{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T09:36:19Z","timestamp":1793957779266,"version":"4.8.0"},"reference-count":102,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T00:00:00Z","timestamp":1490659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"LIM-22, Universidade de Sao Paulo"},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["NIRG-09-131502"],"award-info":[{"award-number":["NIRG-09-131502"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007698","name":"Hospital Israelita Albert Einstein","doi-asserted-by":"crossref","award":["240\/07"],"award-info":[{"award-number":["240\/07"]}],"id":[{"id":"10.13039\/501100007698","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["06\/55318"],"award-info":[{"award-number":["06\/55318"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2009\/09134-4"],"award-info":[{"award-number":["2009\/09134-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/07526-5"],"award-info":[{"award-number":["2012\/07526-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K24AG053435"],"award-info":[{"award-number":["K24AG053435"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosmedicine.org"],"crossmark-restriction":false},"short-container-title":["PLoS Med"],"DOI":"10.1371\/journal.pmed.1002267","type":"journal-article","created":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T18:54:14Z","timestamp":1490727254000},"page":"e1002267","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmed.corrections_policy","source":"Crossref","is-referenced-by-count":128,"title":["Neuropathological diagnoses and clinical correlates in older adults in Brazil: A cross-sectional study"],"prefix":"10.1371","volume":"14","author":[{"given":"Claudia K.","family":"Suemoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata E. L.","family":"Ferretti-Rebustini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6544-7861","authenticated-orcid":true,"given":"Roberta D.","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5878-398X","authenticated-orcid":false,"given":"Renata E. P.","family":"Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9399-8062","authenticated-orcid":false,"given":"Luciana","family":"Soterio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8303-6732","authenticated-orcid":true,"given":"Sonia M. D.","family":"Brucki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3066-3457","authenticated-orcid":false,"given":"Raphael R.","family":"Spera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarcila M.","family":"Cippiciani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"Farfel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Chiavegatto Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel Satya","family":"Naslavsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3970-8025","authenticated-orcid":true,"given":"Mayana","family":"Zatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Pasqualucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson","family":"Jacob-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Nitrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6809-0618","authenticated-orcid":true,"given":"Lea T.","family":"Grinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,3,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jalz.2012.11.007","article-title":"The global prevalence of dementia: a systematic review and metaanalysis","volume":"9","author":"M Prince","year":"2013","journal-title":"Alzheimers Dement"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/S1474-4422(08)70169-8","article-title":"Alzheimer&apos;s disease and vascular dementia in developing countries: prevalence, management, and risk factors","volume":"7","author":"RN Kalaria","year":"2008","journal-title":"Lancet Neurology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1017\/S1041610209009430","article-title":"Prevalence of dementia in Latin America: a collaborative study of population-based cohorts","volume":"21","author":"R Nitrini","year":"2009","journal-title":"International Psychogeriatrics"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00401-009-0532-1","article-title":"Classification and basic pathology of Alzheimer disease","volume":"118","author":"C Duyckaerts","year":"2009","journal-title":"Acta Neuropathol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00401-007-0237-2","article-title":"Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration","volume":"114","author":"NJ Cairns","year":"2007","journal-title":"Acta Neuropathol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00401-011-0845-8","article-title":"A harmonized classification system for FTLD-TDP pathology","volume":"122","author":"IR Mackenzie","year":"2011","journal-title":"Acta Neuropathol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00401-010-0652-7","article-title":"Vascular pathology in the aged human brain","volume":"119","author":"LT Grinberg","year":"2010","journal-title":"Acta Neuropathol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12916-016-0676-5","article-title":"Post-mortem