{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:31:22Z","timestamp":1787319082757,"version":"build-2736575974"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["668303"],"award-info":[{"award-number":["668303"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosmedicine.org"],"crossmark-restriction":false},"short-container-title":["PLoS Med"],"DOI":"10.1371\/journal.pmed.1003208","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T13:30:38Z","timestamp":1597843838000},"page":"e1003208","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmed.corrections_policy","source":"Crossref","is-referenced-by-count":84,"title":["Variation in antibiotic prescription rates in febrile children presenting to emergency departments across Europe (MOFICHE): A\u00a0multicentre\u00a0observational study"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9237-4904","authenticated-orcid":true,"given":"Nienke N.","family":"Hagedoorn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2437-0757","authenticated-orcid":true,"given":"Dorine M.","family":"Borensztajn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9671-8161","authenticated-orcid":true,"given":"Ruud","family":"Nijman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anda","family":"Balode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8411-1071","authenticated-orcid":true,"given":"Ulrich","family":"von Both","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8357-7726","authenticated-orcid":true,"given":"Enitan D.","family":"Carrol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5093-8502","authenticated-orcid":true,"given":"Irini","family":"Eleftheriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2822-3527","authenticated-orcid":true,"given":"Marieke","family":"Emonts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1296-0159","authenticated-orcid":true,"given":"Michiel","family":"van der Flier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"de Groot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6941-6491","authenticated-orcid":true,"given":"Jethro","family":"Herberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0685-689X","authenticated-orcid":true,"given":"Benno","family":"Kohlmaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6319-8550","authenticated-orcid":true,"given":"Ian","family":"Maconochie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9023-581X","authenticated-orcid":true,"given":"Federico","family":"Martinon-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4403-6537","authenticated-orcid":true,"given":"Daan","family":"Nieboer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2341-2791","authenticated-orcid":true,"given":"Marko","family":"Pokorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4163-0503","authenticated-orcid":true,"given":"Franc","family":"Strle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Tsolia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0997-0850","authenticated-orcid":true,"given":"Shunmay","family":"Yeung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4892-3763","authenticated-orcid":true,"given":"Dace","family":"Zavadska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Zenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clementien","family":"Vermont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2767-6919","authenticated-orcid":true,"given":"Michael","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9304-3322","authenticated-orcid":true,"given":"Henri\u00ebtte A.","family":"Moll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the PERFORM consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,8,19]]},"reference":[{"issue":"1","key":"pmed.1003208.ref001","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13052-017-0339-y","article-title":"Comparison of two European paediatric emergency departments: does primary care organisation influence emergency attendance?","volume":"43","author":"F Poropat","year":"2017","journal-title":"Ital J Pediatr"},{"issue":"5","key":"pmed.1003208.ref002","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1136\/emj.2010.106229","article-title":"Medical problems presenting to paediatric emergency departments: 10 years on","volume":"29","author":"R Sands","year":"2012","journal-title":"Emerg Med J"},{"key":"pmed.1003208.ref003","doi-asserted-by":"crossref","first-page":"c1594","DOI":"10.1136\/bmj.c1594","article-title":"The accuracy of clinical symptoms and signs for the diagnosis of serious bacterial infection in young febrile children: prospective cohort study of 15 781 febrile illnesses","volume":"340","author":"JC Craig","year":"2010","journal-title":"BMJ"},{"key":"pmed.1003208.ref004","doi-asserted-by":"crossref","first-page":"f1706","DOI":"10.1136\/bmj.f1706","article-title":"Clinical prediction model to aid emergency doctors managing febrile children at risk of serious bacterial infections: diagnostic study","volume":"346","author":"RG Nijman","year":"2013","journal-title":"BMJ"},{"key":"pmed.1003208.ref005","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/S1473-3099(18)30672-8","article-title":"Antibiotic