{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:51:04Z","timestamp":1791312664620,"version":"4.3.1"},"update-to":[{"DOI":"10.1371\/journal.pmed.1004947","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000}}],"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000910","name":"Conrad N. Hilton Foundation","doi-asserted-by":"publisher","award":["33175"],"award-info":[{"award-number":["33175"]}],"id":[{"id":"10.13039\/100000910","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["NIHR301621"],"award-info":[{"award-number":["NIHR301621"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020171","name":"Foreign, Commonwealth and Development Office","doi-asserted-by":"publisher","award":["(GB-EDU-133903-PENDA)"],"award-info":[{"award-number":["(GB-EDU-133903-PENDA)"]}],"id":[{"id":"10.13039\/501100020171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosmedicine.org"],"crossmark-restriction":false},"short-container-title":["PLoS Med"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mortality is a fundamental marker of population health and equity. Despite major global declines in mortality over recent decades, disparities in survival persist across childhood and adolescence, particularly by disability status. We aimed to synthesise current evidence on all-cause mortality among children and adolescents with disabilities compared to their non-disabled peers through a systematic review and meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods and findings<\/jats:title>\n                    <jats:p>\n                      This review was prospectively registered with PROSPERO (CRD420251072039). We searched Embase, Global Health, MEDLINE, PubMed and PsycInfo to identify relevant studies published from January 1, 2000 to August 20, 2026. We included cohort studies that compared all-cause mortality rates for children and adolescents with and without disabilities (aged 0\u201319 years). We excluded studies without a clear definition of disability, disaggregated mortality data, or a control group. Two authors independently screened studies, with data extraction by one and verification by a second. We assessed risk of bias using a Joanna Briggs Institute critical appraisal tool. We conducted meta-analyses in RevMan for studies reporting age-sex-adjusted or multivariable-adjusted mortality ratios and R software to assess for publication bias. We reported heterogeneity using the\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      and\n                      <jats:italic>\u03c4<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      statistics. We identified 12,664 records of which 29 studies met the inclusion criteria, representing over 35 million children\/adolescents. Sixteen studies were eligible to be included in the meta-analysis. Overall, children with disabilities had a 5.31-fold (95% confidence interval (CI) [3.63,7.77];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001;\n                      <jats:italic>\u03c4<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      \u2009=\u20090.88;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200998%) higher all-cause mortality than their peers. The association between disability and mortality was higher in both younger children 0\u20135 years (Hazard ratio (HR)=7.51: 95%CI [4.70,12.00];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001;\n                      <jats:italic>\u03c4<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      \u2009=\u20090.44;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      \u2009=\u200991%) and children 6\u201319 years (HR\u2009=\u20094.68: 95%CI [2.26,9.69];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001;\n                      <jats:italic>\u03c4<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      \u2009=\u20090.93;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      \u2009=\u200996%). The association varied by disability type and was most stark for children with neurological disabilities (HR\u2009=\u200911.71: 95%CI [7.90,17.35]; p\u2009&lt;\u20090.001;\n                      <jats:italic>\u03c4<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      \u2009=\u20090.19;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      \u2009=\u200976%). Interpretation is limited by substantial between-study heterogeneity, differences in methods used to ascertain disability ascertainment and in the effect measures used, and the small number of studies from low-income and middle-income countries.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Children with disabilities experience substantially higher mortality than their peers without disabilities. There is an urgent need for evidence on what works to close the mortality gap.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pmed.1004947","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:42:45Z","timestamp":1790790165000},"page":"e1004947","update-policy":"https:\/\/doi.org\/10.1371\/journal.pmed.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["The association between disability and mortality among children and adolescents: A systematic review and meta-analysis"],"prefix":"10.1371","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2312-0972","authenticated-orcid":true,"given":"Maureen","family":"Moyo-Chilufya","sequence":"first","affiliation":[{"name":"Stellenbosch University","place":["Cape Town, South Africa"],"department":["Department of Health and Rehabilitation Sciences, Division of Physiotherapy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthemon","family":"Nguweneza","sequence":"additional","affiliation":[{"name":"Stellenbosch University","place":["Cape Town, South Africa"],"department":["Department of Health and Rehabilitation Sciences, Division of Physiotherapy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6164-8877","authenticated-orcid":true,"given":"Sara","family":"Rotenberg","sequence":"additional","affiliation":[{"name":"London School of Hygiene & Tropical Medicine","place":["London, United Kingdom"],"department":["Department of Population Health, International Centre for Evidence in Disability"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8952-0023","authenticated-orcid":true,"given":"Hannah","family":"Kuper","sequence":"additional","affiliation":[{"name":"London School of Hygiene & Tropical Medicine","place":["London, United Kingdom"],"department":["Department of Population Health, International Centre for Evidence in Disability"]},{"name":"Missing Billion Initiative","place":["Seattle, Washington, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3408-7362","authenticated-orcid":true,"given":"Tracey","family":"Smythe","sequence":"additional","affiliation":[{"name":"Stellenbosch University","place":["Cape Town, South Africa"],"department":["Department of Health and Rehabilitation Sciences, Division of Physiotherapy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"pmed.1004947.ref001","volume-title":"Children with disabilities: Every child has the right to live in an inclusive world","author":"UNICEF"},{"key":"pmed.1004947.ref002","volume-title":"Social Inclusion - Social development issues(Disability)","author":"United Nations: Department of Economic and Social Affairs"},{"key":"pmed.1004947.ref003","volume-title":"Study on stigmatization of children with disabilities","author":"Insitute of Social Studies and Analysis","year":"2016"},{"issue":"1","key":"pmed.1004947.ref004","doi-asserted-by":"crossref","DOI":"10.1080\/2331186X.2021.1952824","article-title":"Exclusion of children with disabilities from early childhood education: Including approaches of social exclusion","volume":"8","author":"DA Hirpa","year":"2021","journal-title":"Cogent Education"},{"key":"pmed.1004947.ref005","first-page":"70","article-title":"Exclusion of children with disabilities in community development in Binga Rural Communities, Zimbabwe","volume":"10","author":"Q Mutale","year":"2020","journal-title":"AJSW"},{"key":"pmed.1004947.ref006","unstructured":"Kuper H, Heydt P. 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