{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:50:05Z","timestamp":1788202205870,"version":"build-2803163510"},"update-to":[{"DOI":"10.1371\/journal.pmed.1004925","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000}}],"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009520","name":"Praxis Spinal Cord Institute","doi-asserted-by":"crossref","award":["G2019-21"],"award-info":[{"award-number":["G2019-21"]}],"id":[{"id":"10.13039\/100009520","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100002718","name":"Cervical Spine Research Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosmedicine.org"],"crossmark-restriction":false},"short-container-title":["PLoS Med"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The hemodynamic management of acute spinal cord injury (SCI) aims to improve perfusion and mitigate ischemic secondary injury to the injured spinal cord, traditionally through the augmentation of mean arterial pressure (MAP). Recently, there has been interest in managing spinal cord perfusion pressure (SCPP)\u2014the difference between MAP and intrathecal pressure (ITP) \u2014after acute SCI. SCPP may be more physiologically relevant than MAP for neurologic recovery after traumatic SCI. Drainage of cerebrospinal fluid (CSF) through a lumbar intrathecal catheter to reduce ITP and increase SCPP is commonly performed to reduce the risk of ischemic paralysis in thoracoabdominal aortic aneurysm (TAAA) surgery. We investigated a protocol for CSF drainage through intrathecal catheters to maintain SCPP \u226565 mmHg in participants with acute traumatic SCI. We sought to determine if managing SCPP was associated with better neurologic recovery compared to traditional MAP targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods and findings<\/jats:title>\n                    <jats:p>\n                      Fifty-eight participants with acute SCI (51\u2009\u00b1\u200919 years, 46M\/12F) were enrolled across eight North American sites between August 2019 and May 2024 into this prospective single-arm multi-center clinical trial of CSF drainage for SCPP management (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03911492\" xlink:type=\"simple\">NCT03911492<\/jats:ext-link>\n                      ). Data were compared to data from a historical cohort of 86 participants (44\u2009\u00b1\u200919 years, 72M\/14F) who had intrathecal catheters inserted for SCPP measurement only; these participants were managed according to conventional MAP guidelines with a target MAP of 85\u201390 mmHg (NCT01279811). MAP, ITP, SCPP, intrathecal waveform morphology, vasopressor use, and CSF drainage volume were reported for up to 7 days following SCI. Fifteen participants in the intervention group were lost to follow-up. Neurological assessments at enrollment and 6-months post-SCI were compared. The investigator team ended the trial when it was clear that adherence to the protocol was inconsistent across study sites. Participants managed according to the SCPP management protocol had an intrathecal catheter in place 138 hours (95% CI [129,147]) and 495cc (95% CI [350,641]) of CSF drained. No CSF was drained from seven participants. There were no significant differences in hemodynamic measures such as ITP and SCPP between groups, indicating that the SCPP management protocol did not alter the hemodynamic management. Subsequently, there were no differences in measures of neurological recovery between participants managed according to SCPP management protocol and conventional MAP guidelines (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.897). Participants managed according to an SCPP target had more ITP waveform recordings noted as dampened or fully pulsatile suggesting a patent subarachnoid space\n                      <jats:italic>(p<\/jats:italic>\n                      \u2009=\u20090.006) and were administered vasopressors on fewer hourly observations\n                      <jats:italic>(p<\/jats:italic>\n                      \u2009=\u20090.004). Six reported adverse events were probably related to the intervention. Adherence to a protocol for managing SCPP through CSF drainage across multiple sites was challenging.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ultimately, our protocol resulted in little CSF being drained, limited modification of ITP and SCPP, and no effect on neurological recovery. The relationship between CSF drainage volume and change in ITP was surprisingly unclear. This study revealed that draining CSF is more complex in traumatic SCI than in TAAA surgery patients. Future efforts to reduce ITP through CSF drainage likely need to address the occlusion of the subarachnoid space at the injury site through aggressive surgical decompression techniques.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pmed.1004925","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T18:47:51Z","timestamp":1770317271000},"page":"e1004925","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmed.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Targeting spinal cord perfusion pressure in acute spinal cord injury through cerebrospinal fluid drainage: A prospective multi-center clinical trial"],"prefix":"10.1371","volume":"23","author":[{"given":"Cameron 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