{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T22:39:20Z","timestamp":1793659160928,"version":"4.5.1"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosmedicine.org"],"crossmark-restriction":false},"short-container-title":["PLoS Med"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute neurological manifestation is a common complication of acute Coronavirus Disease 2019 (COVID-19) disease. This retrospective cohort study investigated the 3-year outcomes of patients with and without significant neurological manifestations during initial COVID-19 hospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods and findings<\/jats:title>\n                    <jats:p>\n                      Patients hospitalized for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection between 03\/01\/2020 and 4\/16\/2020 in the Montefiore Health System in the Bronx, an epicenter of the early pandemic, were included. Follow-up data was captured up to 01\/23\/2023 (3 years post-COVID-19). This cohort consisted of 414 patients with COVID-19 with significant neurological manifestations and 1,199 propensity-matched patients (for age and COVID-19 severity score) with COVID-19 without neurological manifestations. Neurological involvement during the acute phase included acute stroke, new or recrudescent seizures, anatomic brain lesions, presence of altered mentation with evidence for impaired cognition or arousal, and neuro-COVID-19 complex (headache, anosmia, ageusia, chemesthesis, vertigo, presyncope, paresthesias, cranial nerve abnormalities, ataxia, dysautonomia, and skeletal muscle injury with normal orientation and arousal signs). There were no significant group differences in female sex composition (44.93% versus 48.21%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.249), ICU and IMV status, white, not Hispanic (6.52% versus 7.84%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.380), and Hispanic (33.57% versus 38.20%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.093), except black non-Hispanic (42.51% versus 36.03%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.019). Primary outcomes were mortality, stroke, heart attack, major adverse cardiovascular events (MACE), reinfection, and hospital readmission post-discharge. Secondary outcomes were neuroimaging findings (hemorrhage, active and prior stroke, mass effect, microhemorrhages, white matter changes, microvascular disease (MVD), and volume loss). More patients in the neurological cohort were discharged to acute rehabilitation (10.39% versus 3.34%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) or skilled nursing facilities (35.75% versus 25.35%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and fewer to home (50.24% versus 66.64%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) than matched controls. Incidence of readmission for any reason (65.70% versus 60.72%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.036), stroke (6.28% versus 2.34%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), and MACE (20.53% versus 16.51%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.032) was higher in the neurological cohort post-discharge. Per Kaplan\u2013Meier univariate survival curve analysis, such patients in the neurological cohort were more likely to die post-discharge compared to controls (hazard ratio: 2.346, (95% confidence interval (CI) [1.586, 3.470];\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001)). Across both cohorts, the major causes of death post-discharge were heart disease (13.79% neurological, 15.38% control), sepsis (8.63%, 17.58%), influenza and pneumonia (13.79%, 9.89%), COVID-19 (10.34%, 7.69%), and acute respiratory distress syndrome (ARDS) (10.34%, 6.59%). Factors associated with mortality after leaving the hospital involved the neurological cohort (odds ratio (OR): 1.802 (95% CI [1.237, 2.608];\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002)), discharge disposition (OR: 1.508 (95% CI [1.276, 1.775];\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001)), congestive heart failure (OR: 2.281 (95% CI [1.429, 3.593];\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001)), higher COVID-19 severity score (OR: 1.177 (95% CI [1.062, 1.304];\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002)), and older age (OR: 1.027 (95% CI [1.010, 1.044];\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002)). There were no group differences in radiological findings, except that the neurological cohort showed significantly more age-adjusted brain volume loss (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.045) than controls. The study\u2019s patient cohort was limited to patients infected with COVID-19 during the first wave of the pandemic, when hospitals were overburdened, vaccines were not yet available, and treatments were limited. Patient profiles might differ when interrogating subsequent waves.