{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:05:42Z","timestamp":1792033542614,"version":"4.4.0"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2010,12,21]],"date-time":"2010-12-21T00:00:00Z","timestamp":1292889600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosmedicine.org"],"crossmark-restriction":false},"short-container-title":["PLoS Med"],"DOI":"10.1371\/journal.pmed.1000384","type":"journal-article","created":{"date-parts":[[2010,12,21]],"date-time":"2010-12-21T20:17:41Z","timestamp":1292962661000},"page":"e1000384","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmed.corrections_policy","source":"Crossref","is-referenced-by-count":248,"title":["Clinical Features and Serum Biomarkers in HIV Immune Reconstitution Inflammatory Syndrome after Cryptococcal Meningitis: A Prospective Cohort Study"],"prefix":"10.1371","volume":"7","author":[{"given":"David R.","family":"Boulware","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Meya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy L.","family":"Bergemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darin L.","family":"Wiesner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Rhein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdu","family":"Musubire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Kambugu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward N.","family":"Janoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Bohjanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2010,12,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1097\/00002030-200205030-00009","article-title":"Cryptococcal infection in a cohort of HIV-1-infected Ugandan adults.","volume":"16","author":"N French","year":"2002","journal-title":"AIDS"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1097\/00002030-200007070-00013","article-title":"Impact of HIV infection on meningitis in Harare, Zimbabwe: a prospective study of 406 predominantly adult patients.","volume":"14","author":"JG Hakim","year":"2000","journal-title":"AIDS"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1086\/339540","article-title":"Morbidity and mortality in South African gold miners: impact of untreated disease due to human immunodeficiency virus.","volume":"34","author":"EL Corbett","year":"2002","journal-title":"Clin Infect Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1111\/j.1365-3156.2007.01874.x","article-title":"Asymptomatic serum cryptococcal antigenemia and early mortality during antiretroviral therapy in rural Uganda.","volume":"12","author":"CA Liechty","year":"2007","journal-title":"Trop Med Int Health"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/QAD.0b013e328322ffac","article-title":"Estimation of the current global burden of cryptococcal meningitis among persons living with HIV\/AIDS.","volume":"23","author":"BJ Park","year":"2009","journal-title":"AIDS"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1086\/516372","article-title":"Combination therapy with fluconazole and flucytosine for cryptococcal meningitis in Ugandan patients with AIDS.","volume":"26","author":"H Mayanja-Kizza","year":"1998","journal-title":"Clin Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1086\/587667","article-title":"Outcomes of cryptococcal meningitis in Uganda before and after the availability of highly active antiretroviral therapy.","volume":"46","author":"A Kambugu","year":"2008","journal-title":"Clin Infect Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1086\/518607","article-title":"Fungal burden, early fungicidal activity, and outcome in cryptococcal meningitis in antiretroviral-naive or antiretroviral-experienced patients treated with amphotericin B or fluconazole.","volume":"45","author":"T Bicanic","year":"2007","journal-title":"Clin Infect Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/QAI.0b013e318183181e","article-title":"The use of HAART is associated with decreased risk of death during initial treatment of cryptococcal meningitis in adults in Botswana.","volume":"49","author":"GP Bisson","year":"2008","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2174\/1570162043351345","article-title":"Immune restoration disease: a consequence of dysregulated immune responses after HAART.","volume":"2","author":"SF Stone","year":"2004","journal-title":"Curr HIV Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/01.aids.0000161769.06158.8a","article-title":"Incidence and risk factors for immune reconstitution inflammatory syndrome during highly active antiretroviral therapy.","volume":"19","author":"SA Shelburne","year":"2005","journal-title":"Aids"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2217\/17520363.2.4.349","article-title":"Biomarkers of HIV immune reconstitution inflammatory syndrome.","volume":"2","author":"S Bonham","year":"2008","journal-title":"Biomark Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1097\/QAI.0b013e3181594c8c","article-title":"Immune reconstitution inflammatory syndrome: risk factors and treatment implications.","volume":"46","author":"YC Manabe","year":"2007","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/QAI.0b013e3181a56f2e","article-title":"Immune reconstitution inflammatory syndrome in HIV-associated cryptococcal meningitis: a prospective study.","volume":"51","author":"T