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Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/nutrition\/topics\/obesity\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/nutrition\/topics\/obesity\/en\/<\/ext-link>. Accessed 3 June 2014."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0140-6736(09)60318-4","article-title":"Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies","volume":"373","author":"G Whitlock","year":"2009","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1056\/NEJMoa1000367","article-title":"Body-mass index and mortality among 1.46 million white adults","volume":"363","author":"A Berrington de Gonzalez","year":"2010","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1161\/CIR.0b013e3182149099","article-title":"Bariatric surgery and cardiovascular risk factors: a scientific statement from the American Heart Association","volume":"123","author":"P Poirier","year":"2011","journal-title":"Circulation"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/1471-2458-13-290","article-title":"Morbid obesity in women on the rise: an observational, population-based study","volume":"13","author":"JA Pasco","year":"2013","journal-title":"BMC Public Health"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1097\/PAF.0b013e318219cd89","article-title":"Extreme obesity and associated cardiovascular disease verified at autopsy","volume":"32","author":"ML Kortelainen","year":"2011","journal-title":"Am J Forensic Med Pathol"},{"key":"ref7","unstructured":"Health and Social Care Information Centre (2011) Health survey for England\u20142010, trend tables. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ic.nhs.uk\/pubs\/hse10trends\" xlink:type=\"simple\">http:\/\/www.ic.nhs.uk\/pubs\/hse10trends<\/ext-link>. Accessed 3 June 2014."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/ijo.2012.159","article-title":"Morbid obesity rates continue to rise rapidly in the United States","volume":"37","author":"R Sturm","year":"2013","journal-title":"Int J Obes (Lond)"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1001\/jama.2012.39","article-title":"Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999\u20132010","volume":"307","author":"KM Flegal","year":"2012","journal-title":"JAMA"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/sj.ijo.0802896","article-title":"Impact of morbid obesity on medical expenditures in adults","volume":"29","author":"DE Arterburn","year":"2005","journal-title":"Int J Obes (Lond)"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1001\/jama.296.1.79","article-title":"Mortality and cardiac and vascular outcomes in extremely obese women","volume":"296","author":"K McTigue","year":"2006","journal-title":"JAMA"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1002\/1097-0142(19890801)64:3<570::AID-CNCR2820640303>3.0.CO;2-4","article-title":"Chronic disease among Seventh-day Adventists, a low-risk group: rationale, methodology, and description of the population","volume":"64","author":"WL Beeson","year":"1989","journal-title":"Cancer"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1289\/ehp.96104362","article-title":"The Agricultural Health Study","volume":"104","author":"MC Alavanja","year":"1996","journal-title":"Environ Health Perspect"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/BF01831376","article-title":"Menopausal estrogen and estrogen-progestin replacement therapy and risk of breast cancer (United States)","volume":"5","author":"C Schairer","year":"1994","journal-title":"Cancer Causes Control"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1023\/A:1019552126105","article-title":"High breast cancer incidence rates among California teachers: results from the California Teachers Study (United States)","volume":"13","author":"L Bernstein","year":"2002","journal-title":"Cancer Causes Control"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1002\/cncr.101970","article-title":"The American Cancer Society Cancer Prevention Study II Nutrition Cohort\u2014rationale, study design and baseline characteristics","volume":"94","author":"E Calle","year":"2002","journal-title":"Cancer"},{"key":"ref17","first-page":"907","article-title":"The risk of developing lung cancer associated with antioxidants in the blood: ascorbic acid, carotenoids, alpha-tocopherol, selenium, and total peroxyl radical absorbing capacity","volume":"6","author":"GW Comstock","year":"1997","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1365-2796.2008.01985.x","article-title":"Combined effects of obesity and physical activity in predicting mortality among men","volume":"264","author":"N Orsini","year":"2008","journal-title":"J Intern Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1093\/aje\/152.3.264","article-title":"Adiposity and mortality in