{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T23:45:17Z","timestamp":1793403917782,"version":"4.5.0"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T00:00:00Z","timestamp":1336435200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosmedicine.org"],"crossmark-restriction":false},"short-container-title":["PLoS Med"],"DOI":"10.1371\/journal.pmed.1001213","type":"journal-article","created":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T20:59:17Z","timestamp":1336510757000},"page":"e1001213","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmed.corrections_policy","source":"Crossref","is-referenced-by-count":70,"title":["Six-Year Follow-Up of Impact of Co-proxamol Withdrawal in England and Wales on Prescribing and Deaths: Time-Series Study"],"prefix":"10.1371","volume":"9","author":[{"given":"Keith","family":"Hawton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Bergen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Simkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Wells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navneet","family":"Kapur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gunnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,5,8]]},"reference":[{"key":"ref1","article-title":"Withdrawal of co-proxamol products and interim updated prescribing information CEM\/CMO\/2005\/2.","year":"2005"},{"key":"ref2","first-page":"11","article-title":"Withdrawal of co-proxamol (Distalgesic, Cosalgesic, Dolgesic).","volume":"31","year":"2006","journal-title":"Current Problems in Pharmacovigilance"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/qjmed\/hci026","article-title":"Co-proxamol and suicide: a review to inform initiatives to prevent the continuing toll of overdose deaths.","volume":"98","author":"S Simkin","year":"2005","journal-title":"Q J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1136\/bmj.326.7397.1006","article-title":"Co-proxamol and suicide: a study of national mortality statistics and local non-fatal self-poisonings.","volume":"326","author":"K Hawton","year":"2003","journal-title":"BMJ"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1136\/dtb.21.5.17","article-title":"Distalgesic and its equivalents: time for action.","volume":"21","year":"1983","journal-title":"Drug Ther Bull"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1136\/bmj.327.7409.287","article-title":"Licence needs to be changed.","volume":"327","author":"DN Bateman","year":"2003","journal-title":"BMJ"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1365-2125.2004.02252.x","article-title":"A multicentre study of coproxamol poisoning suicides based on coroners&apos; records in England.","volume":"59","author":"K Hawton","year":"2005","journal-title":"Br J Clin Pharmacol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1136\/bmj.280.6220.1045","article-title":"Distalgesic poisoning - cause for concern.","volume":"280","author":"RJ Young","year":"1980","journal-title":"BMJ"},{"key":"ref9","first-page":"8","article-title":"Risk: benefit of Co-proxamol.","volume":"30","year":"2004","journal-title":"Current Problems in Pharmacovigilance"},{"key":"ref10","article-title":"European Medicines Agency recommends withdrawal of dextropropoxyphene-containing medicines (press release) EMEA\/401062\/2009","year":"2009"},{"key":"ref11","article-title":"FDA takes action on Darvon, other pain medications containing propoxyphene.","year":"2009"},{"key":"ref12","article-title":"Xanodyne agrees to withdraw propoxyphene from the U.S. market.","year":"2010"},{"key":"ref13","article-title":"Darvon-N (dextropropoxyphene) - recall and withdrawal in Canada - for the public.","year":"2010"},{"key":"ref14","article-title":"Prescription cost analysis: England 2005","year":"2006"},{"key":"ref15","article-title":"Prescription cost analysis: England 2006","year":"2007"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"b2270","DOI":"10.1136\/bmj.b2270","article-title":"Effect of withdrawal of co-proxamol on prescribing and deaths from drug poisoning in England and Wales: time series analysis.","volume":"338","author":"K Hawton","year":"2009","journal-title":"BMJ"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1365-2125.2008.03206.x","article-title":"Co-proxamol withdrawal has reduced suicide from drugs in Scotland.","volume":"66","author":"EA Sandilands","year":"2008","journal-title":"Br J Clin Pharmacol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"Art. 6","DOI":"10.1186\/1472-6904-10-6","article-title":"Use of analgesics in intentional drug overdose presentations to hospital before and after the withdrawal of distalgesic from the Irish market.","volume":"10","author":"P Corcoran","year":"2010","journal-title":"BMC Clin Pharmacol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1027\/0227-5910\/a000063","article-title":"Impact