Bicanic","year":"2009","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1086\/428618","article-title":"The role of immune reconstitution inflammatory syndrome in AIDS-related <italic>Cryptococcus neoformans<\/italic> disease in the era of highly active antiretroviral therapy.","volume":"40","author":"J Darcourt","year":"2005","journal-title":"Clin Infect Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1097\/QAI.0b013e318061b5eb","article-title":"Timing of cryptococcal immune reconstitution inflammatory syndrome after antiretroviral therapy in patients with AIDS and cryptococcal meningitis.","volume":"45","author":"S Sungkanuparph","year":"2007","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1097\/01.aids.0000174450.70874.30","article-title":"Incidence and risk factors of immune reconstitution inflammatory syndrome complicating HIV-associated cryptococcosis in France.","volume":"19","author":"O Lortholary","year":"2005","journal-title":"AIDS"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1097\/01.aids.0000191232.16111.f9","article-title":"Cryptococcocal immune reconstitution disease: a major cause of early mortality in a South African antiretroviral programme.","volume":"19","author":"SD Lawn","year":"2005","journal-title":"AIDS"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1086\/644784","article-title":"Immunopathogenesis and diagnosis of tuberculosis and tuberculosis-associated immune reconstitution inflammatory syndrome during early antiretroviral therapy.","volume":"200","author":"JH Elliott","year":"2009","journal-title":"J Infect Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1089\/aid.2009.0055","article-title":"Immunologic markers as predictors of tuberculosis-associated immune reconstitution inflammatory syndrome in HIV and tuberculosis coinfected persons in Thailand.","volume":"25","author":"HV Tieu","year":"2009","journal-title":"AIDS Res Hum Retroviruses"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1742-6405-6-16","article-title":"Polychromatic immunophenotypic characterization of T cell profiles among HIV-infected patients experiencing immune reconstitution inflammatory syndrome (IRIS).","volume":"6","author":"DM Murdoch","year":"2009","journal-title":"AIDS Res Ther"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1182\/blood-2010-05-285080","article-title":"Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome.","volume":"116","author":"LR Antonelli","year":"2010","journal-title":"Blood"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1097\/01.aids.0000131375.21070.06","article-title":"Immune restoration disease after antiretroviral therapy.","volume":"18","author":"MA French","year":"2004","journal-title":"AIDS"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1126\/science.277.5322.112","article-title":"Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease.","volume":"277","author":"B Autran","year":"1997","journal-title":"Science"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1097\/00002030-200211080-00004","article-title":"Rapid reconstitution of humoral immunity against cytomegalovirus but not HIV following highly active antiretroviral therapy.","volume":"16","author":"JR Deayton","year":"2002","journal-title":"Aids"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1086\/313809","article-title":"Immunorestitution disease involving the innate and adaptive response.","volume":"30","author":"VC Cheng","year":"2000","journal-title":"Clin Infect Dis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"6445","DOI":"10.1128\/IAI.69.10.6445-6455.2001","article-title":"Both Th1 and Th2 cytokines affect the ability of monoclonal antibodies to protect mice against <italic>Cryptococcus neoformans<\/italic>.","volume":"69","author":"DO Beenhouwer","year":"2001","journal-title":"Infect Immun"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1128\/IAI.00297-09","article-title":"Cytokine signaling regulates the outcome of intracellular macrophage parasitism by <italic>Cryptococcus neoformans<\/italic>.","volume":"77","author":"K Voelz","year":"2009","journal-title":"Infect Immun"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"5367","DOI":"10.4049\/jimmunol.179.8.5367","article-title":"IL-13 induces disease-promoting Type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with <italic>Cryptococcus neoformans<\/italic>.","volume":"179","author":"U Muller","year":"2007","journal-title":"J Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1128\/IAI.00274-06","article-title":"Protection against cryptococcosis by using a murine gamma interferon-producing <italic>Cryptococcus neoformans<\/italic> strain.","volume":"75","author":"JR Perfect","year":"2007","journal-title":"Infect Immun"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.4049\/jimmunol.174.2.1027","article-title":"Distinct roles for IL-4 and IL-10 in regulating T2 immunity during allergic bronchopulmonary mycosis.","volume":"174","author":"Y Hernandez","year":"2005","journal-title":"J Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"486","DOI":"10.2353\/ajpath.2009.080598","article-title":"IL-4\/IL-13-dependent alternative activation of macrophages but not microglial cells is associated with uncontrolled cerebral cryptococcosis.","volume":"174","author":"W Stenzel","year":"2009","journal-title":"Am J