assessment in vascular dementia: advances and aspirations","volume":"14","author":"KE McAleese","year":"2016","journal-title":"BMC Med"},{"issue":"11","key":"ref9","doi-asserted-by":"crossref","first-page":"e1000180","DOI":"10.1371\/journal.pmed.1000180","article-title":"Epidemiological pathology of dementia: attributable-risks at death in the Medical Research Council Cognitive Function and Ageing Study","volume":"6","author":"FE Matthews","year":"2009","journal-title":"PLoS Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1212\/01.wnl.0000271090.28148.24","article-title":"Mixed brain pathologies account for most dementia cases in community-dwelling older persons","volume":"69","author":"JA Schneider","year":"2007","journal-title":"Neurology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1016\/S0140-6736(07)61696-1","article-title":"The burden and costs of chronic diseases in low-income and middle-income countries","volume":"370","author":"DO Abegunde","year":"2007","journal-title":"Lancet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.6061\/clinics\/2013(08)13","article-title":"Prevalence of dementia subtypes in a developing country: a clinicopathological study","volume":"68","author":"LT Grinberg","year":"2013","journal-title":"Clinics (Sao Paulo)"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1212\/WNL.0b013e3182a08f1b","article-title":"Very low levels of education and cognitive reserve: a clinicopathologic study","volume":"81","author":"JM Farfel","year":"2013","journal-title":"Neurology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/mp.2011.136","article-title":"African ancestry protects against Alzheimer&apos;s disease-related neuropathology","volume":"18","author":"D Schlesinger","year":"2013","journal-title":"Mol Psychiatry"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/S0140-6736(11)60135-9","article-title":"Chronic non-communicable diseases in Brazil: burden and current challenges","volume":"377","author":"MI Schmidt","year":"2011","journal-title":"Lancet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1212\/01.wnl.0000285287.99923.3c","article-title":"Race\/ethnic differences in AD survival in US Alzheimer&apos;s Disease Centers","volume":"70","author":"KM Mehta","year":"2008","journal-title":"Neurology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1093\/brain\/awr053","article-title":"Hippocampal sclerosis in advanced age: clinical and pathological features","volume":"134","author":"PT Nelson","year":"2011","journal-title":"Brain"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3233\/JAD-2009-1182","article-title":"Neuropathological correlates of dementia in over-80-year-old brain donors from the population-based Cambridge city over-75s cohort (CC75C) study","volume":"18","author":"C Brayne","year":"2009","journal-title":"J Alzheimers Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1212\/WNL.0000000000002480","article-title":"Neuropathologic comorbidity and cognitive impairment in the Nun and Honolulu-Asia Aging Studies","volume":"86","author":"LR White","year":"2016","journal-title":"Neurology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1212\/WNL.0000000000001831","article-title":"Multiple pathologies are common and related to dementia in the oldest-old: The 90+ Study","volume":"85","author":"CH Kawas","year":"2015","journal-title":"Neurology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1159\/000093217","article-title":"Frequency of dementia etiologies in four ethnic groups","volume":"22","author":"CE Hou","year":"2006","journal-title":"Dement Geriatr Cogn Disord"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10561-006-9022-z","article-title":"Brain bank of the Brazilian aging brain study group\u2014a milestone reached and more than 1,600 collected brains","volume":"8","author":"LT Grinberg","year":"2007","journal-title":"Cell Tissue Bank"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1590\/S1980-57642010DN40200011","article-title":"Post-moretem diagnosis of dementia by informant interview","volume":"4","author":"REL Ferretti","year":"2010","journal-title":"Dementia and neuropshycologia"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The Clinical Dementia Rating (CDR): current version and scoring rules","volume":"43","author":"JC Morris","year":"1993","journal-title":"Neurology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1017\/S003329170002691X","article-title":"A short form of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): development and cross-validation","volume":"24","author":"AF Jorm","year":"1994","journal-title":"Psychol Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1001\/archneur.65.8.1091","article-title":"Staging dementia using Clinical Dementia Rating Scale Sum of Boxes scores: a Texas Alzheimer&apos;s research consortium study","volume":"65","author":"SE O'Bryant","year":"2008","journal-title":"Arch Neurol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1017\/S1041610209008849","article-title":"Performance of Brazilian long and short IQCODE on the