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Hospital discharges by diagnosis, in-patients, per 100 000 inhabitants. 2011. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/ec.europa.eu\/eurostat\/web\/health\/health-care\/data\/database\" xlink:type=\"simple\">http:\/\/ec.europa.eu\/eurostat\/web\/health\/health-care\/data\/database<\/ext-link>."},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/oxfordjournals.aje.a113058","article-title":"Incidence and prevalence as used in the analysis of the occurrence of nosocomial infections","volume":"113","author":"FS Rhame","year":"1981","journal-title":"Am J Epidemiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/1471-2458-14-147","article-title":"Measuring underreporting and under-ascertainment in infectious disease datasets: a comparison of methods","volume":"14","author":"CL Gibbons","year":"2014","journal-title":"BMC Public Health"},{"key":"ref25","article-title":"Risk analysis\u2014a quantitative guide","author":"D Vose","year":"2001"},{"key":"ref26","unstructured":"National Institute for Health and Care Excellence (NICE). Guide to the methods of technology appraisal. 2013. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.nice.org.uk\/process\/pmg9\/resources\/guide-to-the-methods-of-technology-appraisal-2013-pdf-2007975843781\" xlink:type=\"simple\">https:\/\/www.nice.org.uk\/process\/pmg9\/resources\/guide-to-the-methods-of-technology-appraisal-2013-pdf-2007975843781<\/ext-link>"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Colzani E. Results from the 2015 Burden of Communicable Diseases in Europe (BCoDE) study. European Public Health Conference; Milan, 2015.","DOI":"10.1093\/eurpub\/ckv167.038"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0140-6736(15)60692-4","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990\u20132013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"386","year":"2015","journal-title":"Lancet"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e44103","DOI":"10.1371\/journal.pone.0044103","article-title":"The impact of infection on population health: results of the Ontario burden of infectious diseases study","volume":"7","author":"JC Kwong","year":"2012","journal-title":"PLoS ONE"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1086\/342691","article-title":"Clostridium difficile-associated diarrhea: epidemiological data from Western Australia associated with a modified antibiotic policy","volume":"35","author":"C Thomas","year":"2002","journal-title":"Clin Infect Dis"},{"issue":"35","key":"ref31","doi-asserted-by":"crossref","DOI":"10.2807\/ese.17.35.20259-en","article-title":"Healthcare-associated infections in European long-term care facilities: how big is the challenge?","volume":"17","author":"C Suetens","year":"2012","journal-title":"Euro Surveill"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1086\/523279","article-title":"Does catheter-associated urinary tract infection increase mortality in critically ill patients?","volume":"28","author":"C Clec'h","year":"2007","journal-title":"Infect Control Hosp Epidemiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1053\/jcrc.2002.33029","article-title":"Incidence and risk factors for acquiring nosocomial urinary tract infection in the critically ill","volume":"17","author":"KB Laupland","year":"2002","journal-title":"J Crit Care"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0196-6553(00)90015-4","article-title":"Clinical and economic consequences of nosocomial catheter-related bacteriuria","volume":"28","author":"S Saint","year":"2000","journal-title":"Am J Infect Control"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1086\/501821","article-title":"Converting incidence and prevalence data of nosocomial infections: results from eight hospitals","volume":"22","author":"P Gastmeier","year":"2001","journal-title":"Infect Control Hosp Epidemiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1086\/513536","article-title":"Conversion of prevalence survey data on nosocomial infections to incidence estimates: a simplified tool for surveillance?","volume":"28","author":"P Berthelot","year":"2007","journal-title":"Infect Control Hosp Epidemiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1086\/502553","article-title":"Behavior of cross-sectional surveys in the hospital setting: a simulation model","volume":"26","author":"J Rossello-Urgell","year":"2005","journal-title":"Infect Control Hosp Epidemiol"},{"key":"ref38","article-title":"Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net)","year":"2015"}],"container-title":["PLOS Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pmed.1002150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T12:57:53Z","timestamp":1657457873000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pmed.1002150"}},"subtitle":[],"editor":[{"given":"Stephan","family":"Harbarth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,10,18]]},"references-count":38,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,10,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pmed.1002150","relation":{"is-referenced-by":[{"id-type":"doi","id":"10.1186\/s12912-026-04527-w","asserted-by":"object"}]},"ISSN":["1549-1676"],"issn-type":[{"value":"1549-1676","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,18]]}}}