{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T02:33:32Z","timestamp":1772678012661,"version":"3.50.1"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2013,12,3]],"date-time":"2013-12-03T00:00:00Z","timestamp":1386028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosmedicine.org"],"crossmark-restriction":false},"short-container-title":["PLoS Med"],"DOI":"10.1371\/journal.pmed.1001564","type":"journal-article","created":{"date-parts":[[2013,12,3]],"date-time":"2013-12-03T21:11:11Z","timestamp":1386105071000},"page":"e1001564","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmed.corrections_policy","source":"Crossref","is-referenced-by-count":67,"title":["The Effect of Dosing Regimens on the Antimalarial Efficacy of Dihydroartemisinin-Piperaquine: A Pooled Analysis of Individual Patient Data"],"prefix":"10.1371","volume":"10","author":[{"name":"The WorldWide Antimalarial Resistance Network (WWARN) DP Study Group","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,12,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e8988","DOI":"10.1371\/journal.pone.0008988","article-title":"Age-patterns of malaria vary with severity, transmission intensity and seasonality in sub-Saharan Africa: a systematic review and pooled analysis","volume":"5","author":"I Carneiro","year":"2010","journal-title":"PLoS One"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0035-9203(98)90750-7","article-title":"Artesunate and mefloquine in the treatment of uncomplicated multidrug-resistant hyperparasitaemic falciparum malaria","volume":"92","author":"R Price","year":"1998","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref3","first-page":"CD007483","article-title":"Artemisinin-based combination therapy for treating uncomplicated malaria","author":"D Sinclair","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"issue":"Suppl 1","key":"ref4","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1186\/1475-2875-7-S1-S8","article-title":"The role of anti-malarial drugs in eliminating malaria","volume":"7","author":"NJ White","year":"2008","journal-title":"Malar J"},{"key":"ref5","unstructured":"WHO (2010) Guidelines for the treatment of malaria, second edition. 2012. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/whqlibdoc.who.int\/publications\/2010\/9789241547925_eng.pdf\" xlink:type=\"simple\">http:\/\/whqlibdoc.who.int\/publications\/2010\/9789241547925_eng.pdf<\/ext-link>."},{"key":"ref6","article-title":"World malaria report 2012. 2012","year":"2012"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.pt.2007.11.008","article-title":"Antimalarial dosing regimens and drug resistance","volume":"24","author":"KI Barnes","year":"2008","journal-title":"Trends Parasitol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/1475-2875-8-253","article-title":"Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance","volume":"8","author":"NJ White","year":"2009","journal-title":"Malar J"},{"key":"ref9","first-page":"CD008492","article-title":"Artemisinin-based combination therapy for treating uncomplicated Plasmodium vivax malaria","author":"D Sinclair","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e6358","DOI":"10.1371\/journal.pone.0006358","article-title":"Safety and efficacy of dihydroartemisinin-piperaquine in falciparum malaria: a prospective multi-centre individual patient data analysis","volume":"4","author":"J Zwang","year":"2009","journal-title":"PLoS One"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e7871","DOI":"10.1371\/journal.pone.0007871","article-title":"Dihydroartemisinin-piperaquine and artemether-lumefantrine for treating uncomplicated malaria in African children: a randomised, non-inferiority trial","volume":"4","author":"Q Bassat","year":"2009","journal-title":"PLoS One"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e1001119","DOI":"10.1371\/journal.pmed.1001119","article-title":"A head-to-head comparison of four artemisinin-based combinations for treating uncomplicated malaria in African children: a randomized trial","volume":"8","year":"2011","journal-title":"PLoS Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e11880","DOI":"10.1371\/journal.pone.0011880","article-title":"An open-label, randomised study of dihydroartemisinin-piperaquine versus artesunate-mefloquine for falciparum malaria in Asia","volume":"5","author":"N Valecha","year":"2010","journal-title":"PLoS One"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2165\/00003495-200565010-00004","article-title":"Piperaquine: a resurgent antimalarial drug","volume":"65","author":"TM Davis","year":"2005","journal-title":"Drugs"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/clpt.2011.254","article-title":"Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria","volume":"91","author":"J Tarning","year":"2012","journal-title":"Clin Pharmacol Ther"},{"key":"ref16","unstructured":"WWARN (2013) Clinical trials review. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.wwarn.org\/resistance\/malaria\/literature\/overview\" xlink:type=\"simple\">http:\/\/www.wwarn.org\/resistance\/malaria\/literature\/overview<\/ext-link>."