{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:34:28Z","timestamp":1790048068984,"version":"4.0.1"},"reference-count":89,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T00:00:00Z","timestamp":1512000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosmedicine.org"],"crossmark-restriction":false},"short-container-title":["PLoS Med"],"DOI":"10.1371\/journal.pmed.1002450","type":"journal-article","created":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T23:16:53Z","timestamp":1512083813000},"page":"e1002450","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmed.corrections_policy","source":"Crossref","is-referenced-by-count":61,"title":["malERA: An updated research agenda for insecticide and drug resistance in malaria elimination and eradication"],"prefix":"10.1371","volume":"14","author":[{"name":"The malERA Refresh Consultative Panel on Insecticide and Drug Resistance","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,11,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature15535","article-title":"The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015","volume":"526","author":"S Bhatt","year":"2015","journal-title":"Nature."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e1000406","DOI":"10.1371\/journal.pmed.1000406","article-title":"A research agenda to underpin malaria eradication","volume":"8","author":"PL Alonso","year":"2011","journal-title":"PLoS Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0140-6736(98)07367-X","article-title":"Averting a malaria disaster","volume":"353","author":"N White","year":"1999","journal-title":"Lancet"},{"key":"ref4","article-title":"Averting a malaria disaster: will insecticide resistance derail malaria control?","author":"J Hemingway","year":"2016","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1756-3305-7-76","article-title":"An online tool for mapping insecticide resistance in major Anopheles vectors of human malaria parasites and review of resistance status for the Afrotropical region","volume":"7","author":"TB Knox","year":"2014","journal-title":"Parasit Vectors"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12936-015-0592-8","article-title":"Development of insecticide resistance in malaria vector Anopheles sinensis populations from Shandong province in China","volume":"14","author":"Y Dai","year":"2015","journal-title":"Malar J"},{"key":"ref7","unstructured":"WHO | World Malaria Report 2015. WHO. World Health Organization; 2016"},{"key":"ref8","first-page":"1691","article-title":"Increased pyrethroid resistance in malaria vectors and decreased bed net effectiveness, Burkina Faso","volume":"20","author":"KH To\u00e9","year":"2014","journal-title":"Emerg Infect Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.pt.2015.11.010","article-title":"Insecticide Resistance in African Anopheles Mosquitoes: A Worsening Situation that Needs Urgent Action to Maintain Malaria Control","volume":"32","author":"H Ranson","year":"2015","journal-title":"Trends Parasitol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1186\/s12936-015-0807-z","article-title":"Long-lasting insecticidal nets no longer effectively kill the highly resistant Anopheles funestus of southern Mozambique","volume":"14","author":"KD Glunt","year":"2015","journal-title":"Malar J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1186\/s12936-015-0877-y","article-title":"Rise of multiple insecticide resistance in Anopheles funestus in Malawi: a major concern for malaria vector control","volume":"14","author":"JM Riveron","year":"2015","journal-title":"Malar J"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1046\/j.1365-2915.2000.00234.x","article-title":"Anopheles funestus resistant to pyrethroid insecticides in South Africa","volume":"14","author":"K Hargreaves","year":"2000","journal-title":"Med Vet Entomol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0035-9203(92)90531-G","article-title":"Chloroquine-resistant Plasmodium vivax in Papua New Guinea","volume":"86","author":"GJ Schuurkamp","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"12689","DOI":"10.1073\/pnas.221440898","article-title":"Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America","volume":"98","author":"RK Mehlotra","year":"2001","journal-title":"Proc Natl Acad Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/nature00813","article-title":"Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum","volume":"418","author":"JC Wootton","year":"2002","journal-title":"Nature"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1475-2875-5-34","article-title":"Invasion of Africa by a single pfcrt allele of South East Asian type","volume":"5","author":"F Ariey","year":"2006","journal-title":"Malar J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/S0140-6736(03)12951-0","article-title":"Antifolate antimalarial resistance in southeast Africa: a population-based analysis","volume":"361","author":"C Roper","year":"2003","journal-title":"Lancet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1093\/infdis\/jir664","article-title":"Limited geographical origin and global spread of sulfadoxine-resistant dhps alleles in Plasmodium falciparum populations","volume":"204","author":"T Mita","year":"2011","journal-title":"J Infect Dis"},{"key":"ref19","first-page":"301","article-title":"Delaying antimalarial drug resistance with combination chemotherapy","volume":"41","author":"NJ White","year":"1999","journal-title":"Parassitologia"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/ng.3189","article-title":"Genetic architecture of artemisinin-resistant Plasmodium falciparum","volume":"47","author":"O Miotto","year":"2015","journal-title":"Nat Genet."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1093\/infdis\/jiu491","article-title":"Independent emergence of artemisinin resistance mutations among Plasmodium falciparum in Southeast Asia","volume":"211","author":"S Takala-Harrison","year":"2015","journal-title":"J Infect Dis"},{"key":"ref22","article-title":"A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms","author":"D M\u00e9nard","year":"2016"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1111\/mmi.12349","article-title":"The interplay between drug resistance and fitness in malaria parasites","volume":"89","author":"PJ Rosenthal","year":"2013","journal-title":"Mol. Microbiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1046\/j.1365-2583.1998.72062.x","article-title":"Molecular characterization of pyrethroid knockdown resistance (kdr) in the major malaria vector Anopheles gambiae s.s","volume":"7","author":"D Martinez-Torres","year":"1998","journal-title":"Insect Mol Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1046\/j.1365-2583.2000.00209.x","article-title":"Identification of a point mutation in the voltage-gated sodium channel gene of Kenyan Anopheles gambiae associated with resistance to DDT and pyrethroids","volume":"9","author":"H Ranson","year":"2000","journal-title":"Insect Mol Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e1001619","DOI":"10.1371\/journal.pmed.1001619","article-title":"The impact of pyrethroid resistance on the efficacy of insecticide-treated bed nets against African anopheline mosquitoes: systematic review and meta-analysis","volume":"11","author":"C Strode","year":"2014","journal-title":"PLoS Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s12936-015-0721-4","article-title":"When a discriminating dose assay is not enough: measuring the intensity of insecticide resistance in malaria vectors","volume":"14","author":"J Bagi","year":"2015","journal-title":"Malar J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/trstmh\/trv017","article-title":"Evolution of insecticide resistance diagnostics in malaria vectors","volume":"109","author":"D Weetman","year":"2015","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/hdy.2015.33","article-title":"Target-site resistance mutations (kdr and RDL), but not metabolic resistance, negatively impact male mating competiveness in the malaria vector Anopheles gambiae","volume":"115","author":"N Platt","year":"2015","journal-title":"Heredity"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e63849","DOI":"10.1371\/journal.pone.0063849","article-title":"Insecticide resistance alleles affect vector competence of Anopheles gambiae s.s. for Plasmodium falciparum field isolates","volume":"8","author":"H Alout","year":"2013","journal-title":"PLoS ONE"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1111\/evo.12063","article-title":"The importance of mosquito behavioural adaptations to malaria control in Africa","volume":"67","author":"ML Gatton","year":"2013","journal-title":"Evolution"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e1001823","DOI":"10.1371\/journal.pmed.1001823","article-title":"Defining the in vivo phenotype of artemisinin-resistant falciparum malaria: a modelling approach","volume":"12","author":"LJ White","year":"2015","journal-title":"PLoS Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S1473-3099(13)70252-4","article-title":"Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies","volume":"13","author":"B Witkowski","year":"2013","journal-title":"Lancet Infect Dis"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature12876","article-title":"A molecular marker of artemisinin-resistant Plasmodium falciparum malaria","volume":"505","author":"F Ariey","year":"2014","journal-title":"Nature"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1126\/science.1260867","article-title":"Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates","volume":"347","author":"J Straimer","year":"2015","journal-title":"Science"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1093\/infdis\/jiu467","article-title":"Absence of putative artemisinin resistance mutations among Plasmodium falciparum in Sub-Saharan Africa: a molecular epidemiologic study","volume":"211","author":"SM Taylor","year":"2015","journal-title":"J Infect Dis"},{"key":"ref37","first-page":"1352","article-title":"K13-propeller polymorphisms in Plasmodium falciparum parasites from sub-Saharan Africa","volume":"211","author":"E Kamau","year":"2015","journal-title":"J Infect Dis"},{"key":"ref38","unstructured":"World Health Organization. Status report on artemisinin and ACT resistance. 