{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:12:47Z","timestamp":1769598767843,"version":"3.49.0"},"reference-count":21,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T00:00:00Z","timestamp":1451347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosmedicine.org"],"crossmark-restriction":false},"short-container-title":["PLoS Med"],"DOI":"10.1371\/journal.pmed.1001932","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T13:46:41Z","timestamp":1451396801000},"page":"e1001932","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmed.corrections_policy","source":"Crossref","is-referenced-by-count":39,"title":["Association between Regimen Composition and Treatment Response in Patients with Multidrug-Resistant Tuberculosis: A Prospective Cohort Study"],"prefix":"10.1371","volume":"12","author":[{"given":"Courtney M.","family":"Yuen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekaterina V.","family":"Kurbatova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thelma","family":"Tupasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice Campos","family":"Caoili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martie","family":"Van Der Walt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Kvasnovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Yagui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Bayona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Contreras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vaira","family":"Leimane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Ershova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura E.","family":"Via","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HeeJin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somsak","family":"Akksilp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris Y.","family":"Kazennyy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grigory V.","family":"Volchenkov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruwen","family":"Jou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Kliiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga V.","family":"Demikhova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina A.","family":"Vasilyeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy","family":"Dalton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Peter","family":"Cegielski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,12,29]]},"reference":[{"key":"ref1","article-title":"Guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update","year":"2011"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1093\/cid\/ciu619","article-title":"Treatment outcomes of patients with multidrug-resistant and extensively drug-resistant tuberculosis according to drug susceptibility testing to first- and second-line drugs: an individual patient data meta-analysis","volume":"59","author":"ML Bastos","year":"2014","journal-title":"Clin Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e58664","DOI":"10.1371\/journal.pone.0058664","article-title":"Aggressive regimens for multidrug-resistant tuberculosis decrease all-cause mortality","volume":"8","author":"CD Mitnick","year":"2013","journal-title":"PLoS ONE"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1093\/cid\/cis1008","article-title":"Aggressive regimens for multidrug-resistant tuberculosis reduce recurrence","volume":"56","author":"MF Franke","year":"2013","journal-title":"Clin Infect Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/cid\/ciu209","article-title":"Improving outcomes for multidrug-resistant tuberculosis: aggressive regimens prevent treatment failure and death","volume":"59","author":"GE Velasquez","year":"2014","journal-title":"Clin Infect Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/S0140-6736(12)60734-X","article-title":"Prevalence of and risk factors for resistance to second-line drugs in people with multidrug-resistant tuberculosis in eight countries: a prospective cohort study","volume":"380","author":"T Dalton","year":"2012","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1093\/cid\/ciu572","article-title":"Extensive drug resistance acquired during treatment of multidrug-resistant tuberculosis","volume":"59","author":"JP Cegielski","year":"2014","journal-title":"Clin Infect Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1183\/09031936.00134712","article-title":"Resistance to fluoroquinolones and second-line injectable drugs: impact on multidrug-resistant TB outcomes","volume":"42","author":"D Falzon","year":"2013","journal-title":"Eur Respir J"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1164\/rccm.201001-0077OC","article-title":"Short, highly effective, and inexpensive standardized treatment of multidrug-resistant tuberculosis","volume":"182","author":"A Van Deun","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"ref10","article-title":"Guidelines for the programmatic management of drug-resistant tuberculosis: emergency update 2008","year":"2008"},{"key":"ref11","first-page":"6","article-title":"The curious characteristics of pyrazinamide: a review","volume":"7","author":"Y Zhang","year":"2003","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1513\/AnnalsATS.201411-538OC","article-title":"Counting pyrazinamide in regimens for multidrug-resistant tuberculosis","volume":"12","author":"MF Franke","year":"2015","journal-title":"Ann Am Thorac Soc"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"39","DOI":"10.5588\/ijtld.13.0307","article-title":"Treatment outcomes and moxifloxacin susceptibility in ofloxacin-resistant multidrug-resistant tuberculosis","volume":"18","author":"KW Jo","year":"2014","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"339","DOI":"10.5588\/ijtld.14.0814","article-title":"Concordance of Mycobacterium tuberculosis fluoroquinolone resistance testing: implications for treatment","volume":"19","author":"MR Farhat","year":"2015","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.5588\/ijtld.10.0679","article-title":"Predictors of delayed culture conversion in patients treated for multidrug-resistant tuberculosis in Pakistan","volume":"15","author":"F Qazi","year":"2011","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.5588\/ijtld.11.0811","article-title":"Predictors of sputum culture conversion among patients treated for multidrug-resistant tuberculosis","volume":"16","author":"EV Kurbatova","year":"2012","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e73975","DOI":"10.1371\/journal.pone.0073975","article-title":"Chest radiograph findings and time to culture conversion in patients with multidrug-resistant tuberculosis and HIV in Tugela Ferry, South Africa","volume":"8","author":"JC Brust","year":"2013","journal-title":"PLoS ONE"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"650","DOI":"10.7326\/0003-4819-144-9-200605020-00008","article-title":"Time to sputum culture conversion in multidrug-resistant tuberculosis: predictors and relationship to treatment outcome","volume":"144","author":"TH Holtz","year":"2006","journal-title":"Ann Intern Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e0117421","DOI":"10.1371\/journal.pone.0117421","article-title":"High rates of ofloxacin resistance in Mycobacterium tuberculosis among both new and previously treated patients in Tamil Nadu, South India","volume":"10","author":"N Selvakumar","year":"2015","journal-title":"PLoS ONE"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"151","DOI":"10.5588\/ijtld.14.0200","article-title":"Anti-tuberculosis drug resistance in Bangladesh: reflections from the first nationwide survey","volume":"19","author":"SM Kamal","year":"2015","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S2213-2600(15)00036-3","article-title":"Sputum culture conversion as a prognostic marker for end-of-treatment outcome in patients with multidrug-resistant tuberculosis: a secondary analysis of data from two observational cohort studies","volume":"3","author":"EV Kurbatova","year":"2015","journal-title":"Lancet Respir Med"}],"container-title":["PLOS Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pmed.1001932","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T17:54:05Z","timestamp":1588960445000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pmed.1001932"}},"subtitle":[],"editor":[{"given":"Madhukar","family":"Pai","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,12,29]]},"references-count":21,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2015,12,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pmed.1001932","relation":{},"ISSN":["1549-1676"],"issn-type":[{"value":"1549-1676","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,29]]}}}