{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:54:08Z","timestamp":1793231648729,"version":"4.5.0"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosmedicine.org"],"crossmark-restriction":false},"short-container-title":["PLoS Med"],"DOI":"10.1371\/journal.pmed.1001967","type":"journal-article","created":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T13:53:09Z","timestamp":1456840389000},"page":"e1001967","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmed.corrections_policy","source":"Crossref","is-referenced-by-count":342,"title":["Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea"],"prefix":"10.1371","volume":"13","clinical-trial-number":[{"clinical-trial-number":"nct02329054","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Daouda","family":"Sissoko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Laouenan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elin","family":"Folkesson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdoul-Bing","family":"M\u2019Lebing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdoul-Habib","family":"Beavogui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Baize","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alseny-Modet","family":"Camara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piet","family":"Maes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Shepherd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Danel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Carazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoudou N.","family":"Conde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Gala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Colin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Savini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Akoi","family":"Bore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Le Marcis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fara Raymond","family":"Koundouno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Petitjean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Claire","family":"Lamah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Diederich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Tounkara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geertrui","family":"Poelart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Berbain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Dindart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Duraffour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabelle","family":"Lefevre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamba","family":"Leno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Peyrouset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9onid","family":"Irenge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u2019Famara","family":"Bangoura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Palich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Hinzmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierno Sadou","family":"Barry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakoba","family":"Berette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Bongono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Seto","family":"Camara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Chanfreau Munoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lancin\u00e9","family":"Doumbouya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Souley Harouna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patient Mumbere","family":"Kighoma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fara Roger","family":"Koundouno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"R\u00e9n\u00e9 Lolamou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9c\u00e9 Moriba","family":"Loua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Massala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinda","family":"Moumouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lia","family":"Provost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nenefing","family":"Samake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conde","family":"Sekou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdoulaye","family":"Soumah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Arnould","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel Saa","family":"Komano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Gustin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Berutto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diarra","family":"Camara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fod\u00e9 Saydou","family":"Camara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joliene","family":"Colpaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9ontine","family":"Delamou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Jansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Kourouma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Loua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Malme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Manfrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Maomou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele","family":"Milinouno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sien","family":"Ombelet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aboubacar