{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:17:49Z","timestamp":1783487869268,"version":"3.55.0"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2012,12,27]],"date-time":"2012-12-27T00:00:00Z","timestamp":1356566400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosmedicine.org"],"crossmark-restriction":false},"short-container-title":["PLoS Med"],"DOI":"10.1371\/journal.pmed.1001361","type":"journal-article","created":{"date-parts":[[2012,12,27]],"date-time":"2012-12-27T23:58:47Z","timestamp":1356652727000},"page":"e1001361","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmed.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["Personalized Prediction of Lifetime Benefits with Statin Therapy for Asymptomatic Individuals: A Modeling Study"],"prefix":"10.1371","volume":"9","author":[{"given":"Bart S.","family":"Ferket","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bob J. H.","family":"van Kempen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Heeringa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Spronk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten E.","family":"Fleischmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogier L. G.","family":"Nijhuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Hofman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewout W.","family":"Steyerberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. G. Myriam","family":"Hunink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,12,27]]},"reference":[{"key":"ref1","unstructured":"Matheny M, McPheeters ML, Glasser A, Mercaldo N, Weaver RB, <etal>et al<\/etal>.. (2011) Systematic review of cardiovascular disease risk assessment tools. Report no. 11-05155-EF-1. Rockville (Maryland): US Agency for Healthcare Research and Quality."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1001\/archinternmed.2009.434","article-title":"Systematic review of guidelines on cardiovascular risk assessment: which recommendations should clinicians follow for a cardiovascular health check?","volume":"170","author":"BS Ferket","year":"2010","journal-title":"Arch Intern Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"b2376","DOI":"10.1136\/bmj.b2376","article-title":"The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials","volume":"338","author":"JJ Brugts","year":"2009","journal-title":"BMJ"},{"key":"ref4","first-page":"CD004816","article-title":"Statins for the primary prevention of cardiovascular disease","volume":"1","author":"F Taylor","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0140-6736(05)70240-3","article-title":"Treatment with drugs to lower blood pressure and blood cholesterol based on an individual&apos;s absolute cardiovascular risk","volume":"365","author":"R Jackson","year":"2005","journal-title":"Lancet"},{"key":"ref6","unstructured":"Col N (2011) Shared decision making. In: Fischhoff B, Brewer NT, Downs JS, editors. Communicating risks and benefits: an evidence-based user&apos;s guide. Silver Spring (Maryland): US Food and Drug Administration."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/S0140-6736(11)61125-2","article-title":"Effects on 11-year mortality and morbidity of lowering LDL cholesterol with simvastatin for about 5 years in 20 536 high-risk individuals: a randomised controlled trial","volume":"378","author":"R Bulbulia","year":"2011","journal-title":"Lancet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1001\/archinte.165.10.1140","article-title":"Decisions on drug therapies by numbers needed to treat: a randomized trial","volume":"165","author":"PA Halvorsen","year":"2005","journal-title":"Arch Intern Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/EDE.0b013e3181a39056","article-title":"Prognostic models with competing risks: methods and application to coronary risk prediction","volume":"20","author":"M Wolbers","year":"2009","journal-title":"Epidemiology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e477","DOI":"10.3399\/bjgp11X588448","article-title":"Therapeutic decisions by number needed to treat and survival gains: a cross-sectional survey of lipid-lowering drug recommendations","volume":"61","author":"PA Halvorsen","year":"2011","journal-title":"Br J Gen Pract"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1056\/NEJM198205273062103","article-title":"On the elicitation of preferences for alternative therapies","volume":"306","author":"BJ McNeil","year":"1982","journal-title":"N Engl J Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1177\/0272989X05284103","article-title":"Apparent and internal validity of a Monte Carlo-Markov model for cardiovascular disease in a cohort follow-up study","volume":"26","author":"RL Nijhuis","year":"2006","journal-title":"Med