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Adult stroke survivors between 6 and 36 months post-stroke with capacity to use the intervention (determined by a score of \u22654 on the Modified Rankin Scale) and who had access and willingness to use the internet were recruited via mail-out invitations from 1 national and 1 regional stroke registry. Participants completed baseline (<jats:italic>n<\/jats:italic> = 399) and 6-month follow-up (<jats:italic>n<\/jats:italic> = 356; 89%) outcome assessments via computer-assisted telephone interviewing (CATI). At baseline the sample had an average age of 66 years (SD 12), and 65% were male. Randomisation occurred at the end of the baseline survey; CATI assessors and independent statisticians were blind to group allocation. The intervention group received remote access for a 12-week period to the online-only P2S program (<jats:italic>n<\/jats:italic> = 199; <jats:italic>n<\/jats:italic> = 28 lost at follow-up). The control group were emailed and posted a list of internet addresses of generic health websites (<jats:italic>n<\/jats:italic> = 200; <jats:italic>n<\/jats:italic> = 15 lost at follow-up). The primary outcome was HRQoL as measured by the EuroQol Visual Analogue Scale (EQ-VAS; self-rated global health); the outcome was assessed for differences between treatment groups at follow-up, adjusting for baseline measures. Secondary outcomes were HRQoL as measured by the EQ-5D (descriptive health state), diet quality, physical activity, alcohol consumption, smoking status, mood, physical functioning, and independent living. All outcomes included the variable \u2018stroke event (stroke\/transient ischaemic attack\/other)\u2019 as a covariate, and analysis was intention-to-treat. At 6 months, median EQ-VAS HRQoL score was significantly higher in the intervention group than the control group (85 vs 80, difference 5, 95% CI 0.79\u20139.21, <jats:italic>p<\/jats:italic> = 0.020). The results were robust to the assumption the data were missing at random; however, the results were not robust to the assumption that the difference in HRQoL between those with complete versus missing data was at least 3 points. Significantly higher proportions of people in the intervention group reported no problems with personal care (OR 2.17, 95% CI 1.05\u20134.48, <jats:italic>p<\/jats:italic> = 0.0359) and usual activities (OR 1.66, 95% CI 1.06\u20132.60, <jats:italic>p<\/jats:italic> = 0.0256) than in the control group. There were no significant differences between groups on all other secondary outcomes. The main limitation of the study is that the sample comprises mostly \u2018well\u2019 stroke survivors with limited to no disability.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The P2S online healthy lifestyle program improved stroke survivors\u2019 self-reported global ratings of HRQoL (as measured by EQ-VAS) at 6-month follow-up. Online platforms represent a promising tool to engage and support some stroke survivors.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Trial registration<\/jats:title>\n<jats:p>Australian New Zealand Clinical Trials Registry <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.anzctr.org.au\/Trial\/Registration\/TrialReview.aspx?id=372659&amp;isReview=true\" xlink:type=\"simple\">ACTRN12617001205325<\/jats:ext-link>.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pmed.1003966","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T17:21:44Z","timestamp":1650388904000},"page":"e1003966","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmed.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["Evaluation of an online intervention for improving stroke survivors\u2019 health-related quality of life: A randomised controlled 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