{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:13:25Z","timestamp":1793106805090,"version":"4.5.0"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ELHRA"}],"content-domain":{"domain":["www.plosmedicine.org"],"crossmark-restriction":false},"short-container-title":["PLoS Med"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Millions of young adolescents in low- and middle-income countries (LMICs) affected by humanitarian crises experience elevated rates of poor mental health. There is a need for scalable programs that can improve the mental health of young adolescents. This study evaluated the effectiveness of a nonspecialist delivered group-based intervention (Early Adolescent Skills for Emotions (EASE)) to improve young adolescents\u2019 mental health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods and findings<\/jats:title>\n                    <jats:p>\n                      In this single-blind, parallel, controlled trial, Syrian refugees aged 10 to 14 years in Jordan were identified through screening of psychological distress as defined by scores \u226515 on the Paediatric Symptom Scale. Participants were randomised to either EASE or enhanced usual care (EUC) involving referral to local psychosocial services (on a 1:1.6 ratio). Participants were aware of treatment allocation but assessors were blinded. Primary outcomes were scores on the Paediatric Symptom Checklist (PSC; internalising, externalising, and attentional difficulty scales) assessed at week 0, 9 weeks, and 3 months after treatment (primary outcome time point). It was hypothesised that EASE would result in greater reductions on internalising symptoms than EUC. Secondary outcomes were depression, posttraumatic stress, well-being, functioning, school belongingness, and caregivers\u2019 parenting and mental health. Between June 2019 and January 2020, 1,842 young adolescent refugees were screened for eligibility on the basis of psychological distress. There were 520 adolescents (28.2%) who screened positive, of whom 471 (90.6%) agreed to enter the trial. Overall, 185 were assigned to EASE and 286 to EUC, and 169 and 254 were retained at 3 months for EASE and EUC, respectively. Intent-to-treat analyses indicated that at 3 months, EASE resulted in greater reduction on the PSC-internalising scale than EUC (estimated mean difference 0.69, 95% CI 0.19 to 1.19;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.007; effect size, 0.38) but there were no differences for PSC-externalising (estimated mean difference 0.24, 95% CI \u22120.43 to 0.91;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.49; effect size, \u22120.10), PSC-attentional problem (estimated mean difference \u22120.01, 95% CI \u22120.51 to 0.54;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.97; effect size, \u22120.01) scores, or on depression, posttraumatic stress, well-being, functioning, or school belongingness. Relative to EUC, caregivers in EASE had less psychological distress (estimated mean difference 1.95, 95% CI 0.71 to 3.19;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002) and inconsistent disciplinary parenting (mean difference 1.54, 95% CI 1.03 to 2.05;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Secondary analyses that (a) focused on adolescents with probable internalising disorders; (b) completed the 3-month assessment; and (c) controlled for trauma exposure did not alter the primary results. Mediation analysis indicated that for caregivers in the EASE condition, reduction in inconsistent disciplinary parenting was associated with reduced attentional (\u03b2 = 0.11, SE 0.07; 95% CI 0.003, 0.274) and internalising (\u03b2 = 0.11, SE 0.07; 95% CI 0.003, 0.274) problems in their children. No adverse events were attributable to the intervention. A limitation was that EUC was not matched to EASE in terms of facilitator attention or group involvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EASE led to reduced internalising problems in young refugee adolescents and was associated with reduced distress and less inconsistent disciplinary parenting in caregivers. This intervention has the potential as a scalable intervention to mitigate young adolescents\u2019 emotional difficulties in LMIC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      Prospectively registered at Australian and New Zealand Clinical Trials Registry:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.anzctr.org.au\/Trial\/Registration\/TrialReview.aspx?id=ACTRN12619000341123\" xlink:type=\"simple\">ACTRN12619000341123<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pmed.1004046","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T13:30:34Z","timestamp":1660311034000},"page":"e1004046","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmed.corrections_policy","source":"Crossref","is-referenced-by-count":49,"title":["Effectiveness of a brief group behavioural intervention on psychological distress in young adolescent Syrian refugees: A randomised controlled trial"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9607-819X","authenticated-orcid":true,"given":"Richard A.","family":"Bryant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiysha","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7558-7059","authenticated-orcid":true,"given":"Ibrahim Said","family":"Aqel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Ghatasheh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rand","family":"Habashneh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6464-1582","authenticated-orcid":true,"given":"Katie S.","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6412-5887","authenticated-orcid":true,"given":"Sarah","family":"Watts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5925-8039","authenticated-orcid":true,"given":"Mark J. 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Goodenow","year":"1993","journal-title":"Psychol Sch"},{"key":"pmed.1004046.ref028","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00127-002-0580-5","article-title":"An alternative approach to cross-cultural function assessment","volume":"37","author":"P Bolton","year":"2002","journal-title":"Soc Psychiatry Psychiatr Epidemiol"},{"key":"pmed.1004046.ref029","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/NMD.0000000000000751","article-title":"Contributors to screening positive for mental illness in Lebanon\u2019s Shatila Palestinian refugee camp","volume":"206","author":"SP Segal","year":"2018","journal-title":"J Nerv Ment Dis"},{"key":"pmed.1004046.ref030","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1017\/S0033291702006074","article-title":"Short screening scales to monitor population prevalences and trends in non-specific psychological distress","volume":"32","author":"RC Kessler","year":"2002","journal-title":"Psychol Med"},{"key":"pmed.1004046.ref031","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1001\/archpsyc.60.2.184","article-title":"Screening for serious mental illness in the general population","volume":"60","author":"RC Kessler","year":"2003","journal-title":"Arch Gen Psychiatry"},{"key":"pmed.1004046.ref032","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1037\/pas0000214","article-title":"Examining the validity of the adapted Alabama Parenting Questionnaire-Parent Global Report Version","volume":"28","author":"E Maguin","year":"2016","journal-title":"Psychol Assess."},{"key":"pmed.1004046.ref033","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s10578-015-0581-8","article-title":"Parenting young Arab children: Psychometric properties of an adapted Arabic brief version of the Alabama Parenting Questionnaire","volume":"47","author":"A Badahdah","year":"2016","journal-title":"Child Psychiatry Hum Dev"},{"key":"pmed.1004046.ref034","volume-title":"Power analysis of trials with multilevel data","author":"M Moerbeek","year":"2016"},{"key":"pmed.1004046.ref035","volume-title":"Introduction to mediation, moderation, and conditional process analysis: A regression-based approach.","author":"AF Hayes","year":"2017"},{"key":"pmed.1004046.ref036","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jaac.2018.06.033","article-title":"Disciplinary parenting practice and child mental health: evidence from the UK Millennium Cohort Study","volume":"58","author":"P Rajyaguru","year":"2019","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"pmed.1004046.ref037","doi-asserted-by":"crossref","first-page":"104512","DOI":"10.1016\/j.chiabu.2020.104512","article-title":"Supporting Syrian families displaced by armed conflict: a pilot randomized controlled trial of the Caregiver Support Intervention","volume":"106","author":"KE Miller","year":"2020","journal-title":"Child Abuse Negl"}],"container-title":["PLOS Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pmed.1004046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T13:31:34Z","timestamp":1660311094000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pmed.1004046"}},"subtitle":[],"editor":[{"given":"Rebecca F.","family":"Grais","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,8,12]]},"references-count":37,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,8,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pmed.1004046","relation":{},"ISSN":["1549-1676"],"issn-type":[{"value":"1549-1676","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,12]]}}}