{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:24:43Z","timestamp":1771338283999,"version":"3.50.1"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["R\/126349"],"award-info":[{"award-number":["R\/126349"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosmedicine.org"],"crossmark-restriction":false},"short-container-title":["PLoS Med"],"DOI":"10.1371\/journal.pmed.1002960","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T13:23:58Z","timestamp":1573565038000},"page":"e1002960","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmed.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["Testosterone replacement in young male cancer survivors: A 6-month double-blind randomised placebo-controlled trial"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7122-2650","authenticated-orcid":true,"given":"Jennifer S.","family":"Walsh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0944-0152","authenticated-orcid":true,"given":"Helen","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8326-1075","authenticated-orcid":true,"given":"Isabelle L.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana M.","family":"Greenfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayne","family":"Swain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Best","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Ashton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia M.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Huddart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Coleman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6819-3476","authenticated-orcid":true,"given":"John A.","family":"Snowden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9222-9678","authenticated-orcid":true,"given":"Richard J.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,11,12]]},"reference":[{"issue":"8","key":"pmed.1002960.ref001","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1210\/jc.2018-01175","article-title":"Hypothalamic-Pituitary and Growth Disorders in Survivors of Childhood Cancer: An Endocrine Society Clinical Practice Guideline","volume":"103","author":"CA Sklar","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"issue":"15","key":"pmed.1002960.ref002","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1056\/NEJMsa060185","article-title":"Chronic health conditions in adult survivors of childhood cancer","volume":"355","author":"KC Oeffinger","year":"2006","journal-title":"The New England journal of medicine"},{"issue":"3","key":"pmed.1002960.ref003","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1210\/er.2018-00092","article-title":"Long-Term Endocrine and Metabolic Consequences of Cancer Treatment: A Systematic Review","volume":"40","author":"J Gebauer","year":"2019","journal-title":"Endocr Rev"},{"issue":"3","key":"pmed.1002960.ref004","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/andr.12177","article-title":"Testosterone deficiency in testicular cancer survivors\u2014a systematic review and meta-analysis","volume":"4","author":"M Bandak","year":"2016","journal-title":"Andrology"},{"issue":"4","key":"pmed.1002960.ref005","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1080\/02841860601166958","article-title":"Gonadal dysfunction and fertility problems in cancer survivors","volume":"46","author":"M Brydoy","year":"2007","journal-title":"Acta Oncol"},{"issue":"11","key":"pmed.1002960.ref006","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1200\/JCO.18.00965","article-title":"Gonadal Functioning and Perceptions of Infertility Risk Among Adult Survivors of Childhood Cancer: A Report From the St Jude Lifetime Cohort Study","volume":"37","author":"V Lehmann","year":"2019","journal-title":"J Clin Oncol"},{"issue":"9","key":"pmed.1002960.ref007","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1210\/jc.2006-2744","article-title":"Prevalence and consequences of androgen deficiency in young male cancer survivors in a controlled cross-sectional study","volume":"92","author":"DM Greenfield","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"pmed.1002960.ref008","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1002\/cncr.24898","article-title":"Quality of life, self-esteem, fatigue, and sexual function in young men after cancer: a controlled cross-sectional study","volume":"116","author":"DM Greenfield","year":"2010","journal-title":"Cancer"},{"issue":"5","key":"pmed.1002960.ref009","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1210\/jc.2018-00229","article-title":"Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline","volume":"103","author":"S Bhasin","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"pmed.1002960.ref010","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1056\/NEJMoa1506119","article-title":"Effects of Testosterone Treatment in Older Men","volume":"374","author":"PJ Snyder","year":"2016","journal-title":"N Engl J Med"},{"issue":"6","key":"pmed.1002960.ref011","doi-asserted-by":"crossref","first-page":"E1172","DOI":"10.1152\/ajpendo.2001.281.6.E1172","article-title":"Testosterone dose-response relationships in healthy young men","volume":"281","author":"S Bhasin","year":"2001","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"2","key":"pmed.1002960.ref012","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1210\/jc.2003-031492","article-title":"Dose-dependent effects of testosterone on regional adipose tissue distribution in healthy young men","volume":"89","author":"LJ Woodhouse","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"pmed.1002960.ref013","first-page":"2839","article-title":"Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men","volume":"85","author":"C Wang","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"pmed.1002960.ref014","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1046\/j.1365-2265.2001.01297.x","article-title":"Randomized placebo-controlled trial of testosterone replacement in men with mild Leydig cell insufficiency following cytotoxic chemotherapy","volume":"55","author":"SJ Howell","year":"2001","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"6890","key":"pmed.1002960.ref015","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1136\/bmj.306.6890.1440","article-title":"The SF36 health survey questionnaire: an outcome measure suitable for routine use within