{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:32:09Z","timestamp":1793316729554,"version":"4.5.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T00:00:00Z","timestamp":1415664000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosmedicine.org"],"crossmark-restriction":false},"short-container-title":["PLoS Med"],"DOI":"10.1371\/journal.pmed.1001759","type":"journal-article","created":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T18:50:40Z","timestamp":1415731840000},"page":"e1001759","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmed.corrections_policy","source":"Crossref","is-referenced-by-count":174,"title":["The kSORT Assay to Detect Renal Transplant Patients at High Risk for Acute Rejection: Results of the Multicenter AART Study"],"prefix":"10.1371","volume":"11","author":[{"given":"Silke","family":"Roedder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Sigdel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Salomonis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriol","family":"Bestard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Metes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Zeevi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albin","family":"Gritsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Cheeseman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Macedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram","family":"Peddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Vincenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Asher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Salvatierra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Kirk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Reed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minnie M.","family":"Sarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,11,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1056\/NEJMoa035588","article-title":"Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling","volume":"349","author":"M Sarwal","year":"2003","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1111\/j.1600-6143.2012.04253.x","article-title":"A peripheral blood diagnostic test for acute rejection in renal transplantation","volume":"12","author":"L Li","year":"2012","journal-title":"Am J Transplant"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1084\/jem.20122709","article-title":"A common rejection module (CRM) for acute rejection across multiple organs identifies novel therapeutics for organ transplantation","volume":"210","author":"P Khatri","year":"2013","journal-title":"J Exp Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e82153","DOI":"10.1371\/journal.pone.0082153","article-title":"Identification of common blood gene signatures for the diagnosis of renal and cardiac acute allograft rejection","volume":"8","author":"L Li","year":"2013","journal-title":"PLoS ONE"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1111\/j.1600-6143.2012.04144.x","article-title":"Subclinical inflammation and chronic renal allograft injury in a randomized trial on steroid avoidance in pediatric kidney transplantation","volume":"12","author":"M Naesens","year":"2012","journal-title":"Am J Transplant"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/j.1600-6143.2005.01230.x","article-title":"Subclinical rejection associated with chronic allograft nephropathy in protocol biopsies as a risk factor for late graft loss","volume":"6","author":"F Moreso","year":"2006","journal-title":"Am J Transplant"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1097\/01.TP.0000082542.99416.11","article-title":"Protocol biopsy of the stable renal transplant: a multicenter study of methods and complication rates","volume":"76","author":"PN Furness","year":"2003","journal-title":"Transplantation"},{"key":"ref8","first-page":"SS31","article-title":"Histopathology of chronic renal allograft dysfunction","volume":"71","author":"PN Furness","year":"2001","journal-title":"Transplantation"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1038\/ki.2011.245","article-title":"Progressive histological damage in renal allografts is associated with expression of innate and adaptive immunity genes","volume":"80","author":"M Naesens","year":"2011","journal-title":"Kidney Int"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/gm253","article-title":"Biomarkers in solid organ transplantation: establishing personalized transplantation medicine","volume":"3","author":"S Roedder","year":"2011","journal-title":"Genome Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects","volume":"310","year":"2013","journal-title":"JAMA"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1111\/j.1600-6143.2012.04145.x","article-title":"Complete steroid avoidance is effective and safe in children with renal transplants: a multicenter randomized trial with three-year follow-up","volume":"12","author":"MM Sarwal","year":"2012","journal-title":"Am J Transplant"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/j.1600-6143.2009.02987.x","article-title":"Banff '09 meeting report: antibody mediated graft deterioration and implementation of Banff working groups","volume":"10","author":"B Sis","year":"2010","journal-title":"Am J Transplant"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.mam.2005.12.003","article-title":"RNA integrity and the effect on the real-time qRT-PCR performance","volume":"27","author":"S Fleige","year":"2006","journal-title":"Mol Aspects Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1471-2199-7-3","article-title":"The RIN: an RNA integrity number for assigning integrity values to RNA measurements","volume":"7","author":"A Schroeder","year":"2006","journal-title":"BMC Mol Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/biostatistics\/kxr039","article-title":"A nonparametric empirical Bayes framework for large-scale multiple testing","volume":"13","author":"R Martin","year":"2012","journal-title":"Biostatistics"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/sim.5712","article-title":"A linear mixed model approach to compare the evolution of multiple biological rhythms","volume":"32","author":"A Fontana","year":"2013","journal-title":"Stat Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nmeth.1439","article-title":"Cell type-specific gene expression differences in complex tissues","volume":"7","author":"SS Shen-Orr","year":"2010","journal-title":"Nat Methods"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v033.i01","article-title":"Regularization paths for generalized linear models via coordinate descent","volume":"33","author":"J Friedman","year":"2010","journal-title":"J Stat