{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T03:32:22Z","timestamp":1794195142195,"version":"4.8.0"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T00:00:00Z","timestamp":1569283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"name":"Boston Scientific Investigator Sponsored Research Program","id":[{"id":"https:\/\/ror.org\/03kjsjz16","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council Singapore","doi-asserted-by":"crossref","award":["NMRC\/CSA\/0052\/2013"],"award-info":[{"award-number":["NMRC\/CSA\/0052\/2013"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"crossref"}]},{"name":"A*STAR Biomedical Research Council ATTRaCT program","award":["SPF2014\/003"],"award-info":[{"award-number":["SPF2014\/003"]}],"id":[{"id":"https:\/\/ror.org\/03xy0wx88","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007659","name":"Bayer Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosmedicine.org"],"crossmark-restriction":false},"short-container-title":["PLoS Med"],"DOI":"10.1371\/journal.pmed.1002916","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T13:22:25Z","timestamp":1569331345000},"page":"e1002916","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmed.corrections_policy","source":"Crossref","is-referenced-by-count":111,"title":["Association of obesity with heart failure outcomes in 11 Asian regions: A cohort study"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8256-902X","authenticated-orcid":true,"given":"Chanchal","family":"Chandramouli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2397-5946","authenticated-orcid":true,"given":"Wan Ting","family":"Tay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurul Sahiddah","family":"Bamadhaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper","family":"Tromp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiew-Hwa Katherine","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5227-8536","authenticated-orcid":true,"given":"Jonathan J. L.","family":"Yap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3501-3592","authenticated-orcid":true,"given":"Michael R.","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2858-3493","authenticated-orcid":true,"given":"Chung-Lieh","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Streng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1563-9774","authenticated-orcid":true,"given":"Ajay","family":"Naik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4596-4247","authenticated-orcid":true,"given":"Gurpreet Singh","family":"Wander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitendra","family":"Sawhney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6063-8530","authenticated-orcid":true,"given":"Lieng Hsi","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Mark","family":"Richards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inder","family":"Anand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriaan A.","family":"Voors","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1903-0018","authenticated-orcid":true,"given":"Carolyn S. P.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of ASIAN-HF Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,9,24]]},"reference":[{"key":"pmed.1002916.ref001","volume-title":"Obesity and overweight","author":"World Health Organization","year":"2018"},{"issue":"41","key":"pmed.1002916.ref002","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1093\/eurheartj\/ehw331","article-title":"Regional and ethnic differences among patients with heart failure in Asia: the Asian sudden cardiac death in heart failure registry","volume":"37","author":"CS Lam","year":"2016","journal-title":"Eur Heart J"},{"issue":"9403","key":"pmed.1002916.ref003","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0140-6736(03)15268-3","article-title":"Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies","volume":"363","author":"WHO Expert Consultation","year":"2004","journal-title":"Lancet"},{"issue":"3","key":"pmed.1002916.ref004","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1161\/CIRCHEARTFAILURE.110.959890","article-title":"Body mass index and adverse cardiovascular outcomes in heart failure patients with preserved ejection fraction: results from the Irbesartan in Heart Failure with Preserved Ejection Fraction (I-PRESERVE) trial","volume":"4","author":"M Haass","year":"2011","journal-title":"Circ Heart Fail"},{"issue":"6","key":"pmed.1002916.ref005","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1161\/CIRCULATIONAHA.106.679779","article-title":"Body mass index and prognosis in patients with chronic heart failure: insights from the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) program","volume":"116","author":"S Kenchaiah","year":"2007","journal-title":"Circulation"},{"issue":"8","key":"pmed.1002916.ref006","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/ijo.2013.203","article-title":"The obesity paradox in heart failure patients with preserved versus reduced ejection fraction: a meta-analysis of individual patient data","volume":"38","author":"R Padwal","year":"2014","journal-title":"Int J Obes (Lond)"},{"issue":"12","key":"pmed.1002916.ref007","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1253\/circj.CJ-10-0599","article-title":"Body mass index is an independent predictor of long-term outcomes in patients hospitalized with heart failure in Japan","volume":"74","author":"S Hamaguchi","year":"2010","journal-title":"Circ J"},{"issue":"7","key":"pmed.1002916.ref008","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.amjcard.2016.06.056","article-title":"The obesity-mortality paradox in patients with heart failure in Taiwan and a collaborative meta-analysis for East Asian patients","volume":"118","author":"GM Lin","year":"2016","journal-title":"Am J Cardiol"},{"issue":"3","key":"pmed.1002916.ref009","doi-asserted-by":"crossref","first-page":"e1002541","DOI":"10.1371\/journal.pmed.1002541","article-title":"Multimorbidity in patients with heart failure from 11 Asian regions: a prospective cohort study using the ASIAN-HF registry","volume":"15","author":"J Tromp","year":"2018","journal-title":"PLoS Med"},{"issue":"13","key":"pmed.1002916.ref010","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1161\/CIRCULATIONAHA.117.029617","article-title":"Cardiovascular and metabolic heterogeneity of obesity: clinical challenges and implications for management","volume":"137","author":"IJ Neeland","year":"2018","journal-title":"Circulation"},{"issue":"17","key":"pmed.1002916.ref011","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1093\/eurheartj\/ehy057","article-title":"The impact of confounding on the associations of different adiposity measures with the incidence of cardiovascular disease: a cohort study of 296 535 adults of white European descent","volume":"39","author":"S Iliodromiti","year":"2018","journal-title":"Eur Heart J"},{"issue":"20","key":"pmed.1002916.ref012","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1136\/heartjnl-2014-305816","article-title":"Body fat percentage, body mass index and waist-to-hip ratio as predictors of mortality and cardiovascular disease","volume":"100","author":"PK Myint","year":"2014","journal-title":"Heart"},{"issue":"22","key":"pmed.1002916.ref013","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1016\/j.jacc.2017.09.1111","article-title":"Abdominal obesity is associated with an increased risk of all-cause mortality in patients with HFpEF","volume":"70","author":"T Tsujimoto","year":"2017","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"pmed.1002916.ref014","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1002\/ejhf.1244","article-title":"Waist-to-hip ratio and mortality in heart failure","volume":"20","author":"KW Streng","year":"2018","journal-title":"Eur J Heart Fail"},{"issue":"8","key":"pmed.1002916.ref015","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1093\/eurjhf\/hft045","article-title":"Asian Sudden Cardiac Death in Heart Failure (ASIAN-HF) registry","volume":"15","author":"CS Lam","year":"2013","journal-title":"Eur J Heart Fail"},{"issue":"11","key":"pmed.1002916.ref016","doi-asserted-by":"crossref","first-page":"e003651","DOI":"10.1161\/CIRCOUTCOMES.116.003651","article-title":"Disparity between indications for and utilization of implantable cardioverter defibrillators in Asian patients with heart failure","volume":"10","author":"YMF Chia","year":"2017","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"pmed.1002916.ref017","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ahj.2017.06.016","article-title":"Multinational and multiethnic variations in health-related quality of life in patients with chronic heart failure","volume":"191","author":"N Luo","year":"2017","journal-title":"Am Heart J"},{"issue":"11","key":"pmed.1002916.ref018","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/sj.ejcn.1601466","article-title":"Accuracy of an eight-point tactile-electrode impedance method in the assessment of total body water","volume":"56","author":"G Bedogni","year":"2002","journal-title":"Eur J Clin Nutr"},{"issue":"5","key":"pmed.1002916.ref019","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.cardfail.2011.01.009","article-title":"Waist circumference, body mass index, and survival in systolic heart failure: the obesity paradox revisited","volume":"17","author":"AL Clark","year":"2011","journal-title":"J Card Fail"},{"issue":"18","key":"pmed.1002916.ref020","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1161\/CIR.0b013e318233bc6a","article-title":"Assessing adiposity: a scientific statement from the American Heart Association","volume":"124","author":"MA Cornier","year":"2011","journal-title":"Circulation"},{"issue":"2","key":"pmed.1002916.ref021","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.cyto.2015.05.005","article-title":"IL-1 family members in the pathogenesis and treatment of metabolic disease: focus on adipose tissue inflammation and insulin resistance","volume":"75","author":"DB Ballak","year":"2015","journal-title":"Cytokine"},{"issue":"2","key":"pmed.1002916.ref022","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/hr.2011.157","article-title":"Cardiac remodeling and diastolic dysfunction in DahlS.Z-Lepr(fa)\/Lepr(fa) rats: a new animal model of metabolic syndrome","volume":"35","author":"T Murase","year":"2012","journal-title":"Hypertens Res"},{"issue":"6","key":"pmed.1002916.ref023","doi-asserted-by":"crossref","first-page":"e004396","DOI":"10.1161\/CIRCIMAGING.115.004396","article-title":"Association of central adiposity with adverse cardiac mechanics: findings from the hypertension genetic epidemiology network study","volume":"9","author":"S Selvaraj","year":"2016","journal-title":"Circ Cardiovasc Imaging"},{"issue":"8","key":"pmed.1002916.ref024","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s11892-018-1017-1","article-title":"Diabetes among non-overweight individuals: an emerging public health challenge","volume":"18","author":"UP Gujral","year":"2018","journal-title":"Curr Diab Rep"},{"issue":"9403","key":"pmed.1002916.ref025","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0140-6736(03)15269-5","article-title":"The Y-Y paradox","volume":"363","author":"CS Yajnik","year":"2004","journal-title":"Lancet"},{"key":"pmed.1002916.ref026","article-title":"Obesity, body composition and cardiorespiratory fitness in heart failure with preserved ejection fraction","author":"S Carbone","year":"2017","journal-title":"Future Cardiol"},{"issue":"4","key":"pmed.1002916.ref027","doi-asserted-by":"crossref","first-page":"714","DOI":"10.3945\/ajcn.112.035758","article-title":"Ethnic influences on the relations between abdominal subcutaneous and visceral adiposity, liver fat, and cardiometabolic risk profile: the International Study of Prediction of Intra-Abdominal Adiposity and Its Relationship With Cardiometabolic Risk\/Intra-Abdominal Adiposity","volume":"96","author":"JA Nazare","year":"2012","journal-title":"Am J Clin Nutr"},{"issue":"8","key":"pmed.1002916.ref028","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.jchf.2018.01.009","article-title":"Obesity-related heart failure with a preserved ejection fraction: the mechanistic rationale for combining inhibitors of aldosterone, neprilysin, and sodium-glucose cotransporter-2","volume":"6","author":"M Packer","year":"2018","journal-title":"JACC Heart Fail"}],"container-title":["PLOS Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pmed.1002916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T15:36:52Z","timestamp":1664465812000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pmed.1002916"}},"subtitle":[],"editor":[{"given":"Kazem","family":"Rahimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,9,24]]},"references-count":28,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pmed.1002916","relation":{},"ISSN":["1549-1676"],"issn-type":[{"value":"1549-1676","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,24]]}}}