prescription for febrile children in European emergency departments: a cross-sectional, observational study","volume":"19","author":"J van de Maat","year":"2019","journal-title":"Lancet Infect Dis"},{"issue":"6","key":"pmed.1003208.ref006","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1542\/peds.2011-1337","article-title":"Antibiotic prescribing in ambulatory pediatrics in the United States","volume":"128","author":"AL Hersh","year":"2011","journal-title":"Pediatrics"},{"issue":"3","key":"pmed.1003208.ref007","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1542\/peds.2013-2903","article-title":"Recent trends in outpatient antibiotic use in children","volume":"133","author":"LE Vaz","year":"2014","journal-title":"Pediatrics"},{"issue":"9459","key":"pmed.1003208.ref008","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0140-6736(05)70799-6","article-title":"ESAC Project Group. Outpatient antibiotic use in Europe and association with resistance: a cross-national database study","volume":"365","author":"H Goossens","year":"2005","journal-title":"Lancet"},{"key":"pmed.1003208.ref009","doi-asserted-by":"crossref","first-page":"c2096","DOI":"10.1136\/bmj.c2096","article-title":"Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis","volume":"340","author":"C Costelloe","year":"2010","journal-title":"BMJ"},{"issue":"17","key":"pmed.1003208.ref010","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1001\/jama.2016.4151","article-title":"Prevalence of inappropriate antibiotic prescriptions among US ambulatory care visits, 2010\u20132011","volume":"315","author":"KE Fleming-Dutra","year":"2016","journal-title":"JAMA"},{"key":"pmed.1003208.ref011","volume-title":"European Centre for Disease Prevention and ControlSurveillance of antimicrobial resistance in Europe 2017\u2014annual report of the European Antimicrobial Resistance Surveillance Network (EARS-Net).","year":"2018"},{"issue":"8","key":"pmed.1003208.ref012","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/S1473-3099(14)70780-7","article-title":"Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data","volume":"14","author":"TP Van Boeckel","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"pmed.1003208.ref013","first-page":"73","article-title":"Variation in antibiotic use among and within different settings: a systematic review","author":"V Zanichelli","year":"2018","journal-title":"J Antimicrob Chemother"},{"issue":"1","key":"pmed.1003208.ref014","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S1473-3099(18)30547-4","article-title":"Consumption of oral antibiotic formulations for young children according to the WHO Access, Watch, Reserve (AWaRe) antibiotic groups: an analysis of sales data from 70 middle-income and high-income countries","volume":"19","author":"Y Hsia","year":"2019","journal-title":"Lancet Infect Dis"},{"issue":"3","key":"pmed.1003208.ref015","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/1475-6773.12260","volume":"50","author":"EM Sarpong","year":"2015","journal-title":"Health Serv Res"},{"key":"pmed.1003208.ref016","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3389\/fped.2018.00260","article-title":"Antibiotic use in febrile children presenting to the emergency department: a systematic review","volume":"6","author":"EMF van de Voort","year":"2018","journal-title":"Front Pediatr."},{"issue":"9","key":"pmed.1003208.ref017","first-page":"1308","article-title":"US outpatient antibiotic prescribing variation according to geography, patient population, and provider specialty in 2011","volume":"60","author":"LA Hicks","year":"2015","journal-title":"Clin Infect Dis"},{"key":"pmed.1003208.ref018","unstructured":"PERFORM. About PERFORM: Personalised Risk assessment in Febrile illness to Optimise Real-life Management London: PERFORM; 2019 [cited 2019 Sep 10]. Available from: https:\/\/www.perform2020.org\/."},{"issue":"1","key":"pmed.1003208.ref019","doi-asserted-by":"crossref","first-page":"e000456","DOI":"10.1136\/bmjpo-2019-000456","article-title":"Diversity in the emergency care for febrile children in Europe: a questionnaire study","volume":"3","author":"D Borensztajn","year":"2019","journal-title":"BMJ Paediatr Open"},{"issue":"12","key":"pmed.1003208.ref020","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/S0895-4356(96)00236-3","article-title":"A simulation study of the number of events per variable in logistic regression analysis","volume":"49","author":"P Peduzzi","year":"1996","journal-title":"J Clin Epidemiol"},{"issue":"2","key":"pmed.1003208.ref021","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2014a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"PA Harris","year":"2009","journal-title":"J Biomed Inform"},{"issue":"6","key":"pmed.1003208.ref022","doi-asserted-by":"crossref","first-page":"e1647","DOI":"10.1542\/peds.2013-3875","article-title":"Pediatric medical complexity algorithm: a new method to stratify children by medical complexity","volume":"133","author":"TD