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Rapport 2004. Recommandations du groupe d&apos;experts. Paris: Flammarion M\u00e9decine-Sciences."},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1097\/01.aids.0000242814.42344.77","article-title":"Mitochondrial dysfunction following perinatal exposure to nucleoside analogues","volume":"20","author":"S Blanche","year":"2006","journal-title":"AIDS"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2165\/00002018-200730030-00004","article-title":"Safety of agents used to prevent mother-to-child transmission of HIV: is there any cause for concern?","volume":"30","author":"C Thorne","year":"2007","journal-title":"Drug Saf"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1097\/QAD.0b013e32832be0df","article-title":"No relation between in-utero exposure to HAART and intrauterine growth retardation","volume":"23","author":"N Briand","year":"2009","journal-title":"AIDS"},{"key":"ref8","article-title":"Metabolic complications of in utero maternal HIV and antiretroviral exposure in HIV-exposed infants","author":"J Jao","year":"2013","journal-title":"Pediatr Infect Dis J"},{"key":"ref9","unstructured":"Bristol-Myers Squibb Company (2006) Sustiva (efavirenz) capsules and tablets leaflet. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2006\/021360s014lbl.pdf\" xlink:type=\"simple\">http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2006\/021360s014lbl.pdf<\/ext-link>. Accessed 6 July 2013."},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1097\/QAD.0b013e32834cdb71","article-title":"Safety of efavirenz in the first trimester of pregnancy: an updated systematic review and meta-analysis","volume":"25","author":"N Ford","year":"2011","journal-title":"AIDS"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1097\/INF.0b013e3181e74a2f","article-title":"Birth defects among children born to human immunodeficiency virus-infected women: pediatric AIDS clinical trials protocols 219 and 219C","volume":"29","author":"SB Brogly","year":"2010","journal-title":"Pediatr Infect Dis J"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/INF.0b013e318235c7aa","article-title":"Prevalence of congenital anomalies in infants with in utero exposure to antiretrovirals","volume":"31","author":"KM Knapp","year":"2012","journal-title":"Pediatr Infect Dis J"},{"key":"ref13","unstructured":"Antiretroviral Pregnancy Registry Steering Committee (2013) The Antiretroviral Pregnancy Registry: interim report\u20141 January 1989 through 31 July 2013. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.apregistry.com\/forms\/interim_report.pdf\" xlink:type=\"simple\">http:\/\/www.apregistry.com\/forms\/interim_report.pdf<\/ext-link>. Accessed 27 January 2014."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1515\/jpm.2010.139","article-title":"Birth defects among a cohort of infants born to HIV-infected women on antiretroviral medication","volume":"39","author":"DH Watts","year":"2011","journal-title":"J Perinat Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1111\/1471-0528.12285","article-title":"Birth defects in a national cohort of pregnant women with HIV infection in Italy, 2001\u20132011","volume":"120","author":"M Floridia","year":"2013","journal-title":"BJOG"},{"key":"ref16","first-page":"253","article-title":"Birth defects in a cohort of uninfected children born to HIV-infected women","volume":"70","author":"M Fernandez Ibieta","year":"2009","journal-title":"An Pediatr (Barc)"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/QAD.0b013e328326ca8e","article-title":"Antiretroviral therapy and congenital abnormalities in infants born to HIV-infected women in the UK and Ireland, 1990\u20132007","volume":"23","author":"CL Townsend","year":"2009","journal-title":"AIDS"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/01.qai.0000156854.99769.a5","article-title":"Does highly active antiretroviral therapy increase the risk of congenital abnormalities in HIV-infected women?","volume":"40","author":"D Patel","year":"2005","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/00126334-200007010-00009","article-title":"Prenatal zidovudine use and congenital anomalies in a medicaid population","volume":"24","author":"CJ Newschaffer","year":"2000","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref20","unstructured":"Yeni P, editor(2006) Prise en charge m\u00e9dicale des personnes infect\u00e9es par le VIH. Recommandations du groupe d&apos;experts.: Flammarion, M\u00e9decine-Sciences."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/00126334-200311010-00013","article-title":"Characteristics of HIV-infected women who do not receive preventive antiretroviral therapy in the French Perinatal Cohort","volume":"34","author":"MJ Mayaux","year":"2003","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref22","unstructured":"EUROCAT (2005) EUROCAT Guide 1.3 and reference documents. Instructions for the Registration and Surveillance of Congenital Anomalies. Available at: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.eurocat-network.eu\/content\/EUROCAT-Guide-1.3.pdf\" xlink:type=\"simple\">http:\/\/www.eurocat-network.eu\/content\/EUROCAT-Guide-1.3.pdf<\/ext-link> last accessed 01\/27\/2014"},{"key":"ref23","unstructured":"EUROCAT (2012) Coding of EUROCAT Subgroups of Congenital Anomalies (Version 2012). Available at: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.eurocat-network.eu\/content\/EUROCAT-Guide-1.3.pdf\" xlink:type=\"simple\">http:\/\/www.eurocat-network.eu\/content\/EUROCAT-Guide-1.3.pdf<\/ext-link> last accessed 01\/27\/2014"},{"key":"ref24","unstructured":"MACDP (2007) Birth Defects and Genetic Diseases Branch 6-digit code for Reportable Congenital Anomalies.Available at: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cdc.gov\/ncbddd\/birthdefects\/documents\/MACDPcode0807.pdf\" xlink:type=\"simple\">http:\/\/www.cdc.gov\/ncbddd\/birthdefects\/documents\/MACDPcode0807.pdf<\/ext-link> last accessed 01\/27\/2014"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/pds.726","article-title":"Birth defect classification by organ system: a novel approach to heighten teratogenic signalling in a pregnancy registry","volume":"11","author":"A Scheuerle","year":"2002","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"ref26","unstructured":"StataCorporation (2009) Stata 11.0 for Windows. College Station, Texas: Stata Corporation"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/QAI.0b013e3181c5c81f","article-title":"Maternal antiretroviral use during pregnancy and infant congenital anomalies: the NISDI perinatal study","volume":"53","author":"EC Joao","year":"2010","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/S0002-9149(96)90080-6","article-title":"High prevalence of muscular ventricular septal defect in preterm neonates","volume":"78","author":"ZD Du","year":"1996","journal-title":"Am J Cardiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e829","DOI":"10.1542\/peds.2011-3279","article-title":"Preterm Birth and Congenital Heart Defects: A Population-based Study","volume":"Oct;130","author":"E Laas","year":"2012","journal-title":"Pediatrics"},{"key":"ref30","unstructured":"Yeni P (2010) Prise en charge m\u00e9dicale des personnes infect\u00e9es par le VIH: rapport 2010\u2014Recommandations du groupe d&apos;experts. Paris: La Documentation Fran\u00e7aise."},{"key":"ref31","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0890-6238(01)00178-2","article-title":"The teratogenic risk of trimethoprim-sulfonamides: a population based case-control study","volume":"15","author":"AE Czeizel","year":"2001","journal-title":"Reprod Toxicol"},{"key":"ref32","first-page":"24","article-title":"Systematic review of the safety of trimethoprim-sulfamethoxazole for prophylaxis in HIV-infected pregnant women: implications for resource-limited settings","volume":"8","author":"F Forna","year":"2006","journal-title":"AIDS Rev"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1136\/sti.77.6.441","article-title":"Is first trimester exposure to the combination of antiretroviral therapy and folate antagonists a risk factor for congenital abnormalities?","volume":"77","author":"EM Jungmann","year":"2001","journal-title":"Sex Transm Infect"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0301-2115(00)00288-8","article-title":"Spinal malformations in the fetuses of HIV infected women receiving combination antiretroviral therapy and co-trimoxazole","volume":"93","author":"MP Richardson","year":"2000","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jacc.2010.08.620","article-title":"Cardiac effects of antiretroviral therapy in HIV-negative infants born to HIV-positive mothers: NHLBI CHAART-1 (National Heart, Lung, and Blood Institute Cardiovascular Status of HAART Therapy in HIV-Exposed Infants and Children cohort study)","volume":"57","author":"SE Lipshultz","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"ref36","first-page":"317695","article-title":"Evaluation of hepatic mitochondria and hematological parameters in zidovudine-treated B6C3F(1) mice","volume":"2012","author":"VG Desai","year":"2012","journal-title":"AIDS Res Treat"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/QAI.0b013e3181ff04e6","article-title":"Pregnancy outcomes in women exposed to efavirenz and nevirapine: an appraisal of the IeDEA West Africa and ANRS Databases, Abidjan, Cote d&apos;Ivoire","volume":"56","author":"DK Ekouevi","year":"2011","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1750-1172-6-64","article-title":"Population-based evaluation of a suggested anatomic and clinical classification of congenital heart defects based on the International Paediatric and Congenital Cardiac Code","volume":"6","author":"L Houyel","year":"2012","journal-title":"Orphanet J Rare Dis"},{"key":"ref39","unstructured":"World Health Organization (2013) Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/hiv\/pub\/guidelines\/arv2013\/download\/en\/index.html\" xlink:type=\"simple\">http:\/\/www.who.int\/hiv\/pub\/guidelines\/arv2013\/download\/en\/index.html<\/ext-link>. Accessed 27 January 2014."},{"key":"ref40","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/00002030-200201250-00025","article-title":"Myelomeningocele in a child with intrauterine exposure to efavirenz","volume":"16","author":"C Fundaro","year":"2002","journal-title":"AIDS"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/sj.jp.7211343","article-title":"Myelomeningocele in an infant with intrauterine exposure to efavirenz","volume":"25","author":"A Saitoh","year":"2005","journal-title":"J Perinatol"},{"key":"ref42","unstructured":"Panel on Treatment of HIV-Infected Pregnant Women and Prevention of Perinatal Transmission (2012) Recommendations for use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to reduce perinatal HIV transmission in the United States. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/aidsinfo.nih.gov\/guidelines\/html\/3\/perinatal-guidelines\/0\" xlink:type=\"simple\">http:\/\/aidsinfo.nih.gov\/guidelines\/html\/3\/perinatal-guidelines\/0<\/ext-link>. Accessed 27 January 2014."},{"key":"ref43","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/1096-9926(200011)62:5<291::AID-TERA3>3.0.CO;2-A","article-title":"Developmental toxicity of the HIV-protease inhibitor indinavir in rats","volume":"62","author":"K Riecke","year":"2000","journal-title":"Teratology"},{"key":"ref44","unstructured":"EUROCAT (2012) Prevalence tables. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.eurocat-network.eu\/accessprevalencedata\/prevalencetables\" xlink:type=\"simple\">http:\/\/www.eurocat-network.eu\/accessprevalencedata\/prevalencetables<\/ext-link>. Accessed 27 January 2014."},{"key":"ref45","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00001648-199001000-00010","article-title":"No adjustments are needed for multiple comparisons","volume":"1","author":"KJ Rothman","year":"1990","journal-title":"Epidemiology"}],"container-title":["PLoS Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pmed.1001635","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T17:52:03Z","timestamp":1588960323000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pmed.1001635"}},"subtitle":[],"editor":[{"given":"Clara","family":"Men\u00e9ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,4,29]]},"references-count":45,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,4,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pmed.1001635","relation":{},"ISSN":["1549-1676"],"issn-type":[{"value":"1549-1676","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,29]]}}}