screening of dementia in elderly people with low education","volume":"21","author":"TR Perroco","year":"2009","journal-title":"Int Psychogeriatr"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1212\/WNL.44.12.2308","article-title":"The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia","volume":"44","author":"JL Cummings","year":"1994","journal-title":"Neurology"},{"key":"ref29","article-title":"Diagnostic and Statistical Manual of Mental Disorders, DSM-IV","year":"1994"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer&apos;s disease: Recommendations from the National Institute on Aging-Alzheimer&apos;s Association workgroups on diagnostic guidelines for Alzheimer&apos;s disease","volume":"7","author":"GM McKhann","year":"2011","journal-title":"Alzheimers & Dementia"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/WNL.43.2.250","article-title":"Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop","volume":"43","author":"GC Roman","year":"1993","journal-title":"Neurology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1212\/01.wnl.0000187889.17253.b1","article-title":"Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium","volume":"65","author":"IG McKeith","year":"2005","journal-title":"Neurology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1002\/mds.21507","article-title":"Clinical diagnostic criteria for dementia associated with Parkinson&apos;s disease","volume":"22","author":"M Emre","year":"2007","journal-title":"Mov Disord"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","article-title":"Classification of primary progressive aphasia and its variants","volume":"76","author":"ML Gorno-Tempini","year":"2011","journal-title":"Neurology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1097\/WAD.0b013e31815c3445","article-title":"Diagnostic criteria for the behavioral variant of frontotemporal dementia (bvFTD): current limitations and future directions","volume":"21","author":"K Rascovsky","year":"2007","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/bpa.12296","article-title":"Higher Prevalence of TDP-43 Proteinopathy in Cognitively Normal Asians: A Clinicopathological Study on a Multiethnic Sample","volume":"26","author":"C Nascimento","year":"2016","journal-title":"Brain Pathol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S0140-6736(08)61002-8","article-title":"Prevalence of dementia in Latin America, India, and China: a population-based cross-sectional survey","volume":"372","author":"JJL Rodriguez","year":"2008","journal-title":"Lancet"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"H Braak","year":"1991","journal-title":"Acta Neuropathol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/WNL.41.4.479","article-title":"The Consortium to Establish a Registry for Alzheimer&apos;s Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer&apos;s disease","volume":"41","author":"SS Mirra","year":"1991","journal-title":"Neurology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson&apos;s disease","volume":"24","author":"H Braak","year":"2003","journal-title":"Neurobiol Aging"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-009-0612-2","article-title":"Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update","volume":"119","author":"IR Mackenzie","year":"2010","journal-title":"Acta Neuropathol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1365-2990.1989.tb01146.x","article-title":"Cortical and subcortical argyrophilic grains characterize a disease associated with adult onset dementia","volume":"15","author":"H Braak","year":"1989","journal-title":"Neuropathol Appl Neurobiol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-011-0910-3","article-title":"National Institute on Aging-Alzheimer&apos;s Association guidelines for the neuropathologic assessment of Alzheimer&apos;s disease: a practical approach","volume":"123","author":"TJ Montine","year":"2012","journal-title":"Acta Neuropathol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1093\/jnen\/nlw034","article-title":"Argyrophilic Grain Disease: Demographics, Clinical, and Neuropathological Features From a Large Autopsy Study","volume":"75","author":"RD Rodriguez","year":"2016","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref45","first-page":"1073","article-title":"Greenfield\u2019s neuropathology","author":"PG Ince","year":"2008"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-008-0406-y","article-title":"A critical reappraisal of current staging of Lewy-related pathology in human brain","volume":"116","author":"KA Jellinger","year":"2008","journal-title":"Acta Neuropathol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00401-010-0652-7","article-title":"Vascular pathology in the aged human brain","volume":"119","author":"LT Grinberg","year":"2010","journal-title":"Acta Neuropathologica"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/NEN.0b013e318292492a","article-title":"Consensus recommendations on pathologic changes in the hippocampus: a postmortem multicenter inter-rater study","volume":"72","author":"T