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with COVID-19 with neurological manifestations had worse long-term outcomes compared to matched controls. These findings raise awareness and the need for closer monitoring and timely interventions for patients with COVID-19 with neurological manifestations, as their disease course involving initial neurological manifestations is associated with enhanced morbidity and mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pmed.1004263","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T13:21:56Z","timestamp":1712236916000},"page":"e1004263","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmed.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["Long-term outcomes of hospitalized patients with SARS-CoV-2\/COVID-19 with and without neurological involvement: 3-year follow-up assessment"],"prefix":"10.1371","volume":"21","author":[{"given":"Anna","family":"Eligulashvili","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3338-6870","authenticated-orcid":true,"given":"Moshe","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy S.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeylin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv","family":"Mehrotra-Varma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jai","family":"Mehrotra-Varma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imanyah","family":"Hilliard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9187-0148","authenticated-orcid":true,"given":"Arleen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8325-2382","authenticated-orcid":true,"given":"Muhammed Amir","family":"Essibayi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9663-956X","authenticated-orcid":true,"given":"Judy","family":"Yee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5130-1378","authenticated-orcid":true,"given":"David J.","family":"Altschul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad","family":"Eskandar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0674-7781","authenticated-orcid":true,"given":"Mark F.","family":"Mehler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6403-2827","authenticated-orcid":true,"given":"Tim Q.","family":"Duong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"key":"pmed.1004263.ref001","doi-asserted-by":"crossref","first-page":"100463","DOI":"10.1016\/j.eclinm.2020.100463","article-title":"Follow-up study of the pulmonary function and related physiological characteristics of COVID-19 survivors three months after recovery.","volume":"25","author":"YM Zhao","year":"2020","journal-title":"EClinicalMedicine."},{"issue":"2","key":"pmed.1004263.ref002","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.cmi.2020.09.052","article-title":"Follow-up of adults with noncritical COVID-19 two months after symptom onset","volume":"27","author":"C Carvalho-Schneider","year":"2020","journal-title":"Clin Microbiol Infect"},{"issue":"14","key":"pmed.1004263.ref003","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1001\/jama.2020.17709","article-title":"As Their Numbers Grow, COVID-19 \u201cLong Haulers","volume":"324","author":"R. 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COVID-19 associated-abnormal liver function test 2 months after hospital discharge.","volume":"12","author":"JY Lu","year":"2022","journal-title":"Sci Rep."},{"key":"pmed.1004263.ref022","doi-asserted-by":"crossref","first-page":"104487","DOI":"10.1016\/j.ebiom.2023.104487","article-title":"Incidence of new-onset in-hospital and persistent diabetes in COVID-19 patients: comparison with influenza.","volume":"90","author":"JY Lu","year":"2023","journal-title":"EBioMedicine."},{"issue":"1","key":"pmed.1004263.ref023","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s15010-021-01646-1","article-title":"Longitudinal prediction of hospital-acquired acute kidney injury in COVID-19: a two-center study.","volume":"50","author":"JY Lu","year":"2022","journal-title":"Infection."},{"key":"pmed.1004263.ref024","article-title":"Long-term outcomes of COVID-19 survivors with hospital AKI: association with time to recovery from AKI.","author":"JY Lu","year":"2023","journal-title":"Nephrol Dial Transplant."},{"key":"pmed.1004263.ref025","first-page":"574","article-title":"Observational Health Data Sciences and Informatics (OHDSI): Opportunities for Observational Researchers.","volume":"216","author":"G Hripcsak","year":"2015","journal-title":"Stud Health Technol Inform."