Pathol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1093\/infdis\/171.6.1448","article-title":"Beneficial effect of recombinant human granulocyte colony-stimulating factor on fungicidal activity of polymorphonuclear leukocytes from patients with AIDS.","volume":"171","author":"A Vecchiarelli","year":"1995","journal-title":"J Infect Dis"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1172\/JCI2117","article-title":"Granulocyte colony-stimulating factor administration to HIV-infected subjects augments reduced leukotriene synthesis and anticryptococcal activity in neutrophils.","volume":"102","author":"MJ Coffey","year":"1998","journal-title":"J Clin Investigat"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/00002030-199901140-00007","article-title":"Granulocyte-macrophage colony-stimulating factor and fluconazole enhance anti-cryptococcal activity of monocytes from AIDS patients.","volume":"13","author":"C Tascini","year":"1999","journal-title":"AIDS"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/mmy.40.1.21.26","article-title":"Effect of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor on polymorphonuclear neutrophils, monocytes or monocyte-derived macrophages combined with voriconazole against <italic>Cryptococcus neoformans<\/italic>.","volume":"40","author":"T Chiller","year":"2002","journal-title":"Medical Mycol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S1473-3099(10)70170-5","article-title":"Cryptococcal immune reconstitution inflammatory syndrome: literature review and proposed clinical case definitions.","volume":"10","author":"LJ Haddow","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1111\/j.1469-0691.2007.01756.x","article-title":"Comparison of broad-range bacterial PCR and culture of cerebrospinal fluid for diagnosis of community-acquired bacterial meningitis.","volume":"13","author":"C Welinder-Olsson","year":"2007","journal-title":"Clin Microbiol Infect"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing.","volume":"57","author":"Y Benjamini","year":"1995","journal-title":"J R Stat Soc Ser B"},{"key":"ref40","article-title":"Serum inflammatory biomarkers predict HIV immune reconstitution inflammatory syndrome and death after cryptococcal meningitis.","author":"DR Boulware","year":"2009"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.2517-6161.1996.tb02080.x","article-title":"Regression shrinkage and selection via the Lasso.","volume":"58","author":"R Tibshirani","year":"1996","journal-title":"J R Statist Soc B"},{"key":"ref42","article-title":"R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing.","year":"2009"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.publhealth.20.1.145","article-title":"Time-dependent covariates in the Cox proportional-hazards regression model.","volume":"20","author":"LD Fisher","year":"1999","journal-title":"Annual Review of Public Health"},{"key":"ref44","article-title":"The statistical analysis of failure time data.","author":"JD Kalbfleisch","year":"1980"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1086\/516298","article-title":"Cryptococcal meningitis in human immunodeficiency virus-infected patients in Harare, Zimbabwe.","volume":"26","author":"RS Heyderman","year":"1998","journal-title":"Clin Infect Dis"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1086\/655785","article-title":"Paucity of initial cerebrospinal fluid inflammation in cryptococcal meningitis is associated with subsequent Immune Reconstitution Inflammatory Syndrome.","volume":"202","author":"DR Boulware","year":"2010","journal-title":"J Infect Dis"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1086\/652652","article-title":"Early versus delayed initiation of antiretroviral therapy for concurrent HIV infection and cryptococcal meningitis in Sub-Saharan Africa.","volume":"50","author":"AT Makadzange","year":"2010","journal-title":"Clin Infect Dis"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.2353\/ajpath.2007.060595","article-title":"Role of granulocyte macrophage colony-stimulating factor in host defense against pulmonary <italic>Cryptococcus neoformans<\/italic> infection during murine allergic bronchopulmonary mycosis.","volume":"170","author":"GH Chen","year":"2007","journal-title":"Am J Pathol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1002\/eji.1830220617","article-title":"Cytokine enhancement of complement-dependent phagocytosis by macrophages: synergy of tumor necrosis factor-alpha and granulocyte-macrophage colony-stimulating factor for phagocytosis of <italic>Cryptococcus neoformans<\/italic>.","volume":"22","author":"HL Collins","year":"1992","journal-title":"Eur J Immunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"e5575","DOI":"10.1371\/journal.pone.0005575","article-title":"Early antiretroviral therapy reduces AIDS progression\/death in individuals with acute opportunistic infections: a multicenter randomized strategy trial.","volume":"4","author":"A Zolopa","year":"2009","journal-title":"PLoS One"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1086\/425742","article-title":"Determinants of immune reconstitution inflammatory syndrome in HIV type 1-infected patients with tuberculosis after initiation of antiretroviral therapy.","volume":"39","author":"G Breton","year":"2004","journal-title":"Clin Infect