{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:57:07Z","timestamp":1791331027013,"version":"4.3.1"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2007,5,8]],"date-time":"2007-05-08T00:00:00Z","timestamp":1178582400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosmedicine.org"],"crossmark-restriction":false},"short-container-title":["PLoS Med"],"DOI":"10.1371\/journal.pmed.0040176","type":"journal-article","created":{"date-parts":[[2007,5,3]],"date-time":"2007-05-03T18:13:07Z","timestamp":1178215987000},"page":"e176","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmed.corrections_policy","source":"Crossref","is-referenced-by-count":117,"title":["Down-Regulation of the Interferon Signaling Pathway in T Lymphocytes from Patients with Metastatic Melanoma"],"prefix":"10.1371","volume":"4","author":[{"given":"Rebecca J","family":"Critchley-Thorne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serban","family":"Nacu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan P","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter P","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2007,5,8]]},"reference":[{"key":"journal-pmed-0040176-b001","first-page":"1178","volume":"95","author":"Staveley-O&apos;Carroll","year":"1998","journal-title":"Proc Natl Acad Sci U S A","ISSN":"https:\/\/id.crossref.org\/issn\/1091-6490","issn-type":"print"},{"key":"journal-pmed-0040176-b002","first-page":"677","volume":"5","author":"Lee","year":"1999","journal-title":"Nat Med","ISSN":"https:\/\/id.crossref.org\/issn\/1078-8956","issn-type":"print"},{"key":"journal-pmed-0040176-b003","first-page":"651","volume":"190","author":"Anichini","year":"1999","journal-title":"J Exp Med","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1007","issn-type":"print"},{"key":"journal-pmed-0040176-b004","first-page":"1351","volume":"6","author":"Saito","year":"2000","journal-title":"Clin Cancer Res","ISSN":"https:\/\/id.crossref.org\/issn\/1078-0432","issn-type":"print"},{"key":"journal-pmed-0040176-b005","first-page":"2553","volume":"8","author":"Hoffmann","year":"2002","journal-title":"Clin Cancer Res","ISSN":"https:\/\/id.crossref.org\/issn\/1078-0432","issn-type":"print"},{"key":"journal-pmed-0040176-b006","first-page":"2865","volume":"64","author":"Zippelius","year":"2004","journal-title":"Cancer Res","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"key":"journal-pmed-0040176-b007","first-page":"1965","volume":"183","author":"Topalian","year":"1996","journal-title":"J Exp Med","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1007","issn-type":"print"},{"key":"journal-pmed-0040176-b008","first-page":"2357","volume":"188","author":"Hung","year":"1998","journal-title":"J Exp Med","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1007","issn-type":"print"},{"key":"journal-pmed-0040176-b009","first-page":"321","volume":"4","author":"Rosenberg","year":"1998","journal-title":"Nat Med","ISSN":"https:\/\/id.crossref.org\/issn\/1078-8956","issn-type":"print"},{"key":"journal-pmed-0040176-b010","first-page":"16168","volume":"99","author":"Yee","year":"2002","journal-title":"Proc Natl Acad Sci U S A","ISSN":"https:\/\/id.crossref.org\/issn\/1091-6490","issn-type":"print"},{"key":"journal-pmed-0040176-b011","first-page":"6292","volume":"163","author":"Lee","year":"1999","journal-title":"J Immunol","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1767","issn-type":"print"},{"key":"journal-pmed-0040176-b012","first-page":"186","volume":"97","author":"Weber","year":"2003","journal-title":"Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0765-7846","issn-type":"print"},{"key":"journal-pmed-0040176-b013","first-page":"505","volume":"28","author":"Banchereau","year":"2005","journal-title":"J Immunother","ISSN":"https:\/\/id.crossref.org\/issn\/1053-8550","issn-type":"print"},{"key":"journal-pmed-0040176-b014","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2144\/mar03dudoit","author":"Dudoit","year":"2003","journal-title":"Biotechniques"},{"key":"journal-pmed-0040176-b015","first-page":"289","volume":"57","author":"Benjamini","year":"1995","journal-title":"J Roy Statist Soc Ser B","ISSN":"https:\/\/id.crossref.org\/issn\/1369-7412","issn-type":"print"},{"key":"journal-pmed-0040176-b016","first-page":"147","volume":"13","author":"Polacek","year":"2003","journal-title":"Physiol