Softw"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/biostatistics\/kxg046","article-title":"Classification of gene microarrays by penalized logistic regression","volume":"5","author":"J Zhu","year":"2004","journal-title":"Biostatistics"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1504\/IJDMB.2008.019097","article-title":"Discovery of metabolite features for the modelling and analysis of high-resolution NMR spectra","volume":"2","author":"HW Cho","year":"2008","journal-title":"Int J Data Min Bioinform"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1148\/radiology.143.1.7063747","article-title":"The meaning and use of the area under a receiver operating characteristic (ROC) curve","volume":"143","author":"JA Hanley","year":"1982","journal-title":"Radiology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3109\/07853899209147843","article-title":"Empirical Bayes methods for testing associations with large numbers of candidate genes in the presence of environmental risk factors, with applications to HLA associations in IDDM","volume":"24","author":"D Thomas","year":"1992","journal-title":"Ann Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"R130","DOI":"10.1186\/gb-2009-10-11-r130","article-title":"BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources","volume":"10","author":"C Wu","year":"2009","journal-title":"Genome Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2217\/bmm.12.29","article-title":"Protein and peptide biomarkers in organ transplantation","volume":"6","author":"TK Sigdel","year":"2012","journal-title":"Biomark Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1056\/NEJMoa020009","article-title":"The natural history of chronic allograft nephropathy","volume":"349","author":"BJ Nankivell","year":"2003","journal-title":"N Engl J Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1159\/000356189","article-title":"The state of RT-quantitative PCR: firsthand observations of implementation of minimum information for the publication of quantitative real-time PCR experiments (MIQE)","volume":"24","author":"SC Taylor","year":"2014","journal-title":"J Mol Microbiol Biotechnol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1756-0500-5-1","article-title":"Peripheral blood gene expression: it all boils down to the RNA collection tubes","volume":"5","author":"A Menke","year":"2012","journal-title":"BMC Res Notes"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jim.2008.08.003","article-title":"Assessment of sample collection and storage methods for multicenter immunologic research in children","volume":"339","author":"LA Matheson","year":"2008","journal-title":"J Immunol Methods"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1152\/physiolgenomics.00216.2007","article-title":"Interference of globin genes with biomarker discovery for allograft rejection in peripheral blood samples","volume":"32","author":"L Li","year":"2008","journal-title":"Physiol Genomics"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1600-6143.2005.01175.x","article-title":"Noninvasive discrimination of rejection in cardiac allograft recipients using gene expression profiling","volume":"6","author":"MC Deng","year":"2006","journal-title":"Am J Transplant"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"425","DOI":"10.7326\/0003-4819-153-7-201010050-00005","article-title":"Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients","volume":"153","author":"S Rosenberg","year":"2010","journal-title":"Ann Intern Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1056\/NEJMoa1302506","article-title":"Complement-binding anti-HLA antibodies and kidney-allograft survival","volume":"369","author":"A Loupy","year":"2013","journal-title":"N Engl J Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1038\/ki.2013.236","article-title":"Prospective assessment of antidonor cellular alloreactivity is a tool for guidance of immunosuppression in kidney transplantation","volume":"84","author":"O Bestard","year":"2013","journal-title":"Kidney Int"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/TP.0b013e3182985504","article-title":"Anti-donor HLA class I antibodies: pathways to endothelial cell activation and cell-mediated allograft rejection","volume":"96","author":"FM Naemi","year":"2013","journal-title":"Transplantation"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1399-0039.2007.00995.x","article-title":"Follicular associated T cells and their B-cell helper qualities","volume":"71","author":"NM Haynes","year":"2008","journal-title":"Tissue Antigens"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/ajt.12150","article-title":"Molecular diagnosis of antibody-mediated rejection in human kidney transplants","volume":"13","author":"J Sellares","year":"2013","journal-title":"Am J Transplant"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"15448","DOI":"10.1073\/pnas.0705834104","article-title":"Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance","volume":"104","author":"S Brouard","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref40","first-page":"2845","article-title":"Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients","volume":"118","author":"M Martinez-Llordella","year":"2008","journal-title":"J Clin Invest"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1111\/j.1600-6143.2011.03638.x","article-title":"Comparison of transcriptional and blood cell-phenotypic markers between operationally tolerant liver and kidney recipients","volume":"11","author":"JJ Lozano","year":"2011","journal-title":"Am J Transplant"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1681\/ASN.2011060543","article-title":"Upregulation of miR-142-3p in peripheral blood mononuclear cells of operationally tolerant patients with a renal transplant","volume":"23","author":"R Danger","year":"2012","journal-title":"J Am Soc Nephrol"}],"updated-by":[{"DOI":"10.1371\/journal.pmed.1001790","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2015,2,20]],"date-time":"2015-02-20T00:00:00Z","timestamp":1424390400000}}],"container-title":["PLoS Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pmed.1001759","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T04:46:05Z","timestamp":1540269965000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pmed.1001759"}},"subtitle":[],"editor":[{"given":"Giuseppe","family":"Remuzzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,11,11]]},"references-count":42,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2014,11,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pmed.1001759","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pmed.1001790","asserted-by":"object"}]},"ISSN":["1549-1676"],"issn-type":[{"value":"1549-1676","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,11]]}}}