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Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/esa.un.org\/wpp\/Excel-Data\/population.htm\" xlink:type=\"simple\">http:\/\/esa.un.org\/wpp\/Excel-Data\/population.htm<\/ext-link>."},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1471-2296-10-24","article-title":"Reasons of general practitioners for not prescribing lipid-lowering medication to patients with diabetes: a qualitative study","volume":"10","author":"E AB","year":"2009","journal-title":"BMC Fam Pract"},{"issue":"494","key":"ref42","first-page":"684","article-title":"A qualitative study of barriers to the use of statins and the implementation of coronary heart disease prevention in primary care","volume":"53","author":"J Kedward","year":"2003","journal-title":"Br J Gen Pract"},{"issue":"4","key":"ref43","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1177\/2047487314525531","article-title":"What proportion of symptomatic side effects in patients taking statins are genuinely caused by the drug? 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