of withdrawal of the analgesic co-proxamol in the UK on non-fatal self-poisoning.","volume":"32","author":"K Hawton","year":"2011","journal-title":"Crisis"},{"key":"ref20","first-page":"279","article-title":"Restriction of access to methods of suicide as a means of suicide prevention.","author":"K Hawton","year":"2005"},{"key":"ref21","first-page":"1","article-title":"Deaths related to drug poisoning in England and Wales, 2010.","year":"2011"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1057\/hsq.2011.4","article-title":"Narrative verdicts and their impact on mortality statistics in England and Wales.","volume":"49","author":"C Hill","year":"2011","journal-title":"Health Stat Q"},{"key":"ref23","first-page":"13","article-title":"Suicides 1961\u201374.","volume":"2","author":"A Adelstein","year":"1975","journal-title":"Popul Trends"},{"key":"ref24","first-page":"6","article-title":"Suicide trends and geographical variations in the United Kingdom, 1991\u20132004.","volume":"31","author":"A Brock","year":"2006","journal-title":"Health Stat Q"},{"key":"ref25","article-title":"Stata Statistical software: release 10","year":"2007"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1017\/S0266462303000576","article-title":"Interrupted time series designs in health technology assessment: lessons from two systematic reviews of behavior change strategies.","volume":"19","author":"CR Ramsay","year":"2003","journal-title":"Int J Technol Assess"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1046\/j.1365-2710.2002.00430.x","article-title":"Segmented regression analysis of interrupted time series studies in medication use research.","volume":"27","author":"AK Wagner","year":"2002","journal-title":"J Clin Pharm Ther"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1136\/bmj.330.7481.9-c","article-title":"Warnings issued over COX 2 inhibitors in US and UK.","volume":"330","author":"S Gottlieb","year":"2005","journal-title":"BMJ"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1136\/bmj.38253.572581.7C","article-title":"UK legislation on analgesic packs: Before and after study of long term effect on poisonings.","volume":"329","author":"K Hawton","year":"2004","journal-title":"BMJ"},{"key":"ref30","first-page":"1456","article-title":"The economic crisis and suicide. Consequences may be serious and warrant early attention.","volume":"338","author":"D Gunnell","year":"2009","journal-title":"BMJ"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0140-6736(11)61079-9","article-title":"Effects of the 2008 recession on health: a first look at European data.","volume":"378","author":"D Stuckler","year":"2011","journal-title":"Lancet"},{"key":"ref32","first-page":"86","article-title":"The coal gas story: United Kingdom suicide rates 1960\u20131971.","volume":"30","author":"N Kreitman","year":"1976","journal-title":"Br J Prev Soc Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1093\/ije\/dym164","article-title":"The impact of pesticide regulations on suicide in Sri Lanka.","volume":"36","author":"D Gunnell","year":"2007","journal-title":"Int J Epidemiol"},{"key":"ref34","article-title":"The medicines (sales or supply) (miscellaneous provisions) amendment (no 2) regulations 1997","year":"1997"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1136\/bmj.322.7296.1203","article-title":"Effects of legislation restricting pack sizes of paracetamol and salicylates on self poisoning in the United Kingdom: before and after study.","volume":"322","author":"K Hawton","year":"2001","journal-title":"BMJ"},{"key":"ref36","article-title":"Drugs and chemicals of concern.","year":"2009"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.aap.2005.03.004","article-title":"Suicide prevention through means restriction: assessing the risk of substitution: a critical review and synthesis.","volume":"37","author":"MS Daigle","year":"2005","journal-title":"Accid Anal Prev"},{"key":"ref38","article-title":"Estimating confidence intervals around relative changes in outcomes in segmented regression analyses of time series data.","author":"F Zhang","year":"2002"}],"container-title":["PLoS Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pmed.1001213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T05:43:51Z","timestamp":1642225431000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pmed.1001213"}},"subtitle":[],"editor":[{"given":"Graham","family":"Thornicroft","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,5,8]]},"references-count":38,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,5,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pmed.1001213","relation":{},"ISSN":["1549-1676"],"issn-type":[{"value":"1549-1676","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,8]]}}}