Rauramaa","year":"2013","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s00401-013-1154-1","article-title":"Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease","volume":"126","author":"PT Nelson","year":"2013","journal-title":"Acta Neuropathol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1093\/jnen\/61.3.282","article-title":"Two types of sporadic cerebral amyloid angiopathy","volume":"61","author":"DR Thal","year":"2002","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jneumeth.2009.06.033","article-title":"Apolipoprotein E genotyping method by real time PCR, a fast and cost-effective alternative to the TaqMan and FRET assays","volume":"183","author":"O Calero","year":"2009","journal-title":"J Neurosci Methods"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.295.7.801","article-title":"Development and validation of a prognostic index for 4-year mortality in older adults","volume":"295","author":"SJ Lee","year":"2006","journal-title":"Jama"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s11606-009-1073-y","article-title":"Index to predict 5-year mortality of community-dwelling adults aged 65 and older using data from the National Health Interview Survey","volume":"24","author":"MA Schonberg","year":"2009","journal-title":"J Gen Intern Med"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.parkreldis.2013.05.010","article-title":"Neuropathology of dementia in a large cohort of patients with Parkinson&apos;s disease","volume":"19","author":"J Horvath","year":"2013","journal-title":"Parkinsonism Relat Disord"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"7281","DOI":"10.1523\/JNEUROSCI.0490-10.2010","article-title":"Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline","volume":"30","author":"LK Clinton","year":"2010","journal-title":"J Neurosci"},{"key":"ref56","unstructured":"Tabnet DATASUS. Mortality data from Sao Paulo city: Prefeitura de Sao Paulo. 2016 <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/tabnet.saude.prefeitura.sp.gov.br\/cgi\/deftohtm3.exe?secretarias\/saude\/TABNET\/SIM\/obito\" xlink:type=\"simple\">http:\/\/tabnet.saude.prefeitura.sp.gov.br\/cgi\/deftohtm3.exe?secretarias\/saude\/TABNET\/SIM\/obito<\/ext-link>"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1750-3639.1998.tb00160.x","article-title":"Senile dementia with tangles (tangle predominant form of senile dementia)","volume":"8","author":"KA Jellinger","year":"1998","journal-title":"Brain Pathol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/00002093-200210000-00001","article-title":"Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotemporal dementia, and hippocampal sclerosis in the State of Florida Brain Bank","volume":"16","author":"WW Barker","year":"2002","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.archger.2008.06.005","article-title":"Prevalence of dementia subtypes: a 30-year retrospective survey of neuropathological reports","volume":"49","author":"H Brunnstrom","year":"2009","journal-title":"Arch Gerontol Geriatr"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0022-510X(02)00028-X","article-title":"Subtype analysis of neuropathologically diagnosed patients in a Japanese geriatric hospital","volume":"196","author":"H Akatsu","year":"2002","journal-title":"J Neurol Sci"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13195-014-0082-1","article-title":"Prevalence of mixed pathologies in the aging brain","volume":"6","author":"J Rahimi","year":"2014","journal-title":"Alzheimers Res Ther"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.3233\/JAD-2010-100603","article-title":"Prevalence and Pathology of Vascular Dementia in the Oldest-Old","volume":"21","author":"KA Jellinger","year":"2010","journal-title":"Journal of Alzheimers Disease"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/mp.2011.136","article-title":"African ancestry protects against Alzheimer&apos;s disease-related neuropathology","volume":"18","author":"D Schlesinger","year":"2013","journal-title":"Mol Psychiatry"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1097\/01.jnen.0000229986.17548.27","article-title":"Interlaboratory comparison of assessments of Alzheimer disease-related lesions: a study of the BrainNet Europe Consortium","volume":"65","author":"I Alafuzoff","year":"2006","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00401-008-0358-2","article-title":"Inter-laboratory comparison of neuropathological assessments of beta-amyloid protein: a study of the BrainNet Europe consortium","volume":"115","author":"I Alafuzoff","year":"2008","journal-title":"Acta Neuropathol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jns.2010.08.055","article-title":"Toward a pathological definition of vascular dementia","volume":"299","author":"LT Grinberg","year":"2010","journal-title":"J Neurol Sci"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.exger.2012.05.023","article-title":"Vascular dementia: different forms of vessel disorders contribute to the development of dementia in the elderly brain","volume":"47","author":"DR