{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T20:57:51Z","timestamp":1783198671246,"version":"3.54.6"},"update-to":[{"DOI":"10.1371\/journal.pmed.1004687","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000}}],"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The National Key R&D Program of China","award":["2017YFC0908200"],"award-info":[{"award-number":["2017YFC0908200"]}]},{"name":"the Key R&D Program of Zhejiang","award":["2023C03049"],"award-info":[{"award-number":["2023C03049"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82072360"],"award-info":[{"award-number":["82072360"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072624"],"award-info":[{"award-number":["82072624"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["Q23H260015"],"award-info":[{"award-number":["Q23H260015"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Project of the regional diagnosis and treatment center of the Health Planning Committee","award":["JBZX-201903"],"award-info":[{"award-number":["JBZX-201903"]}]},{"name":"the Natural Science Fund for Distinguished Young Scholars of Zhejiang Province","award":["LR22H260001"],"award-info":[{"award-number":["LR22H260001"]}]},{"DOI":"10.13039\/501100001809","name":"the National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["82204019"],"award-info":[{"award-number":["82204019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosmedicine.org"],"crossmark-restriction":false},"short-container-title":["PLoS Med"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Although the fecal immunochemical test (FIT) is widely utilized in colorectal cancer (CRC) screening because of its noninvasive, rapid, and cost-effective characteristics, its effectiveness in post-adenoma resection surveillance remains unclear. This study aims to evaluate the benefits of follow-up FIT surveillance in individuals with adenoma resection and to identify risk factors associated with adenoma recurrence.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods and findings<\/jats:title>\n<jats:p>As part of China\u2019s National Screening Project, we identified a total of 5,911 individuals who underwent adenoma removal during the first round of CRC screening in Jiashan and Haining between 2006 and 2021. All individuals with adenoma removal were invited to participate in a second CRC screening; 2,448 accepted and chose either direct colonoscopy surveillance (<jats:italic>n<\/jats:italic>\u2009=\u2009989) or FIT surveillance (<jats:italic>n<\/jats:italic>\u2009=\u20091,459), while 3,463 declined. The Clone-Censor-Weight method was applied to mitigate time-related biases. Cox proportional hazards and Poisson regression models were used to evaluate the benefits of follow-up surveillance strategies after adenoma resection, adjusting for age, sex, baseline adenoma grade, family history of CRC in first-degree relatives, symptoms, chronic appendicitis or cholecystitis, and stressful life events. Additionally, we examined the risk factors associated with adenoma recurrence using logistic regression. The outcomes were the long-term incidence of CRC and the recurrence of adenomas following adenoma resection. Over average follow-up of 7.79 and 7.46 years, participants who underwent protocol-adherent follow-up FIT surveillance had a 44% lower CRC risk (hazard ratio [HR] = 0.56, 95% confidence interval [CI]: 0.31, 0.98; <jats:italic>p<\/jats:italic>\u2009=\u20090.044), and those who underwent direct colonoscopy had a 51% lower risk (HR\u2009=\u20090.49, 95% CI [0.27, 0.89]; <jats:italic>p<\/jats:italic>\u2009=\u20090.019), compared to individuals who refused follow-up surveillance. Compared with the direct follow-up colonoscopy group (53.56 per 100,000 person-years), the long-term CRC incidence rates were 70.38 for the follow-up negative FIT group and 80.14 for the positive FIT with adherence to colonoscopy group, with no statistically significant differences (<jats:italic>p<\/jats:italic>\u2009=\u20090.852; <jats:italic>p<\/jats:italic>\u2009=\u20090.834). Notably, participants who did not undergo colonoscopy following a positive FIT had a significantly increased CRC risk compared to those in the direct follow-up colonoscopy group, with an adjusted incidence rate ratio (aIRR) of 6.64 (95% CI [1.11, 39.83]; <jats:italic>p<\/jats:italic>\u2009=\u20090.038). Alcohol consumption (nondrinkers versus\u2009&gt;3 times per week: adjusted odds ratio [aOR] = 0.43, 95% CI [0.27, 0.69]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) was associated with adenoma recurrence. Moreover, smoking (current smokers versus nonsmokers: aOR = 3.72, 95% CI [1.19, 11.60]; <jats:italic>p<\/jats:italic>\u2009=\u20090.024), obesity (obese versus normal: aOR = 3.21, 95% CI [1.17, 8.80]; <jats:italic>p<\/jats:italic>\u2009=\u20090.023), and having advanced adenomas at baseline (aOR = 3.30, 95% CI [1.41, 7.69]; <jats:italic>p<\/jats:italic>\u2009=\u20090.006) were associated with recurrence of advanced adenomas. Given the limited number of incident CRC cases and the observational study design, conclusions regarding the impact of follow-up FIT surveillance after adenoma removal should be interpreted with caution.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Protocol-adherent follow-up FIT surveillance after adenoma removal was associated with reduced long-term CRC risk, comparable to that observed with direct colonoscopy. However, improving adherence to colonoscopy after a positive FIT surveillance is crucial.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pmed.1004687","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T17:55:48Z","timestamp":1756835748000},"page":"e1004687","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmed.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fecal immunochemical test surveillance in colorectal cancer following adenoma resection: A longitudinal, population-based linked cohort study in 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