Dis"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1086\/605497","article-title":"Cryptococcal immune reconstitution inflammatory syndrome after antiretroviral therapy in AIDS patients with cryptococcal meningitis: a prospective multicenter study.","volume":"49","author":"S Sungkanuparph","year":"2009","journal-title":"Clin Infect Dis"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"e128","DOI":"10.1086\/344467","article-title":"Immune reconstitution cryptococcosis after initiation of successful highly active antiretroviral therapy.","volume":"35","author":"ER Jenny-Avital","year":"2002","journal-title":"Clin Infect Dis"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"e11416","DOI":"10.1371\/journal.pone.0011416","article-title":"Risk factor analyses for immune reconstitution inflammatory syndrome in a randomized study of early vs. deferred ART during an opportunistic infection.","volume":"5","author":"PM Grant","year":"2010","journal-title":"PLoS One"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S1473-3099(05)70302-9","article-title":"Mycobacterium-associated immune reconstitution disease: macrophages running wild?","volume":"6","author":"R Van den Bergh","year":"2006","journal-title":"Lancet Infect Dis -"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1046\/j.1464-2662.2001.00096.x","article-title":"Levels of IL-6 and soluble IL-6 receptor are increased in HIV patients with a history of immune restoration disease after HAART.","volume":"3","author":"SF Stone","year":"2002","journal-title":"HIV Med"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1086\/323599","article-title":"Plasma bioavailable interleukin-6 is elevated in human immunodeficiency virus-infected patients who experience herpesvirus-associated immune restoration disease after start of highly active antiretroviral therapy.","volume":"184","author":"SF Stone","year":"2001","journal-title":"J Infect Dis"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.immunol.021908.132532","article-title":"Alternative activation of macrophages: an immunologic functional perspective.","volume":"27","author":"FO Martinez","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1086\/656191","article-title":"Metallomic analysis of macrophages infected with Histoplasma capsulatum reveals a fundamental role for zinc in host defenses.","volume":"202","author":"MS Winters","year":"2010","journal-title":"J Infect Dis"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/COH.0b013e328302ebbb","article-title":"Immunopathogenesis of immune reconstitution disease in HIV patients responding to antiretroviral therapy.","volume":"3","author":"L Kestens","year":"2008","journal-title":"Curr Opin HIV AIDS"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1086\/595006","article-title":"HIV\/AIDS: Immune Reconstitution Inflammatory Syndrome: a reappraisal.","volume":"48","author":"MA French","year":"2009","journal-title":"Clin Infect Dis"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1002\/eji.201040391","article-title":"IL-6: Regulator of Treg\/Th17 balance.","volume":"40","author":"A Kimura","year":"2010","journal-title":"Eur J Immunol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1128\/IAI.71.1.68-74.2003","article-title":"Effects of tumor necrosis factor alpha on dendritic cell accumulation in lymph nodes draining the immunization site and the impact on the anticryptococcal cell-mediated immune response.","volume":"71","author":"SK Bauman","year":"2003","journal-title":"Infect Immun"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1086\/423849","article-title":"Intrathecal production and secretion of vascular endothelial growth factor during cryptococcal meningitis.","volume":"190","author":"FA Coenjaerts","year":"2004","journal-title":"J Infect Dis"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"545","DOI":"10.4049\/jimmunol.0900397","article-title":"Cutting edge: Vascular endothelial growth factor-mediated signaling in human CD45RO+ CD4+ T cells promotes Akt and ERK activation and costimulates IFN-gamma production.","volume":"184","author":"A Basu","year":"2010","journal-title":"J Immunol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1310\/NQXR-ULMG-MM1B-3T2B","article-title":"Clinical utility of monitoring serum cryptococcal antigen (sCRAG) titers in patients with AIDS-related cryptococcal disease.","volume":"1","author":"JA Aberg","year":"2000","journal-title":"HIV Clin Trials"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/QAI.0b013e3181ce6b19","article-title":"The prevalence and clinical course of HIV-associated pulmonary cryptococcosis in Uganda.","volume":"54","author":"S Deok-jong Yoo","year":"2010","journal-title":"J Acquir Immune Defic Syndr"}],"container-title":["PLoS Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pmed.1000384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:34:20Z","timestamp":1740789260000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pmed.1000384"}},"subtitle":[],"editor":[{"given":"David G.","family":"Lalloo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,12,21]]},"references-count":67,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2010,12,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pmed.1000384","relation":{},"ISSN":["1549-1676"],"issn-type":[{"value":"1549-1676","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,21]]}}}