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Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cphiv.dk\/Portals\/0\/files\/Study%20documents\/DAD_MOOP_revised2013.pdf\" xlink:type=\"simple\">http:\/\/www.cphiv.dk\/Portals\/0\/files\/Study%20documents\/DAD_MOOP_revised2013.pdf<\/ext-link>. 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