men","volume":"152","author":"I Baik","year":"2000","journal-title":"Am J Epidemiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1001\/jama.1993.03500040049035","article-title":"Body fat distribution and 5-year risk of death in older women","volume":"269","author":"AR Folsom","year":"1993","journal-title":"JAMA"},{"key":"ref21","first-page":"69","article-title":"The Melbourne Collaborative Cohort Study","volume":"156","author":"GG Giles","year":"2002","journal-title":"IARC Sci Publ"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1093\/jnci\/87.3.190","article-title":"A prospective study of endogenous estrogens and breast cancer in postmenopausal women","volume":"87","author":"PG Toniolo","year":"1995","journal-title":"J Natl Cancer Inst"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1093\/aje\/154.12.1119","article-title":"Design and serendipity in establishing a large cohort with wide dietary intake distributions: the National Institutes of Health-American Association of Retired Persons Diet and Health Study","volume":"154","author":"A Schatzkin","year":"2001","journal-title":"Am J Epidemiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1056\/NEJMoa042135","article-title":"Adiposity as compared with physical activity in predicting mortality among women","volume":"351","author":"FB Hu","year":"2004","journal-title":"N Engl J Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S1047-2797(99)00042-3","article-title":"Design of Physicians&apos; Health Study II\u2014a randomized trial of beta-carotene, vitamins E and C, and multivitamins, in prevention of cancer, cardiovascular disease, and eye disease, and review of results of completed trials","volume":"10","author":"WG Christen","year":"2000","journal-title":"Ann Epidemiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"349S","DOI":"10.1016\/S0197-2456(00)00101-X","article-title":"Etiologic and early marker studies in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial","volume":"21","author":"RB Hayes","year":"2000","journal-title":"Control Clin Trials"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1001\/jama.296.11.1371","article-title":"Long-term fatty fish consumption and renal cell carcinoma incidence in women","volume":"296","author":"A Wolk","year":"2006","journal-title":"JAMA"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1158\/1055-9965.1121.13.7","article-title":"A prospective study of body size in different periods of life and risk of premenopausal breast cancer","volume":"13","author":"E Weiderpass","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/sj.ijo.0803193","article-title":"Body mass index and all-cause mortality in a nationwide US cohort","volume":"30","author":"DM Freedman","year":"2006","journal-title":"Int J Obes (Lond)"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/aje\/kwh010","article-title":"VITamins and Lifestyle cohort study: study design and characteristics of supplement users","volume":"159","author":"E White","year":"2004","journal-title":"Am J Epidemiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1089\/152460900318911","article-title":"Baseline characteristics of participants in the Women&apos;s Health Study","volume":"9","author":"KM Rexrode","year":"2000","journal-title":"J Womens Health Gend Based Med"},{"key":"ref32","unstructured":"Surveillance Epidemiology, and End Results Program (2012) SEER cause of death recode 1969+ (04\/16\/2012). Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/seer.cancer.gov\/codrecode\/1969_d04162012\/index.html\" xlink:type=\"simple\">http:\/\/seer.cancer.gov\/codrecode\/1969+_d04162012\/index.html<\/ext-link>. Accessed 3 June 2014."},{"key":"ref33","unstructured":"World Health Organization (1967) International classification of diseases, 1965 revision (ICD-8). Geneva: World Health Organization."},{"key":"ref34","unstructured":"World Health Organization (1977) International classification of diseases, 1975 revision (ICD-9). Geneva: World Health Organization."},{"key":"ref35","unstructured":"World Health Organization (2010) International statistical classification of diseases and health related problems, tenth revision. Geneva: World Health Organization."