{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:51:30Z","timestamp":1792511490299,"version":"4.5.0"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T00:00:00Z","timestamp":1548115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI099631"],"award-info":[{"award-number":["R01 AI099631"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["P01 AI106695"],"award-info":[{"award-number":["P01 AI106695"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U19 AI118610"],"award-info":[{"award-number":["U19 AI118610"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["PDVI VE-1"],"award-info":[{"award-number":["PDVI VE-1"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosmedicine.org"],"crossmark-restriction":false},"short-container-title":["PLoS Med"],"DOI":"10.1371\/journal.pmed.1002726","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T13:25:23Z","timestamp":1548163523000},"page":"e1002726","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmed.corrections_policy","source":"Crossref","is-referenced-by-count":157,"title":["Prior dengue virus infection and risk of Zika: A pediatric cohort in Nicaragua"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9352-7877","authenticated-orcid":true,"given":"Aubree","family":"Gordon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2333-1748","authenticated-orcid":true,"given":"Lionel","family":"Gresh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Ojeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1033-6758","authenticated-orcid":true,"given":"Leah C.","family":"Katzelnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nery","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Mercado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2194-2251","authenticated-orcid":true,"given":"Gerardo","family":"Chowell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Elizondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefina","family":"Coloma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8179-4145","authenticated-orcid":true,"given":"Raquel","family":"Burger-Calderon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermina","family":"Kuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Balmaseda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7238-4037","authenticated-orcid":true,"given":"Eva","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,1,22]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0035-9203(52)90042-4","article-title":"Zika virus. I. Isolations and serological specificity","volume":"46","author":"GW Dick","year":"1952","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0035-9203(52)90043-6","article-title":"Zika virus. II. Pathogenicity and physical properties","volume":"46","author":"GW Dick","year":"1952","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0035-9203(64)90201-9","article-title":"Zika virus infection in man","volume":"58","author":"DI Simpson","year":"1964","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"e2636","DOI":"10.1371\/journal.pntd.0002636","article-title":"Molecular evolution of Zika virus during its emergence in the 20(th) century","volume":"8","author":"O Faye","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"issue":"24","key":"ref5","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1056\/NEJMoa0805715","article-title":"Zika virus outbreak on Yap Island, Federated States of Micronesia","volume":"360","author":"MR Duffy","year":"2009","journal-title":"N Engl J Med"},{"issue":"8","key":"ref6","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.3201\/eid1408.080287","article-title":"Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007","volume":"14","author":"RS Lanciotti","year":"2008","journal-title":"Emerg Infect Dis"},{"issue":"6","key":"ref7","first-page":"1085","article-title":"Zika virus, French Polynesia, South Pacific, 2013","volume":"20","author":"VM Cao-Lormeau","year":"2014","journal-title":"Emerg Infect Dis"},{"issue":"10027","key":"ref8","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/S0140-6736(16)00562-6","article-title":"Guillain-Barre syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study","volume":"387","author":"VM Cao-Lormeau","year":"2016","journal-title":"Lancet"},{"issue":"9","key":"ref9","doi-asserted-by":"crossref","first-page":"20720","DOI":"10.2807\/1560-7917.ES2014.19.9.20720","article-title":"Zika virus infection complicated by Guillain-Barre syndrome\u2014case report, French Polynesia, December 2013","volume":"19","author":"E Oehler","year":"2014","journal-title":"Euro Surveill"},{"issue":"16","key":"ref10","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1056\/NEJMoa1605564","article-title":"Guillain-Barre syndrome associated with Zika virus infection in Colombia","volume":"375","author":"B Parra","year":"2016","journal-title":"N Engl J Med"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"e1002203","DOI":"10.1371\/journal.pmed.1002203","article-title":"Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barre syndrome: systematic review","volume":"14","author":"F Krauer","year":"2017","journal-title":"PLoS Med"},{"issue":"20","key":"ref12","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1056\/NEJMsr1604338","article-title":"Zika virus and birth defects\u2014reviewing the evidence for causality","volume":"374","author":"SA Rasmussen","year":"2016","journal-title":"N Engl J Med"},{"issue":"5","key":"ref13","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/oxfordjournals.aje.a113932","article-title":"Risk factors in dengue shock syndrome: a prospective epidemiologic study in Rayong, Thailand. I. The 1980 outbreak","volume":"120","author":"N Sangkawibha","year":"1984","journal-title":"Am J