the NHS?","volume":"306","author":"AM Garratt","year":"1993","journal-title":"BMJ"},{"key":"pmed.1002960.ref016","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1477-7525-1-79","article-title":"The Functional Assessment of Chronic Illness Therapy (FACIT) Measurement System: properties, applications, and interpretation","volume":"1","author":"K Webster","year":"2003","journal-title":"Health Qual Life Outcomes"},{"issue":"4","key":"pmed.1002960.ref017","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1080\/00926239708403933","article-title":"The Derogatis Interview for Sexual Functioning (DISF\/DISF-SR): an introductory report","volume":"23","author":"LR Derogatis","year":"1997","journal-title":"J Sex Marital Ther"},{"key":"pmed.1002960.ref018","author":"M Rosenberg","year":"1965"},{"issue":"8","key":"pmed.1002960.ref019","first-page":"2670","article-title":"Effects of testosterone replacement in hypogonadal men","volume":"85","author":"PJ Snyder","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"pmed.1002960.ref020","first-page":"3469","article-title":"Effects of testosterone replacement on muscle mass and muscle protein synthesis in hypogonadal men\u2014a clinical research center study","volume":"81","author":"IG Brodsky","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"pmed.1002960.ref021","first-page":"407","article-title":"Testosterone replacement increases fat-free mass and muscle size in hypogonadal men","volume":"82","author":"S Bhasin","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"pmed.1002960.ref022","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3109\/13685538.2012.699562","article-title":"A randomized, double-blind, placebo-controlled trial of testosterone gel on body composition and health-related quality-of-life in men with hypogonadal to low-normal levels of serum testosterone and symptoms of androgen deficiency over 6 months with 12 months open-label follow-up","volume":"15","author":"HM Behre","year":"2012","journal-title":"Aging Male"},{"issue":"5","key":"pmed.1002960.ref023","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1210\/jc.2003-032006","article-title":"Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men","volume":"89","author":"C Wang","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"pmed.1002960.ref024","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1111\/jsm.12114","article-title":"Medication adherence and treatment patterns for hypogonadal patients treated with topical testosterone therapy: a retrospective medical claims analysis","volume":"10","author":"MJ Schoenfeld","year":"2013","journal-title":"J Sex Med"},{"issue":"12","key":"pmed.1002960.ref025","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1507\/endocrj.EJ12-0134","article-title":"Increased frequency of anxiety, depression, quality of life and sexual life in young hypogonadotropic hypogonadal males and impacts of testosterone replacement therapy on these conditions","volume":"59","author":"U Aydogan","year":"2012","journal-title":"Endocr J"},{"issue":"12","key":"pmed.1002960.ref026","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1111\/j.1743-6109.2008.01015.x","article-title":"Health-related quality of life instruments in studies of adult men with testosterone deficiency syndrome: a critical assessment","volume":"5","author":"S Langham","year":"2008","journal-title":"J Sex Med"},{"issue":"13","key":"pmed.1002960.ref027","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1200\/JCO.2001.19.13.3163","article-title":"Late mortality experience in five-year survivors of childhood and adolescent cancer: the Childhood Cancer Survivor Study","volume":"19","author":"AC Mertens","year":"2001","journal-title":"J Clin Oncol"},{"key":"pmed.1002960.ref028","article-title":"Evaluation of adipocytokines and traditional cardiometabolic risk factors in young male cancer survivors: an age-matched control study","author":"DM Greenfield","year":"2015","journal-title":"Clinical endocrinology"},{"issue":"11","key":"pmed.1002960.ref029","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1210\/jc.2006-0128","article-title":"Hyperinsulinemia, impaired glucose tolerance, and diabetes mellitus in survivors of childhood cancer: prevalence and risk factors","volume":"91","author":"KA Neville","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"pmed.1002960.ref030","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/bmt.2016.203","article-title":"Metabolic syndrome and cardiovascular disease following hematopoietic cell transplantation: screening and preventive practice recommendations from CIBMTR and EBMT","volume":"52","author":"Z DeFilipp","year":"2017","journal-title":"Bone Marrow Transplant"},{"issue":"25","key":"pmed.1002960.ref031","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.1161\/01.cir.0000437739.71477.ee","article-title":"2013 AHA\/ACC\/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines and The Obesity Society","volume":"129","author":"MD Jensen","year":"2014","journal-title":"Circulation"},{"issue":"30","key":"pmed.1002960.ref032","doi-asserted-by":"crossref","first-page":"4649","DOI":"10.1200\/JCO.2010.29.9362","article-title":"Cardiovascular risk factors and morbidity in long-term survivors of testicular cancer: a 20-year follow-up study","volume":"28","author":"HS Haugnes","year":"2010","journal-title":"J Clin Oncol"},{"issue":"5","key":"pmed.1002960.ref033","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1530\/EJE-11-0221","article-title":"Onset of effects of testosterone treatment and time span until maximum effects are achieved","volume":"165","author":"F Saad","year":"2011","journal-title":"Eur J Endocrinol"}],"container-title":["PLOS Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pmed.1002960","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T13:24:12Z","timestamp":1573565052000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pmed.1002960"}},"subtitle":[],"editor":[{"given":"Sanjay","family":"Basu","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,11,12]]},"references-count":33,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,11,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pmed.1002960","relation":{},"ISSN":["1549-1676"],"issn-type":[{"value":"1549-1676","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,12]]}}}