},{"key":"ref36","first-page":"1","article-title":"Deaths: final data for 2000","volume":"50","author":"AM Mini\u00f1o","year":"2002","journal-title":"Natl Vital Stat Rep"},{"key":"ref37","first-page":"1","article-title":"Direct standardization (age-adjusted death rates)","volume":"6","author":"LR Curtin","year":"1995","journal-title":"Healthy People 2000 Stat Notes"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1001\/jama.286.12.1494","article-title":"Comparison of 2 methods for calculating adjusted survival curves from proportional hazards models","volume":"286","author":"WA Ghali","year":"2001","journal-title":"JAMA"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0021-9681(82)90058-3","article-title":"Adjusted survival curve estimation using covariates","volume":"35","author":"RW Makuch","year":"1982","journal-title":"J Chronic Dis"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1037\/1082-989X.11.2.193","article-title":"Assessing heterogeneity in meta-analysis: Q statistic or I<sup>2<\/sup> index?","volume":"11","author":"TB Huedo-Medina","year":"2006","journal-title":"Psychol Methods"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"e39471","DOI":"10.1371\/journal.pone.0039471","article-title":"Evolution of heterogeneity (I<sup>2<\/sup>) estimates and their 95% confidence intervals in large meta-analyses","volume":"7","author":"K Thorlund","year":"2012","journal-title":"PLoS ONE"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1586\/erc.12.74","article-title":"Obesity and metabolic syndrome as related to cardiovascular disease","volume":"10","author":"A Nikolopoulou","year":"2012","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1381\/096089204323093345","article-title":"The chronic inflammatory hypothesis for the morbidity associated with morbid obesity: implications and effects of weight loss","volume":"14","author":"DR Cottam","year":"2004","journal-title":"Obes Surg"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00592-013-0460-3","article-title":"Very severely obese patients have a high prevalence of type 2 diabetes mellitus and cardiovascular disease","volume":"50","author":"F Vinciguerra","year":"2013","journal-title":"Acta Diabetol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.mcna.2012.10.010","article-title":"Obesity and diabetic kidney disease","volume":"97","author":"C Maric-Bilkan","year":"2013","journal-title":"Med Clin North Am"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1530\/EJE-10-0514","article-title":"Obesity-related cardiovascular risk factors after weight loss: a clinical trial comparing gastric bypass surgery and intensive lifestyle intervention","volume":"163","author":"D Hofs\u00f8","year":"2010","journal-title":"Eur J Endocrinol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1001\/jama.2010.1505","article-title":"Effects of diet and physical activity interventions on weight loss and cardiometabolic risk factors in severely obese adults: a randomized trial","volume":"304","author":"BH Goodpaster","year":"2010","journal-title":"JAMA"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1001\/archinternmed.2009.508","article-title":"Nonsurgical weight loss for extreme obesity in primary care settings: results of the Louisiana Obese Subjects Study","volume":"170","author":"DH Ryan","year":"2010","journal-title":"Arch Intern Med"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.2337\/dc11-0874","article-title":"Effectiveness of lifestyle interventions for individuals with severe obesity and type 2 diabetes: results from the Look AHEAD trial","volume":"34","author":"JL Unick","year":"2011","journal-title":"Diabetes Care"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/SMJ.0b013e3181d394b4","article-title":"Obesity and mortality in persons with obstructive lung disease using data from the NHANES III","volume":"103","author":"JG Jordan Jr","year":"2010","journal-title":"South Med J"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1079\/PHN2001322","article-title":"Validity of self-reported height and weight in 4808 EPIC-Oxford participants","volume":"5","author":"EA Spencer","year":"2002","journal-title":"Public Health Nutr"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/oby.2007.504","article-title":"Comparison of self-reported and measured BMI as correlates of disease markers in US adults","volume":"15","author":"MA McAdams","year":"2007","journal-title":"Obesity (Silver Spring)"},{"key":"ref53","first-page":"77","article-title":"Effects of measurement on obesity and morbidity","volume":"19","author":"M Shields","year":"2008","journal-title":"Health Rep"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1046\/j.1467-789x.2001.00031.x","article-title":"Beyond body mass index","volume":"2","author":"AM Prentice","year":"2001","journal-title":"Obes Rev"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1093\/aje\/kwq306","article-title":"Comparison of dual-energy x-ray absorptiometric and anthropometric measures of adiposity in relation to adiposity-related biologic factors","volume":"172","author":"Q Sun","year":"2010","journal-title":"Am J Epidemiol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2174\/1573399810602040367","article-title":"Metabolic obesity: the paradox between visceral and subcutaneous fat","volume":"2","author":"O Hamdy","year":"2006","journal-title":"Curr 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