Epidemiol"},{"issue":"9966","key":"ref14","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0140-6736(14)60572-9","article-title":"Dengue. Lancet","volume":"385","author":"MG Guzman","year":"2015","journal-title":"Dengue. Lancet"},{"issue":"6365","key":"ref15","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1126\/science.aan6836","article-title":"Antibody-dependent enhancement of severe dengue disease in humans","volume":"358","author":"LC Katzelnick","year":"2017","journal-title":"Science"},{"issue":"6301","key":"ref16","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1126\/science.aaf8505","article-title":"Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection","volume":"353","author":"K Stettler","year":"2016","journal-title":"Science"},{"issue":"9","key":"ref17","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/ni.3515","article-title":"Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with Zika virus","volume":"17","author":"W Dejnirattisai","year":"2016","journal-title":"Nat Immunol"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cell.2017.09.002","article-title":"A human bi-specific antibody against Zika virus with high therapeutic potential","volume":"171","author":"J Wang","year":"2017","journal-title":"Cell"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1038\/s41467-017-01669-z","article-title":"Dengue virus-reactive CD8(+) T cells mediate cross-protection against subsequent Zika virus challenge","volume":"8","author":"J Wen","year":"2017","journal-title":"Nat Commun"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"15674","DOI":"10.1038\/ncomms15674","article-title":"Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus","volume":"8","author":"P Pantoja","year":"2017","journal-title":"Nat Commun"},{"issue":"8","key":"ref21","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1093\/cid\/cix558","article-title":"Viral load and cytokine response profile does not support antibody-dependent enhancement in dengue-primed Zika virus-infected patients","volume":"65","author":"ACB Terzian","year":"2017","journal-title":"Clin Infect Dis"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"e140","DOI":"10.1016\/S2214-109X(17)30496-5","article-title":"Does immunity after Zika virus infection cross-protect against dengue?","volume":"6","author":"GS Ribeiro","year":"2018","journal-title":"Lancet Glob Health"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.coviro.2018.03.004","article-title":"The use of longitudinal cohorts for studies of dengue viral pathogenesis and protection","volume":"29","author":"LC Katzelnick","year":"2018","journal-title":"Curr Opin Virol"},{"issue":"9","key":"ref24","doi-asserted-by":"crossref","first-page":"e2462","DOI":"10.1371\/journal.pntd.0002462","article-title":"The Nicaraguan pediatric dengue cohort study: incidence of inapparent and symptomatic dengue virus infections, 2004\u20132010","volume":"7","author":"A Gordon","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/aje\/kwp092","article-title":"The Nicaraguan Pediatric Dengue Cohort Study: study design, methods, use of information technology, and extension to other infectious diseases","volume":"170","author":"G Kuan","year":"2009","journal-title":"Am J Epidemiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1086\/648592","article-title":"Trends in patterns of dengue transmission in a pediatric cohort study in Nicaragua","volume":"201","author":"A Balmaseda","year":"2010","journal-title":"J Infect Dis"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"397","DOI":"10.4269\/ajtmh.15-0413","article-title":"Clinical attack rate of chikungunya in a cohort of Nicaraguan children","volume":"94","author":"A Balmaseda","year":"2016","journal-title":"Am J Trop Med Hyg"},{"key":"ref28","article-title":"Technical guide for diagnosis, surveillance, prevention and control of dengue haemorrhagic fever","year":"1975"},{"key":"ref29","article-title":"Dengue haemorrhagic fever: diagnosis, treatment, prevention, and control","year":"1997"},{"key":"ref30","article-title":"Dengue guidelines for diagnosis, treatment, prevention and control: new edition","year":"2009"},{"issue":"7","key":"ref31","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.3201\/eid2207.160326","article-title":"Single-reaction multiplex reverse transcription PCR for detection of Zika, chikungunya, and dengue viruses","volume":"22","author":"JJ Waggoner","year":"2016","journal-title":"Emerg Infect Dis"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/s41467-018-03772-1","article-title":"Performance of the Trioplex real-time RT-PCR assay for detection of Zika, dengue, and chikungunya viruses","volume":"9","author":"GA Santiago","year":"2018","journal-title":"Nat Commun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jcv.2016.01.007","article-title":"Clinical evaluation of a single-reaction real-time RT-PCR for pan-dengue and chikungunya virus detection","volume":"78","author":"JJ Waggoner","year":"2016","journal-title":"J Clin Virol"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"e01785","DOI":"10.1128\/JCM.01785-17","article-title":"Comparison of four serological methods and two reverse transcription-pcr assays for diagnosis and surveillance of Zika virus infection","volume":"56","author":"A Balmaseda","year":"2018","journal-title":"J Clin Microbiol"},{"issue":"31","key":"ref35","doi-asserted-by":"crossref","first-page":"8384","DOI":"10.1073\/pnas.1704984114","article-title":"Antibody-based assay discriminates Zika virus infection from other flaviviruses","volume":"114","author":"A Balmaseda","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref36","author":"AB Terry T","year":"2017"},{"key":"ref37","article-title":"R: a language and environment for statistical