Genomics","ISSN":"https:\/\/id.crossref.org\/issn\/1531-2267","issn-type":"print"},{"key":"journal-pmed-0040176-b017","first-page":"465","volume":"4","author":"Kendziorski","year":"2003","journal-title":"Biostatistics","ISSN":"https:\/\/id.crossref.org\/issn\/1465-4644","issn-type":"print"},{"key":"journal-pmed-0040176-b018","first-page":"4252","volume":"102","author":"Kendziorski","year":"2005","journal-title":"Proc Natl Acad Sci U S A","ISSN":"https:\/\/id.crossref.org\/issn\/1091-6490","issn-type":"print"},{"key":"journal-pmed-0040176-b019","first-page":"37","volume":"45","author":"Roederer","year":"2001","journal-title":"Cytometry","ISSN":"https:\/\/id.crossref.org\/issn\/0196-4763","issn-type":"print"},{"key":"journal-pmed-0040176-b020","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"key":"journal-pmed-0040176-b021","first-page":"4465","volume":"174","author":"Curtsinger","year":"2005","journal-title":"J Immunol","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1767","issn-type":"print"},{"key":"journal-pmed-0040176-b022","first-page":"1415","volume":"264","author":"Darnell","year":"1994","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0193-4511","issn-type":"print"},{"key":"journal-pmed-0040176-b023","first-page":"375","volume":"5","author":"Platanias","year":"2005","journal-title":"Nat Rev Immunol","ISSN":"https:\/\/id.crossref.org\/issn\/1474-1733","issn-type":"print"},{"key":"journal-pmed-0040176-b024","first-page":"3740","volume":"173","author":"Dondi","year":"2004","journal-title":"J Immunol","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1767","issn-type":"print"},{"key":"journal-pmed-0040176-b025","first-page":"637","volume":"202","author":"Kolumam","year":"2005","journal-title":"J Exp Med","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1007","issn-type":"print"},{"key":"journal-pmed-0040176-b026","first-page":"3315","volume":"176","author":"Havenar-Daughton","year":"2006","journal-title":"J Immunol","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1767","issn-type":"print"},{"key":"journal-pmed-0040176-b027","first-page":"2074","volume":"176","author":"Le Bon","year":"2006","journal-title":"J Immunol","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1767","issn-type":"print"},{"key":"journal-pmed-0040176-b028","first-page":"4682","volume":"176","author":"Le Bon","year":"2006","journal-title":"J Immunol","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1767","issn-type":"print"},{"key":"journal-pmed-0040176-b029","first-page":"1363","volume":"274","author":"Hahne","year":"1996","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0193-4511","issn-type":"print"},{"key":"journal-pmed-0040176-b030","first-page":"3137","volume":"8","author":"Reichert","year":"2002","journal-title":"Clin Cancer Res","ISSN":"https:\/\/id.crossref.org\/issn\/1078-0432","issn-type":"print"},{"key":"journal-pmed-0040176-b031","first-page":"5113","volume":"9","author":"Taylor","year":"2003","journal-title":"Clin Cancer Res","ISSN":"https:\/\/id.crossref.org\/issn\/1078-0432","issn-type":"print"},{"key":"journal-pmed-0040176-b032","first-page":"6816","volume":"66","author":"Biswas","year":"2006","journal-title":"Cancer Res","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"key":"journal-pmed-0040176-b033","first-page":"311","volume":"38","author":"Dumontet","year":"1994","journal-title":"Cancer Immunol Immunother","ISSN":"https:\/\/id.crossref.org\/issn\/0340-7004","issn-type":"print"},{"key":"journal-pmed-0040176-b034","first-page":"161","volume":"2","author":"Lai","year":"1996","journal-title":"Clin Cancer Res","ISSN":"https:\/\/id.crossref.org\/issn\/1078-0432","issn-type":"print"},{"key":"journal-pmed-0040176-b035","first-page":"947s","volume":"7","author":"Dworacki","year":"2001","journal-title":"Clin Cancer Res","ISSN":"https:\/\/id.crossref.org\/issn\/1078-0432","issn-type":"print"},{"key":"journal-pmed-0040176-b036","first-page":"1382","volume":"155","author":"Wang","year":"1995","journal-title":"J Immunol","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1767","issn-type":"print"},{"key":"journal-pmed-0040176-b037","first-page":"1327","volume":"1","author":"Zea","year":"1995","journal-title":"Clin Cancer Res","ISSN":"https:\/\/id.crossref.org\/issn\/1078-0432","issn-type":"print"},{"key":"journal-pmed-0040176-b038","first-page":"352","volume":"44","author":"He","year":"2006","journal-title":"Hepatology","ISSN":"https:\/\/id.crossref.org\/issn\/0270-9139","issn-type":"print"},{"key":"journal-pmed-0040176-b039","first-page":"205","volume":"129","author":"Feng","year":"2002","journal-title":"J