Simon","year":"2014","journal-title":"Pediatrics"},{"key":"pmed.1003208.ref023","volume-title":"Fever in under 5s: assessment and initial management. Clinical guideline CG160","author":"National Institute for Health and Care Excellence","year":"2013"},{"issue":"1","key":"pmed.1003208.ref024","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1186\/s12879-018-3300-9","article-title":"Observational multi-centre, prospective study to characterize novel pathogen-and host-related factors in hospitalized patients with lower respiratory tract infections and\/or sepsis\u2014the \u201cTAILORED-Treatment\u201d study","volume":"18","author":"CB van Houten","year":"2018","journal-title":"BMC Infect Dis"},{"issue":"8","key":"pmed.1003208.ref025","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1001\/jama.2016.11236","article-title":"Diagnostic test accuracy of a 2-transcript host RNA signature for discriminating bacterial vs viral infection in febrile children","volume":"316","author":"JA Herberg","year":"2016","journal-title":"JAMA"},{"issue":"6","key":"pmed.1003208.ref026","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S2352-4642(18)30113-5","article-title":"Life-threatening infections in children in Europe (the EUCLIDS Project): a prospective cohort study","volume":"2","author":"F Martinon-Torres","year":"2018","journal-title":"Lancet Child Adolesc Health"},{"issue":"8","key":"pmed.1003208.ref027","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1093\/jac\/dkw117","article-title":"Antibiotic prescribing in Danish general practice 2004\u201313","volume":"71","author":"R Aabenhus","year":"2016","journal-title":"J Antimicrob Chemother"},{"issue":"23","key":"pmed.1003208.ref028","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1001\/jama.2017.18715","article-title":"Association of broad- vs narrow-spectrum antibiotics with treatment failure, adverse events, and quality of life in children with acute respiratory tract infections","volume":"318","author":"JS Gerber","year":"2017","journal-title":"JAMA"},{"key":"pmed.1003208.ref029","unstructured":"National Institute for Health and Care Excellence. Antimicrobial prescribing guidelines. London: National Institute for Health and Care Excellence; 2020 [cited 2020 Feb 17]. Available from: https:\/\/www.nice.org.uk\/about\/what-we-do\/our-programmes\/nice-guidance\/antimicrobial-prescribing-guidelines."},{"key":"pmed.1003208.ref030","unstructured":"Public Health England, National Institute for Health and Care Excellence. Managing common infections: guidance for primary care. London: Public Health England; 2019 [cited 2020 Feb 17]. Available from: https:\/\/www.gov.uk\/government\/publications\/managing-common-infections-guidance-for-primary-care."},{"key":"pmed.1003208.ref031","doi-asserted-by":"crossref","first-page":"l440","DOI":"10.1136\/bmj.l440","article-title":"Duration of antibiotic treatment for common infections in English primary care: cross sectional analysis and comparison with guidelines","volume":"364","author":"KB Pouwels","year":"2019","journal-title":"BMJ"},{"issue":"1","key":"pmed.1003208.ref032","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1467-9531.2007.00180.x","article-title":"Regression with missing Ys: an improved strategy for analyzing multiply imputed data","volume":"37","author":"PT von Hippel","year":"2007","journal-title":"Sociol Methodol"},{"key":"pmed.1003208.ref033","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting linear mixed-effects models using lme4","volume":"67","author":"D Bates","year":"2015","journal-title":"J Stat Softw"},{"issue":"9717","key":"pmed.1003208.ref034","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/S0140-6736(09)62000-6","article-title":"European Research Network on Recognising Serious Infection investigators. Diagnostic value of clinical features at presentation to identify serious infection in children in developed countries: a systematic review","volume":"375","author":"A Van den Bruel","year":"2010","journal-title":"Lancet"},{"issue":"12","key":"pmed.1003208.ref035","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1136\/adc.2009.176800","article-title":"Validation of a laboratory risk index score for the identification of severe bacterial infection in children with fever without source","volume":"95","author":"A Galetto-Lacour","year":"2010","journal-title":"Arch Dis Child"},{"key":"pmed.1003208.ref036","doi-asserted-by":"crossref","first-page":"d3082","DOI":"10.1136\/bmj.d3082","article-title":"Diagnostic value of laboratory tests in identifying serious infections in febrile children: systematic review","volume":"342","author":"A Van den Bruel","year":"2011","journal-title":"BMJ"},{"key":"pmed.1003208.ref037","first-page":"0046958015571130","article-title":"The volume-quality relationship in antibiotic prescribing: when more isn\u2019t better","volume":"52","author":"CA Gidengil","year":"2015","journal-title":"Inquiry"},{"key":"pmed.1003208.ref038","doi-asserted-by":"crossref","first-page":"702053","DOI":"10.1155\/2014\/702053","article-title":"Management of fever in postpneumococcal