Thal","year":"2012","journal-title":"Exp Gerontol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1159\/000285518","article-title":"Prevalence and impact of cerebrovascular lesions in Alzheimer and lewy body diseases","volume":"7","author":"KA Jellinger","year":"2010","journal-title":"Neurodegener Dis"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00415-009-5324-y","article-title":"Low sensitivity in clinical diagnoses of dementia with Lewy bodies","volume":"257","author":"PT Nelson","year":"2010","journal-title":"J Neurol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s00401-003-0750-x","article-title":"Age-associated prevalence and risk factors of Lewy body pathology in a general population: the Hisayama study","volume":"106","author":"Y Wakisaka","year":"2003","journal-title":"Acta Neuropathol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1097\/NEN.0b013e31822e8ae9","article-title":"Alzheimer disease pathology in subjects without dementia in 2 studies of aging: the Nun Study and the Adult Changes in Thought Study","volume":"70","author":"KS SantaCruz","year":"2011","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1212\/WNL.55.3.370","article-title":"&quot;Preclinical&quot; AD revisited\u2014Neuropathology of cognitively normal older adults","volume":"55","author":"FA Schmitt","year":"2000","journal-title":"Neurology"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/jnen\/62.11.1087","article-title":"Neuropathology of cognitively normal elderly","volume":"62","author":"DS Knopman","year":"2003","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0140-6736(00)03589-3","article-title":"Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS)","volume":"357","year":"2001","journal-title":"Lancet"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1212\/WNL.56.12.1690","article-title":"Prevalence of Alzheimer&apos;s disease in very elderly people: a prospective neuropathological study","volume":"56","author":"T Polvikoski","year":"2001","journal-title":"Neurology"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1001\/archneur.57.5.713","article-title":"The relative frequency of &quot;dementia of unknown etiology&quot; increases with age and is nearly 50% in nonagenarians","volume":"57","author":"HA Crystal","year":"2000","journal-title":"Arch Neurol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1212\/01.wnl.0000219668.47116.e6","article-title":"Neuropathology of older persons without cognitive impairment from two community-based studies","volume":"66","author":"DA Bennett","year":"2006","journal-title":"Neurology"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/S1474-4422(16)30029-1","article-title":"Relation of cerebral vessel disease to Alzheimer&apos;s disease dementia and cognitive function in elderly people: a cross-sectional study","volume":"15","author":"Z Arvanitakis","year":"2016","journal-title":"Lancet Neurol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/nen.0b013e31815c5efb","article-title":"Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles &quot;do count&quot; when staging disease severity","volume":"66","author":"PT Nelson","year":"2007","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3233\/JAD-130281","article-title":"Neuropathologic correlates of cognition in a population-based sample","volume":"36","author":"B Cholerton","year":"2013","journal-title":"J Alzheimers Dis"},{"issue":"19","key":"ref81","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1212\/WNL.0b013e318236f0cf","article-title":"Neuropathologic features associated with Alzheimer disease diagnosis: age matters","volume":"77","author":"LE Middleton","year":"2011","journal-title":"Neurology"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00401-013-1157-y","article-title":"Non-Alzheimer neurodegenerative pathologies and their combinations are more frequent than commonly believed in the elderly brain: a community-based autopsy series","volume":"126","author":"GG Kovacs","year":"2013","journal-title":"Acta Neuropathol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3233\/JAD-2011-111268","article-title":"Impact of less common and &quot;disregarded&quot; neurodegenerative pathologies on dementia burden in a population-based cohort","volume":"28","author":"HA Keage","year":"2012","journal-title":"J Alzheimers Dis"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-006-0144-y","article-title":"Assessing the cognitive impact of Alzheimer disease pathology and vascular burden in the aging brain: the Geneva experience","volume":"113","author":"P Giannakopoulos","year":"2007","journal-title":"Acta Neuropathol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00401-013-1080-2","article-title":"Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation","volume":"125","author":"LT Grinberg","year":"2013","journal-title":"Acta Neuropathol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1097\/JGP.0b013e3181a6516e","article-title":"Clinicopathological concordance in dementia diagnostics","volume":"17","author":"H