Youla","family":"Sidiboun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Verreckt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Yombouno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Bocquin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Carbonnelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Carmoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Frange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Mely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinh-Kim","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Pannetier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Taburet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Treluyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Kolie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul","family":"Moh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minerva Cervantes","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eeva","family":"Kuisma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Liedigk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Ngabo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Rudolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Thom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romy","family":"Kerber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Gabriel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Di Caro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"W\u00f6lfel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamal","family":"Badir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Bentahir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Deccache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Dumont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Durant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"El Bakkouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Gasasira Uwamahoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Smits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Toufik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Van Cauwenberghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Ezzedine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Dortenzio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Pizarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Etienne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9mie","family":"Guedj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Fizet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Barte de Sainte Fare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette","family":"Murgue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuan","family":"Tran-Minh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Rapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Piguet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Poncin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Draguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Allaford Duverger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solenne","family":"Barbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Baret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Defourny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miles","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Raoul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustin","family":"Augier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge P.","family":"Eholie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazdan","family":"Yazdanpanah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Levy-Marchal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"Antierrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Van Herp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"G\u00fcnther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"de Lamballerie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakoba","family":"Ke\u00efta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"France","family":"Mentre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Anglaret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Malvy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"JIKI Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,3,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1056\/NEJMoa1404505","article-title":"Emergence of Zaire Ebola virus disease in Guinea\u2014preliminary report","volume":"371","author":"S Baize","year":"2014","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"4760","DOI":"10.3390\/v6114760","article-title":"Nomenclature- and database-compatible names for the two Ebola virus variants that emerged in Guinea and the Democratic Republic of the Congo in 2014","volume":"6","author":"J Kuhn","year":"2014","journal-title":"Viruses"},{"key":"ref3","first-page":"89","article-title":"Ebola virus disease (EVD) in West Africa: an extraordinary epidemic","volume":"90","year":"2015","journal-title":"Wkly Epidemiol Rec"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1016\/S0140-6736(00)02405-3","article-title":"Human asymptomatic Ebola infection and strong inflammatory response","volume":"355","author":"E Leroy","year":"2000","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0140-6736(10)60667-8","article-title":"Ebola haemorrhagic fever","volume":"377","author":"H Feldmann","year":"2011","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1513\/AnnalsATS.201410-481PS","article-title":"Clinical presentation and management of severe Ebola virus disease","volume":"11","author":"TE West","year":"2014","journal-title":"Ann Am Thorac Soc"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1056\/NEJMoa1411680","article-title":"Clinical