{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:33:42Z","timestamp":1791347622874,"version":"4.3.1"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2008,6,17]],"date-time":"2008-06-17T00:00:00Z","timestamp":1213660800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosmedicine.org"],"crossmark-restriction":false},"short-container-title":["PLoS Med"],"DOI":"10.1371\/journal.pmed.0050128","type":"journal-article","created":{"date-parts":[[2008,6,11]],"date-time":"2008-06-11T14:48:41Z","timestamp":1213195721000},"page":"e128","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmed.corrections_policy","source":"Crossref","is-referenced-by-count":457,"title":["Multidrug-Resistant Plasmodium vivax Associated with Severe and Fatal Malaria: A Prospective Study in Papua, Indonesia"],"prefix":"10.1371","volume":"5","author":[{"given":"Emiliana","family":"Tjitra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M","family":"Anstey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulus","family":"Sugiarto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah","family":"Warikar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enny","family":"Kenangalem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Karyana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A","family":"Lampah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ric N","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2008,6,17]]},"reference":[{"key":"journal-pmed-0050128-b001","first-page":"214","volume":"434","author":"Snow","year":"2005","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"journal-pmed-0050128-b002","first-page":"97","volume":"64","author":"Mendis","year":"2001","journal-title":"Am J Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"journal-pmed-0050128-b003","first-page":"79","volume":"77","author":"Price","year":"2007","journal-title":"Am J Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"journal-pmed-0050128-b004","first-page":"533","volume":"23","author":"Baird","year":"2007","journal-title":"Trends Parasitol","ISSN":"https:\/\/id.crossref.org\/issn\/1471-4922","issn-type":"print"},{"key":"journal-pmed-0050128-b005","author":"Yacoub","year":"2008","journal-title":"Lancet Infect Dis"},{"key":"journal-pmed-0050128-b006","first-page":"4075","volume":"48","author":"Baird","year":"2004","journal-title":"Antimicrob Agents Chemother","ISSN":"https:\/\/id.crossref.org\/issn\/0066-4804","issn-type":"print"},{"key":"journal-pmed-0050128-b007","first-page":"1597","volume":"13","author":"Santos-Ciminera","year":"2007","journal-title":"Emerg Infect Dis","ISSN":"https:\/\/id.crossref.org\/issn\/1080-6040","issn-type":"print"},{"key":"journal-pmed-0050128-b008","first-page":"416","volume":"68","author":"Sumawinata","year":"2003","journal-title":"Am J Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"journal-pmed-0050128-b009","first-page":"3947","volume":"46","author":"Tjitra","year":"2002","journal-title":"Antimicrob Agents Chemother","ISSN":"https:\/\/id.crossref.org\/issn\/0066-4804","issn-type":"print"},{"key":"journal-pmed-0050128-b010","first-page":"351","volume":"101","author":"Ratcliff","year":"2007","journal-title":"Trans R Soc Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0035-9203","issn-type":"print"},{"key":"journal-pmed-0050128-b011","first-page":"341","volume":"11","author":"Lee","year":"1980","journal-title":"Southeast Asian J Trop Med Public Health","ISSN":"https:\/\/id.crossref.org\/issn\/0038-3619","issn-type":"print"},{"key":"journal-pmed-0050128-b012","first-page":"228","volume":"29","author":"Pribadi","year":"1998","journal-title":"Southeast Asian J Trop Med Public Health","ISSN":"https:\/\/id.crossref.org\/issn\/0038-3619","issn-type":"print"},{"key":"journal-pmed-0050128-b014","first-page":"717","volume":"366","author":"Dondorp","year":"2005","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"key":"journal-pmed-0050128-b015","first-page":"757","volume":"369","author":"Ratcliff","year":"2007","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"key":"journal-pmed-0050128-b016","first-page":"256","volume":"91","author":"Luxemburger","year":"1997","journal-title":"Trans R Soc Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0035-9203","issn-type":"print"},{"key":"journal-pmed-0050128-b017","first-page":"614","volume":"90","author":"Maitland","year":"1996","journal-title":"Trans R Soc Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0035-9203","issn-type":"print"},{"key":"journal-pmed-0050128-b018","first-page":"614","volume":"65","author":"Price","year":"2001","journal-title":"Am J Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"journal-pmed-0050128-b019","first-page":"327","volume":"4","author":"Hay","year":"2004","journal-title":"Lancet Infect Dis","ISSN":"https:\/\/id.crossref.org\/issn\/1473-3099","issn-type":"print"},{"key":"journal-pmed-0050128-b020","first-page":"212","volume":"32","author":"Buck","year":"1983","journal-title":"Am J Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"journal-pmed-0050128-b021","volume":"3","author":"Carrara","year":"2006","journal-title":"PLoS Med","ISSN":"https:\/\/id.crossref.org\/issn\/1549-1676","issn-type":"print"},{"key":"journal-pmed-0050128-b022","first-page":"562","volume":"91","author":"Maitland","year":"1997","journal-title":"Trans R