{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T10:11:46Z","timestamp":1782727906304,"version":"3.54.5"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T00:00:00Z","timestamp":1508198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Oxford Martin School"},{"name":"NIHR Career Development Fellowship"},{"name":"NIHR Oxford BRC"},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosmedicine.org"],"crossmark-restriction":false},"short-container-title":["PLoS Med"],"DOI":"10.1371\/journal.pmed.1002404","type":"journal-article","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T13:35:32Z","timestamp":1508247332000},"page":"e1002404","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmed.corrections_policy","source":"Crossref","is-referenced-by-count":38,"title":["Elevated blood pressure and risk of mitral regurgitation: A longitudinal cohort study of 5.5 million United Kingdom adults"],"prefix":"10.1371","volume":"14","author":[{"given":"Kazem","family":"Rahimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Mohseni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0527-9392","authenticated-orcid":true,"given":"Catherine M.","family":"Otto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5027-5481","authenticated-orcid":true,"given":"Nathalie","family":"Conrad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0576-8874","authenticated-orcid":true,"given":"Milad","family":"Nazarzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Woodward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2091-7663","authenticated-orcid":true,"given":"Terence","family":"Dwyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2064-7699","authenticated-orcid":true,"given":"Stephen","family":"MacMahon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,10,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1136\/heartjnl-2014-307020","article-title":"The modern epidemiology of heart valve disease","volume":"102","author":"S Coffey","year":"2016","journal-title":"Heart"},{"key":"ref2","first-page":"heartjnl-2016-310894","article-title":"Epidemiology of valvular heart disease in a Swedish nationwide hospital-based register study","volume":"0","author":"P Andell","year":"2017","journal-title":"Heart"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/S0140-6736(16)00558-4","article-title":"Mitral valve disease\u2014Current management and future challenges","volume":"387","author":"RA Nishimura","year":"2016","journal-title":"Lancet. Elsevier"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nrcardio.2010.202","article-title":"Epidemiology of valvular heart disease in the adult","volume":"8","author":"B Iung","year":"2011","journal-title":"Nat Rev Cardiol. Nature"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1161\/CIRCRESAHA.116.304723","article-title":"The epidemiology of blood pressure and its worldwide management","volume":"116","author":"K Rahimi","year":"2015","journal-title":"Circ Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0002-9149(98)01064-9","article-title":"Prevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (the Framingham Heart Study)","volume":"83","author":"JP Singh","year":"1999","journal-title":"Am J Cardiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/ije\/dyv098","article-title":"Data Resource Profile: Clinical Practice Research Datalink (CPRD)","volume":"44","author":"E Herrett","year":"2015","journal-title":"Int J Epidemiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S0140-6736(97)04248-7","article-title":"The UK General Practice Research Database","volume":"350","author":"T Walley","year":"1997","journal-title":"Lancet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1046\/j.1365-2125.2000.00199.x","article-title":"Validation of the diagnosis of venous thromboembolism in general practice database studies","volume":"49","author":"R Lawrenson","year":"2000","journal-title":"Br J Clin Pharmacol. Wiley-Blackwell"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"h4865","DOI":"10.1136\/bmj.h4865","article-title":"Usual blood pressure, peripheral arterial disease, and vascular risk: cohort study of 4.2 million adults","volume":"351","author":"CA Emdin","year":"2015","journal-title":"BMJ"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.jacc.2015.07.059","article-title":"Usual Blood Pressure and Risk of New-Onset Diabetes: Evidence From 4.1 Million Adults and a Meta-Analysis of Prospective Studies","volume":"66","author":"CA Emdin","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1093\/eurheartj\/ehw229","article-title":"Large-scale community echocardiographic screening reveals a major burden of undiagnosed valvular heart disease in older people: the OxVALVE Population Cohort Study","volume":"37","author":"JL d\u2019Arcy","year":"2016","journal-title":"Eur Heart J"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0140-6736(02)11911-8","article-title":"Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies","volume":"360","year":"2002","journal-title":"Lancet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1016\/S0140-6736(14)60685-1","article-title":"Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1\u00b725 million people","volume":"383","author":"E Rapsomaniki","year":"2014","journal-title":"Lancet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1001\/jama.287.20.2677","article-title":"Pulse pressure and cardiovascular disease-related mortality: follow-up study of the Multiple Risk Factor Intervention Trial (MRFIT)","volume":"287","author":"M Domanski","journal-title":"JAMA"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"c2289","DOI":"10.1136\/bmj.c2289","article-title":"Random measurement error and regression dilution bias","volume":"340","author":"JA Hutcheon","year":"2010","journal-title":"BMJ"},{"key":"ref17","article-title":"Usual blood pressure, atrial fibrillation and vascular risk: evidence from 4.3 million adults","author":"CA Emdin","year":"2016","journal-title":"Int J Epidemiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1002\/sim.4780100703","article-title":"Floating absolute risk: an alternative to relative risk in survival and case-control analysis avoiding an arbitrary reference group","volume":"10","author":"DF Easton","year":"1991","journal-title":"Stat Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v045.i07","article-title":"Amelia II: A Program for Missing Data","volume":"45","author":"J Honaker","year":"2011","journal-title":"J Stat Softw"},{"key":"ref20","article-title":"Multiple imputation for non-response in surveys","author":"D Rubin","year":"1987"},{"key":"ref21","article-title":"Epidemiology: study design and data analysis","author":"M Woodward","year":"2014"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e297","DOI":"10.1371\/journal.pmed.0040297","article-title":"Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration","volume":"4","author":"JP Vandenbroucke","year":"2007","journal-title":"PLoS Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1161\/STROKEAHA.116.012658","article-title":"Blood Pressure and Risk of Vascular Dementia","volume":"47","author":"CA Emdin","year":"2016","journal-title":"Stroke."},{"key":"ref24","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ijcard.2010.11.004","article-title":"Biology of mitral valve prolapse: the harvest is big, but the workers are few","volume":"151","author":"C Loardi","year":"2011","journal-title":"Int J Cardiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1016\/j.jacc.2015.08.872","article-title":"Mitral Annulus Calcification","volume":"66","author":"Y Abramowitz","year":"2015","journal-title":"J Am Coll Cardiol."},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1002\/sim.2165","article-title":"Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure","volume":"24","author":"MD Tobin","year":"2005","journal-title":"Stat Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/oxfordjournals.aje.a010013","article-title":"Underestimation of risk associations due to regression dilution in long-term follow-up of prospective studies","volume":"150","author":"R Clarke","year":"1999","journal-title":"Am J Epidemiol"}],"container-title":["PLOS Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pmed.1002404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T20:04:27Z","timestamp":1540325067000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pmed.1002404"}},"subtitle":[],"editor":[{"given":"Aziz","family":"Sheikh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,10,17]]},"references-count":27,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pmed.1002404","relation":{},"ISSN":["1549-1676"],"issn-type":[{"value":"1549-1676","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,17]]}}}