Brunnstrom","year":"2009","journal-title":"Am J Geriatr Psychiatry"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1161\/01.STR.27.1.30","article-title":"Comparison of different diagnostic criteria for vascular dementia (ADDTC, DSM-IV, ICD-10, NINDS-AIREN)","volume":"27","author":"T Wetterling","year":"1996","journal-title":"Stroke"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1161\/01.STR.31.12.2952","article-title":"Comparison of different clinical criteria (DSM-III, ADDTC, ICD-10, NINDS-AIREN, DSM-IV) for the diagnosis of vascular dementia. National Institute of Neurological Disorders and Stroke-Association Internationale pour la Recherche et l&apos;Enseignement en Neurosciences","volume":"31","author":"T Pohjasvaara","year":"2000","journal-title":"Stroke"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fnagi.2013.00017","article-title":"Pathology and pathogenesis of vascular cognitive impairment\u2014a critical update","volume":"5","author":"KA Jellinger","year":"2013","journal-title":"Front Aging Neurosci"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1212\/01.WNL.0000069923.64550.9F","article-title":"Education modifies the relation of AD pathology to level of cognitive function in older persons","volume":"60","author":"DA Bennett","year":"2003","journal-title":"Neurology"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/ana.22055","article-title":"Atherosclerosis, Dementia, and Alzheimer Disease in the Baltimore Longitudinal Study of Aging Cohort","volume":"68","author":"H Dolan","year":"2010","journal-title":"Annals of Neurology"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"e426","DOI":"10.1111\/j.1467-789X.2010.00825.x","article-title":"Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies","volume":"12","author":"KJ Anstey","year":"2011","journal-title":"Obes Rev"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1097\/EDE.0b013e31822708b5","article-title":"The association between blood pressure and incident Alzheimer disease: a systematic review and meta-analysis","volume":"22","author":"MC Power","year":"2011","journal-title":"Epidemiology"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1097\/EDE.0b013e31816bbe14","article-title":"Cigarette smoking and dementia: potential selection bias in the elderly","volume":"19","author":"MA Hernan","year":"2008","journal-title":"Epidemiology"},{"key":"ref95","article-title":"TDP-43 stage, mixed pathologies, and clinical Alzheimer&apos;s-type dementia","author":"BD James","year":"2016","journal-title":"Brain"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00401-014-1269-z","article-title":"TDP-43 is a key player in the clinical features associated with Alzheimer&apos;s disease","volume":"127","author":"KA Josephs","year":"2014","journal-title":"Acta Neuropathol"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"664","DOI":"10.2174\/156720512801322618","article-title":"The Honolulu-Asia Aging Study: epidemiologic and neuropathologic research on cognitive impairment","volume":"9","author":"RP Gelber","year":"2012","journal-title":"Curr Alzheimer Res"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1001\/jama.1997.03540340047031","article-title":"Brain infarction and the clinical expression of Alzheimer disease. The Nun Study","volume":"277","author":"DA Snowdon","year":"1997","journal-title":"Jama"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"691","DOI":"10.3233\/JAD-2009-1227","article-title":"The neuropathology of older persons with and without dementia from community versus clinic cohorts","volume":"18","author":"JA Schneider","year":"2009","journal-title":"J Alzheimers Dis"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1212\/WNL.56.12.1690","article-title":"Prevalence of Alzheimer&apos;s disease in very elderly people\u2014A prospective neuropathological study","volume":"56","author":"T Polvikoski","year":"2001","journal-title":"Neurology"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1093\/brain\/awq141","article-title":"Age, Alzheimer&apos;s disease and dementia in the Baltimore Longitudinal Study of Ageing","volume":"133","author":"D Dolan","year":"2010","journal-title":"Brain"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1212\/WNL.54.1.105","article-title":"The Oregon Brain Aging Study\u2014Neuropathology accompanying healthy aging in the oldest old","volume":"54","author":"MS Green","year":"2000","journal-title":"Neurology"}],"container-title":["PLOS Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pmed.1002267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T09:07:38Z","timestamp":1719133658000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pmed.1002267"}},"subtitle":[],"editor":[{"given":"Carol","family":"Brayne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,3,28]]},"references-count":102,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,3,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pmed.1002267","relation":{},"ISSN":["1549-1676"],"issn-type":[{"value":"1549-1676","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,28]]}}}