Decis Making"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s10654-011-9610-5","article-title":"The Rotterdam Study: 2012 objectives and design update","volume":"26","author":"A Hofman","year":"2011","journal-title":"Eur J Epidemiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1002\/sim.4384","article-title":"Competing risks and the clinical community: irrelevance or ignorance?","volume":"31","author":"MT Koller","year":"2011","journal-title":"Stat Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4","article-title":"Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors","volume":"15","author":"FE Harrell Jr","year":"1996","journal-title":"Stat Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/HJR.0b013e328337cca2","article-title":"Evaluation of cardiovascular risk predicted by different SCORE equations: the Netherlands as an example","volume":"17","author":"I van Dis","year":"2010","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0195-668X(03)00114-3","article-title":"Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project","volume":"24","author":"RM Conroy","year":"2003","journal-title":"Eur Heart J"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1001\/jama.292.21.2585","article-title":"Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs","volume":"292","author":"DJ Graham","year":"2004","journal-title":"JAMA"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0140-6736(05)67394-1","article-title":"Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins","volume":"366","author":"C Baigent","year":"2005","journal-title":"Lancet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"488","DOI":"10.7326\/0003-4819-152-8-201004200-00005","article-title":"Rosuvastatin for primary prevention in older persons with elevated C-reactive protein and low to average low-density lipoprotein cholesterol levels: exploratory analysis of a randomized trial","volume":"152","author":"RJ Glynn","year":"2010","journal-title":"Ann Intern Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"d5888","DOI":"10.1136\/bmj.d5888","article-title":"Estimating treatment effects for individual patients based on the results of randomised clinical trials","volume":"343","author":"JA Dorresteijn","year":"2011","journal-title":"BMJ"},{"key":"ref22","unstructured":"ClinRisk (2012) QIntervention [calculator]. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/qintervention.org\/index.php\" xlink:type=\"simple\">http:\/\/qintervention.org\/index.php<\/ext-link>. Accessed 20 February 2012."},{"key":"ref23","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1136\/bmj.320.7236.709","article-title":"Updated New Zealand cardiovascular disease risk-benefit prediction guide","volume":"320","author":"R Jackson","year":"2000","journal-title":"BMJ"},{"key":"ref24","unstructured":"HealthDecision (2011) HealthDecision [calculator]. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.healthdecision.org\/index\/tool#\" xlink:type=\"simple\">https:\/\/www.healthdecision.org\/index\/tool#<\/ext-link>. Accessed 20 February 2012."},{"key":"ref25","unstructured":"The University of Edinburgh (2010) Cardiovascular risk calculator [calculator]. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/cvrisk.mvm.ed.ac.uk\/calculator\/calc.asp\" xlink:type=\"simple\">http:\/\/cvrisk.mvm.ed.ac.uk\/calculator\/calc.asp<\/ext-link>. Accessed 20 February 2012."},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1001\/archinte.167.21.2296","article-title":"Patient knowledge of coronary risk profile improves the effectiveness of dyslipidemia therapy: the CHECK-UP study: a randomized controlled trial","volume":"167","author":"SA Grover","year":"2007","journal-title":"Arch Intern Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/qjmed\/hcq167","article-title":"The new Sheffield risk and benefit tables for the elderly","volume":"104","author":"ND Weatherley","year":"2011","journal-title":"QJM"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1001\/jama.1992.03480060062031","article-title":"The benefits of treating hyperlipidemia to prevent coronary heart disease. Estimating changes in life expectancy and morbidity","volume":"267","author":"SA Grover","year":"1992","journal-title":"JAMA"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1056\/NEJM199808063390606","article-title":"Gains in life expectancy from medical interventions\u2014standardizing data on outcomes","volume":"339","author":"JC Wright","year":"1998","journal-title":"N Engl J Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1161\/CIRCULATIONAHA.108.816694","article-title":"Predicting the 30-year risk of cardiovascular disease: the Framingham Heart Study","volume":"119","author":"MJ Pencina","year":"2009","journal-title":"Circulation"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1001\/jama.1997.03540310033031","article-title":"The recent decline in mortality from coronary heart disease, 1980\u20131990. The effect of secular trends in risk factors and treatment","volume":"277","author":"MG Hunink","year":"1997","journal-title":"JAMA"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1136\/bmj.38561.633345.8F","article-title":"Modelling the decline in coronary heart disease deaths in England and Wales, 1981\u20132000: comparing contributions from primary prevention and secondary prevention","volume":"331","author":"B Unal","year":"2005","journal-title":"BMJ"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"c6624","DOI":"10.1136\/bmj.c6624","article-title":"Derivation, validation, and evaluation of a new QRISK model to estimate lifetime risk of cardiovascular disease: cohort study using QResearch database","volume":"341","author":"J Hippisley-Cox","year":"2010","journal-title":"BMJ"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/S0140-6736(07)61778-4","article-title":"Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths","volume":"370","author":"S Lewington","year":"2007","journal-title":"Lancet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0140-6736(12)60367-5","article-title":"The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials","volume":"380","author":"B Mihaylova","year":"2012","journal-title":"Lancet"},{"key":"ref36","first-page":"2337","article-title":"[Revision of consensus cholesterol.]","volume":"135","author":"DW Erkelens","year":"1991","journal-title":"Ned Tijdschr Geneeskd"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/j.jacc.2010.06.029","article-title":"Coronary calcium score improves classification of coronary heart disease risk in the elderly: the Rotterdam study","volume":"56","author":"SE Elias-Smale","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1161\/STROKEAHA.110.599084","article-title":"Retinal vascular calibers and the risk of intracerebral hemorrhage and cerebral infarction: the Rotterdam Study","volume":"41","author":"RG Wieberdink","year":"2010","journal-title":"Stroke"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/j.amjcard.2007.07.015","article-title":"Meta-analysis of effect of statin treatment on risk of sudden death","volume":"100","author":"G Levantesi","year":"2007","journal-title":"Am J Cardiol"},{"key":"ref40","unstructured":"Organisation for Economic Co-operation and Development (2011) OECD.StatExtracts: health status [database]. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/stats.oecd.org\/index.aspx?DataSetCode=HEALTH_STAT\" xlink:type=\"simple\">http:\/\/stats.oecd.org\/index.aspx?DataSetCode=HEALTH_STAT<\/ext-link>. Accessed 20 February 2012."},{"key":"ref41","doi-asserted-by":"crossref","first-page":"243","DOI":"10.7326\/0003-4819-150-4-200902170-00005","article-title":"Comparing impact and cost-effectiveness of primary prevention strategies for lipid-lowering","volume":"150","author":"MJ Pletcher","year":"2009","journal-title":"Ann Intern Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1161\/CIRCULATIONAHA.110.986349","article-title":"Cost-effectiveness of statin therapy for primary prevention in a low-cost statin era","volume":"124","author":"LD Lazar","year":"2011","journal-title":"Circulation"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1161\/01.CIR.97.18.1837","article-title":"Prediction of coronary heart disease using risk factor categories","volume":"97","author":"PW Wilson","year":"1998","journal-title":"Circulation"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/CIRCULATIONAHA.107.699579","article-title":"General cardiovascular risk profile for use in primary care: the Framingham Heart Study","volume":"117","author":"RB D'Agostino Sr","year":"2008","journal-title":"Circulation"},{"key":"ref45","first-page":"CD001431","article-title":"Decision aids for people facing health treatment or screening decisions","volume":"8","author":"AM O'Connor","year":"2009","journal-title":"Cochrane Database Syst Rev"}],"container-title":["PLoS Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pmed.1001361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:04:39Z","timestamp":1540339479000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pmed.1001361"}},"subtitle":[],"editor":[{"given":"Anushka","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,12,27]]},"references-count":45,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2012,12,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pmed.1001361","relation":{},"ISSN":["1549-1676"],"issn-type":[{"value":"1549-1676","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,27]]}}}