vaccine era: comparison of management practices by pediatric emergency medicine and general emergency medicine physicians","volume":"2014","author":"H Khine","year":"2014","journal-title":"Emerg Med Int"},{"key":"pmed.1003208.ref039","article-title":"A pragmatic study to evaluate the use of a rapid diagnostic test to detect group A streptococcal pharyngitis in children with the aim of reducing antibiotic use in a UK emergency department","author":"C Bird","year":"2018","journal-title":"Pediatr Emerg Care"},{"issue":"668","key":"pmed.1003208.ref040","doi-asserted-by":"crossref","first-page":"e204","DOI":"10.3399\/bjgp18X695033","article-title":"Reducing inappropriate antibiotic prescribing for children in primary care: a cluster randomised controlled trial of two interventions","volume":"68","author":"MB Lemiengre","year":"2018","journal-title":"Br J Gen Pract"},{"key":"pmed.1003208.ref041","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1471-2288-12-28","article-title":"Hospital-level associations with 30-day patient mortality after cardiac surgery: a tutorial on the application and interpretation of marginal and multilevel logistic regression","volume":"12","author":"M Sanagou","year":"2012","journal-title":"BMC Med Res Methodol"},{"issue":"1","key":"pmed.1003208.ref042","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1186\/s12889-017-4905-4","article-title":"Prevalence of antibiotic prescription in pediatric outpatients in Italy: the role of local health districts and primary care physicians in determining variation. A multilevel design for healthcare decision support","volume":"17","author":"M Di Martino","year":"2017","journal-title":"BMC Public Health"},{"key":"pmed.1003208.ref043","author":"World Health Organization","year":"2017"},{"key":"pmed.1003208.ref044","volume-title":"WHO model list of essential medicines for children","author":"World Health Organization","year":"2017"},{"issue":"7","key":"pmed.1003208.ref045","doi-asserted-by":"crossref","first-page":"e861","DOI":"10.1016\/S2214-109X(19)30071-3","article-title":"Use of the WHO Access, Watch, and Reserve classification to define patterns of hospital antibiotic use (AWaRe): an analysis of paediatric survey data from 56 countries","volume":"7","author":"Y Hsia","year":"2019","journal-title":"Lancet Glob Health"},{"issue":"2","key":"pmed.1003208.ref046","doi-asserted-by":"crossref","first-page":"e20181056","DOI":"10.1542\/peds.2018-1056","article-title":"Antibiotic prescribing for children in United States emergency departments: 2009\u20132014","volume":"143","author":"NM Poole","year":"2019","journal-title":"Pediatrics"},{"issue":"12","key":"pmed.1003208.ref047","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1001\/jamainternmed.2016.6625","article-title":"Outpatient Antibiotic Use Target-Setting Workgroup. Frequency of first-line antibiotic selection among US ambulatory care visits for otitis media, sinusitis, and pharyngitis","volume":"176","author":"AL Hersh","year":"2016","journal-title":"JAMA Intern Med"},{"issue":"11","key":"pmed.1003208.ref048","doi-asserted-by":"crossref","first-page":"e01060","DOI":"10.1128\/AAC.01060-19","article-title":"First-line antibiotic selection in outpatient settings","volume":"63","author":"DL Palms","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"key":"pmed.1003208.ref049","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jpeds.2018.07.044","article-title":"Variability in antibiotic prescribing for upper respiratory illnesses by provider specialty","volume":"203","author":"HM Frost","year":"2018","journal-title":"J Pediatr"},{"issue":"12","key":"pmed.1003208.ref050","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1097\/INF.0000000000002004","article-title":"Variation in outpatient antibiotic dispensing for respiratory infections in children by clinician specialty and treatment setting","volume":"37","author":"A Agiro","year":"2018","journal-title":"Pediatr Infect Dis J"},{"key":"pmed.1003208.ref051","volume-title":"WHO UNICEF review of national immunization coverage","author":"World Health Organization","year":"1980"},{"issue":"5","key":"pmed.1003208.ref052","doi-asserted-by":"crossref","first-page":"e1141","DOI":"10.1542\/peds.2013-1614","article-title":"Narrow vs broad-spectrum antimicrobial therapy for children hospitalized with pneumonia","volume":"132","author":"DJ Williams","year":"2013","journal-title":"Pediatrics"}],"container-title":["PLOS Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pmed.1003208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T13:31:41Z","timestamp":1597843901000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pmed.1003208"}},"subtitle":[],"editor":[{"given":"Jean-Louis","family":"Vincent","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,8,19]]},"references-count":52,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,8,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pmed.1003208","relation":{},"ISSN":["1549-1676"],"issn-type":[{"value":"1549-1676","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,19]]}}}