Neuroimmunol","ISSN":"https:\/\/id.crossref.org\/issn\/0165-5728","issn-type":"print"},{"key":"journal-pmed-0040176-b040","first-page":"10626","volume":"95","author":"Liu","year":"1998","journal-title":"Proc Natl Acad Sci U S A","ISSN":"https:\/\/id.crossref.org\/issn\/1091-6490","issn-type":"print"},{"key":"journal-pmed-0040176-b041","first-page":"917","volume":"387","author":"Starr","year":"1997","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"journal-pmed-0040176-b042","first-page":"755","volume":"56","author":"Chen","year":"1994","journal-title":"Int J Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0020-7136","issn-type":"print"},{"key":"journal-pmed-0040176-b043","first-page":"1492","volume":"77","author":"Krasagakis","year":"1998","journal-title":"Br J Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0007-0920","issn-type":"print"},{"key":"journal-pmed-0040176-b044","first-page":"4489","volume":"20","author":"Saito","year":"2000","journal-title":"Anticancer Res","ISSN":"https:\/\/id.crossref.org\/issn\/0250-7005","issn-type":"print"},{"key":"journal-pmed-0040176-b045","first-page":"1611","volume":"90","author":"Lee","year":"1997","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"key":"journal-pmed-0040176-b046","first-page":"47","volume":"16","author":"Botella-Estrada","year":"2005","journal-title":"Eur Cytokine Netw","ISSN":"https:\/\/id.crossref.org\/issn\/1148-5493","issn-type":"print"},{"key":"journal-pmed-0040176-b047","first-page":"1456","volume":"93","author":"Ito","year":"1999","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"key":"journal-pmed-0040176-b048","first-page":"2880","volume":"94","author":"Cassatella","year":"1999","journal-title":"Blood","ISSN":"https:\/\/id.crossref.org\/issn\/0006-4971","issn-type":"print"},{"key":"journal-pmed-0040176-b049","first-page":"1944","volume":"150","author":"Larner","year":"1993","journal-title":"J Immunol","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1767","issn-type":"print"},{"key":"journal-pmed-0040176-b050","first-page":"3679","volume":"170","author":"Fox","year":"2003","journal-title":"J Immunol","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1767","issn-type":"print"},{"key":"journal-pmed-0040176-b051","first-page":"5666","volume":"175","author":"Park","year":"2005","journal-title":"J Immunol","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1767","issn-type":"print"},{"key":"journal-pmed-0040176-b052","first-page":"2756","volume":"169","author":"Liyanage","year":"2002","journal-title":"J Immunol","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1767","issn-type":"print"},{"key":"journal-pmed-0040176-b053","first-page":"1444","volume":"173","author":"Viguier","year":"2004","journal-title":"J Immunol","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1767","issn-type":"print"},{"key":"journal-pmed-0040176-b054","first-page":"3164","volume":"24","author":"Moschos","year":"2006","journal-title":"J Clin Oncol","ISSN":"https:\/\/id.crossref.org\/issn\/0732-183X","issn-type":"print"},{"key":"journal-pmed-0040176-b055","first-page":"1101","volume":"95","author":"Kirkwood","year":"2002","journal-title":"Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0765-7846","issn-type":"print"},{"key":"journal-pmed-0040176-b056","first-page":"709","volume":"354","author":"Gogas","year":"2006","journal-title":"N Engl J Med","ISSN":"https:\/\/id.crossref.org\/issn\/1533-4406","issn-type":"print"},{"key":"journal-pmed-0040176-b057","first-page":"2474","volume":"19","author":"Bowman","year":"2000","journal-title":"Oncogene","ISSN":"https:\/\/id.crossref.org\/issn\/0950-9232","issn-type":"print"}],"container-title":["PLoS Medicine"],"original-title":[],"language":"en","deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T17:54:51Z","timestamp":1556387691000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pmed.0040176"}},"subtitle":[],"editor":[{"given":"Franco M","family":"Marincola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2007,5,8]]},"references-count":57,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2007,5,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pmed.0040176","relation":{},"ISSN":["1549-1676"],"issn-type":[{"value":"1549-1676","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,8]]}}}