illness and outcomes in patients with Ebola in Sierra Leone","volume":"371","author":"JS Schieffelin","year":"2014","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e1001857","DOI":"10.1371\/journal.pmed.1001857","article-title":"Ebola virus disease: experience and decision making for the first patients outside of Africa","volume":"12","author":"DS Stephens","year":"2015","journal-title":"PLoS Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1056\/NEJMoa1409838","article-title":"Clinical care of two patients with Ebola virus disease in the United States","volume":"371","author":"GM Lyon","year":"2014","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/S2213-2600(15)00180-0","article-title":"Acute respiratory distress syndrome after convalescent plasma use: treatment of a patient with Ebola virus disease contracted in Madrid, Spain","volume":"3","author":"M Mora-Rillo","year":"2015","journal-title":"Lancet Respir Med"},{"key":"ref11","unstructured":"World Health Organization. Categorization and prioritization of drugs for consideration for testing or use in patients infected with Ebola. 2015 Jan 19 [cited 15 Sep 2015]. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/medicines\/ebola-treatment\/cat_prioritization_drugs_testing\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/medicines\/ebola-treatment\/cat_prioritization_drugs_testing\/en\/<\/ext-link>."},{"key":"ref12","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.antiviral.2014.01.012","article-title":"Post-exposure efficacy of oral T-705 (favipiravir) against inhalational Ebola virus infection in a mouse model","volume":"104","author":"SJ Smither","year":"2014","journal-title":"Antiviral Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.antiviral.2013.09.015","article-title":"Favipiravir (T-705), a novel viral RNA polymerase inhibitor","volume":"100","author":"Y Furuta","year":"2013","journal-title":"Antiviral Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1128\/AAC.46.4.977-981.2002","article-title":"In vitro and in vivo activities of anti-influenza virus compound T-705","volume":"46","author":"Y Furuta","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.antiviral.2014.02.014","article-title":"Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model","volume":"105","author":"L Oestereich","year":"2014","journal-title":"Antiviral Res"},{"key":"ref16","unstructured":"MDVI. Phase 3 efficacy and safety study of favipiravir for treatment of uncomplicated influenza in Adults. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/ClinicalTrials.gov\" xlink:type=\"simple\">ClinicalTrials.gov<\/ext-link>. 2013 Dec 8 [cited 15 Sep 2015]. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02008344\" xlink:type=\"simple\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02008344<\/ext-link>."},{"key":"ref17","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.antiviral.2015.08.015","article-title":"Ebola virus dynamics in mice treated with favipiravir","volume":"123","author":"V Madelain","year":"2015","journal-title":"Antiviral Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S1473-3099(14)71047-3","article-title":"Dose regimen of favipiravir for Ebola virus disease","volume":"15","author":"F Mentre","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0140-6736(15)60232-X","article-title":"Favipiravir for children with Ebola","volume":"385","author":"N Bouazza","year":"2015","journal-title":"Lancet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1086\/514318","article-title":"Clinical, virologic, and immunologic follow-up of convalescent Ebola hemorrhagic fever patients and their household contacts, Kikwit, Democratic Republic of the Congo","volume":"179","author":"AK Rowe","year":"1999","journal-title":"J Infect Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"S177","DOI":"10.1086\/514321","article-title":"Clinical virology of Ebola hemorrhagic fever (EHF): virus, virus antigen, and IgG and IgM antibody findings among EHF patients in Kikwit, Democratic Republic of the Congo, 1995","volume":"179","author":"T Ksiazek","year":"1999","journal-title":"J Infect Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"4330","DOI":"10.1128\/JVI.78.8.4330-4341.2004","article-title":"Rapid diagnosis of Ebola hemorrhagic fever by reverse transcription-PCR in an outbreak setting and assessment of patient viral load as a predictor of outcome","volume":"78","author":"JS Towner","year":"2004","journal-title":"J Virol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1097\/INF.0000000000000707","article-title":"Ebola virus disease: focus on children","volume":"34","author":"AP Kourtis","year":"2015","journal-title":"Pediatr Infect Dis J"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"S364","DOI":"10.1086\/520613","article-title":"Blood chemistry measurements and D-dimer levels associated with fatal and nonfatal outcomes in humans infected with Sudan Ebola virus","volume":"196","author":"PE Rollin","journal-title":"J Infect Dis2007"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"S810","DOI":"10.1093\/infdis\/jir299","article-title":"Basic clinical and laboratory features of filoviral hemorrhagic fever","volume":"204","author":"MG Kortepeter","year":"2011","journal-title":"J Infect Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1056\/NEJMoa1411249","article-title":"Clinical presentation of patients with Ebola virus disease in Conakry, Guinea","volume":"372","author":"EI Bah","year":"2015","journal-title":"N Engl J Med"},{"key":"ref27","unstructured":"ACAPS. Ebola in West Africa\u2014Guinea: resistance to the Ebola response. ACAPS Thematic Note. 2015 Apr 24 [cited 15 Sep 2015]. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/acaps.org\/img\/documents\/t-acaps_ebola_guinea-resistance-to-ebola-response_24-april-2015.pdf\" xlink:type=\"simple\">http:\/\/acaps.org\/img\/documents\/t-acaps_ebola_guinea-resistance-to-ebola-response_24-april-2015.pdf<\/ext-link>."},{"key":"ref28","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.socscimed.2015.10.063","article-title":"Reaching out to Ebola victims: coercion, persuasion or an appeal for self-sacrifice?","volume":"147","author":"P Calain","year":"2015","journal-title":"Soc Sci Med"},{"key":"ref29","unstructured":"Presidential Commission for the Study of Bioethical Issues. Ethics and Ebola: public health planning and response. 2015 Feb [cited 28 Jan 2015]. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/bioethics.gov\/sites\/default\/files\/Ethics-and-Ebola_PCSBI_508.pdf\" xlink:type=\"simple\">http:\/\/bioethics.gov\/sites\/default\/files\/Ethics-and-Ebola_PCSBI_508.pdf<\/ext-link>."},{"key":"ref30","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s12250-012-3252-y","article-title":"Rapid detection of filoviruses by real-time TaqMan polymerase chain reaction assays","volume":"27","author":"Y Huang","year":"2012","journal-title":"Virol Sin"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"186","DOI":"10.2471\/BLT.14.141390","article-title":"Participants understanding of informed consent in clinical trials over three decades: systematic review and meta-analysis","volume":"93","author":"NT Tam","year":"2015","journal-title":"Bull World Health Organ"},{"key":"ref32","author":"J Whitehead","year":"1997"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/(SICI)1097-0258(19980430)17:8<857::AID-SIM777>3.0.CO;2-E","article-title":"Two-sided confidence intervals for the single proportion: comparison of seven methods","volume":"17","author":"R Newcombe","year":"1998","journal-title":"Stat Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2105\/AJPH.2012.300897","article-title":"Multivariate or multivariable regression","volume":"103","author":"B Hidalgo","year":"2013","journal-title":"Am J Public Health"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2307\/2348040","article-title":"Plotting p against x","volume":"32","author":"J Copas","year":"1983","journal-title":"Appl Stat"},{"key":"ref36","unstructured":"Sissoko S, Folkesson E, Abdoul M, Beavogui A, Gunther S, Shepherd S, et al. Favipiravir in patients with Ebola virus disease: early results of the JIKI trial in Guinea. Abstract 103-ALB. 22nd Conference on Retroviruses and Opportunistic Infections; 23\u201326 Feb 2015; Seattle, Washington, US. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.croiconference.org\/sessions\/favipiravir-patients-ebola-virus-disease-early-results-jiki-trial-guinea\" xlink:type=\"simple\">http:\/\/www.croiconference.org\/sessions\/favipiravir-patients-ebola-virus-disease-early-results-jiki-trial-guinea<\/ext-link>."},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.csda.2004.07.002","article-title":"Maximum likelihood estimation in nonlinear mixed effects models","volume":"49","author":"E Kuhn","year":"2005","journal-title":"Comput Stat Data Anal"},{"key":"ref38","first-page":"386","article-title":"Ebola transmission linked to a single traditional funeral ceremony\u2014Kissidougou, Guinea, December, 2014\u2013January 2015","volume":"64","author":"KR Victory","year":"2015","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/S1473-3099(15)70106-4","article-title":"Are adaptive randomised trials or non-randomised studies the best way to address the Ebola outbreak in west Africa?","volume":"15","author":"S Lanini","year":"2015","journal-title":"Lancet Infect Dis"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1001\/jama.2014.12867","article-title":"Evaluating novel therapies during the Ebola epidemic","volume":"312","author":"S Joffe","year":"2014","journal-title":"JAMA"},{"key":"ref41","unstructured":"Chimerix. An open-label, multicenter study of the safety and anti viral activity of brincidofovir (BCV, CMX001) for Ebola virus disease. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/ClinicalTrials.gov\" xlink:type=\"simple\">ClinicalTrials.gov<\/ext-link>. 2014 Oct 7 [cited 15 Sep 2015]. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02271347\" xlink:type=\"simple\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02271347<\/ext-link>."},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1056\/NEJMoa1511812","article-title":"Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea","volume":"374","author":"J van Griensven","year":"2016","journal-title":"N Engl J Med"},{"key":"ref43","unstructured":"National Institute of Allergy and Infectious Diseases. Putative investigational therapeutics in the treatment of patients with known Ebola infection. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/ClinicalTrials.gov\" xlink:type=\"simple\">ClinicalTrials.gov<\/ext-link>. 2015 Feb 13 [cited 15 Sep 2015]. Available at: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02363322\" xlink:type=\"simple\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02363322<\/ext-link>."