2015."},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1093\/infdis\/jiv752","article-title":"Independent Emergence of the Plasmodium falciparum Kelch Propeller Domain Mutant Allele C580Y in Guyana","volume":"213","author":"SM Chenet","year":"2016","journal-title":"J Infect Dis"},{"key":"ref40","article-title":"New genetic markers for piperaquine resistance in Plasmodium falciparum","author":"AM Dondorp","journal-title":"Lancet Infectious Diseases"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4269\/ajtmh.2012.12-0058","article-title":"No evidence of delayed parasite clearance after oral artesunate treatment of uncomplicated falciparum malaria in Mali","volume":"87","author":"AW Maiga","year":"2012","journal-title":"Am J Trop Med Hyg"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1126\/science.1260403","article-title":"Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance","volume":"347","author":"S Mok","year":"2015","journal-title":"Science"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"4631","DOI":"10.1128\/AAC.00366-15","article-title":"Ex Vivo Drug Susceptibility Testing and Molecular Profiling of Clinical Plasmodium falciparum Isolates from Cambodia from 2008 to 2013 Suggest Emerging Piperaquine Resistance","volume":"59","author":"S Chaorattanakawee","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1128\/AAC.00835-15","article-title":"Evidence of Plasmodium falciparum Malaria Multidrug Resistance to Artemisinin and Piperaquine in Western Cambodia: Dihydroartemisinin-Piperaquine Open-Label Multicenter Clinical Assessment","volume":"59","author":"R Leang","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S1368-7646(98)80014-9","article-title":"P. falciparum dihydrofolate reductase and dihydropteroate synthase mutations: epidemiology and role in clinical resistance to antifolates","volume":"1","author":"C V Plowe","year":"1998","journal-title":"Drug Resist Updat"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1093\/infdis\/jiu141","article-title":"Comparative impacts over 5 years of artemisinin-based combination therapies on Plasmodium falciparum polymorphisms that modulate drug sensitivity in Ugandan children","volume":"210","author":"MD Conrad","year":"2014","journal-title":"J Infect Dis"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"536","DOI":"10.4269\/ajtmh.12-0525","article-title":"Rapid selection of Plasmodium falciparum chloroquine resistance transporter gene and multidrug resistance gene-1 haplotypes associated with past chloroquine and present artemether-lumefantrine use in Inhambane District, southern Mozambique","volume":"88","author":"TT Thomsen","year":"2013","journal-title":"Am J Trop Med Hyg"},{"key":"ref48","unstructured":"WHO Global Malaria Programme. Minutes of the Technical Expert Group on Drug Efficacy and Response. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/malaria\/mpac\/mpac-oct2017-teg-drug-efficacy-response-session3.pdf?ua=1\" xlink:type=\"simple\">http:\/\/www.who.int\/malaria\/mpac\/mpac-oct2017-teg-drug-efficacy-response-session3.pdf?ua=1<\/ext-link>. Date accessed 14 Nov 2017."},{"key":"ref49","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1473-3099(15)00487-9","article-title":"Dihydroartemisinin\u2013piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study","volume":"16","author":"C Amaratunga","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/cid\/cir631","article-title":"Dihydroartemisinin-piperaquine versus chloroquine in the treatment of Plasmodium vivax malaria in Thailand: a randomized controlled trial","volume":"53","author":"AP Phyo","year":"2011","journal-title":"Clin Infect Dis"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/S1473-3099(14)70855-2","article-title":"Global extent of chloroquine-resistant Plasmodium vivax: a systematic review and meta-analysis","volume":"14","author":"RN Price","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"e0004196","DOI":"10.1371\/journal.pntd.0004196","article-title":"Multiple Origins of Mutations in the mdr1 Gene\u2014A Putative Marker of Chloroquine Resistance in P. vivax","volume":"9","author":"ML Schousboe","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"833","DOI":"10.4269\/ajtmh.14-0031","article-title":"Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine","volume":"91","author":"M Venkatesan","year":"2014","journal-title":"Am J Trop Med Hyg"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1475-2875-12-77","article-title":"Effects of pyrethroid resistance on the cost effectiveness of a mass distribution of long-lasting insecticidal nets: a modelling study","volume":"12","author":"OJ Bri\u00ebt","year":"2013","journal-title":"Malar