Soc Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0035-9203","issn-type":"print"},{"key":"journal-pmed-0050128-b023","first-page":"385","volume":"36","author":"Vannaphan","year":"2005","journal-title":"Southeast Asian J Trop Med Public Health","ISSN":"https:\/\/id.crossref.org\/issn\/0038-3619","issn-type":"print"},{"key":"journal-pmed-0050128-b024","first-page":"51","volume":"89","author":"Gopinathan","year":"1986","journal-title":"J Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0022-5304","issn-type":"print"},{"key":"journal-pmed-0050128-b025","first-page":"984","volume":"77","author":"Barcus","year":"2007","journal-title":"Am J Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"journal-pmed-0050128-b026","first-page":"37","volume":"12","author":"Beg","year":"2008","journal-title":"Int J Infect Dis","ISSN":"https:\/\/id.crossref.org\/issn\/1201-9712","issn-type":"print"},{"key":"journal-pmed-0050128-b027","first-page":"94","volume":"54","author":"Rodriguez-Morales","year":"2008","journal-title":"J Trop Pediatr","ISSN":"https:\/\/id.crossref.org\/issn\/0142-6338","issn-type":"print"},{"key":"journal-pmed-0050128-b028","first-page":"997","volume":"76","author":"Michon","year":"2007","journal-title":"Am J Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"journal-pmed-0050128-b029","first-page":"105","volume":"90","author":"Luxemburger","year":"1996","journal-title":"Trans R Soc Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0035-9203","issn-type":"print"},{"key":"journal-pmed-0050128-b030","first-page":"123","volume":"69","author":"Kurtis","year":"2001","journal-title":"Infect Immun","ISSN":"https:\/\/id.crossref.org\/issn\/0019-9567","issn-type":"print"},{"key":"journal-pmed-0050128-b031","first-page":"39","volume":"352","author":"Berkley","year":"2005","journal-title":"N Engl J Med","ISSN":"https:\/\/id.crossref.org\/issn\/1533-4406","issn-type":"print"},{"key":"journal-pmed-0050128-b032","volume":"4","author":"Bejon","year":"2007","journal-title":"PLoS Med","ISSN":"https:\/\/id.crossref.org\/issn\/1549-1676","issn-type":"print"},{"key":"journal-pmed-0050128-b033","first-page":"1399","volume":"332","author":"Marsh","year":"1995","journal-title":"N Engl J Med","ISSN":"https:\/\/id.crossref.org\/issn\/1533-4406","issn-type":"print"},{"key":"journal-pmed-0050128-b034","first-page":"589","volume":"195","author":"Anstey","year":"2007","journal-title":"J Infect Dis","ISSN":"https:\/\/id.crossref.org\/issn\/1537-6613","issn-type":"print"},{"key":"journal-pmed-0050128-b035","first-page":"233","volume":"20","author":"Mayxay","year":"2004","journal-title":"Trends Parasitol","ISSN":"https:\/\/id.crossref.org\/issn\/1471-4922","issn-type":"print"},{"key":"journal-pmed-0050128-b036","volume":"4","author":"Anstey","year":"2007","journal-title":"PLoS Med","ISSN":"https:\/\/id.crossref.org\/issn\/1549-1676","issn-type":"print"},{"key":"journal-pmed-0050128-b037","first-page":"689","volume":"321","author":"Trape","year":"1998","journal-title":"C R Acad Sci III","ISSN":"https:\/\/id.crossref.org\/issn\/0764-4469","issn-type":"print"},{"key":"journal-pmed-0050128-b038","volume":"5","author":"Genton","year":"2008","journal-title":"PLoS Med","ISSN":"https:\/\/id.crossref.org\/issn\/1549-1676","issn-type":"print"},{"key":"journal-pmed-0050128-b039","first-page":"947","volume":"77","author":"Marfurt","year":"2007","journal-title":"Am J Trop Med Hyg","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9637","issn-type":"print"},{"key":"journal-pmed-0050128-b040","first-page":"1336","volume":"39","author":"Baird","year":"2004","journal-title":"Clin Infect Dis","ISSN":"https:\/\/id.crossref.org\/issn\/1058-4838","issn-type":"print"},{"key":"journal-pmed-0050128-b041","first-page":"369","volume":"14","author":"Alles","year":"1998","journal-title":"Parasitol Today","ISSN":"https:\/\/id.crossref.org\/issn\/0169-4758","issn-type":"print"},{"key":"journal-pmed-0050128-b042","first-page":"1599","volume":"37","author":"Reilly","year":"2007","journal-title":"Int J Parasitol","ISSN":"https:\/\/id.crossref.org\/issn\/0020-7519","issn-type":"print"},{"key":"journal-pmed-0050128-b043","first-page":"1040","volume":"52","author":"Russell","year":"2008","journal-title":"Antimicrob Agents Chemother","ISSN":"https:\/\/id.crossref.org\/issn\/0066-4804","issn-type":"print"},{"key":"journal-pmed-0050128-b044","first-page":"1206","volume":"181","author":"Chotivanich","year":"2000","journal-title":"J Infect Dis","ISSN":"https:\/\/id.crossref.org\/issn\/1537-6613","issn-type":"print"}],"container-title":["PLoS Medicine"],"original-title":[],"language":"en","deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T17:54:18Z","timestamp":1540317258000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pmed.0050128"}},"subtitle":[],"editor":[{"given":"Stephen","family":"Rogerson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2008,6,17]]},"references-count":43,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2008,6,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pmed.0050128","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1116890.580349","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1116890.572978","asserted-by":"object"}]},"ISSN":["1549-1676"],"issn-type":[{"value":"1549-1676","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,17]]}}}