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Shao","year":"2006","journal-title":"Lancet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.3201\/eid1909.130160","article-title":"Spread of <italic>Neisseria meningitidis<\/italic> serogroup W clone, China","volume":"19","author":"H Zhou","year":"2013","journal-title":"Emerg Infect Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3109\/02813432.2011.629156","article-title":"Antibiotic prescribing in nursing homes in an area with low prevalence of antibiotic resistance: compliance with national guidelines","volume":"30","author":"M Fagan","year":"2012","journal-title":"Scand J Prim Health Care"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1086\/511866","article-title":"Adherence to the Infectious Diseases Society of America guidelines in the treatment of uncomplicated urinary tract infection","volume":"44","author":"Y Taur","year":"2007","journal-title":"Clin Infect Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1086\/318514","article-title":"Practice guidelines for the management of infectious diarrhea","volume":"32","author":"RL Guerrant","year":"2001","journal-title":"Clin Infect Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1183\/09031936.00145810","article-title":"Antibiotic prescribing for adults with acute cough\/lower respiratory tract infection: congruence with guidelines","volume":"38","author":"J Wood","year":"2011","journal-title":"Eur Respir J"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1532-5415.2008.02098.x","article-title":"Consensus guidelines for oral dosing of primarily renally cleared medications in older adults","volume":"57","author":"JT Hanlon","year":"2009","journal-title":"J Am Geriatr Soc"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"170","DOI":"10.2165\/00003495-199300453-00034","article-title":"Surveillance of bacterial resistance to quinolones","volume":"45","author":"F Wang","year":"1993","journal-title":"Drugs"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/S1473-3099(14)70780-7","article-title":"Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data","volume":"14","author":"TP Van Boeckel","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"ref23","first-page":"1236","article-title":"<italic>Neisseria meningitidis<\/italic> serogroup W135 sequence type 11, Anhui Province, China, 2011\u20132013","volume":"20","author":"S Hu","year":"2014","journal-title":"Emerg Infect Dis"},{"key":"ref24","first-page":"692","article-title":"Investigation of resistance of animal Escherichia coli from food in different periods of China","volume":"39","author":"L Song","year":"2009","journal-title":"Sci China Life Sci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1128\/JCM.00918-11","article-title":"Development of a multiplex PCR assay for detection and genogrouping of <italic>Neisseria meningitidis<\/italic>","volume":"50","author":"H Zhu","year":"2012","journal-title":"J Clin Microbiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1128\/JCM.42.1.320-328.2004","article-title":"Use of real-time PCR to resolve slide agglutination discrepancies in serogroup identification of <italic>Neisseria meningitidis<\/italic>","volume":"42","author":"EA Mothershed","year":"2004","journal-title":"J Clin Microbiol"},{"key":"ref27","unstructured":"Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing: twenty-third informational supplement. M100-S23. Wayne (Pennsylvania): Clinical and Laboratory Standards Institute; 2013."},{"key":"ref28","doi-asserted-by":"crossref","first-page":"6007","DOI":"10.1128\/JCM.43.12.6007-6014.2005","article-title":"Multilocus sequence typing of <italic>Neisseria meningitidis<\/italic> directly from clinical samples and application of the method to the investigation of meningococcal disease case clusters","volume":"43","author":"A Birtles","year":"2005","journal-title":"J Clin Microbiol"},{"key":"ref29","unstructured":"PubMLST. <italic>Neisseria<\/italic> sequence typing home page. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/pubmlst.org\/neisseria\/\" xlink:type=\"simple\">http:\/\/pubmlst.org\/neisseria\/<\/ext-link>. Accessed October 21, 2014."},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1128\/JB.186.5.1518-1530.2004","article-title":"eBURST: inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data","volume":"186","author":"EJ Feil","year":"2004","journal-title":"J Bacteriol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1128\/JCM.39.1.75-85.2001","article-title":"Evaluation of pulsed-field gel electrophoresis in epidemiological investigations of meningococcal disease outbreaks caused by <italic>Neisseria meningitidis<\/italic> serogroup C","volume":"39","author":"T Popovic","year":"2001","journal-title":"J Clin Microbiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/jac\/47.2.219","article-title":"Rifampicin-resistant meningococci causing invasive