computing","year":"2016"},{"issue":"8","key":"ref38","doi-asserted-by":"crossref","first-page":"e2357","DOI":"10.1371\/journal.pntd.0002357","article-title":"Symptomatic versus inapparent outcome in repeat dengue virus infections is influenced by the time interval between infections and study year","volume":"7","author":"M Montoya","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"issue":"123","key":"ref39","doi-asserted-by":"crossref","first-page":"20160659","DOI":"10.1098\/rsif.2016.0659","article-title":"Characterizing the reproduction number of epidemics with early subexponential growth dynamics","volume":"13","author":"G Chowell","year":"2016","journal-title":"J R Soc Interface"},{"issue":"6297","key":"ref40","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.aag0219","article-title":"Countering the Zika epidemic in Latin America","volume":"353","author":"NM Ferguson","year":"2016","journal-title":"Science"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.epidem.2016.01.002","article-title":"A generalized-growth model to characterize the early ascending phase of infectious disease outbreaks","volume":"15","author":"C Viboud","year":"2016","journal-title":"Epidemics"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"28070","DOI":"10.1038\/srep28070","article-title":"Prevention and control of Zika as a mosquito-borne and sexually transmitted disease: a mathematical modeling analysis","volume":"6","author":"D Gao","year":"2016","journal-title":"Sci Rep"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.epidem.2016.10.003","article-title":"Estimate of the reproduction number of the 2015 Zika virus outbreak in Barranquilla, Colombia, and estimation of the relative role of sexual transmission","volume":"17","author":"S Towers","year":"2016","journal-title":"Epidemics"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijid.2016.02.017","article-title":"Transmission potential of Zika virus infection in the South Pacific","volume":"45","author":"H Nishiura","year":"2016","journal-title":"Int J Infect Dis"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.epidem.2017.01.001","article-title":"A comparative analysis of chikungunya and Zika transmission","volume":"19","author":"J Riou","year":"2017","journal-title":"Epidemics"},{"issue":"5","key":"ref46","doi-asserted-by":"crossref","first-page":"e0004726","DOI":"10.1371\/journal.pntd.0004726","article-title":"Transmission dynamics of Zika virus in island populations: a modelling analysis of the 2013\u201314 French Polynesia outbreak","volume":"10","author":"AJ Kucharski","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"issue":"6","key":"ref47","doi-asserted-by":"crossref","first-page":"e01390","DOI":"10.1128\/mBio.01390-17","article-title":"High Zika virus seroprevalence in Salvador, northeastern Brazil limits the potential for further outbreaks","volume":"8","author":"EM Netto","year":"2017","journal-title":"MBio"},{"issue":"8","key":"ref48","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1017\/S0950268817000358","article-title":"Zika in Rio de Janeiro: assessment of basic reproduction number and comparison with dengue outbreaks","volume":"145","author":"DAM Villela","year":"2017","journal-title":"Epidemiol Infect"},{"issue":"Pt 12","key":"ref49","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1099\/vir.0.031641-0","article-title":"Flavivirus-induced antibody cross-reactivity","volume":"92","author":"KL Mansfield","year":"2011","journal-title":"J Gen Virol"},{"issue":"4","key":"ref50","doi-asserted-by":"crossref","first-page":"e01123","DOI":"10.1128\/mBio.01123-16","article-title":"Dengue virus envelope dimer epitope monoclonal antibodies isolated from dengue patients are protective against Zika virus","volume":"7","author":"JA Swanstrom","year":"2016","journal-title":"MBio"},{"issue":"5","key":"ref51","doi-asserted-by":"crossref","first-page":"773","DOI":"10.3201\/eid2305.161630","article-title":"Lack of durable cross-neutralizing antibodies against Zika virus from dengue virus infection","volume":"23","author":"MH Collins","year":"2017","journal-title":"Emerg Infect Dis"},{"issue":"4","key":"ref52","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1093\/infdis\/jiy164","article-title":"longitudinal analysis of antibody cross-neutralization following Zika and dengue virus infection in Asia and the Americas","volume":"218","author":"M Montoya","year":"2018","journal-title":"J Infect Dis"},{"key":"ref53","article-title":"Prior dengue virus exposure shapes T cell immunity to Zika virus in humans","author":"A Grifoni","year":"2017","journal-title":"J Virol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"17036","DOI":"10.1038\/nmicrobiol.2017.36","article-title":"Identification of Zika virus epitopes reveals immunodominant and protective roles for dengue virus cross-reactive CD8(+) T cells","volume":"2","author":"J Wen","year":"2017","journal-title":"Nat Microbiol"},{"issue":"37","key":"ref55","doi-asserted-by":"crossref","first-page":"9294","DOI":"10.1073\/pnas.1804672115","article-title":"Seroprevalence, risk factor, and spatial analyses of Zika virus infection after the 2016 epidemic in Managua, Nicaragua","volume":"115","author":"JV Zambrana","year":"2018","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["PLOS Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pmed.1002726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T18:25:41Z","timestamp":1588962341000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pmed.1002726"}},"subtitle":[],"editor":[{"given":"Lorenz","family":"von Seidlein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,1,22]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pmed.1002726","relation":{},"ISSN":["1549-1676"],"issn-type":[{"value":"1549-1676","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,22]]}}}