{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:48:21Z","timestamp":1793742501040,"version":"4.6.1"},"update-to":[{"DOI":"10.1371\/journal.pmed.1003528","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000}}],"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["HEALTH-2010-F2-265396"],"award-info":[{"award-number":["HEALTH-2010-F2-265396"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosmedicine.org"],"crossmark-restriction":false},"short-container-title":["PLoS Med"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Cervical cancer screening strategies using visual inspection or cytology may have suboptimal diagnostic accuracy for detection of precancer in women living with HIV (WLHIV). The optimal screen and screen\u2013triage strategy, age to initiate, and frequency of screening for WLHIV remain unclear. This study evaluated the sensitivity, specificity, and positive predictive value of different cervical cancer strategies in WLHIV in Africa.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods and findings<\/jats:title>\n<jats:p>WLHIV aged 25\u201350 years attending HIV treatment centres in Burkina Faso (BF) and South Africa (SA) from 5 December 2011 to 30 October 2012 were enrolled in a prospective evaluation study of visual inspection using acetic acid (VIA) or visual inspection using Lugol\u2019s iodine (VILI), high-risk human papillomavirus DNA test (Hybrid Capture 2 [HC2] or careHPV), and cytology for histology-verified high-grade cervical intraepithelial neoplasia (CIN2+\/CIN3+) at baseline and endline, a median 16 months later. Among 1,238 women (BF: 615; SA: 623), median age was 36 and 34 years (<jats:italic>p &lt;<\/jats:italic> 0.001), 28.6% and 49.6% ever had prior cervical cancer screening (<jats:italic>p &lt;<\/jats:italic> 0.001), and 69.9% and 64.2% were taking ART at enrolment (<jats:italic>p =<\/jats:italic> 0.045) in BF and SA, respectively. CIN2+ prevalence was 5.8% and 22.4% in BF and SA (<jats:italic>p &lt;<\/jats:italic> 0.001), respectively. VIA had low sensitivity for CIN2+ (44.7%, 95% confidence interval [CI] 36.9%\u201352.7%) and CIN3+ (56.1%, 95% CI 43.3%\u201368.3%) in both countries, with specificity for \u2264CIN1 of 78.7% (95% CI 76.0%\u201381.3%). HC2 had sensitivity of 88.8% (95% CI 82.9%\u201393.2%) for CIN2+ and 86.4% (95% CI 75.7%\u201393.6%) for CIN3+. Specificity for \u2264CIN1 was 55.4% (95% CI 52.2%\u201358.6%), and screen positivity was 51.3%. Specificity was higher with a restricted genotype (HPV16\/18\/31\/33\/35\/45\/52\/58) approach (73.5%, 95% CI 70.6%\u201376.2%), with lower screen positivity (33.7%), although there was lower sensitivity for CIN3+ (77.3%, 95% CI 65.3%\u201386.7%). In BF, HC2 was more sensitive for CIN2+\/CIN3+ compared to VIA\/VILI (relative sensitivity for CIN2+ = 1.72, 95% CI 1.28\u20132.32; CIN3+: 1.18, 95% CI 0.94\u20131.49). Triage of HC2-positive women with VIA\/VILI reduced the number of colposcopy referrals, but with loss in sensitivity for CIN2+ (58.1%) but not for CIN3+ (84.6%). In SA, cytology high-grade squamous intraepithelial lesion or greater (HSIL+) had best combination of sensitivity (CIN2+: 70.1%, 95% CI 61.3%\u201377.9%; CIN3+: 80.8%, 95% CI 67.5%\u201390.4%) and specificity (81.6%, 95% CI 77.6%\u201385.1%). HC2 had similar sensitivity for CIN3+ (83.0%, 95% CI 70.2%\u201391.9%) but lower specificity compared to HSIL+ (42.7%, 95% CI 38.4%\u201347.1%; relative specificity = 0.57, 95% CI 0.52\u20130.63), resulting in almost twice as many referrals. Compared to HC2, triage of HC2-positive women with HSIL+ resulted in a 40% reduction in colposcopy referrals but was associated with some loss in sensitivity. CIN2+ incidence over a median 16 months was highest among VIA baseline screen-negative women (2.2%, 95% CI 1.3%\u20133.7%) and women who were baseline double-negative with HC2 and VIA (2.1%, 95% CI 1.3%\u20133.5%) and lowest among HC2 baseline screen-negative women (0.5%, 95% CI 0.1%\u20131.8%). Limitations of our study are that WLHIV included in the study may not reflect a contemporary cohort of WLHIV initiating ART in the universal ART era and that we did not evaluate HPV tests available in study settings today.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>In this cohort study among WLHIV in Africa, a human papillomavirus (HPV) test targeting 14 high-risk (HR) types had higher sensitivity to detect CIN2+ compared to visual inspection but had low specificity, although a restricted genotype approach targeting 8 HR types decreased the number of unnecessary colposcopy referrals. Cytology HSIL+ had optimal performance for CIN2+\/CIN3+ detection in SA. Triage of HPV-positive women with HSIL+ maintained high specificity but with some loss in sensitivity compared to HC2 alone.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pmed.1003528","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T19:06:56Z","timestamp":1614884816000},"page":"e1003528","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmed.corrections_policy","source":"Crossref","is-referenced-by-count":38,"title":["Diagnostic accuracy of cervical cancer screening and screening\u2013triage strategies among women living with HIV-1 in Burkina Faso and South Africa: A cohort study"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5547-3807","authenticated-orcid":true,"given":"Helen 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