},{"issue":"12","key":"pmed.1004263.ref026","doi-asserted-by":"crossref","first-page":"e020910","DOI":"10.1161\/JAHA.121.020910","article-title":"Association of Kidney Disease With Outcomes in COVID-19: Results From the American Heart Association COVID-19 Cardiovascular Disease Registry.","volume":"10","author":"A Rao","year":"2021","journal-title":"J Am Heart Assoc."},{"issue":"10","key":"pmed.1004263.ref027","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1093\/cvr\/cvac068","article-title":"Association between BNT162b2 or CoronaVac COVID-19 vaccines and major adverse cardiovascular events among individuals with cardiovascular disease","volume":"118","author":"X Ye","year":"2022","journal-title":"Cardiovasc Res"},{"issue":"45","key":"pmed.1004263.ref028","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.15585\/mmwr.mm6945e2","article-title":"Characteristics of Hospitalized COVID-19 Patients Discharged and Experiencing Same-Hospital Readmission\u2014United States, March-August 2020.","volume":"69","author":"Lavery AMPL","year":"2020","journal-title":"MMWR Morb Mortal Wkly Rep."},{"issue":"1","key":"pmed.1004263.ref029","doi-asserted-by":"crossref","first-page":"21039","DOI":"10.1038\/s41598-021-00246-1","article-title":"Characterizing non-critically ill COVID-19 survivors with and without in-hospital rehabilitation.","volume":"11","author":"B Musheyev","year":"2021","journal-title":"Sci Rep."},{"issue":"1","key":"pmed.1004263.ref030","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40560-021-00542-y","article-title":"Functional status of mechanically ventilated COVID-19 survivors at ICU and hospital discharge.","volume":"9","author":"B Musheyev","year":"2021","journal-title":"J Intensive Care"},{"issue":"2","key":"pmed.1004263.ref031","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s11739-023-03195-x","article-title":"Longitudinal medical subspecialty follow-up of critically and non-critically ill hospitalized COVID-19 survivors up to 24 months after discharge.","volume":"18","author":"B Musheyev","year":"2023","journal-title":"Intern Emerg Med"},{"key":"pmed.1004263.ref032","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijid.2023.01.038","article-title":"Discharge disposition and clinical outcomes of patients hospitalized with COVID-19","volume":"130","author":"S Patel","year":"2023","journal-title":"Int J Infect Dis"},{"issue":"1","key":"pmed.1004263.ref033","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/jmv.27281","article-title":"Epidemiologic characteristics of cases with reinfection, recurrence, and hospital readmission due to COVID-19: A systematic review and meta-analysis","volume":"94","author":"STN Sotoodeh Ghorbani","year":"2022","journal-title":"J Med Virol"},{"issue":"11","key":"pmed.1004263.ref034","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1590\/1806-9282.20210675","article-title":"Readmission rates of patients with COVID-19 after hospital discharge.","volume":"67","author":"KM Alanli R","year":"2021","journal-title":"Rev Assoc Med Bras (1992)."},{"key":"pmed.1004263.ref035","doi-asserted-by":"crossref","first-page":"100061","DOI":"10.1016\/j.clinsp.2022.100061","article-title":"Frequency and factors associated with hospital readmission after COVID-19 hospitalization: the importance of post-COVID diarrhea.","volume":"77","author":"Freire MPOM","year":"2022","journal-title":"Clinics (Sao Paulo)."},{"key":"pmed.1004263.ref036","doi-asserted-by":"crossref","first-page":"n693","DOI":"10.1136\/bmj.n693","article-title":"Post-covid syndrome in individuals admitted to hospital with covid-19: retrospective cohort study","volume":"372","author":"D Ayoubkhani","year":"2021","journal-title":"BMJ"},{"issue":"7","key":"pmed.1004263.ref037","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s11883-022-01032-8","article-title":"Long-Term Cardiovascular Effects of COVID-19: Emerging Data Relevant to the Cardiovascular Clinician.","volume":"24","author":"DLPA Tobler","year":"2022","journal-title":"Curr Atheroscler Rep."},{"issue":"4","key":"pmed.1004263.ref038","doi-asserted-by":"crossref","first-page":"700","DOI":"10.3390\/v13040700","article-title":"Long-COVID and Post-COVID Health Complications: An Up-to-Date Review on Clinical Conditions and Their Possible Molecular Mechanisms.","volume":"13","author":"BSS Silva Andrade","year":"2021","journal-title":"Viruses."},{"issue":"12","key":"pmed.1004263.ref039","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1007\/s11886-022-01793-3","article-title":"Cardiac Manifestations of Post-Acute 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