J"},{"key":"ref55","article-title":"The Public Health Impact of Chloroquine Resistance in Africa","author":"J-F Trape","year":"2001","journal-title":"American Society of Tropical Medicine and Hygiene"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"e1001575","DOI":"10.1371\/journal.pmed.1001575","article-title":"Major burden of severe anemia from non-falciparum malaria species in Southern Papua: a hospital-based surveillance study","volume":"10","author":"NM Douglas","year":"2013","journal-title":"PLoS Med"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1574-695X.2009.00641.x","article-title":"A molecular map of chloroquine resistance in Mali","volume":"58","author":"AA Djimde","year":"2010","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1086\/422758","article-title":"Molecular Diagnosis of Resistance to Antimalarial Drugs during Epidemics and in War Zones","volume":"190","author":"AA Djimd\u00e9","year":"2004","journal-title":"J Infect Dis"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1128\/AAC.05163-14","article-title":"Decreasing pfmdr1 copy number suggests that Plasmodium falciparum in Western Cambodia is regaining in vitro susceptibility to mefloquine","volume":"59","author":"P Lim","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"ref60","article-title":"The impact of insecticide resistance in <italic>Anopheles arabiensis<\/italic> on malaria incidence and prevalence in Sudan and the costs of mitigation","author":"K Hmooda Toto","journal-title":"Proc. Natl Acad. Sci"},{"key":"ref61","article-title":"The Importance of Insecticide Resistance Monitoring to Maintain IRS Program Effectiveness","author":"Ricks Philip","year":"2015"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"770","DOI":"10.7196\/SAMJ.7446","article-title":"Malaria in South Africa: 110 years of learning to control the disease","volume":"103","author":"M Coetzee","year":"2013","journal-title":"S Afr Med J"},{"key":"ref63","article-title":"Global plan for insecticide resistance management in malaria vectors","year":"2015"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"9397","DOI":"10.1073\/pnas.1307656110","article-title":"Country-level operational implementation of the Global Plan for Insecticide Resistance Management","volume":"110","author":"J Hemingway","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.pt.2006.05.003","article-title":"The Innovative Vector Control Consortium: improved control of mosquito-borne diseases","volume":"22","author":"J Hemingway","year":"2006","journal-title":"Trends Parasitol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"773","DOI":"10.3201\/eid2205.150984","article-title":"An Operational Framework for Insecticide Resistance Management Planning","volume":"22","author":"E Chanda","year":"2016","journal-title":"Emerg Infect Dis"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"e1001564","DOI":"10.1371\/journal.pmed.1001564","article-title":"The effect of dosing regimens on the antimalarial efficacy of dihydroartemisinin-piperaquine: a pooled analysis of individual patient data","volume":"10","year":"2013","journal-title":"PLoS Med"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"14216","DOI":"10.1073\/pnas.0804628105","article-title":"Benefits of using multiple first-line therapies against malaria","volume":"105","author":"MF Boni","year":"2008","journal-title":"Proc Natl Acad Sci"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/1475-2875-9-217","article-title":"Prospective strategies to delay the evolution of anti-malarial drug resistance: weighing the uncertainty","volume":"9","author":"DL Smith","year":"2010","journal-title":"Malar J. B"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"e758","DOI":"10.1016\/S2214-109X(15)00162-X","article-title":"Optimum population-level use of artemisinin combination therapies: a modelling study","volume":"3","author":"TD Nguyen","year":"2015","journal-title":"Lancet Glob Heal"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/1475-2875-7-229","article-title":"Spread of anti-malarial drug resistance: mathematical model with implications for ACT drug policies","volume":"7","author":"W Pongtavornpinyo","year":"2008","journal-title":"Malar J"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"e1001984","DOI":"10.1371\/journal.pmed.1001984","article-title":"The Community As the Patient in Malaria-Endemic Areas: Preempting Drug Resistance with Multiple First-Line Therapies","volume":"13","author":"MF Boni","year":"2016","journal-title":"PLoS Med"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nm0316-220","article-title":"Back on TRAC: New trial launched in bid to outpace multidrug-resistant malaria","volume":"22","author":"A Maxmen","year":"2016","journal-title":"Nat Med. Nature Research"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5897\/CRO15.0098","article-title":"Impact of seasonal malaria chemoprevention of sulphadoxinepyrimethamine plus amodiaquine on molecular markers resistance of Plasmodium falciparum malaria: A review in West Africa","volume":"7","author":"M Hamma","year":"2016","journal-title":"Clin Rev Opin"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1186\/s12936-015-0782-4","article-title":"Design of a study to determine the impact of insecticide resistance on malaria vector control: a multi-country investigation","volume":"14","author":"I Kleinschmidt","year":"2015","journal-title":"Malar J"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"e99822","DOI":"10.1371\/journal.pone.0099822","article-title":"Underpinning sustainable vector control through informed insecticide resistance management","volume":"9","author":"EK Thomsen","year":"2014","journal-title":"PLoS ONE"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"696","DOI":"10.4269\/ajtmh.2004.71.696","article-title":"Therapeutic efficacy of sulfadoxine-pyrimethamine and prevalence of resistance markers in Tanzania prior to revision of malaria treatment policy: Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase mutations in monitoring in vivo re","volume":"71","author":"K Mugittu","year":"2004","journal-title":"Am J Trop Med Hyg"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.pt.2015.11.010","article-title":"Insecticide Resistance in African Anopheles Mosquitoes: A Worsening Situation that Needs Urgent Action to Maintain Malaria Control","volume":"32","author":"H Ranson","year":"2015","journal-title":"Trends Parasitol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s12936-015-0721-4","article-title":"When a discriminating dose assay is not enough: measuring the intensity of insecticide resistance in malaria vectors","volume":"14","author":"J Bagi","year":"2015","journal-title":"Malar J"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"e58322","DOI":"10.1371\/journal.pone.0058322","article-title":"Effects of age and larval nutrition on phenotypic expression of insecticide-resistance in Anopheles mosquitoes","volume":"8","author":"K Kulma","year":"2013","journal-title":"PLoS ONE"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1186\/1756-3305-7-390","article-title":"The effect of multiple blood-feeding on the longevity and insecticide resistant phenotype in the major malaria vector Anopheles arabiensis (Diptera: Culicidae)","volume":"7","author":"S V Oliver","year":"2014","journal-title":"Parasit Vectors"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1186\/1475-2875-13-350","article-title":"Environmental temperatures significantly change the impact of insecticides measured using WHOPES protocols","volume":"13","author":"KD Glunt","year":"2014","journal-title":"Malar J"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1365-2583.2006.00667.x","article-title":"Differential expression of the detoxification genes in the different life stages of the malaria vector Anopheles gambiae","volume":"15","author":"C Strode","year":"2006","journal-title":"Insect Mol Biol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"e90657","DOI":"10.1371\/journal.pone.0090657","article-title":"Using a near-infrared spectrometer to estimate the age of anopheles mosquitoes exposed to pyrethroids","volume":"9","author":"MT Sikulu","year":"2014","journal-title":"PLoS ONE"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.pt.2015.12.001","article-title":"Identification, Validation, and Application of Molecular Diagnostics for Insecticide Resistance in Malaria Vectors","volume":"32","author":"MJ Donnelly","year":"2015","journal-title":"Trends Parasitol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1186\/1475-2875-13-452","article-title":"Artemisinin resistance\u2014modelling the potential human and economic costs","volume":"13","author":"Y Lubell","year":"2014","journal-title":"Malar J"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0140-6736(10)60676-9","article-title":"Antiretroviral therapy and management of HIV infection","volume":"376","author":"PA Volberding","year":"2010","journal-title":"Lancet"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.cell.2012.02.021","article-title":"Outwitting evolution: fighting drug-resistant TB, malaria, and HIV","volume":"148","author":"DE Goldberg","year":"2012","journal-title":"Cell"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/B978-0-12-396955-2.00002-3","article-title":"Chapter 2 \u2013Valuing Pest Susceptibility to Control","author":"PD Mitchell","year":"2014","journal-title":"Insect Resistance Management"}],"container-title":["PLOS Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pmed.1002450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T00:36:28Z","timestamp":1588984588000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pmed.1002450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,30]]},"references-count":89,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,11,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pmed.1002450","relation":{},"ISSN":["1549-1676"],"issn-type":[{"value":"1549-1676","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,30]]}}}