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Global health sector strategies 2016\u20132021 for HIV, STIs and viral hepatitis. Regional consultation: Johannesburg, South Africa, 28\u201330 April, 2015. Meeting report. Geneva: World Health Organization; 2015 [cited 2018 Jan 31]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/reproductivehealth\/AFRConsultation-report.pdf?ua=1\" xlink:type=\"simple\">http:\/\/www.who.int\/reproductivehealth\/AFRConsultation-report.pdf?ua=1<\/ext-link>"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1093\/ije\/dys081","article-title":"The INDEPTH network: filling vital gaps in global epidemiology","volume":"41","author":"O Sankoh","year":"2012","journal-title":"Int J Epidemiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1097\/QAD.0b013e328362e832","article-title":"Dramatic increase in HIV prevalence after scale-up of antiretroviral treatment","volume":"27","author":"J Zaidi","year":"2013","journal-title":"AIDS"},{"issue":"10","key":"ref14","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1371\/journal.pmed.0040296","article-title":"The Strengthening the Reporting of 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AIDS 2016 Conference; 2016 Jul 18\u201322; Durban, South Africa."},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e470","DOI":"10.1016\/S2214-109X(15)00087-X","article-title":"Length of secondary schooling and risk of HIV infection in Botswana: evidence from a natural experiment","volume":"3","author":"J-W De Neve","year":"2015","journal-title":"Lancet Glob Health"},{"issue":"10","key":"ref41","doi-asserted-by":"crossref","first-page":"e591","DOI":"10.1016\/S2214-109X(15)00167-9","article-title":"Secondary schooling might be as good an HIV investment as male circumcision","volume":"3","author":"M Remme","year":"2015","journal-title":"Lancet Glob Health"},{"key":"ref42","unstructured":"Shanaube K, Mwate JC, Macleod D, Schaap A, Floyd S, Jani C, et al. Community intervention improves adolescent HIV status knowledge: HPTN 071 study Zambia. Conference on Retroviruses and Opportunistic Infections; 2017 Feb 13\u201316; Seattle, Washington, US. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.croiconference.org\/sessions\/community-intervention-improves-adolescent-hiv-status-knowledgehptn-071-study-zambia\" xlink:type=\"simple\">http:\/\/www.croiconference.org\/sessions\/community-intervention-improves-adolescent-hiv-status-knowledgehptn-071-study-zambia<\/ext-link>."},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e252","DOI":"10.1016\/S2352-3018(15)00045-4","article-title":"Migration, sexual behaviour, and HIV risk: a general population cohort in rural South Africa","volume":"2","author":"N McGrath","year":"2015","journal-title":"Lancet HIV"},{"key":"ref44","first-page":"43","article-title":"Population mobility and household dynamics in rural South Africa: implications for demographic and health research","volume":"10","author":"V Hosegood","year":"2013","journal-title":"South Afr J Demogr"},{"key":"ref45","doi-asserted-by":"crossref","DOI":"10.5771\/9780739135808","article-title":"Young people\u2019s lives and sexual relationships in rural Africa: findings from a large qualitative study in Tanzania","author":"ML Plummer","year":"2011"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/j.1365-3156.2009.02464.x","article-title":"How to improve the validity of sexual behaviour reporting: systematic review of questionnaire delivery modes in developing countries","volume":"15","author":"LF Langhaug","year":"2010","journal-title":"Trop Med Int Health"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/S1054-139X(03)00052-1","article-title":"Assessment of factors affecting the validity of self-reported health-risk behavior among adolescents: evidence from the scientific literature","volume":"33","author":"ND Brener","year":"2003","journal-title":"J Adolesc Health"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1080\/13691050801948102","article-title":"What is \u201csex\u201d exactly? 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