{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:33:56Z","timestamp":1790220836548,"version":"4.1.0"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:00:00Z","timestamp":1592265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosmedicine.org"],"crossmark-restriction":false},"short-container-title":["PLoS Med"],"DOI":"10.1371\/journal.pmed.1003130","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T13:22:35Z","timestamp":1592313755000},"page":"e1003130","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmed.corrections_policy","source":"Crossref","is-referenced-by-count":86,"title":["Clinical and epidemiological characteristics of pediatric SARS-CoV-2 infections in China: A multicenter case series"],"prefix":"10.1371","volume":"17","author":[{"given":"Che","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaowei","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanjing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1564-0110","authenticated-orcid":true,"given":"Li","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3055-164X","authenticated-orcid":true,"given":"Xihui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,6,16]]},"reference":[{"key":"pmed.1003130.ref001","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"W Guan","year":"2020","journal-title":"N Engl J Med"},{"key":"pmed.1003130.ref002","unstructured":"WHO [Internet]. Novel coronavirus (2019-nCoV) situation report-11 [cited 2020 Apr 18]. Available from: https:\/\/www.who.int\/docs\/default-source\/coronaviruse\/situation-reports\/20200131-sitrep-11-ncov.pdf?sfvrsn=de7c0f7_4."},{"key":"pmed.1003130.ref003","unstructured":"WHO [Internet]. Coronavirus disease 2019 (COVID-19) situation report-89 [cited 2020 Apr 19]. Available from: https:\/\/www.who.int\/docs\/default-source\/coronaviruse\/situation-reports\/20200418-sitrep-89-covid-19.pdf?sfvrsn=3643dd38_2."},{"key":"pmed.1003130.ref004","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A novel coronavirus from patients with pneumonia in China, 2019","volume":"382","author":"N Zhu","year":"2020","journal-title":"N Engl J Med"},{"issue":"10223","key":"pmed.1003130.ref005","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"C Huang","year":"2020","journal-title":"Lancet"},{"issue":"10223","key":"pmed.1003130.ref006","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(20)30211-7","article-title":"Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study","volume":"395","author":"N Chen","year":"2020","journal-title":"Lancet"},{"issue":"11","key":"pmed.1003130.ref007","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/jama.2020.1585","article-title":"Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China","volume":"323","author":"D Wang","year":"2020","journal-title":"JAMA"},{"key":"pmed.1003130.ref008","unstructured":"WHO [Internet]. Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected [cited 2020 Apr 18]. Available from: https:\/\/www.who.int\/publications-detail\/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected."},{"issue":"2","key":"pmed.1003130.ref009","first-page":"96","article-title":"Recommendation for the diagnosis and treatment of novel coronavirus infection in children in Hubei (Trial version 1)","volume":"22","author":"Pediatric Branch of Hubei Medical Association, Pediatric Branch of Wuhan Medical Association, Pediatric Medical Quality Control Center of Hubei","year":"2020","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"pmed.1003130.ref010","unstructured":"nhc.gov.cn [Internet]. National recommendations for diagnosis and treatment of COVID-2019 (version 7) [cited 2020 Apr 18]. Available from: www.nhc.gov.cn\/yzygj\/s7653p\/202003\/46c9294a7dfe4cef80dc7f5912eb1989\/files\/ce3e6945832a438eaae415350a8ce964.pdf."},{"key":"pmed.1003130.ref011","unstructured":"nhc.gov.cn [Internet]. Prevention and control strategy of 2019-novel coronavirus (version 5) [cited 2020 Apr 18]. Available from: http:\/\/www.nhc.gov.cn\/jkj\/s3577\/202002\/a5d6f7b8c48c451c87dba14889b30147.shtml."},{"issue":"14","key":"pmed.1003130.ref012","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1001\/jama.2020.4344","article-title":"Coronavirus disease 2019 (COVID-19) in Italy","volume":"323","author":"E Livingston","year":"2020","journal-title":"JAMA"},{"key":"pmed.1003130.ref013","doi-asserted-by":"crossref","first-page":"343","DOI":"10.15585\/mmwr.mm6912e2","article-title":"Severe outcomes among patients with coronavirus disease 2019 (COVID-19)\u2014United States, February 12-March 16, 2020","volume":"69","author":"CDC COVID-19 Response Team","year":"2020","journal-title":"Morb Mortal Wkly Rep"},{"key":"pmed.1003130.ref014","first-page":"e20200702","article-title":"Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China","author":"Y Dong","year":"2020","journal-title":"Pediatrics"},{"issue":"17","key":"pmed.1003130.ref015","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1056\/NEJMc2005073","article-title":"SARS-CoV-2 infection in children","volume":"382","author":"X Lu","year":"2020","journal-title":"N Engl J Med"},{"issue":"1821","key":"pmed.1003130.ref016","article-title":"Evolution of the immune system in humans from infancy to old age","volume":"282","author":"AK Simon","year":"2015","journal-title":"Proc Biol Sci"},{"issue":"6","key":"pmed.1003130.ref017","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1111\/apa.15270","article-title":"Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults","volume":"109","author":"JF Ludvigsson","year":"2020","journal-title":"Acta Paediatr"},{"key":"pmed.1003130.ref018","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/s41591-020-0817-4","article-title":"Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding","volume":"26","author":"Y Xu","year":"2020","journal-title":"Nat Med"},{"issue":"3","key":"pmed.1003130.ref019","doi-asserted-by":"crossref","first-page":"e230548","DOI":"10.1371\/journal.pone.0230548","article-title":"Association of radiologic findings with mortality of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"15","author":"M Yuan","year":"2020","journal-title":"PLoS ONE"},{"key":"pmed.1003130.ref020","first-page":"200370","article-title":"Time course of lung changes on chest CT during recovery from 2019 novel coronavirus (COVID-19) pneumonia","author":"F Pan","year":"2020","journal-title":"Radiology"},{"issue":"4","key":"pmed.1003130.ref021","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1473-3099(20)30086-4","article-title":"Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study","volume":"20","author":"H Shi","year":"2020","journal-title":"Lancet Infect Dis"},{"issue":"3","key":"pmed.1003130.ref022","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1148\/radiol.2020200463","article-title":"Chest CT findings in coronavirus disease-19 (COVID-19): relationship to duration of infection","volume":"295","author":"A Bernheim","year":"2020","journal-title":"Radiology"},{"issue":"1","key":"pmed.1003130.ref023","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1373\/clinchem.2004.031229","article-title":"Protein chip array profiling analysis in patients with severe acute respiratory syndrome identified serum amyloid A protein as a biomarker potentially useful in monitoring the extent of pneumonia","volume":"51","author":"TT Yip","year":"2004","journal-title":"Clin Chem"},{"key":"pmed.1003130.ref024","article-title":"Laboratory abnormalities in children with novel coronavirus disease 2019","author":"BM Henry","journal-title":"Clin Chem Lab Med"},{"issue":"3","key":"pmed.1003130.ref025","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.jfma.2020.02.009","article-title":"SARS-CoV-2 infection in children: Transmission dynamics and clinical characteristics","volume":"119","author":"Q Cao","year":"2020","journal-title":"J Formos Med Assoc"}],"container-title":["PLOS Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pmed.1003130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T13:23:05Z","timestamp":1592313785000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pmed.1003130"}},"subtitle":[],"editor":[{"given":"Lars \u00c5ke","family":"Persson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,6,16]]},"references-count":25,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pmed.1003130","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.03.12.20034686","asserted-by":"object"}]},"ISSN":["1549-1676"],"issn-type":[{"value":"1549-1676","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,16]]}}}