},{"key":"ref17","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1179\/136485910X12743554760144","article-title":"Dihydroartemisinin-piperaquine versus artemether-lumefantrine, in the treatment of uncomplicated Plasmodium falciparum malaria in central Sudan","volume":"104","author":"I Adam","year":"2010","journal-title":"Ann Trop Med Parasitol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1086\/647946","article-title":"Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan children","volume":"49","author":"E Arinaitwe","year":"2009","journal-title":"Clin Infect Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1086\/425015","article-title":"Randomized, controlled dose-optimization studies of dihydroartemisinin-piperaquine for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand","volume":"190","author":"EA Ashley","year":"2004","journal-title":"J Infect Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1086\/432011","article-title":"A randomized, controlled study of a simple, once-daily regimen of dihydroartemisinin-piperaquine for the treatment of uncomplicated, multidrug-resistant falciparum malaria","volume":"41","author":"EA Ashley","year":"2005","journal-title":"Clin Infect Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e26005","DOI":"10.1371\/journal.pone.0026005","article-title":"Declining responsiveness of Plasmodium falciparum infections to artemisinin-based combination treatments on the Kenyan coast","volume":"6","author":"S Borrmann","year":"2011","journal-title":"PLoS One"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e1101","DOI":"10.1371\/journal.pone.0001101","article-title":"A randomised controlled trial to assess the efficacy of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Peru","volume":"2","author":"T Grande","year":"2007","journal-title":"PLoS One"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1086\/512677","article-title":"Dihydroartemisinin-piperaquine versus artesunate-amodiaquine: superior efficacy and posttreatment prophylaxis against multidrug-resistant Plasmodium falciparum and Plasmodium vivax malaria","volume":"44","author":"AR Hasugian","year":"2007","journal-title":"Clin Infect Dis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1365-3156.2006.01786.x","article-title":"A randomized open study to assess the efficacy and tolerability of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Cambodia","volume":"12","author":"B Janssens","year":"2007","journal-title":"Trop Med Int Heal"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1371\/journal.pctr.0020020","article-title":"Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial","volume":"2","author":"MR Kamya","year":"2007","journal-title":"PLoS Clin Trials"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.trstmh.2006.01.001","article-title":"Safety and efficacy of dihydroartemisinin\/piperaquine (Artekin) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan children","volume":"100","author":"C Karema","year":"2006","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1056\/NEJMoa0804915","article-title":"A trial of combination antimalarial therapies in children from Papua New Guinea","volume":"359","author":"HA Karunajeewa","year":"2008","journal-title":"N Engl J Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/j.1365-3156.2006.01671.x","article-title":"An open, randomized comparison of artesunate plus mefloquine vs. dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Lao People&apos;s Democratic Republic (Laos)","volume":"11","author":"M Mayxay","year":"2006","journal-title":"Trop Med Int Heal"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/1475-2875-7-237","article-title":"A randomized trial to monitor the efficacy and effectiveness by QT-NASBA of artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment and transmission control of uncomplicated Plasmodium falciparum malaria in western Kenya","volume":"7","author":"PF Mens","year":"2008","journal-title":"Malar J"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0140-6736(07)60160-3","article-title":"Two fixed-dose artemisinin combinations for drug-resistant falciparum and vivax malaria in Papua, Indonesia: an open-label randomised comparison","volume":"369","author":"A Ratcliff","year":"2007","journal-title":"Lancet"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1093\/infdis\/jit077","article-title":"Malaria transmission after artemether-lumefantrine and dihydroartemisinin-piperaquine: a randomized trial","volume":"207","author":"P Sawa","year":"2013","journal-title":"J Infect Dis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1016\/S0140-6736(06)68931-9","article-title":"Efficacy and effectiveness of dihydroartemisinin-piperaquine versus artesunate-mefloquine in falciparum malaria: an open-label randomised comparison","volume":"367","author":"F Smithuis","year":"2006","journal-title":"Lancet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S1473-3099(10)70187-0","article-title":"Effectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trial","volume":"10","author":"F Smithuis","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1186\/1475-2875-11-355","article-title":"In vivo susceptibility of Plasmodium falciparum to artesunate in Binh Phuoc Province, Vietnam","volume":"11","author":"TH Tran","year":"2012","journal-title":"Malar J"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/1475-2875-10-198","article-title":"Multicentric assessment of the efficacy and tolerability of dihydroartemisinin-piperaquine compared to artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in sub-Saharan Africa","volume":"10","author":"W Yavo","year":"2011","journal-title":"Malar J"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e2390","DOI":"10.1371\/journal.pone.0002390","article-title":"Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda","volume":"3","author":"A Yeka","year":"2008","journal-title":"PLoS One"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1086\/522985","article-title":"Randomized comparison of amodiaquine plus sulfadoxine-pyrimethamine, artemether-lumefantrine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Burkina Faso","volume":"45","author":"I Zongo","year":"2007","journal-title":"Clin Infect Dis"},{"key":"ref38","unstructured":"WWARN (2012) Clinical Module: Data Management and Statistical Analysis Plan Version 1.2. Oxford. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.wwarn.org\/sites\/default\/files\/ClinicalDMSAP.pdf\" xlink:type=\"simple\">http:\/\/www.wwarn.org\/sites\/default\/files\/ClinicalDMSAP.pdf<\/ext-link>."},{"key":"ref39","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1186\/1475-2875-10-378","article-title":"A new world malaria map: Plasmodium falciparum endemicity in 2010","volume":"10","author":"PW Gething","year":"2011","journal-title":"Malar J"},{"key":"ref40","unstructured":"WWARN (2012) Statistical Analysis Plan DHA-PQP Dose Impact Study Group. Version 1.9. Oxford. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.wwarn.org\/sites\/default\/files\/DHA-PQPDoseImpactStudyGroupSAP.pdf\" xlink:type=\"simple\">http:\/\/www.wwarn.org\/sites\/default\/files\/DHA-PQPDoseImpactStudyGroupSAP.pdf<\/ext-link>."},{"key":"ref41","first-page":"531","article-title":"The occurrence of lung cancer in man","volume":"9","author":"ML Levin","year":"1953","journal-title":"Acta Unio Int Contra Cancrum"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMoa0808859","article-title":"Artemisinin resistance in Plasmodium falciparum malaria","volume":"361","author":"AM Dondorp","year":"2009","journal-title":"N Engl J Med"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1016\/S0140-6736(12)60484-X","article-title":"Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study","volume":"379","author":"AP Phyo","year":"2012","journal-title":"Lancet"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1128\/AAC.00686-12","article-title":"Efficacy of dihydroartemisinin-piperaquine for treatment of uncomplicated Plasmodium falciparum and Plasmodium vivax in Cambodia, 2008 to 2010","volume":"57","author":"R Leang","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"4090","DOI":"10.1128\/AAC.00486-07","article-title":"Clinical and pharmacological determinants of the therapeutic response to dihydroartemisinin-piperaquine for drug-resistant malaria","volume":"51","author":"RN Price","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.trstmh.2003.10.005","article-title":"Seasonal variation in hyperparasitaemia and gametocyte carriage in patients with Plasmodium falciparum malaria on the Thai-Burmese border","volume":"98","author":"M Nacher","year":"2004","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1475-2875-7-9","article-title":"How antimalarial drug resistance affects post-treatment prophylaxis","volume":"7","author":"NJ White","year":"2008","journal-title":"Malar J"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.clpt.2006.08.016","article-title":"Sulfadoxine-pyrimethamine pharmacokinetics in malaria: pediatric dosing implications","volume":"80","author":"KI Barnes","year":"2006","journal-title":"Clin Pharmacol Ther"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1093\/infdis\/jit078","article-title":"Pharmacokinetic predictors for recurrent malaria after dihydroartemisinin-piperaquine treatment of uncomplicated malaria in Ugandan infants","volume":"207","author":"DJ Creek","year":"2013","journal-title":"J Infect Dis"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1128\/AAC.00679-09","article-title":"Pharmacokinetics of artemether-lumefantrine and artesunate-amodiaquine in children in Kampala, Uganda","volume":"54","author":"J Mwesigwa","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.1128\/AAC.06232-11","article-title":"Pharmacokinetic comparison of two piperaquine-containing artemisinin combination therapies in Papua New Guinean children with uncomplicated malaria","volume":"56","author":"S Salman","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0140-6736(03)15163-X","article-title":"Dihydroartemisinin-piperaquine against multidrug-resistant Plasmodium falciparum malaria in Vietnam: randomised clinical trial","volume":"363","author":"TH Tran","year":"2004","journal-title":"Lancet"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1086\/650301","article-title":"In vivo parasitological measures of artemisinin susceptibility","volume":"201","author":"K Stepniewska","year":"2010","journal-title":"J Infect Dis"}],"updated-by":[{"DOI":"10.1371\/annotation\/3db421e4-3e27-4442-8092-2ad1b778f371","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T00:00:00Z","timestamp":1387843200000}}],"container-title":["PLoS Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pmed.1001564","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T07:54:37Z","timestamp":1589010877000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pmed.1001564"}},"subtitle":[],"editor":[{"given":"Paul","family":"Garner","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,12,3]]},"references-count":53,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pmed.1001564","relation":{"correction":[{"id-type":"doi","id":"10.1371\/annotation\/3db421e4-3e27-4442-8092-2ad1b778f371","asserted-by":"object"}]},"ISSN":["1549-1676"],"issn-type":[{"value":"1549-1676","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,3]]}}}