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[Cited 1 January 2018]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/optn.transplant.hrsa.gov\/data\/\" xlink:type=\"simple\">http:\/\/optn.transplant.hrsa.gov\/data\/<\/ext-link>."},{"key":"ref4","unstructured":"Eurotransplant Annual Report. [Cited 1 January 2018]. 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Surrogate Endpoints for Clinical Trials in Kidney Transplantation 28 September 2015. [Cited 1 January 2018]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.fda.gov\/downloads\/Drugs\/NewsEvents\/UCM470429.pdf\" xlink:type=\"simple\">https:\/\/www.fda.gov\/downloads\/Drugs\/NewsEvents\/UCM470429.pdf<\/ext-link>."},{"key":"ref32","unstructured":"Transplant Therapeutics Consortium. [Cited 1 January 2018]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/c-path.org\/programs\/ttc\/\" xlink:type=\"simple\">https:\/\/c-path.org\/programs\/ttc\/<\/ext-link>."},{"key":"ref33","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"PRISMA Group. Preferred reporting items for systematic reviews and meta\u2013analyses: the PRISMA statement","volume":"339","author":"D Moher","year":"2009","journal-title":"BMJ"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group","volume":"283","author":"DF Stroup","year":"2000","journal-title":"JAMA"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.trim.2013.09.005","article-title":"The complement interference phenomenon as a cause for sharp fluctuations of serum anti-HLA antibody strength in kidney transplant patients","volume":"29","author":"G Guidicelli","year":"2013","journal-title":"Transpl Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1084\/jem.178.2.661","article-title":"Structural features of human immunoglobulin G that determine isotype\u2013specific differences in complement activation","volume":"178","author":"MH Tao","year":"1993","journal-title":"J Exp Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/ajt.14107","article-title":"The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology","volume":"17","author":"A Loupy","year":"2017","journal-title":"Am J Transplant"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/hep.510310337","article-title":"Update of the International Banff Schema for Liver Allograft Rejection: working recommendations for the histopathologic staging and reporting of chronic rejection. 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Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp\" xlink:type=\"simple\">http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp<\/ext-link>."},{"key":"ref41","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1136\/eb-2014-101794","article-title":"How to interpret meta-analysis models: fixed effect and random effects meta\u2013analyses","volume":"17","author":"A Nikolakopoulou","year":"2014","journal-title":"Evid Based Ment Health"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta\u2013analyses","volume":"327","author":"JPT Higgins","year":"2003","journal-title":"BMJ"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"JPT 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Vasculopathy in Pediatric Heart Transplant Recipients","volume":"102","author":"BB Das","year":"2018","journal-title":"Transplantation"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.trim.2017.08.001","article-title":"Deleterious impact of C3d\u2013binding donor-specific anti-HLA antibodies after pediatric liver transplantation","volume":"45","author":"E Couchonnal","year":"2017","journal-title":"Transpl Immunol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1097\/TP.0000000000002002","article-title":"Prognostic Value of the Persistence of C1q\u2013Binding Anti-HLA Antibodies in Acute Antibody\u2013Mediated Rejection in Kidney Transplantation","volume":"102","author":"E Bailly","year":"2018","journal-title":"Transplantation"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.3389\/fimmu.2017.01310","article-title":"Impact of Preformed Donor-specific Anti\u2013Human Leukocyte Antigen Antibody C1q\u2013Binding Ability on Kidney Allograft Outcome","volume":"8","author":"J Molina","year":"2017","journal-title":"Front Immunol"},{"key":"ref72","unstructured":"Global Observatory on Donation and Transplantation. [Cited 1 January 2018]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.transplant-observatory.org\/\" xlink:type=\"simple\">http:\/\/www.transplant-observatory.org\/<\/ext-link>."},{"key":"ref73","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/MOT.0000000000000454","article-title":"Application, technical issues, and interpretation of C1q for graft outcome","volume":"22","author":"DB Tyan","year":"2017","journal-title":"Curr Opin Organ Transplant"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1111\/ajt.13295","article-title":"Assessing Antibody Strength: Comparison of MFI, C1q, and Titer Information","volume":"15","author":"AR Tambur","year":"2015","journal-title":"Am J Transplant"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/tan.13062","article-title":"Effects of weak\/non\u2013complement\u2013binding HLA antibodies on C1q\u2013binding","volume":"90","author":"G H\u00f6nger","year":"2017","journal-title":"HLA"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1001\/jama.2012.366","article-title":"Association of LDL cholesterol, non\u2013HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis","volume":"307","author":"SM Boekholdt","year":"2012","journal-title":"JAMA"},{"key":"ref77","first-page":"2849","article-title":"Prognostic value of microRNAs in gastric cancer: a meta-analysis","volume":"6","author":"Y Zhang","year":"2017","journal-title":"Oncotarget"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"e277","DOI":"10.1016\/S2468-2667(17)30074-9","article-title":"Overweight, obesity, and risk of cardiometabolic multimorbidity: pooled analysis of individual\u2013level data for 120 813 adults from 16 cohort studies from the USA and Europe","volume":"2","author":"M Kivim\u00e4ki","year":"2017","journal-title":"Lancet Public Health"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0140-6736(09)61717-7","article-title":"C\u2013reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis","volume":"375","author":"S Kaptoge","year":"2010","journal-title":"Lancet"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/TP.0000000000000592","article-title":"A phase I\/II placebo\u2013controlled trial of C1\u2013inhibitor for prevention of antibody\u2013mediated rejection in HLA sensitized patients","volume":"99","author":"AA Vo","year":"2015","journal-title":"Transplantation"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1111\/ajt.13663","article-title":"C1 Inhibitor in Acute Antibody\u2013Mediated Rejection Nonresponsive to Conventional Therapy in Kidney Transplant Recipients: A Pilot Study","volume":"16","author":"D Viglietti","year":"2016","journal-title":"Am J Transplant"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1056\/NEJMoa1612567","article-title":"IgG Endopeptidase in Highly Sensitized Patients Undergoing Transplantation","volume":"377","author":"SC Jordan","year":"2017","journal-title":"N Engl J Med"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1111\/ajt.14001","article-title":"Eculizumab Therapy for Chronic Antibody\u2013Mediated Injury in Kidney Transplant Recipients: A Pilot Randomized Controlled Trial","volume":"17","author":"S Kulkarni","year":"2017","journal-title":"Am J Transplant"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1681\/ASN.2017050589","article-title":"Complement-activating Anti-HLA Antibodies in Kidney Transplantation: Allograft Gene Expression Profiling and Response to Treatment","volume":"29","author":"C Lefaucheur","year":"2018","journal-title":"J 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