},{"key":"ref44","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nature13777","article-title":"Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp","volume":"514","author":"X Qiu","year":"2014","journal-title":"Nature"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"e1001815","DOI":"10.1371\/journal.pmed.1001815","article-title":"Evaluating clinical trial designs for investigational treatments of Ebola virus disease","volume":"12","author":"BS Cooper","year":"2015","journal-title":"PLoS Med"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/S0140-6736(14)61734-7","article-title":"Randomised controlled trials for Ebola: practical and ethical issues","volume":"384","author":"C Adebamowo","year":"2014","journal-title":"Lancet"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"10370","DOI":"10.1128\/JVI.78.19.10370-10377.2004","article-title":"Analysis of human peripheral blood samples from fatal and nonfatal cases of Ebola (Sudan) hemorrhagic fever: cellular responses, virus load, and nitric oxide levels","volume":"78","author":"A Sanchez","year":"2004","journal-title":"J Virol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1093\/infdis\/jiu088","article-title":"Ebola hemorrhagic fever: novel biomarker correlates of clinical outcome","volume":"210","author":"AK McElroy","year":"2014","journal-title":"J Infect Dis"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1093\/infdis\/jiv304","article-title":"The contribution of Ebola viral load at admission and other patient characteristics to mortality in a Medecins Sans Frontieres Ebola case management centre, Kailahun, Sierra Leone, June\u2013October 2014","volume":"212","author":"G Fitzpatrick","year":"2015","journal-title":"J Infect Dis"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/S1473-3099(15)00144-9","article-title":"Clinical presentation, biochemical, and haematological parameters and their association with outcome in patients with Ebola virus disease: an observational cohort study","volume":"15","author":"L Hunt","year":"2015","journal-title":"Lancet Infect Dis"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/S1473-3099(15)00229-7","article-title":"Clinical features and viral kinetics in a rapidly cured patient with Ebola virus disease: a case report","volume":"15","author":"M Schibler","year":"2015","journal-title":"Lancet Infect Dis"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1056\/NEJMra1208623","article-title":"Severe sepsis and septic shock","volume":"369","author":"DC Angus","year":"2013","journal-title":"N Engl J Med"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/S0140-6736(11)61454-2","article-title":"Acute kidney injury","volume":"380","author":"R Bellomo","year":"2012","journal-title":"Lancet"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1128\/CMR.00001-08","article-title":"Bacterial, fungal, parasitic, and viral myositis","volume":"21","author":"NF Crum-Cianflone","year":"2008","journal-title":"Clin Microbiol Rev"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"861","DOI":"10.7326\/0003-4819-119-8-199310150-00024","article-title":"Tumor necrosis factor and coxsackie B4 rhabdomyolysis","volume":"119","author":"RJ Konrad","year":"1993","journal-title":"Ann Intern Med"},{"key":"ref56","first-page":"819","article-title":"Sporadic viral myositis in two adults","volume":"137","author":"C Naylor","year":"1987","journal-title":"CMAJ"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1056\/NEJMra0801327","article-title":"Rhabdomyolysis and acute kidney injury","volume":"361","author":"X Bosch","year":"2009","journal-title":"N Engl J Med"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.3390\/v3091634","article-title":"Filoviral immune evasion mechanisms","volume":"3","author":"P Ramanan","year":"2011","journal-title":"Viruses"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"20661","DOI":"10.1073\/pnas.1213559109","article-title":"Structural basis for Marburg virus VP35-mediated immune evasion mechanisms","volume":"109","author":"P Ramanan","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0140-6736(15)61042-X","article-title":"ReEBOV Antigen Rapid Test kit for point-of-care and laboratory-based testing for Ebola virus disease: a field validation study","volume":"386","author":"M Broadhurst","year":"2015","journal-title":"Lancet"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.antiviral.2015.07.003","article-title":"Alterations in favipiravir (T-705) pharmacokinetics and biodistribution in a hamster model of viral hemorrhagic fever","volume":"121","author":"BB Gowen","year":"2015","journal-title":"Antiviral Res"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ccc.2010.09.006","article-title":"Antimicrobial pharmacokinetic and pharmacodynamic issues in the critically ill with severe sepsis and septic shock","volume":"27","author":"JM Varghese","year":"2011","journal-title":"Crit Care Clin"}],"updated-by":[{"DOI":"10.1371\/journal.pmed.1002066","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T00:00:00Z","timestamp":1465516800000}},{"DOI":"10.1371\/journal.pmed.1002009","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2016,4,5]],"date-time":"2016-04-05T00:00:00Z","timestamp":1459814400000}}],"container-title":["PLOS Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pmed.1001967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T00:36:25Z","timestamp":1567643785000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pmed.1001967"}},"subtitle":[],"editor":[{"given":"Marc","family":"Lipsitch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,3,1]]},"references-count":62,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pmed.1001967","relation":{},"ISSN":["1549-1676"],"issn-type":[{"value":"1549-1676","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,1]]}}}