disease: detection of point mutations in the rpoB gene and molecular characterization of the strains","volume":"47","author":"P Stefanelli","year":"2001","journal-title":"J Antimicrob Chemother"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s11684-012-0214-6","article-title":"PulseNet China, a model for future laboratory-based bacterial infectious disease surveillance in China","volume":"6","author":"W Li","year":"2012","journal-title":"Front Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ygeno.2007.10.004","article-title":"Characterization of ST-4821 complex, a unique <italic>Neisseria meningitidis<\/italic> clone","volume":"91","author":"J Peng","year":"2008","journal-title":"Genomics"},{"key":"ref35","unstructured":"Dean AG, Sullivan KM, Soe MM. OpenEpi: Open Source Epidemiologic Statistics for Public Health, version 3.01a. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.OpenEpi.com\" xlink:type=\"simple\">http:\/\/www.OpenEpi.com<\/ext-link>. Accessed September 22, 2014."},{"key":"ref36","first-page":"427","article-title":"Handbook of meningococcal disease: infection biology, vaccination, clinical management","author":"P Brandtzaeg","year":"2006"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1093\/jac\/dkq291","article-title":"Invasive <italic>Neisseria meningitidis<\/italic> with decreased susceptibility to fluoroquinolones in South Africa, 2009","volume":"65","author":"M du Plessis","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1099\/jmm.0.078600-0","article-title":"Genetic diversity and clonal characteristics of ciprofloxacin-resistant meningococcal strains in China","volume":"63","author":"B Zhu","year":"2014","journal-title":"J Med Microbiol"},{"key":"ref39","first-page":"470","article-title":"Scheduled immunology","author":"F Li","year":"2010"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1017\/S0950268811001865","article-title":"Distribution of serogroups and sequence types in disease-associated and carrier strains of <italic>Neisseria meningitidis<\/italic> isolated in China between 2003 and 2008","volume":"140","author":"H Zhou","year":"2012","journal-title":"Epidemiol Infect"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jinf.2013.12.011","article-title":"Meningococcal serogroup Y lpxL1 variants from South Africa are associated with clonal complex 23 among young adults","volume":"68","author":"M du Plessis","year":"2014","journal-title":"J Infect"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0140-6736(13)61612-8","article-title":"Effect of a serogroup A meningococcal conjugate vaccine (PsA-TT) on serogroup A meningococcal meningitis and carriage in Chad: a community study","volume":"383","author":"DM Daugla","year":"2014","journal-title":"Lancet"},{"key":"ref43","first-page":"218","article-title":"Analysis on the epidemic situation of cerebro-spinal meningitis and its prevention and control measures in 2004 in Hefei City","volume":"12","author":"Y Jin","year":"2006","journal-title":"Anhui J Prev Med"},{"key":"ref44","first-page":"923","article-title":"Investigation of the first case of meningococcal meningitis W135 in Tongling, Anhui","volume":"27","author":"F Zhang","year":"2012","journal-title":"Dis Surveill"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1097\/00006454-199809000-00013","article-title":"Azithromycin compared with rifampin for eradication of nasopharyngeal colonization by Neisseria meningitidis","volume":"17","author":"N Girgis","year":"1998","journal-title":"Pediatr Infect Dis J"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"5234","DOI":"10.1073\/pnas.061386098","article-title":"Fit genotypes and escape variants of subgroup III <italic>Neisseria meningitidis<\/italic> during three pandemics of epidemic meningitis","volume":"98","author":"P Zhu","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref47","first-page":"321","article-title":"Clinical epidemiology of epidemic cerebrospinal meningitis in children in Shanghai area from 1984 to 2003","volume":"4","author":"Y Li","year":"2004","journal-title":"Chin J Infect Chemother"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1093\/molbev\/mst012","article-title":"Building phylogenetic trees from molecular data with MEGA","volume":"30","author":"BG Hall","year":"2013","journal-title":"Mol Biol Evol"}],"container-title":["PLOS Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pmed.1001838","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T05:01:36Z","timestamp":1599109296000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pmed.1001838"}},"subtitle":[],"editor":[{"given":"Keith P","family":"Klugman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,6,9]]},"references-count":48,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pmed.1001838","relation":{},"ISSN":["1549-1676"],"issn-type":[{"value":"1549-1676","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,9]]}}}