.crossref.org\/issn\/0305-7453","issn-type":"print"},{"key":"journal-pmed-0030466-b014","first-page":"18","volume":"20","author":"Woods","year":"2002","journal-title":"Clinical and Laboratory Standards Institute","ISSN":"https:\/\/id.crossref.org\/issn\/0273-3099","issn-type":"print"},{"key":"journal-pmed-0030466-b015","first-page":"265","volume":"31","author":"Emoto","year":"2001","journal-title":"Xenobiotica","ISSN":"https:\/\/id.crossref.org\/issn\/0049-8254","issn-type":"print"},{"key":"journal-pmed-0030466-b016","first-page":"115","volume":"16","author":"Ikeda","year":"2001","journal-title":"Xenobio Metabol and Dispos","ISSN":"https:\/\/id.crossref.org\/issn\/0049-8254","issn-type":"print"},{"key":"journal-pmed-0030466-b017","first-page":"682","volume":"25","author":"Umehara","year":"2002","journal-title":"Biol Pharm Bull","ISSN":"https:\/\/id.crossref.org\/issn\/0918-6158","issn-type":"print"},{"key":"journal-pmed-0030466-b018","first-page":"607","author":"Correia","year":"1995","journal-title":"Cytochrome P450: Structure, mechanism, and biochemistry"},{"key":"journal-pmed-0030466-b019","first-page":"651","volume":"29","author":"Sesardic","year":"1990","journal-title":"Br J Clin Pharmacol","ISSN":"https:\/\/id.crossref.org\/issn\/0306-5251","issn-type":"print"},{"key":"journal-pmed-0030466-b020","first-page":"1389","volume":"282","author":"Stevens","year":"1997","journal-title":"J Pharmacol Exp Ther","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3565","issn-type":"print"},{"key":"journal-pmed-0030466-b021","first-page":"5543","volume":"54","author":"Rahman","year":"1994","journal-title":"Cancer Res","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"key":"journal-pmed-0030466-b022","first-page":"54","volume":"5","author":"Rettie","year":"1992","journal-title":"Chem Res Toxicol","ISSN":"https:\/\/id.crossref.org\/issn\/0893-228X","issn-type":"print"},{"key":"journal-pmed-0030466-b023","first-page":"443","volume":"13","author":"Inaba","year":"1985","journal-title":"Drug Metab Dispos","ISSN":"https:\/\/id.crossref.org\/issn\/0090-9556","issn-type":"print"},{"key":"journal-pmed-0030466-b024","first-page":"29","volume":"28","author":"Broly","year":"1989","journal-title":"Br J Clin Pharmacol","ISSN":"https:\/\/id.crossref.org\/issn\/0306-5251","issn-type":"print"},{"key":"journal-pmed-0030466-b025","first-page":"168","volume":"4","author":"Guengerich","year":"1991","journal-title":"Chem Res Toxicol","ISSN":"https:\/\/id.crossref.org\/issn\/0893-228X","issn-type":"print"},{"key":"journal-pmed-0030466-b026","first-page":"261","volume":"25","author":"Baldwin","year":"1995","journal-title":"Xenobiotica","ISSN":"https:\/\/id.crossref.org\/issn\/0049-8254","issn-type":"print"},{"key":"journal-pmed-0030466-b027","first-page":"483","volume":"60","author":"Matsumiya","year":"1985","journal-title":"Kekkaku","ISSN":"https:\/\/id.crossref.org\/issn\/0022-9776","issn-type":"print"},{"key":"journal-pmed-0030466-b028","first-page":"78","volume":"27","author":"Israili","year":"1987","journal-title":"J Clin Pharmacol","ISSN":"https:\/\/id.crossref.org\/issn\/0091-2700","issn-type":"print"},{"key":"journal-pmed-0030466-b029","first-page":"686","volume":"22","author":"Zhu","year":"2002","journal-title":"Pharmacotherapy","ISSN":"https:\/\/id.crossref.org\/issn\/0277-0008","issn-type":"print"},{"key":"journal-pmed-0030466-b030","first-page":"537","volume":"393","author":"Cole","year":"1998","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"journal-pmed-0030466-b031","first-page":"962","volume":"405","author":"Stover","year":"2000","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"journal-pmed-0030466-b032","first-page":"431","volume":"103","author":"Manjunatha","year":"2006","journal-title":"Proc Natl Acad Sci U S A","ISSN":"https:\/\/id.crossref.org\/issn\/1091-6490","issn-type":"print"},{"key":"journal-pmed-0030466-b033","first-page":"9","volume":"31","author":"Edwards","year":"1993","journal-title":"J Antimicrob Chemother","ISSN":"https:\/\/id.crossref.org\/issn\/0305-7453","issn-type":"print"},{"key":"journal-pmed-0030466-b034","first-page":"277","volume":"25","author":"Shen","year":"1995","journal-title":"Int J Psychiatry Med","ISSN":"https:\/\/id.crossref.org\/issn\/0091-2174","issn-type":"print"},{"key":"journal-pmed-0030466-b035","first-page":"84S","volume":"15","author":"Riesenman","year":"1995","journal-title":"Pharmacotherapy","ISSN":"https:\/\/id.crossref.org\/issn\/0277-0008","issn-type":"print"},{"key":"journal-pmed-0030466-b036","first-page":"321","volume":"12","author":"Somogyi","year":"1987","journal-title":"Clin Pharmacokinet","ISSN":"https:\/\/id.crossref.org\/issn\/0312-5963","issn-type":"print"},{"key":"journal-pmed-0030466-b037","first-page":"17","volume":"107","author":"Li","year":"1997","journal-title":"Chem Biol Interact","ISSN":"https:\/\/id.crossref.org\/issn\/0009-2797","issn-type":"print"},{"key":"journal-pmed-0030466-b038","first-page":"2705","volume":"293","author":"Hampton","year":"2005","journal-title":"JAMA","ISSN":"https:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"}],"container-title":["PLoS Medicine"],"original-title":[],"language":"en","deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T16:50:07Z","timestamp":1540227007000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pmed.0030466"}},"subtitle":[],"editor":[{"given":"Philip","family":"Hopewell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2006,11,28]]},"references-count":35,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2006,11,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pmed.0030466","relation":{},"ISSN":["1549-1676"],"issn-type":[{"value":"1549-1676","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,28]]}}}